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| 1 | Survival analysis of cholangiocarcinoma:A 10-year experience in Malaysia显示文摘AIM:To investigate the clinical features and survival of patients treated for cholangiocarcinoma in our institution and to analyze the factors affecting their survival.METHODS:This retrospective cohort study assessed patients diagnosed with cholangiocarcinoma between January 1997 and December 2007 at the University Malaya Medical Centre in Malaysia.The clinical data and associated outcomes were collected using a structured proforma.RESULTS:Of the 69 patients diagnosed with cholangiocarcinoma,38 (55%) were male;mean patient age was 61 years.Twelve patients (17%) had intrahepatic,38 (55%) had perihilar and 19 (28%) had distal tumors.Only 12 patients underwent curative surgery,including seven R0 resections.Only one patient died within 30 d after surgery.The overall median survival was 4 mo,whereas the median survival of R0 resected patients was 16 mo.The overall 1-,2-and 3-year cumulative survival rates were 67%,17% and 17%,respectively.Survival rates were significantly associated with curative resection (P=0.002),intrahepatic tumor (P=0.003),negative margin status (P=0.013),early tumor stage (P=0.016),higher tumor differentiation (P=0.032) and absence of jaundice (P=0.038).Multivariate analysis showed that tumor location was a significant independent predictor of patient survival.CONCLUSION:Curative,margin-negative resection of early stage,well-differentiated intrahepatic tumors is associated with improved patient survival. | Ahmad Ramzi Yusoff Mohd Muzammil Abdul Razak Yoong Boon Koon R Vijeyasingam Siti Zuraidah Mahmud | 2012 | World Journal of Gastroenterology2012，18，5： | 7 |
| 2 | Germline mutation analysis of MLH1 and MSH2 in Malaysian Lynch syndrome patients显示文摘AIM: To investigate the protein expression profi le of mismatch repair (MMR) genes in suspected cases of Lynch syndrome and to characterize the associated germline mutations. METHODS: Immunohistochemical analysis of tumor samples was performed to determine the protein expression profile of MMR protein. Germline mutation screening was carried out on peripheral blood samples. The entire exon regions of MLH1 and MSH2 geneswere amplifi ed by polymerase chain reaction, screened by denaturing high performance liquid chromatography (dHPLC) and analyzed by DNA sequencing to characterize the germline mutations. RESULTS: Three out of 34 tissue samples (8.8%) and four out of 34 tissue samples (11.8%) showed loss of nuclear staining by immunohistochemistry, indicating the absence of MLH1 and MSH2 protein expression in carcinoma cells, respectively. dHPLC analysis followed by DNA sequencing showed these samples to have germline mutations of MSH2 gene. However, no deleterious mutations were identifi ed in any of the 19 exons or coding regions of MLH1 gene, but we were able to identify MLH1 promoter polymorphism, -93G > A (rs1800734), in 21 out of 34 patients (61.8%). We identified one novel mutation, transversion mutation c.2005G > C, which resulted in a missense mutation (Gly669Arg), a transversion mutation in exon 1, c.142G > T, which resulted in a nonsense mutation (Glu48Stop) and splice-site mutation, c.2006-6T > C, which was adjacent to exon 13 of MSH2 gene. CONCLUSION: Germline mutations were identified in four Malaysian Lynch syndrome patients. Immunohistochemical analysis of tumor tissue proved to be a good pre-screening test before proceeding to germline mutation analysis of DNA MMR genes. | Mohd Nizam Zahary Ravindran Ankathi Human Genome Centre Gurjeet Kaur Muhammad Radzi Abu Hassan Harjinder Singh Venkatesh R Naik | 2012 | World Journal of Gastroenterology2012，18，8： | 3 |
