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| 1 | TT virus infection in patients with chronic hepatitis B and response of TTV to lamivudine显示文摘AIM: To investigate the responses of TT virus (TTV) and hepatitis B virus (HBV) to a long-term lamivudine therapy.METHODS: Sixteen patients infected with both TTV and HBV were treated with lamivudine 100 mg daily for 30 months. Blood samples were drawn at the beginning of the therapy and subsequently at month 3, 6, 9, 12 and 30.Serum TTV was quantified by real time PCR and serum HBV was detected by hybridization assay and nested polymerase chain reaction.RESULTS: TTV infection was detected in 100 % of HBV-infected patients. Loss of serum TTV DNA after one year of treatment occurred in 1/16 (6 %) patients. At the end of therapy, TTV DNA was positive in 94 % of them. The decline of HBV viremia was evident at 3 months after therapy and the response rate was 31%, 44 %, 63 %, 50 % and 50 %at month 3, 6, 9, 12 and 30, respectively.CONCLUSION: TTV replication is not sensitive to lamivudine and is highly prevalent in HBV-infected patients. | Javier Moreno Garcia Rafael Barcena Marugan Gloria Moraleda Garcia M Luisa Mateos Lindeman Jesus Fortun Abete Santos del Campo Terron | 2003 | World Journal of Gastroenterology2003，9，6： | 9 |
| 2 | Chronic model of tympanic perforation in rats with mitomycin C and dexamethasone显示文摘A rat model of chronic tympanic membrane perforation was developed to be used in the search of new materials for the sealing of these perforations. A longitudinal study was carried out in rats subjected to incisional myr-ingotomy followed by the application of mitomycin C alone or with dexamethasone. Rats were checked at days 3, 7,1 0,1 4 and weekly thereafter until perforation closure, for up to 6 months. The addition of dexamethasone is a key component in order to obtain a chronic opening. Myringotomies treated w ith saline had a mean healing time of 8.5 days. At 8 weeks, between 62.5% and 77.7% of tympanic membranes treated w ith mitomycin C and dexamethasone remained perforated and at 6 months this number fell to 21.4%. This technique is able to maintain most tympanic membrane perforations patent for at least 8 weeks. This rat model is adequate for its use in preclinical or translational research. | Tomás Esteban Noemí M.Atucha Jose María Moraleda Joaquín Garcia-Esta? Carmen L.Insausti Javier Moraleda-Deleyto | 2019 | Journal of Otology2019，14，1： | 2 |
| 3 | Prevention of de novo HBV infection by the presence of anti-HBs in transplanted patients receiving core antibody-positive livers显示文摘瞄准:分析在肝的 anti-HBs 的存在是否移植接受者在阻止 HBV 感染是有效的。方法:23 个病人收到 anti-HBc 积极的肝被学习。九个接受者是由于以前的 HBV 感染积极的 anti-HBc。他们,一个人也收到了在肝前移植时期期间疫苗的 HBV。十四个接受者是由于在预先移植经期期间管理的 HBV 疫苗积极的 anti-HBs。肝活体检视在 10/14 anti-HBc negative/anti-HBs 被获得积极接受者并且在 4/9 anti-HBc 积极接受者。结果:在 46 个月的一个吝啬的后续时期以后,有保护的浆液 anti-HBs 层次的 1 个接受者作为有免疫力的逃跑 HBV 异种的后果得了 de novo HBV 感染。在 14 之中种牛痘的 anti-HBc negative/anti-HBs 积极接受者,有可得到的肝活体检视(10%) 的 1/10 病人在 13 瞬间有肝 HBV-DNA 没有浆液的肝以后的移植病毒的标记并且没得 de novo HBV 感染。种牛痘的 anti-HBc 没有 HBV 疫苗的反应的积极接受者是在浆液和肝积极的 HBV-DNA,病毒的 DNA 在下列测试是连续地否定的,自发的 seroconversion 因此被诊断。结论:由于 HBV 疫苗或过去的 HBV 感染的 anti-HBs 的存在似乎在保护从 anti-HBc 收到肝的病人有效积极施主。然而,有免疫力的逃跑 HBV 异种的出现,能躲避 anti-HBs 保护,应该被看作 HBV 感染的风险。 | Rafael Barcena Gloria Moraleda Javier Moreno M Dolores Martín Emilio de Vicente Jesús Nuo M Luisa Mateos Santos del Campo | 2006 | World Journal of Gastroenterology2006，12，13： | 2 |
