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| 1 | Osteoarticular manifestations of human brucellosis:A review显示文摘Brucellosis is a common global zoonotic disease, which is responsible for a range of clinical manifestations. Fever, sweating and musculoskeletal pains are observed in most patients. The most frequent complication of brucellosis is osteoarticular involvement, with 10% to 85% of patients affected. The sacroiliac(up to 80%) and spinal joints(up to 54%) are the most common affected sites.Spondylitis and spondylodiscitis are the most frequent complications of brucellar spinal involvement. Peripheral arthritis, osteomyelitis, discitis, bursitis and tenosynovitis are other osteoarticular manifestations, but with a lower prevalence. Spinal brucellosis has two forms: focal and diffuse. Epidural abscess is a rare complication of spinal brucellosis but can lead to permanent neurological deficits or even death if not treated promptly. Spondylodiscitis is the most severe form of osteoarticular involvement by brucellosis, and can have single-or multifocal involvement. Early and appropriate diagnosis and treatment of the disease is important in order to have a successful management of the patients with osteoarticular brucellosis. Brucellosis should be considered as a differential diagnosis for sciatic and back pain, especially in endemic regions. Patients with septic arthritis living in endemic areas also need to be evaluated in terms of brucellosis. Physical examination, laboratory tests and imaging techniques are needed to diagnose the disease. Radiography, computed tomography, magnetic resonance imaging(MRI) and bone scintigraphy are imaging techniques for the diagnosis of osteoarticular brucellosis. MRI is helpful to differentiate between pyogenic spondylitis and brucellar spondylitis. Drug medications(antibiotics)and surgery are the only two options for the treatment and cure of osteoarticular brucellosis. | Seyed Mokhtar Esmaeilnejad-Ganji Seyed Mohammad Reza Esmaeilnejad-Ganji | 2019 | World Journal of Orthopedics2019，10，2： | 52 |
| 2 | p16 promoter hypermethylation:A useful serum marker for early detection of gastric cancer显示文摘AIM: To determine p16 promoter hypermethylation in gastric tumoral tissue and serum samples, its impact on p16-protein expression, and correlation with clinical and histological features. METHODS: Samples were obtained from 52 histologically confirmed cases of gastric adenocarcinoma. Gastric tissue and serum of 50 age- and sex-matched individuals with normal gastroscopy and biopsy were obtained as control samples. Methylation-specific polymerase chain reaction (MSP) was used to evaluate methylation status of p16 promoter. p16-protein expression was analyzed by immunohistochemical staining on paraffin-embedded sections. RESULTS: Methylation was detected in 44.2% (23/52) of tumoral tissues. 60.9% of them were also methylated in serum, i.e., 26.9% of all patients (14/52). Methylation was not detected in tissue and sera of control samples. p16-protein expression was decreased in 61.5% of cases (32/52), and was significantly associated with promoter hypermethylation (P < 0.001). Methylation was significantly more frequent in higher pathological grades (P < 0.05). Methylation was not associated with other clinicopathological features and environmental factors including H pylori infection and smoking. CONCLUSION: p16 promoter hypermethylation is an important event in gastric carcinogenesis. It is the principle mechanism of p16 gene silencing. It is related to malignant tumor behavior. Detection of DNA methylation in serum may be a biomarker for early detection of gastric cancer. | Mohammad Reza Abbaszadegan Omeed Moaven Hamid Reza Sima Kamran Ghafarzadegan Azadeh A'rabi Mohammad Naser Forghani Hamid Reza Raziee Ali Mashhadinejad Mostafa Jafarzadeh Ehsan Esmaili-Shandiz Ezzat Dadkhah | 2008 | World Journal of Gastroenterology2008，14，13： | 50 |
