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| 1 | Efficacy of pancreatoscopy for pancreatic duct stones:A systematic review and meta-analysis显示文摘BACKGROUND Pancreatic duct stones can lead to significant abdominal pain for patients.Per oral pancreatoscopy(POP)-guided intracorporal lithotripsy is being increasingly used for the management of main pancreatic duct calculi(PDC)in chronic pancreatitis.POP uses two techniques:Electrohydraulic lithotripsy(EHL)and laser lithotripsy(LL).Data on the safety and efficacy are limited for this procedure.We performed a systematic review and meta-analysis with a primary aim to calculate the pooled technical and clinical success rates of POP.The secondary aim was to assess pooled rates of technical success,clinical success for the two individual techniques,and adverse event rates.AIM To perform a systematic review and meta-analysis of POP,EHL and LL for management of PDC in chronic pancreatitis.METHODS We conducted a comprehensive search of multiple electronic databases and conference proceedings including PubMed,EMBASE,Cochrane,Google Scholar and Web of Science databases(from 1999 to October 2019)to identify studies with patient age greater than 17 and any gender that reported on outcomes of POP,EHL and LL.The primary outcome assessed involved the pooled technical success and clinical success rate of POP.The secondary outcome included the pooled technical success and clinical success rate for EHL and LL.We also assessed the pooled rate of adverse events for POP,EHL and LL including a subgroup analysis for the rate of adverse event subtypes for POP:Hemorrhage,post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP),perforation,abdominal pain,fever and infections.Technical success was defined as the rate of clearing pancreatic duct stones and clinical success as the improvement in pain.Randomeffects model was used for analysis.Heterogeneity between study-specific estimates was calculated using the Cochran Q statistical test and I2 statistics.Publication bias was ascertained,qualitatively by visual inspection of funnel plot and quantitatively by the Egger test.RESULTS A total of 16 studies including 383 patients met the inclusion criteria.The technical success rate of POP was 76.4%(95%CI:65.9-84.5;I2=64%)and clinical success rate was 76.8%(95%CI:65.2-85.4;I2=66%).The technical success rate of EHL was 70.3%(95%CI:57.8-80.3;I2=36%)and clinical success rate of EHL was 66.5%(95%CI:55.2-76.2;I2=19%).The technical success rate of LL was 89.3%(95%CI:70.5-96.7;I2=70%)and clinical success rate of LL was 88.2%(95%CI:66.4-96.6;I2=77%).The incidence of pooled adverse events for POP was 14.9%(95%CI:9.2-23.2;I2=49%),for EHL was 11.2%(95%CI:5.9-20.3;I2=15%)and for LL was 13.1%(95%CI:6.3-25.4;I2=31%).Subgroup analysis of adverse events showed rates of PEP at 7%(95%CI:3.5-13.6;I2=38%),fever at 3.7%(95%CI:2-6.9;I2=0),abdominal pain at 4.7%(95%CI:2.7-7.8;I2=0),perforation at 4.3%(95%CI:2.1-8.4;I2=0),hemorrhage at 3.4%(95%CI:1.7-6.6;I2=0)and no mortality.There was evidence of publication bias based on funnel plot analysis and Egger’s test.CONCLUSION Our study highlights the high technical and clinical success rates for POP,EHL and LL.POP-guided lithotripsy could be a viable option for management of chronic pancreatitis with PDC. | Syed M Saghir Harmeet S Mashiana Babu P Mohan Banreet S Dhindsa Amaninder Dhaliwal Saurabh Chandan Neil Bhogal Ishfaq Bhat Shailender Singh Douglas G Adler | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 2 | 化学气体污染突发事件中的人群疏散:横断面调查显示文摘目的比较一个塑料工厂发生化学事故后躲藏和被疏散人群的健康结局。设计横断面调查。背景英格兰西南的市区。研究对象该地区1750位曾暴露于化学烟雾的居民,其中472人被疏散,剩下的1278人被建议躲藏在室内。主要结局测定不利于健康的症状数目。出现4个或以上症状者被确定为一个病例。主要的结果1096位居民(63%;299人被疏散,797人躲藏起来)为本分析提供了资料。被疏散人群的平均症状分值和病例的比例比躲藏人群的要高(疏散者:症状分值1.9,病例比例19.7%(n=59);躲藏者:症状分值1.0,病例比例9.5%(n=76),二者比较P<0.001)。在事故发生后两周末时二组间的差异明显变小。成为病例的两个主要可变更危险因子是疏散(比值比2.5,95%可信区间1.7~3.8)和在事故当天直接暴露于烟雾的时间超过2小时(比值比2.0,95%可信区间1.7~2.3)。住所距工厂的距离或是干预前(头6个小时)暴露的水平对于研究对象成为病例的作用不大。结论在此次化学事故中躲藏起来可能是优于疏散人群的保护措施。这与专家们普遍认为的观点一致。尽管本研究有一定的局限性,但它是基于一场真实的事件。疏散本身有一定的风险和资源上的限制,认识上的增加可能会有助于减少将来不必要的疏散。 | S Kinra G Lewendon R Nelder N Herriott R Mohan M Hort S Harrison V Murray 陈雷(译) | 2005 | 英国医学杂志中文版2005，8，5： | 3 |
| 3 | Artificial neural network based peak load forecasting using conjugate gradient methods显示文摘 | Mohan Saiti L Kumar Soni M | 2002 | IEEE Trans on Power Systems2002，17，3： | 2 |
