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| 1 | Active compounds of medicinal plants,mechanism for antioxidant and beneficial effects显示文摘An increased interest in the antioxidant effects of medicinal plants has developed in recent years.Identifying antioxidant compounds present in medicinal plants and elucidating the mechanism by which they prevent oxidation have been the focus of the research community.We performed a systematic and exhaustive review aimed at analyzing the available data regarding the beneficial effects of secondary metabolites in plants.The result of this review is presented as a description of free radicals,as well as cellular and physiological oxidative stress,is provided.The origin and source of antioxidant compounds,and the cellular and molecular mechanism by which they exert antioxidant effects,have been reported.The absorption,distribution and,elimination of antioxidants are mentioned.The beneficial effects of secondary metabolites of medicinal plants in various high incidence disease conditions were also reviewed.Finally,disease states that benefit from antioxidant compounds includes diabetes,cancer,cardiovascular diseases,and liver,brain and,intestinal diseases. | Orozco Montes F A Vázquez-Hernández B Fenton-Navarro | 2019 | Phyton-International Journal of Experimental Botany2019，88，1： | 5 |
| 2 | Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients显示文摘AIM To investigate the relationships among diverse metalloproteases(MMPs) and their tissue inhibitors(TIMPs) and non-alcoholic liver fibrosis in human immunodeficiency virus(HIV)-infected patients.METHODS Single nucleotide polymorphisms(SNPs) in MMPs, TNF-α and CCR5 genes, and serum levels of MMPs and TIMPs were determined in HIV-infected individuals with/out hepatitis C virus(HCV) coinfection. A total of 158 patients were included, 57 of whom were HCVcoinfected. All patients drank < 50 g ethanol/day. Diverse SNPs(MMP-1-1607 1G/2G, MMP-8-799C/T, MMP-9-1562 C/T, MMP-13-77A/G, TNF-α-308 G/A,CCR5-?32), and serum levels of MMPs(2, 3, 8, 9 and 10) and TIMPs(1, 2 and 4) were assessed. Liver fibrosis was determined by transient elastometry, although other non-invasive markers of fibrosis were also considered. Significant liver fibrosis(F ≥ 2) was defined by a transient elastometry value ≥ 7.1 kP a.RESULTS A total of 34 patients(21.5%) had liver fibrosis ≥ F2. MMP-2 and TIMP-2 serum levels were higher in patients with liver fibrosis ≥ F2(P = 0.02 and P = 0.03, respectively) and correlated positively with transient elastometry values(P = 0.02 and P = 0.0009, respectively), whereas MMP-9 values were negatively correlated with transient elastometry measurements(P = 0.01). Multivariate analyses showed that high levels of MMP-2(OR = 2.397; 95%CI: 1.191-4.827, P = 0.014) were independently associated with liver fibrosis ≥ F2 in the patients as a whole. MMP-2(OR = 7.179; 95%CI: 1.210-42.581, P = 0.03) and male gender(OR = 10.040; 95%CI: 1.621-62.11, P = 0.013) were also independent predictors of fibrosis ≥ F2 in the HCV-infected subgroup. Likewise, MMP-2, TIMP-2 and MMP-9 were independently associated with transient elastometry values and other non-invasive markers of liver fibrosis. None of the six SNPs evaluated had any significant association with liver fibrosis ≥ F2.CONCLUSION Certain MMPs and TIMPs, particularly MMP-2, seems to be associated with non-alcoholic liver fibrosis in HIVinfected patients with/without HCV coinfection. | Julio Collazos Eulalia Valle-Garay Tomás Suárez-Zarracina Angel-Hugo Montes José A Cartón Víctor Asensi | 2017 | World Journal of Virology2017，6，2： | 3 |
