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| 1 | Locally advanced rectal cancer:The importance of a multidisciplinary approach显示文摘Rectal cancer accounts for a relevant part of colorectal cancer cases,with a mortality of 4-10/100000 per year.The development of locoregional recurrences and the occurrence of distant metastases both influences the prognosis of these patients.In the last two decades,new multimodality strategies have improved the prognosis of locally advanced rectal cancer with a significant reduction of local relapse and an increase in terms of overall survival.Radical surgery still remains the principal curative treatment and the introduction of total mesorectal excision has significantly achieved a reduction in terms of local recurrence rates.The employment of neoadjuvant treatment,delivered before surgery,also achieved an improved local control and an increasedsphincter preservation rate in low-lying tumors,with an acceptable acute and late toxicity.This review describes the multidisciplinary management of rectal cancer,focusing on the effectiveness of neoadjuvant chemoradiotherapy and of post-operative adjuvant chemotherapy both in the standard combined modality treatment programs and in the ongoing research to improve these regimens. | Rossana Berardi Elena Maccaroni Azzurra Onofri Francesca Morgese Mariangela Torniai Michela Tiberi Consuelo Ferrini Stefano Cascinu | 2014 | World Journal of Gastroenterology2014，20，46： | 5 |
| 2 | Medical treatment for gastro-entero-pancreatic neuroendocrine tumours显示文摘Gastro-entero-pancreatic neuroendocrine neoplasms(GEPNENs) represents a various family of rare tumours. Surgery is the first choice in GEP-NENs patients with localized disease whilst in the metastatic setting many other treatment options are available. Somatostatin analogues are indicated for symptoms control in functioning tumours. Furthermore they may be effective to inhibit tumour progression. GEP-NENs pathogenesis has been extensively studied in the last years therefore several driver mutations pathway genes have been identified as crucial factors in their tumourigenesis. GEP-NENs can over-express vascular endothelial growth factor(VEGF), basic-fibroblastic growth factor, transforming growth factor(TGF-α and-β), platelet derived growth factor(PDGF), insulin-like growth factor-1(IGF-1) and their receptors PDGF receptor, IGF-1 receptor, epidermal growth factor receptor, VEGF receptor, and c-kit(stem cell factor receptor) that can be considered as potential targets. The availability of new targeted agents, such as everolimus and sunitinib that are effective in advanced and metastatic pancreatic neuroendocrine tumours, has provided new treatment opportunities. Many trials combing new drugs are ongoing. | Rossana Berardi Francesca Morgese Mariangela Torniai Agnese Savini Stefano Partelli Silvia Rinaldi Miriam Caramanti Consuelo Ferrini Massimo Falconi Stefano Cascinu | 2016 | World Journal of Gastrointestinal Oncology2016，8，4： | 2 |
| 3 | New trends in the etiopathogenesis of diabetic peripheral neuropathy显示文摘 | Verrotti A Giuva PT Morgese G | 2001 | J Child Neurol2001，16，6： | 1 |
| 4 | Premature thelarche: a long-term follow-up显示文摘 | Verrotti A Ferrari M Morgese G | 1996 | Gynecol Endocrinol1996，10，4： | 1 |
| 5 | Role of maspin in cancer显示文摘 | Berardi R Morgese F Onofri A | 2013 | Clin Transl Med2013，2，1： | 1 |
| 6 | New trends inthe etio pathogenesis of Diabetic Peripheral Neuropathy显示文摘 | Verrolti A Giuva P T Morgese G | 2001 | J Child Neurol2001，，16： | 1 |
| 7 | New trends in the etiopathogenesis of Diabetic Peripheral Neuropathy 显示文摘 | Verrotti A Giuva P T Morgese G | 2001 | J Child Neurol2001，16，： | 1 |
| 8 | Valproate-induced hyperammonemic encephalopathy 显示文摘 | Verroni A Trotia D Morgese G | 2002 | Metab Brain Dis2002，17，4： | 1 |
| 9 | Regional white matter integrity differentiates between vascular dementia and Alzheimer disease显示文摘 | Zarei M Damoiseaux JS Morgese C | 2009 | Stroke2009，40，： | 1 |
| 10 | New trends in the etiopathogenesis of diabetic peripheral neuropathy显示文摘 | Verrotti A Giuva PT Morgese G | 2001 | J Child Neurol2001，16，6： | 1 |
| 11 | New trends in the etiopathogen- esis of diabetic peripheral Neuropathy 显示文摘 | Verrotti A Giuva P T Morgese G | 2001 | J Child Neurol2001，16，6： | 1 |
| 12 | New tyends in the etiopathogenesis of diabetic peripheral 显示文摘 | Verrottia Giuva PT Morgese G | 2001 | J Child Neurol2001，16，6： | 1 |
| 13 | New trends in the etiopathogenesis of diabetic peripheral neuropathy显示文摘 | Verrotti A Giuva PT Morgese G | 2001 | J Child Neurol2001，16，6： | 1 |
| 14 | Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson's disease : role of CB ( 1 ) and TRPV1 receptors 显示文摘 | Morgese MG Cassano T Cuomo V | 2007 | Exp Neurol2007，208，： | 1 |
| 15 | Regio- nal white matter integrity differentiates between vascular dementia and Alzheimer disease显示文摘 | ZAREI M DAMOISEAUX J S MORGESE C el al | 2009 | Stroke2009，40，3： | 1 |
| 16 | New antiepileptic drugs in childhood显示文摘 | Trotta D Morgese G | 2002 | Panminerva Med2002，44，3： | 1 |
| 17 | New trends in the etiopathogeneses of diabetic peripheral neuropathy 显示文摘 | Verrotti A Giuva PT Morgese G | 2001 | Child Neurol2001，16，： | 1 |
| 18 | Neurochemical consequence of steroid abuse: Stanozolol-induced monoaminergic changes显示文摘 | Paolo Tucci Maria Grazia Morgese Marilena Colaianna Margherita Zotti Stefania Schiavone Vincenzo Cuomo Luigia Trabace | 2011 | Steroids2011，，3： | 1 |
| 19 | New trends in the etiopathogeneses of diabetic peripheral neuropathy显示文摘 | Verrotti A Giuva PT Morgese G | 2001 | J Child Neurol2001，16，： | 1 |
| 20 | Valproate - induced hy- perammonemic encephalopathy 显示文摘 | Verrotti A Trotta D Morgese G | 2002 | Metab Brain Dis2002，17，4： | 1 |
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