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| 1 | 肽酰基精氨酸脱亚氨酶4和中性粒细胞胞外诱捕网形成在实验性动脉粥样硬化和动脉损伤中的作用:浅表糜烂的影响显示文摘中性粒细胞可能促进人类动脉粥样硬化的血栓并发症的发生。特别是中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)可加剧局部炎症,并放大和加剧动脉内膜损伤和血栓形成。肽酰基精氨酸脱亚氨酶4(peptidyl arginine deiminase 4,PAD4)参与NET的形成,但对该酶在动脉粥样硬化血栓形成中的作用的认识仍然不足。 | 刘青 叶鹏 Franck G Mawson TL Folco EJ Molinaro R Ruvkun V Engelbertsen D Liu X Tesmenitsky Y Shvartz F Sukhova GK Michel JB Nicoletti A Lichtman AH Wagner DD Croce KJ Libby P | 2018 | 中华高血压杂志2018，26，5： | 13 |
| 2 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 3 | An algorithm for finding the zero crossing of time signals with Lipschitzean derivatives显示文摘 | Daponte P Grimaldi D Molinaro A | 1995 | Measurement1995，16，1： | 1 |
| 4 | Association between increased mortality and mild thyroid dysfunction in cardiac patients 显示文摘 | IERVASI G MOLINARO S LANDI P | 2007 | Arch Intern Med2007，167，14： | 1 |
| 5 | Neolignans from arum italicum显示文摘 | Greca M D Molinaro A Monaco P | 1994 | Phytochemistry1994，35，3： | 1 |
| 6 | Targeted disruption of Na+ /Ca^2+ exchanger 3(NCX3) gene leads to a worsening of ischemic brain damage显示文摘 | Molinaro P Cuomo O Pignataro G | 2008 | J Neurosci2008，28，5： | 1 |
| 7 | Association between increased mortality and mild thyroid dysfunction in cardiac patients 显示文摘 | Iervasi G Molinaro S Landi P | 2007 | Arch ln- tern Med2007，167，14： | 1 |
| 8 | Lignans from Arum italicum显示文摘 | Greca M D Molinaro A Monaco P | 1994 | Phytochemistry1994，35，3： | 1 |
| 9 | HIF-1alpha reveals a binding activity to the promoter of iNOs gene after permanent middle cerebral artery occlusion显示文摘 | Matrone C Pignataro G Molinaro P | 2004 | J Neurochem2004，90，2： | 1 |
| 10 | Absence of effect of chronic angiotensin Ⅱ type 1 receptor blockade on endogenous kinin concentrations in the carrageenan-induced paw edema model in the rat显示文摘 | Blais C Leelair P Molinaro G | 1999 | Peptides1999，20，3： | 1 |
| 11 | Association between in- creased mortality and mild thyroid dysfunction in cardiac pa- tients显示文摘 | Iervasi G Molinaro S Landi P | 2007 | Arch Intern Med2007，167，14： | 1 |
| 12 | Neolignans from Arum italicaum显示文摘 | Molinaro A Monaco P | 1994 | Phytochemisty1994，35，： | 1 |
| 13 | Targeted disruption of Na+/Ca2+ exchanger 3 (NCX3) gene leads to a worsening of ischemic brain damage显示文摘 | Molinaro P Cuomo O Pignataro G | 2008 | J Neurosci2008，28，5： | 1 |
| 14 | Recombinant human TSH (rhTSH) in 2009: new perspectives in diagnosis and therapy显示文摘 | Molinaro E Viola D Passannanti P | 2009 | The Quarterly journal of nuclear medicine and molecular imaging2009，53，5： | 1 |
| 15 | Targeted disruption ofNa7Ca2+ exchanger 3 (NCX3) gene leads to a worsening of ischemicbrain damage显示文摘 | Molinaro P Cuomo 0 Pignataro G | 2008 | J Neurosci2008，28，5： | 1 |
| 16 | Three biologically active phenylpropanoid glucosides from Myriophyllum verticillatum 显示文摘 | ALIOTTA G MOLINARO A MONACO P | 1992 | Phytochemistry1992，31，1： | 1 |
| 17 | Recombinant human TSH(rhTSH)in 2009:new perspectives in diagnosis and therapy显示文摘 | MOLINARO E VIOLA D PASSANNANTI P | 2009 | Q J Nucl Med Mol Imaging2009，53，5： | 1 |
| 18 | Association between increased mortality and mild thyroid dysfunction in cardiac patients 显示文摘 | lervasi G Molinaro S Landi P | 2007 | Arch Intern Med2007，167，14： | 1 |
| 19 | ChemBioChem显示文摘 | Marchetti R Canales A Lanzetta R Nilsson I Vogel C Reed D E AuCoin D P Barbero J J Molinaro A Silipo A | 2013 | 14(12):14852013，14，12： | 1 |
| 20 | On the performance of CAC algorithms in multimedia geostationary satellite networks显示文摘 | Iera A Molinaro A Aloi3 G Pace P and Marano S | 2000 | IEEE2000，，： | 1 |
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