| 3 | Influence of personal mastery on organization- al performance through organizational learning and inno- vation in large firms and SMEs 显示文摘 | Garcia - Morales V J Llor6ns - Montes F J Verd6 - Jover A J | 2007 | Technovation2007，27，： | 1 |
| 4 | Enthalpies of combustion, vapour pressures, and enthalpies of sublimation of 8- hydroxyquinoline, 5-nitro-8-hydroxyquinoline, and 2-methyl-8-hydroxyquinoline显示文摘 | Ribeiro Da Silva M A V Monte M J S Matos M A R | 1989 | Chem Thermodyn1989，，21： | 1 |
| 5 | Endovascular management for intracranial ruptured aneurysms in elderly patients:outcome and technical aspects显示文摘 | Mont'alverne F Musacchio M Tolentino V | 2005 | Neuroradiology2005，47，： | 1 |
| 6 | The body-mass index,airflow obstruction,dyspnea,and exercise capacity index in chronic obstructive pulmonary disease显示文摘 | Celli BR Cote CG Marin JM Casanova C Montes de Oca M Mendez RA Pinto Plata V Cabral HJ | 2004 | N Engl J Med2004，350，10： | 1 |
| 7 | Endothelial (NOS3 E298D) and inducible (NOS2 exon 22) nitric oxide synthase polymorphisms, as well as plasma NOx, influence sepsis development显示文摘 | Martin G Asensi V Montes AH | 2014 | Nitric Oxide2014，42，： | 1 |
| 8 | Multifocal osteonecrosis显示文摘 | Laporte DM Mont MA Mohan V | | 0，，10： | 1 |
| 9 | Produc- tion and refinement of oil from carp ( Cyprinus carpio) vis- cera 显示文摘 | CREXI V T MONTE M L SOARES L A S | 2010 | Food Chem2010，119，3： | 1 |
| 10 | AtYDical Cogan~ syndrome associated with sudden deafness and glucocorticoid response显示文摘 | Montes S Rodr i guez-Muguruza S Soria V | 2014 | Reumatol Clin2014，10，4： | 1 |
| 11 | Major ozonated autohemotherapy in chronic limb isehemia with ulcerations 显示文摘 | de Monte A H van der Zee V Bocei | 2005 | J Altem Complement Med2005，11，2： | 1 |
| 12 | Bronchopulmonary dysplasia显示文摘 | Luciana F Monte V Luiz VF | 2005 | J Pediatr2005，81，2： | 1 |
| 13 | Differential gene expression of pro - inflammatory and anti - inflammatory cytokines in acute and chronic liver injury 显示文摘 | Salazar -Montes A Delgado - Rizo V Armendariz - Borunda J | 2000 | Hepatology Res2000，16，3： | 1 |
| 14 | Environment - flexibility coalignment and performance: an analysis in large versus small firms 显示文摘 | Verdu - Jover A J Llorens - Montes F J J Garcia - Morales V | 2006 | Journal of Small Business Management2006，44，3： | 1 |
| 15 | Osteorecrosis of humeral head treated by core decompression显示文摘 | Laporte DM Mont MA Mohan V | 1998 | Clin Orthop1998，335，： | 1 |
| 16 | Gibberellimsignal nuclear import of PHOR1, a photoperioc-responsive protein with homology to Drosophila armadillo 显示文摘 | AMADOR V MONTE E GARCIA-MARTINEZ J L ct al | 2001 | Cell2001，106，3： | 1 |
| 17 | Hydro xyquinolines with extended fluorophores: Arrays for turn-on and ratiometric sensing of cations 显示文摘 | Palacios M A Wang Z Montes V A | 2007 | Chem Commun2007，，36： | 1 |
| 18 | Influence of support leadership and teamwork cohesion on organizational learning, innovation and performance: an empirical examination 显示文摘 | MONTES F J L MORENO A R MORALES V G | 2005 | Technovation2005，25，： | 1 |
| 19 | The Toll-like receptor 4 (Asp299Gly) polymorphisrn is a risk factor for Gram-negative and haematogenous osteomyelitis 显示文摘 | Montes AH Asensl V Alvarez V eta/ | 2006 | Clin Exp lmmunol2006，143，3： | 1 |
| 20 | Sepsis, mitochondrial failure and multiple organ dys- function显示文摘 | Duran - Bedolla J Montes de Oca - Sandoval MA Saldafia - Na- vor V | 2014 | Clinlnvest Med2014，37，2： | 1 |
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