| 3 | Development of solid-based paper strips for rapid diagnosis of Pseudorabies infection显示文摘 | Joon Tam Y Mohd Lila M A Bahaman A R | 2004 | Trop Biomed2004，21，2： | 1 |
| 4 | Identification polypeptide biomarkers of porcine skin gelatin by two-dimensional electrophoresis显示文摘 | Aina M A Amin I Raja Mohd Hafidz R N | | 0，，03： | 1 |
| 5 | A retrospec- tive review of diabetic nephropathy patients during refer- ral to the suburban nephrology clinic显示文摘 | Menon R Mohd Noor FS Draman CR | 2012 | Sandi J Kidney Dis Transpl2012，23，5： | 1 |
| 6 | Development of solid-based paper strips for rapid diagnosis of Pseudorabies infection显示文摘 | Joon Tam Y Mohd Lila M A Bahaman A R | 2004 | Trop Biomed2004，21，2： | 1 |
| 7 | Development of solid- based papers trips for rapid diagnosis of pseudorabies infection 显示文摘 | Joon Tam Y Mohd Lila M A Bahaman A R | 2004 | Trop Biomed2004，21，2： | 1 |
| 8 | Adsorption of methylene blue on low-cost adsorbents:A review显示文摘 | Mohd R Othman S Rokiah H | 2010 | J Hazard Mater2010，177，123： | 1 |
| 9 | A blackboard-based negotiation for collaborative supply chain system显示文摘 | TERUAKI I MOHD R S | 2000 | Journal of Materials Processing Technology2000，107，22： | 1 |
| 10 | The Effect of Lift Thickness on Permeabili- ty and the Time Available for Compaction of Hot MixAsphalt Pavement Under Tropical Climate Condition 显示文摘 | HAININ M R YUSOFF N I M MOHD SATAR M K I | 2013 | Construction and Building Materials2013，48，： | 1 |
| 11 | Finite element model of machining with high pressure coolant for Ti 6A1-4V alloy 显示文摘 | MOHD H A B IZAMSHAH R SITI S A | 2013 | Procedia Eng2013，53，62： | 1 |
| 12 | Flammability and mechanical properties of wood flour- filled polypropylene composites显示文摘 | Abu Bakar M B Mohd Ishak Z A Mat Taib R | 2010 | Journal of Applied Polymer Science2010，116，5： | 1 |
| 13 | Assessment of fluid status in CAPD patients using the body composition monitor 显示文摘 | Cader RA Gafor HA Mohd R | 2012 | J Clin Nurs2012，22，56： | 1 |
| 14 | Fluidized bed catalytic chemical vapor deposition synthesis of carbon nanotubes-A review显示文摘 | Danafar F Fakhru R A Mohd Salleh M A | | 0，，： | 1 |
| 15 | A Blackboard-based Negotiation for Collaborative Supply Chain System显示文摘 | Ito T Mohd S R B | 2000 | Journal of Materials Processing Technology2000，107，13： | 1 |
| 16 | Optimization of epi- demic router by new forwarding queue mode TS-MF 显示文摘 | Qaisar A Sulma R Mohd S M | 2010 | International Journal of Computer Applications2010，7，11： | 1 |
| 17 | Effect of edible coating and gamma irradiation on inhibition of mould growth and quality retention of strawberry during refrigerated storage显示文摘 | Peerzada R Hussain Mohd A Dar Ali M Wani | 2012 | International Journal of Food Science and Technology2012，47，11： | 1 |
| 18 | Flammability and mechanical properties of wood flour- filled polypropylene composites 显示文摘 | ABU BAKAR M B MOHD ISHAK Z A MAT TAI R | 2010 | Appl Polym Sci2010，116，： | 1 |
| 19 | Effect of Reac- tive Sputtering Parameters on TiA1N Nanocoating Structure and Morphology显示文摘 | Budi Esmar Razali M Mohd Nizam A R Md | 2010 | AIP Conf Proc2010，1284，： | 1 |
| 20 | Interleukin-27 signaling promotes immunity against endogenously arising murine tumors 显示文摘 | NATIVIDAD K D JUNANKAR S R MOHD REDZWAN N | 2013 | PLoS One2013，8，57： | 1 |
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