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| 1 | Impact of concomitant use of proton pump inhibitors and clopidogrel or ticagrelor on clinical outcomes in patients with acute coronary syndrome显示文摘BackgroundThere 是在质子泵禁止者(PPI ) 和 clopidogrel 之间的可能的不利相互作用上的大争论。另外, PPI 的使用是否少些影响 ticagrelor 遗体的临床的功效,知道。在经皮的冠的干预(一种总线标准) .MethodsWe 回顾地从 “ 分析了数据以后,我们试图与急性冠的症候群(交流)在病人在临床的结果上决定 PPI 和 clopidogrel 或 ticagrelor 的伴随物管理的影响;真实 world” ;,国际,在 2003 和 2014 之间的多中心登记( n = 15,401 )并且在1年的合成主要端点上估计了 PPI 和 clopidogrel 或 ticagrelor 的伴随物管理的影响(所有原因死亡收到 PPI 的病人更老,更经常女性,并且是更可能的有 comorbidities。没有协会为收到 clopidogrel 的病人在 PPI 使用和主要端点之间被观察(调整 HR:1.036;95% CI:0.903-1.189 ) 或 ticagrelor (调整 HR:2.320;95% CI:0.875-6.151 )(P 相互作用 = 0.2004 ) 。同样, PPI 的使用没与所有原因死亡,重新梗塞,或与交流后面的一种总线标准的为与任何一个 clopidogrel 对待的病人或 ticagrelor.ConclusionsIn 病人的严重流血的减少的风险的增加的风险被联系, PPI 的伴随物使用没在收到 clopidogrel 或 ticagrelor 的病人与不利结果的增加的风险被联系。我们的调查结果显示与 clopidogrel 或 ticagrelor 在联合使用 PPI 是合理的,特别在有胃肠的流血的更高的风险的病人。 | Yan YAN Xiao WANG Jing-Yao FAN Shao-Ping NIE Sergio Raposeiras-Roubin Emad Abu-Assi Jose P Simao Henriques Fabrizio D'Ascenzo Jorge Saucedo Jose R Gonzfilez-Juanatey Stephen B Wilton Wouter J Kikkert Ivlin Nufiez-Gil Albert Ariza-Sole Xian-Tao SONG Dimitrios Alexopoulos Christoph Liebetrau Tetsuma Kawaji Claudio Moretti Zenon Huczek Toshiharu Fujii Luis C Correia Masa-aki Kawashiril Sasko Kedev | 2016 | Journal of Geriatric Cardiology2016,13,3: | 12 |
| 2 | P2Y12受体抑制剂联合质子泵抑制剂对急性冠脉综合征患者缺血事件影响的临床分析显示文摘目的本研究旨在分析P2Y12受体抑制剂联合质子泵抑制剂(PPI)治疗对经皮冠状动脉介入(PCI)术后的急性冠脉综合征患者缺血事件的影响。方法基于国际多中心回顾性注册登记研究,纳入2003至2014年因急性冠脉综合征人院行PCI术的患者,分为PPI组及非PPI组并随访1年,主要临床终点为全因死亡/再发心肌梗死的复合终点。根据P2Y12受体抑制剂种类,将入组患者分为氯吡格雷组及替格瑞洛组,并比较不同药物与PPI联用发生临床终点事件的风险。结果研究入选9429例患者,PPI组占54.8%,具有更多高危因素。Cox回归结果提示PPI组较非PPI组全因死亡/再发心肌梗死复合事件的发生差异无统计学意义(HR1.00,95%CI 0.86—1.18)。根据P2Y12抑制剂种类不同分为氯吡格雷组和替格瑞洛组,不同P2Y12受体抑制剂联用PPI较未联用PPI患者的临床终点无差异,联用PPI的氯吡格雷组与替格瑞洛组的临床终点差异也无统计学意义。结论急性冠脉综合征患者PPI与P2Y12受体抑制剂联用不增加全因死亡和再发心肌梗死风险,尤其PPI联用氯吡格雷在患者的缺血事件上与替格瑞洛比较差异无统计学意义。 | 冯斯婷 严妍 范婧尧 王晓 郑文 聂绍平 Sergio Raposeiras-Roubin Emad Abu-Assi Jose P Simao Henriques Fabrizio D' Ascenzo Jorge Saucedo Jose R Conzalez-Juanatey Stephen B Wilton Wouter J Kikkert Ivan Nunez-Gil Albert Ariza-Sole Dimitrios Alexopoulos Christoph Liebetrau Tetsuma Kawaji Claudio Moretti Zenon Huczek Toshiharu Fujii Luis C Correia Masa-aki Kawashiri Sasko Kedev | 2016 | 中华医学杂志2016,96,33: | 6 |
| 3 | 欧洲和中国的心脏与肾脏远程缺血预适应研究:一项随机对照试验显示文摘远程缺血预适应(remote ischemic preconditioning,RIPC)对经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后造影剂肾病(contrast-induced nephropathy,CIN)的潜在保护作用尚待确定。该研究为双盲、随机、安慰剂对照的多中心研究,纳入年龄〈85岁,肾清除率为30~60mL/(min·1.73m^2)的有临床适应证的患者,除了直接PCI外均按1∶1给予RIPC或标准治疗。主要终点是CIN的发生率。次要终点是围手术期心肌梗死(peri-procedural myocardial infarction,PMI)的发生率。 | 刘青 叶鹏 Moretti C Cerrato E Cavallero E Lin S Rossi ML Picchi A Sanguineti F Ugo F Palazzuoli A Bertaina M Presbitero P Shao-Liang C Pozzi R Giammaria M Limbruno U Lefèvre T Gasparetto V Garbo R OmedèP Sheiban I Escaned J Biondi-Zoccai G Gaita F Perl L D'Ascenzo F | 2018 | 中华高血压杂志2018,26,4: | 3 |
| 4 | Vitamin B12 and folate depletion in cognition:A review显示文摘 | Moretti R Torre P Antonello RM | 2004 | Neurol India2004,52,3: | 1 |