| 3 | Validation of nutritional risk index method against patientgenerated subjective global assessment in screening malnutrition in colorectal cancer patients显示文摘Objective:To validate malnutrition screening tool of nutrition risk index(NRI)against patient-generated subjective global assessment(PG-SGA)as a gold standard tool in colorectal cancer patients before radiotherapy.Methods:Nutritional status of 52 volunteer colorectal cancer patients with a mean age of 54.1±16.8 years who referred to radiotherapy center were assessed by PG-SGA(gold standard method)and NRI.Serum albumin levels of patients were determined by colorimetric method.A contingency table was used to determine the sensitivity,specificity,and predictive value of the NRI in screening patients at risk of malnutrition,in comparison with the PG-SGA in patients before radiotherapy.Results:The findings of PG-SGA and NRI showed that 52%and 45%of patients in our study were moderately or severely malnourished respectively.The NRI had a sensitivity of 66%and a specificity of 60%against PG-SGA.The positive predictive value was 64%and the negative predicative value was 62%.The agreement between NRI and PG-SGA was statistically insignificant(kappa=0.267;P>0.05).Conclusions:The findings of present study showed that the prevalence of malnutrition was high in patients with colorectal cancer.Moreover,NRI method had low sensitivity and specificity in assessing nutritional status of patients with cancer.It seems that the combination of anthropometric,laboratory parameters and a subjective scoring system may be helpful tools in screening of malnutrition in cancer patients. | Elnaz Faramarzi Reza Mahdavi Mohammad Mohammad-Zadeh Behnam Nasirimotlagh | 2013 | Chinese Journal of Cancer Research2013，25，5： | 23 |
| 4 | Diabetes mellitus and cognitive impairments显示文摘There is strong evidence that diabetes mellitus increases the risk of cognitive impairment and dementia. Insulin signaling dysregulation and small vessel disease in the base of diabetes may be important contributing factors in Alzheimer's disease and vascular dementia pathogenesis, respectively. Optimal glycemic control in type 1 diabetes and identification of diabetic risk factors and prophylactic approach in type 2 diabetes are very important in the prevention of cognitive complications. In addition, hypoglycemic attacks in children and elderly should be avoided. Anti-diabetic medications especially Insulin may have a role in the management of cognitive dysfunction and dementia but further investigation is needed to validate these findings. | Elham Saedi Mohammad Reza Gheini Firoozeh Faiz Mohammad Ali Arami | 2016 | World Journal of Diabetes2016，7，17： | 23 |
| 5 | Sublethal effects of imidacloprid and pymetrozine on population growth parameters of cabbage aphid, Brevicoryne brassicae on rapeseed, Brassica napus L.显示文摘菜蚜的人口生长参数上的 imidacloprid 和 pymetrozine 的效率, Brevicoryne brassicae L。( Homoptera:Aphididae ) 被叶剧降方法用人口统计的毒物学决定。起初,生物鉴定测试被执行。为 imidacloprid 和 pymetrozine 的 LC_(50 ) 价值和置信界限是 1.61 x 10 ^(-5) mol/L (0.74 x 10 ^(-5)-2.66 x10^(-5)) 和 2.14 x 10 ^(-4) mol/L (1.24 x 10 ^(-4)-3.40 x 10 ^(-4)), 分别地。在菜蚜的人口生长参数上评估二杀虫药剂的尚不致命的效果, imidacloprid 和 pymetrozine 的 LC_(30 ) 集中在 5 mol/L 和 30 mol/L 被使用。实验在 20 ±在一个孵卵器被执行 1 ℃, 60% ± 5% RH 并且 16:8 (L:D ) canolaseedlings 上的光周期, Brassica 马来麝 L。var。“ PF ”。网肥沃率在两 insecticide-treatedpopulations 减少了。增加(r_m ) 的内在的率比在控制在 imidacloprid 和 pymetrozine 处理是更低的。内在的出生率也在对待的人口减少了。处于对待的人口的内在的死亡率有相对增加。吝啬的产生时间和倍增时间在比在控制与杀虫药剂对待的人口也是更低的。在作为与控制相比每女性复制的美女的平均数字有可观的减小。在控制的女成年人的平均长寿与与 imidacloprid 和 pymetrozine 对待的那些显著地不同。然而,在在二张对待杀虫药剂的人口之间的蚜虫生活桌子参数没有重要差别(P >
0.01 ) 。 | MOHAMMAD REZA LASHKARI AHAD SAHRAGARD MOHAMMAD GHADAMYARI | 2007 | Insect Science2007，14，3： | 18 |
| 6 | Optimal PD/PID control of smart base isolated buildings equipped with piezoelectric friction dampers显示文摘Long-period pulses in near-field earthquakes lead to large displacements in the base of isolated structures.To dissipate energy in isolated structures using semi-active control,piezoelectric friction dampers(PFD) can be employed.The performance of a PFD is highly dependent on the strategy applied to adjust its contact force.In this paper,the seismic control of a benchmark isolated building equipped with PFD using PD/PID controllers is developed.Using genetic algorithms,these controllers are optimized to create a balance between the performance and robustness of the closed-loop structural system.One advantage of this technique is that the controller forces can easily be estimated.In addition,the structure is equipped with only a single sensor at the base floor to measure the base displacement.Considering seven pairs of earthquakes and nine performance indices,the performance of the closed-loop system is evaluated.Then,the results are compared with those given by two well-known methods:the maximum possive operation of piezoelectric friction dampers and LQG controllers.The simulation results show that the proposed controllers perform better than the others in terms of simultaneous reduction of floor acceleration and maximum displacement of the isolator.Moreover,they are able to reduce the displacement of the isolator systems for different earthquakes without losing the advantages of isolation. | Sadegh Etedali Mohammad Reza Sohrabi Saeed Tavakoli | 2013 | Earthquake Engineering and Engineering Vibration2013，12，1： | 17 |
