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| 1 | Direct-acting antivirals and hepatocellular carcinoma in chronic hepatitis C: A few lights and many shadows显示文摘With the introduction of direct-acting antiviral agents(DAA), the rate of sustained virological response(SVR) in the treatment of hepatitis C virus(HCV) has radically improved to over 95%. Robust scientific evidence supports a beneficial role of SVR after interferon therapy in the progression of cirrhosis, resulting in a decreased incidence of hepatocellular carcinoma(HCC). However, a debate on the impact of DAAs on the development of HCC is ongoing. This review aimed to analyse the scientific literature regarding the risk of HCC in terms of its recurrence and occurrence after the use of DAAs to eradicate HCV infection. Among 11 studies examining HCC occurrence, the de novo incidence rate ranged from 0 to 7.4%(maximum follow-up: 18 mo). Among 18 studies regarding HCC recurrence, the rate ranged from 0 to 54.4%(maximum 'not well-defined' followup: 32 mo). This review highlights the major difficulties in interpreting data and reconciling the results of the included studies. These difficulties include heterogeneous cohorts, potential misclassifications of HCC prior to DAA therapy, the absence of an adequate control group, short follow-up times and different kinds of follow-up. Moreover, no clinical feature-based scoring system accounts for the molecular characteristics and pathobiology of the tumours. Nonetheless, this review does not suggest that there is a higher rate of de novo HCC occurrence or recurrence after DAA therapy in patients with previous HCV infection. | Maria Guarino Anna Sessa Valentina Cossiga Federica Morando Nicola Caporaso Filomena Morisco | 2018 | World Journal of Gastroenterology2018，24，24： | 2 |
| 2 | Nitrogen effects on yield and canopy of White Muscat'grapevine显示文摘 | Eynard G G Morando A | 2000 | ActaHorticulture2000，512，： | 1 |
| 3 | Surface & Coatings Technology显示文摘 | Lasorsaa C Morando P J Rodrigo A | 2005 | 194: 42 - 472005，194，： | 1 |
| 4 | Increased frequency of micronucleated kidney cells in rats exposed to halogenated anaesthetics 显示文摘 | Robbiano L Mereto E Morando AM | 1998 | Murat Res1998，413，： | 1 |
| 5 | A molecular phylogeny of the lizard genus Phymaturus(Squamata: Liolaemini) : implications for species diversity and historical biogeography of southern South America显示文摘 | Morando M Avila LJ Perez CH | 2013 | Mol Phylogenet Evol2013，66，3： | 1 |
| 6 | Dynamic analysis of a high- speed train 显示文摘 | Leva S Morando A P Colombaioni P | 2008 | Vehicular Technology2008，57，1： | 1 |
| 7 | Mimicking chitin:chemical synthesis,conformational analysis,and molecular recognition of theβ (1 →3) N-Acetylchitopentaose analogue显示文摘 | Maria Morando Yanping Yao Sonsoles Martín-Santamaría | | 0，，： | 1 |
| 8 | Impact of body mass index on short-term outcome after acute myocardial infarction: does excess body weight have a paradoxical protective role?显示文摘 | Nieoletti I Cicoira M Morando G | 2006 | Inter J Cardiol2006，107，3： | 1 |
| 9 | Neuroprotective mesen- chymal stem cells are endowed with a potent antioxidant effect in vivo显示文摘 | Lanza C Morando S Voci A | 2009 | J Neuroehem2009，110，5： | 1 |
| 10 | Synovial membrane expres sion of matrix metalloproteinases and tissue inhibitor 1 in juvenile idiopathic arthritides显示文摘 | Gattorno M Gerloni V Morando A | 2002 | J Rheumatol2002，29，8： | 1 |
| 11 | Dynamic analysis of a high-speed train显示文摘 | LEVA S MORANDO A P COLOMBAIONI P | 2008 | Vehicular Technology2008，57，1： | 1 |
| 12 | Mesenchymal stem cells impair ill vivo T-cell priming by dendritic cells显示文摘 | Chiesa S Morbelli S Morando S | 2011 | Proc Natl Acad Sci USA2011，108，17： | 1 |
| 13 | Open data quality measurement framework: Definition and application to Open Govern- ment Data 显示文摘 | Antonio Vetr Lorenzo Canova Marco Torchiano Camilo Orozco Minotas Raimondo Iemma Federico Morando | 2016 | Government Information Quarterly2016，33，2： | 1 |
| 14 | Impact of body mass index on short-term outcome after acute myocardial infarction:Does excess body weight have a paradoxical protective role显示文摘 | Nicoletti I Cicoiro M Morando G | 2006 | Inter J Cardiol2006，107，3： | 1 |
| 15 | The development of macrostructure in ingots of increasing size显示文摘 | MORANDO R BILONI H COLE G S | 1970 | Metallurgical and Materials Transactions1970，1，5： | 1 |
| 16 | Mesenchymal stem cells impair in vivo T-cell priming by dendritic cells 显示文摘 | Chiesa S Morbelli S Morando S | 2011 | Proc Ncad Sci U S A2011，108，17： | 1 |
| 17 | Measurement of hydrostatic pressures during simulated post cementation 显示文摘 | Morando G Leupold RJ Meiers JC | 1995 | J Prosthet Dent1995，74，6： | 1 |
| 18 | Natural materials for treatment of industrial effluents:comparative study of the retention of Cd, Zn and Co by calcite and hydroxyapatite 显示文摘 | GOMEZ J A MORANDO P J CICERONE D S | 2004 | Journal of Environmental Manage- ment2004，71，2： | 1 |
| 19 | Early environmental en- richment moderates the behavioral and synaptic phenotype of MeCP2 null mice 显示文摘 | Lonetti G Angelucci A Morando L | 2010 | Biol Psychiatry2010，67，： | 1 |
| 20 | Evaluation of the Acute Kidney Injury Network criteria in hospitalized patients with cirrhosis and ascites显示文摘 | Salvatore Piano Silvia Rosi Giulio Maresio Silvano Fasolato Marta Cavallin Antonietta Romano Filippo Morando Elisabetta Gola Anna Chiara Frigo Angelo Gatta Paolo Angeli | 2013 | Journal of Hepatology2013，，： | 1 |
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