| 5 | The effect of long-term treatment with erdosteine on chronic obstructive pulmonary disease: the EQUALIFE Study 显示文摘 | Moretti M Bottrighi P Dallari R | 2004 | Drags Exp Clin Res2004,30,: | 1 |
| 6 | Discrete random walk models for space-time fractional diffusion显示文摘 | GORENFLOR MAINARDI F MORETTI D PAGNINI G PARADISI P | 2002 | Chemical Physics2002,284,: | 1 |
| 7 | Fractional diffusion: probability distributions and random walk models显示文摘 | GORENFLO R MAINARDI F MORETTI D PAGNINI G PARADISI P | 2002 | Physica A2002,305,: | 1 |
| 8 | Cerebellitis in an adult with abnormal magnetic resonance imaging findings prior to the onset of ataxia显示文摘 | Gruis KL Moretti P Gebarski SS | | 0,,: | 1 |
| 9 | On the behavior and ductility of reinforced concrete coupling beams of shear walls显示文摘 | Theodosios P Tassios Marina Moretti Antonios Bezas | 1996 | ACI Structural Journal1996,93,6: | 1 |
| 10 | Over-expression of sphingosinekinase-1 enhances a progenitor phenotype in humanendothelial cells显示文摘 | Barrett Jeffrey M Parham Kate A Pippal Jyotsna B CockshellMichaelia P Moretti Paul A B Brice Sarah L Pitson StuartM Bonder Claudine S | 2011 | Microcirculation2011,187,: | 1 |
| 11 | Vitamin B12 and folate depletion in cognition:A review显示文摘 | Moretti R Torre P Antonello RM | 2004 | Neurol India2004,52,: | 1 |
| 12 | Soft-sediment deformation structures induced by earthquakes(seismites)in Pliocene lacustrine deposits(Guadix-Baza Basin,Central Betic Cordillera)显示文摘 | Alfaro P Moretti M Soria J M | 1997 | Ecological Geologicae Helvetiae1997,90,: | 1 |
| 13 | Determinagon of estrogem in animal tissues by GC - MS with ion chemical ionization显示文摘 | BASICO F MORETTI G CARTONI G P | 1992 | J High Resol Chromatogr1992,15,2: | 1 |
| 14 | Risk factors for vascular dementia: hypotension as a key point 显示文摘 | Moretti R Torre P Antonello RM | 2008 | Vasc Health Risk Manag2008,4,2: | 1 |
| 15 | Assessment of malignancy in pulmonary lesions: FDG dual-head coincidence gamma camera imaging in association with serum tumor marker measurement 显示文摘 | Bousson V Moretti JL Weinmann P | 2000 | J Nucl Med2000,41,11: | 1 |
| 16 | Mode of delivery is associated with different hematological profiles in the new- born calf 显示文摘 | Probo M Giordano A Moretti P | 2012 | Theriogenology2012,77,5: | 1 |
| 17 | Insulin-like growth fac- tor-I promotes migration in human androgen-independent prostate cancer cell via the alphav/beta3 integrin and PI3K/Akt signaling显示文摘 | Marelli MM Moretti RM Piocacci P | 2006 | Int J Oncol2006,28,3: | 1 |
| 18 | Keratinocyte dysfunction in vitiligo epidermis: cytokine microenvironment and correla- tion to keratinocyte apoptosis 显示文摘 | Moretti S Fabbri P Baroni G | 2009 | Histol Histopathol Jul2009,24,7: | 1 |
| 19 | An open-label pilot study comparing rivastigmine and low dose aspirin for the treat ment of symptoms specific to Patients with subcortical vascular Dementia显示文摘 | Moretti R Torre P Antonello RM | 2002 | Curr Ther Res2002,63,7: | 1 |
| 20 | Mesenchymal Stromal Cells Derived from Human Umbilical Cord Tissues: Primitive Cells with Potential for Clinical and Tissue Engineering Applications 显示文摘 | Moretti P Hatlapatka T Marten D | 2010 | Adv Biochem Eng Biot2010,123,12: | 1 |