| 4 | A robotic system for internal inspection of water pipelines显示文摘 | Moraleda J Ollero A Orte M | 1999 | IEEE Robotics & Automation Magazine1999，3，6： | 1 |
| 5 | Inhibition of duck hepatitis B Virus replication by hypericin显示文摘 | Moraleda G Wu TT Jilber AR etal | 1993 | Antiviral Research1993，20，： | 1 |
| 6 | Gastrointestinal autonomic nerve tumor:a casereport with ultrastructural and immunohistochemical study显示文摘 | Moraleda FP Gonzalez MA Carcavilla CB | 1992 | Histopathology1992，20，： | 1 |
| 7 | Lack of effet of antiviral therapy in nondividing hepatocyte cultures on the closed circular DNA of woodchuck hepatitis virus显示文摘 | Moraleda G Saputell J Aldrich CE | 1997 | J Virol1997，71，12： | 1 |
| 8 | Anterior approach in low cervical fractures prodited by hyperflexion or tear drop 显示文摘 | Isla A Perez-Lopez C Moraleda S | 2004 | Neurocirugia2004，4，： | 1 |
| 9 | Cavernous angioma of the conus medullaris as a cause of paraplegia显示文摘 | Hernandez D Moraleda S Royo A | 1999 | Spinal Cord1999，37，1： | 1 |
| 10 | Host RNA polymerase requirements for transcription of the human hepatitis delta virus genome 显示文摘 | Moraleda G Taylor J | 2001 | J Virol2001，75，10： | 1 |
| 11 | Lack of effect of antiviral therapy in nondividing hepatocyte cultures on the closed circular DNA of woodchuck hepatitis virus显示文摘 | MORALEDA G SAPUTELLI J ALDRICH CE | 1997 | J Vi- rol1997，71，12： | 1 |
| 12 | New high-intensity ultrasonic technology for food dehydration显示文摘 | Roderiguez Corral G Galvez Moraleda J C | 1999 | Drying Technology1999，17，3： | 1 |
| 13 | Vascular anatomy of the dorsum of the foot显示文摘 | Garcia-Pumarino R Moraleda E | 2010 | Plast Reconstr Surg2010，126，： | 1 |
| 14 | Limitations to replication of hepatitis delta virus in avian cells显示文摘 | Chang J Moraleda G Taylor J | 2000 | J Virol2000，74，： | 1 |
| 15 | Mesenchymal dental pulp stem cells: a new tool in sinus lift显示文摘 | Rodriguez LF Moraleda JM | 2011 | J Craniofac Surg2011，22，2： | 1 |
| 16 | Lack of effect of antiviral therapy in nondividing hepatocyte cultures on the closed circular DNA of woodchuck hepatitis virus显示文摘 | Moraleda G SaputeUi J Aldrich CE Averett D Condreay L Mason WS | | 0，，： | 1 |
| 17 | Otalgia as presentation of primary nasopharynx tuberculosis 显示文摘 | Plaza Mayor G Pinedo Moraleda F Ferrando Alvarez-Cortina J | 2005 | An Otorrinolaringol Ibero Am2005，32，6： | 1 |
| 18 | Lamivudine therapy of WHV-infected woodchucks显示文摘 | Mason WS Cullen J Moraleda G Saputelli J Aldrich CE Miller DS | | 0，，： | 1 |
| 19 | Host RNA polymerase requirements for transcription of the human hepatitis delta virus genome显示文摘 | Moraleda G Taylor J | 2001 | J Virol2001，75，10： | 1 |
| 20 | Ozone therapy in the advanced stages of arteriosclerosis obliterans显示文摘 | Romero Valdés A Menéndez Cepero S Gómez Moraleda M | 1993 | Angiología1993，，04： | 1 |
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