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1086篇 您的检索式：作者名="Morrison C"

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	题名	作者	年代	出处	被引量
1	Murine hepatocellular carcinoma derived stem cells reveal epithelial-to-mesenchymal plasticity显示文摘AIM To establish a model to enrich and characterize stemlike cells from murine normal liver and hepatocellular carcinoma(HCC) cell lines and to further investigate stem-like cell association with epithelial-to-mesenchymal transition(EMT).METHODS In this study,we utilized a stem cell conditioned serumfree medium to enrich stem-like cells from mouse HCC and normal liver cell lines,Hepa 1-6 and AML12,respectively.We isolated the 3-dimensional spheres and assessed their stemness characteristics by evaluating theRNA levels of stemness genes and a cell surface stem cell marker by quantitative reverse transcriptase-PCR(q RTPCR).Next,we examined the relationship between stem cells and EMT using q RT-PCR.RESULTS Three-dimensional spheres were enriched by culturing murine HCC and normal hepatocyte cell lines in stem cell conditioned serum-free medium supplemented with epidermal growth factor,basic fibroblast growth factor and heparin sulfate.The 3-dimensional spheres had enhanced stemness markers such as Klf4 and Bmi1 and hepatic cancer stem cell(CSC) marker Cd44 compared to parental cells grown as adherent cultures.We report that epithelial markers E-cadherin and ZO-1 were downregulated,while mesenchymal markers Vimentin and Fibronectin were upregulated in 3-dimensional spheres.The 3-dimensional spheres also exhibited changes in expression of Snai,Zeb and Twist family of EMT transcription factors.CONCLUSION Our novel method successfully enriched stem-like cells which possessed an EMT phenotype.The isolation and characterization of murine hepatic CSCs could establish a precise target for the development of more effective therapies for HCC.	Aparna Jayachandran Ritu Shrestha Bijay Dhungel I-Tao Huang Marianna Yumi Kawashima Vasconcelos Brian J Morrison Charmaine A Ramlogan-Steel Jason C Steel	2017	World Journal of Stem Cells2017，9，9：	4
2	Prospective identification, isolation by flow cytometry, and in vivo self-renewal ofmultipotent mammalian neural crest stem cells显示文摘	Morrison SJ White PM Zock C		0，，：	2
3	Crystal-field analysis of triply ionized rare earth ions in lanthanum trifluoride显示文摘	MORRISON C A LEAVITT R P	1979	J Chem Phys1979，71，6：	2
4	CDX2 is a useful marker of intestinal-type differentiation : a tissue microarray-based study of 629 tumors from various sites 显示文摘	De Lott LB Morrison C Suster S	2005	Arch Pathol Lab MED2005，129，9：	1
5	Circadian rhythm of intraocular pressure in the rat显示文摘	MOORE C G JOHNSON E C MORRISON J C	1996	Curr Eye Res1996，15，：	1
6	Surgical management of intractable pain in chronic pancreatitis: past and present显示文摘	Morrison CP Wemyss-Holden SA Partensky C	2002	J Hepatobiliary Pancreat Surg2002，9，6：	1
7	Social Networking显示文摘	Weaver A C Morrison B B	2008	Computer2008，41，2：	1
8	Matrix metalloproteinases: What do they not do? New substrates and biological roles identified by murine models and proteomics显示文摘	Rodriguez D Morrison C J Overall CM	2010	Biochim Biophys Acta2010，1803，1：	1
9	Cloning of a delta opioid receptor by functional expression显示文摘	Evans C J Keith D E Morrison H	1992	Science1992，258，5090：	1
10	Airport infrastructure spillovers in a network system显示文摘	Cohen J P Morrison Paul C J	2003	Journal of Urban Economics2003，54，3：	1
11	Angiotensin Ⅱ type-1 receptor and ACE polymorphisms and risk of myocardial infarction in men and women显示文摘	Kee F Morrison C Poirier O	2000	Eur J Clin Invest2000，30，12：	1
12	Angiotensin Ⅱ type - Ⅰ receptor and ACE polymorphisms and risk of myocardial infarction in men and women显示文摘	Kee F Morrison C Poirier O	2000	Eur J Clin Invest2000，30，12：	1
13	Targeted deletion of A2A adenosine receptors attenuates the protective effects of myocardial postconditioning显示文摘	Morrison RR Tan XL Ledent C	2007	Am J Physiol Heart Circ Physiol2007，293，4：	1
14	The development of primary bud necrosis in Thompson Seedless and Flame Seedless grapevines显示文摘	Morrison J C Iodi M	1990	Vitis1990，29，：	1
15	A study of the history of the digestive tract of the Nile tilapia显示文摘	MORRISON C M WRIGHT J R	1999	J Fish Biol1999，54，：	1
16	International Attention and Multinational Enterprise Performance显示文摘	BOUQUET C MORRISON A BIRKINSHAW J	2009	Journal of International Business Studies2009，40，1：	1
17	SAR image autofocus by sharpness optimization:a theoretical study显示文摘	Morrison R L Do M N Munson D C		0，，09：	1
18	Ca Cu3Ti4O12:One-step internal barrier layer capacitor显示文摘	Sinclair D C Adams T B Morrison F D	2002	Applied Physics Letters2002，80，12：	1
19	Cost - effectiveness analysis of woodland ecosystem restoration 显示文摘	Macmillan D C Harley D Morrison R	1998	Ecological Economics1998，27，3：	1
20	Cognitive impairment following high fat diet consumption is associated with brain inflammation显示文摘	PISTELL P J MORRISON C D GUPTA S eta	2010	J Neuroimmunol2010，219，12：	1

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