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3篇 您的检索式:作者名="Moise Bendayan"
    题名 作者 年代 出处 被引量
1Alteration of chaperonin60 and pancreatic enzyme in pancreatic acinar cell under pathological condition显示文摘AIM: To investigate the changes of chaperonin60 (Cpn60)and pancreatic enzymes in pancreatic acinar cells, and to explore their roles in the development of experimental diabetes and acute pancreatitis (AP).METHODS: Two different pathological models were replicated in Sprague-Dawley rats: streptozotocininduced diabetes and sodium deoxycholate-induced AP. The contents of Cpn60 and pancreatic enzymes in different compartments of the acinar cells were measured by quantitative immunocytochemistry.RESULTS: The levels of Cpn60 significantly increased in diabetes, but decreased in AP, especially in the zymogen granules of the pancreatic acinar cells. The elevation of Cpn60 was accompanied with the increased levels of pancreatic lipase and chymotrypsinogen in diabetes.However, a decreased Cpn60 level was accompanied by high levels of lipase and chymotrypsinogen in AP.The amylase level was markedly reduced in both the pathological conditions.CONCLUSION: The equilibrium between Cpn60 and pancreatic enzymes in the acinar cells breaks in AP, and Cpn60 content decreases, suggesting an insufficient chaperone capacity. This may promote the aggregation and autoactivation of the premature enzymes in the pancreatic acinar cells and play roles in the development of AP.Yong-Yu Li Moise Bendayan 2005World Journal of Gastroenterology2005,11,46:2
2Cross-talk between adipose and gastric leptins for the control of food intake and energy metabolism显示文摘Philippe G. Cammisotto émile Levy Ludwik J. Bukowiecki Moise Bendayan 2010Progress in Histochemistry and Cytochemistry2010,,3:1
3Compartmentalization of secretory proteins in pancreatic zymogen granules as revealed by immunolabeling on cryo-fixed and molecular distillation processed tissue显示文摘Diane Gingras Moise Bendayan 1994Biology of the Cell1994,81,2:1
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