| 4 | Anti-oxidant and anti-inflammatory activity of leaf extracts and fractions of Mangifera indica显示文摘Objective:To evaluate the anti-oxidani and anti-inflammatory activity of leaf extracts and fractions of Mangifera indica in in vitro conditions.Methods:In vitro DPPH radical scavenging activity and lipoxygenase(LOX) inhibition assays were used to evaluate the anti-oxidant and anti-inflammatory activities respectively.Methanolic extract(MEMI),successive water extract (SWMI) and ethyl acetate fraction(EMEMI),n-butanol fraction(BMEMI) and water soluble fraction (WMEMI) of methanolic extract were evaluated along with respective reference standards. Results:In in ritro DPPH radical scavenging activity,the MEMI,EMEMI and BMEMI have offered significant antioxidant activity with IC50 values of 13.37.3.55 and 14.19μig/mL respectively.Gallic acid,a reference standard showed significant antioxidant activity with IC? value of 1.88 and found to be more potent compared to all the extracts and fractions.In m vitro LOX inhibition assay,the MEMI,EMEMI and BMEMI have showed significant inhibition of LOX enzyme activity with IC50 values of 96.71.63.21 and 107.44μg/mL respectively.While,reference drug Indometlhacin also offered significant inhibtion against LOX enzyme activity with IC50 of 57.75.Furthermore,MEMI was found to more potent than SWMI and among the fractions EMEMI was found to possess more potent antioxidant and anti-inflammatory activity.Conclusions:These findings suggest that the MEMI and F.MEMT possess potent anti-oxidani and anti-inflammatory activities in in vitro conditions. | Mohan CG Deepak M Viswanatha GL Savinay G Hanumantharaju V Rajendra CE Praveen D Halemani | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，4： | 2 |
| 5 | Distributed interactive video arrays for event capture and enhanced situational awareness显示文摘 | Mohan M Trivedi Tarak L Gandhi Kohsia S Huang | 2005 | IEEE Intelligent Systems2005，20，5： | 1 |
| 6 | DC reactive magnetron sputtering of titanium - structural and optical characterization of TiO2 films显示文摘 | Suhail M H Rao G M Mohan S | 1992 | J Appl Phys1992，71，： | 1 |
| 7 | Hybrid Active Filtering of Harmonic Currents in Power Systems显示文摘 | Rastogi M Mohan N Edris A A | 1995 | IEEE Trans on PD1995，10，4： | 1 |
| 8 | CAD approach for simulation of generation machining and identification of contact lines显示文摘 | Mohan L V Shunmugam M S | 2004 | International Journal of Machine Tools & Manufacture2004，44，78： | 1 |
| 9 | Synthesis, characterization and effect of reaction parameters on swelling properties of acrylamide-sodium methacrylate superabsorbent copolymers 显示文摘 | Mohan Y M Murthy P S K Raju K M | 2005 | Reactive & Functional Polymers2005，63，： | 1 |
| 10 | Oxidative DNA damage and augmentation of poly (ADP-ribose) polymerase/nuclear factor-kappa B signaling in patients with type 2 diabetes and microangiopathy 显示文摘 | Adaikalakoteswari A Rema M Mohan V | 2007 | Int J Biochem Cell Biol2007，39，9： | 1 |
| 11 | An unusual site of epidermoid cyst 显示文摘 | Jyothi SR Mohan M Sathyaki DC | 2013 | J Ewlut Med Dent Sci2013，2，： | 1 |
| 12 | Preparation and swelling behavior of macroporous poly (acrylamide-co-sodium methacrylate) superabsorbent hydrogels显示文摘 | Mohan Y M Murthy P S K Raju K M | 2006 | Journal of Applied Polymer Science2006，101，5： | 1 |
| 13 | Changes in protein synthesis during drought conditioning in roots of jack pine seedlings 显示文摘 | Michael B M Mohan S Terence J B | 1994 | Tree Physiology1994，14，： | 1 |
| 14 | Stereophonic acoustic echo cancellation-an overview of the fundamental problem显示文摘 | M Mohan Sondhi Dennis R Morgan Joseph L Hall | 1995 | IEEE Signal Processing Letters1995，2，8： | 1 |
| 15 | Biofilm vaccine of Aeromonas hydrophila-standardization of dose and duration for oral vaccination of carps 显示文摘 | Azad I S Shanker K M Mohan C V | 1999 | Fish & Shellfish Immunology1999，9，： | 1 |
| 16 | Effects of malate, lactate, and pyruvate on myoglobin redox stability in homogenates of three bovine muscles显示文摘 | MOHAN A HUNT M C BARSTOW T J | 2010 | Meat Science2010，86，2： | 1 |
| 17 | Analysis of integrated solenoid inductor with closed magnetic core 显示文摘 | WRIGHT J M LEE D W MOHAN Av | 2010 | IEEE Transactions on Magnetics2010，46，： | 1 |
| 18 | Identification and characterization of a principal oxidation impurity in clopidogrel drug substance and drug product显示文摘 | Mohan A Hariharan M Vikraman E Subbaiah G Venkataraman B R Saravanan D | 2008 | J Pharm Biomed Anal2008，47，： | 1 |
| 19 | Head pose estimation in computer vision:a survey显示文摘 | Eric M C Mohan M T | 2009 | IEEE Transactions on Pattern Analysis and Machine Intelligence2009，31，4： | 1 |
| 20 | Effect of A1C13, CH3 SO3 H on thickness, current efficiency and cor- rosion properties of brush plated Cr ( III) formate urea baths 显示文摘 | Saravanan G Mohan S Gnanamuthu R M | 2008 | Surface Engineering2008，24，6： | 1 |
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