| 7 | Human papillomavirus in squamous cell carcinoma of esophagus in a high-risk population显示文摘AIM: To investigate the relation of human papillomavirus (HPV) and esophageal squamous cell carcinoma (ESCC)in Iranian patients as compared to normal controls.METHODS: Using MY09/MY11 consensus primers, we compared the prevalence of a HPV L1 gene in tumor tissues from 38 ESCC cases and biopsied tissues from 38endoscopically normal Iranian individuals. We also compared the presence of HPV16 and HPV18 in the same samples using type-specific E6/E7 primers.RESULTS: Fourteen (36.8%) of the 38 ESCC samples but only 5 (13.2%) of the 38 control samples were positive for the HPV L1 gene (P = 0.02). Five (13.2%) of the ESCC samples but none of the control samples were positive for the HPV16 E6/E7gene (P = 0.05). Three (7.9%) of the ESCC samples and 5 (13.2%) of the control samples were positive for the HPV18 E6/E7gene (P = 0.71).CONCLUSION: Our data are consistent with HPV DNA studies conducted in other high-risk areas for ESCC. HPV should be considered as a potential factor contributing to the high incidence of ESCC in Iran and other high-incidence areas of the world. | Mohammad Farhadi Zahra Tahmasebi Shahin Merat Farin Kamangar Dariush Nasrollahzadeh Reza Malekzadeh | 2005 | World Journal of Gastroenterology2005，11，8： | 16 |
| 8 | Mineral processing plant location using the analytic hierarchy process——a case study:the Sangan iron ore mine(phase 1)显示文摘Locating the mineral processing plant near a mine is the most important parameter that affects the whole process.Many factors,and their preferences,should be considered in this stage.The factors include economical,geological,technical,environmental and tectonic parameters.A multi-criteria decision making method is necessary to rank the alternatives.In this paper we describe how plant location is selected by using the Analytic Hierarchy Process(AHP).This method,with eight criteria,was used to select a location for the mineral processing plant at the Sangan iron ore mine(phase 1).Three alternatives for the processing plant were evaluated.The main criteria were distance from the mine,access to heavy machinery transport,the amount of excavation required for grading,bed mixture capacity,belt conveyor length,distance from the tailing dam,distance from the waste dumps and surface water diversion requirements.Finally,the alternatives were ranked and the best location was proposed. | SAFARI Mohsen ATAEI Mohammad KHALOKAKAIE Reza KARAMOZIAN Mohammad | 2010 | Mining Science and Technology2010，20，5： | 15 |
| 9 | Efficacy of premedication with activated Dimethicone or N-acetylcysteine in improving visibility during upper endoscopy显示文摘AIM:To assess the efficacy of N-acetylcysteine(NAC) and activated Dimethicone in improving endoscopic mucosal visibility.METHODS:A total of 148 patients were randomly allocated into four groups to receive one of the following premedications:group A:100 mL water alone;group B:activated Dimethicone plus water(up to 100 mL);group C:NAC plus water(up to 100 mL);and group D:activated Dimethicone and NAC plus water(up to 100 mL).A single endoscopist blinded to the patients group assessed the gastric mucosal visibility scores(range 1-4) at four sites.The sum of the scores from the four sites was considered as the total mucosal visibility score(TMVS).RESULTS:The patients in group B showed a significantly lower TMVS than those of groups A and C(P < 0.001).The TMVS in patients of group D was significantly lower than that of groups A and C(P < 0.001).The TMVS did not significantly differ between groups B and D(P > 0.05).The difference between TMVS of groups C and A was not significant(P > 0.05).CONCLUSION:Premedication with activated Dimethicone 20 min prior to the upper endoscopy leads to the best visibility.NAC does not improve visualization by itself. | Seyed Mohammad Kazem Hosseini Asl Gholam Reza Sivandzadeh | 2011 | World Journal of Gastroenterology2011，17，37： | 15 |
| 10 | Stool-based DNA testing,a new noninvasive method for colorectal cancer screening,the first report from Iran显示文摘AIM:To detect tumor-associated DNA changes in stool samples among Iranian patients with colorectal cancer(CRC)compared to healthy individuals using BAT-26,p16 hypermethylation and long DNA markers.METHODS:Stool DNA was isolated from 45 subjects including 25 CRC patients and 20 healthy individuals using a new,fast and easy extraction method.Long DNA associated with tumor was detected using polymerase chain reaction method.Microsatellite studies were performed utilizing denaturating polyacrylamide gel to determine the instability of BAT-26.Methylation status of p16 promoter was analyzed using methylation-specific PCR(MSP).RESULTS:The results showed a significant difference in existence of long DNA(16 in patients vs 1 in controls,P < 0.001)and p16(5 in patients vs none in controls,P = 0.043)in the stool samples of two groups.Long DNA was detected in 64% of CRC patients;whereas just one of the healthy individuals was positive for Long DNA.p16 methylation was found in 20% of patients and in none of healthy individuals.Instability of BAT-26 was not detected in any of stool samples.CONCLUSION:We could detect colorectal cancer related genetic alterations by analyzing stool DNA witha sensitivity of 64% and 20% and a specificity of 95% and 100% for Long DNA and p16 respectively.A non-invasive molecular stool-based DNA testing can provide a screening strategy in high-risk individuals.However,additional testing on more samples is necessary from Iranian subjects to determine the exact specificity and sensitivity of these markers. | Mohammad Reza Abbaszadegan Alireza Tavasoli Arash Velayati Hamid Reza Sima Hassan Vosooghinia Mehdi Farzadnia Hamid Asadzedeh Mehran Gholamin Ezzat Dadkhah Azadeh Aarabi | 2007 | World Journal of Gastroenterology2007，13，10： | 14 |
| 11 | Tree-Temperature Monitoring for Frost Protection of Orchards in Semi-Arid Regions Using Sprinkler Irrigation显示文摘Automated over-tree sprinkler irrigation systems were developed and tested in two orchards located in two separate locations in southern Iran(a 0.17 ha peach orchard and a 0.24 ha orange orchard) to protect peach blossoms and orange trees leaves and fruits from low temperature damage.The experiment used a system that monitored the trees and air temperatures using two thermistors.The water application rate by the irrigation system was determined by an energy balance as implemented by the software FROSTPRO.In the peach orchard,the system was tested during three frost events during the spring of 2003 and three other events during the spring of 2004.The system successfully kept peach flowers above the critical temperature,i.e.,-4.0°C in spring 2004(control block -4.12°C,and sprinkled block +0.5°C) during all events.Similar results were obtained in the orange orchard during three frost events in the winter of 2004,during which the tree temperatures were at least 2.5°C above the critical temperature.Results from field tests show that the system can effectively protect the peach blossoms from damage.Determination done after the frost events showed a 12% blossom kill in the sprinkled blocks while in the unsprinkled control block a 41.5% blossom kill.Calculations indicated that when using variable application rates,the amount of water used can be reduced by 54.3%.Spatial distribution of minimum temperatures during the three frosts was also studied in Jahrom,Iran.Results showed a significant temperature control in the experimental block,especially in the central part of the orchard,but the block margins(about 3.6% of the total area) were at the risk of low temperature due to the wind drift effects. | Ali Asghar Ghaemi Mohammad Rafie Rafiee Ali Reza Sepaskhah | 2009 | Agricultural Sciences in China2009，8，1： | 14 |
| 12 | Sublethal effects of hexaflumuron on development and reproduction of the diamondback moth, Plutella xylostella (Lepidoptera: Yponomeutidae)显示文摘在 10% 致命的集中(LC10 ) 和在开发和有菱形斑纹的蛾的繁殖参数的 LC25 的 hexaflumuron 的效果, Plutella xylostella (Linnaeus, 1753 )(Lep:Yponomeutidae ) 被调查。估计的 LC50, LC10 和 P 的第三个中间形态幼虫上的 hexaflumuron 的叶剧降生物鉴定的 LC25 价值。xylostella 分别地是 1.48, 0.59 和 0.91 mg/L。Hexaflumuron 减少了在在尚不致命的集中的父母产生,但是在后代产生的蛹的重量,这效果没被观察。尚不致命的集中增加了鸡蛋,第一和第二幼虫的中间形态和蛹发展时间和成年人的弄短的寿命,但是没改变第三和第四幼虫的中间形态和蛹前发展时期。另外,女性的肥沃显著地减少了,但是处理和控制的 hatchability 是类似的。成年人前阶段的幸存率在 LC25 集中显著地衰退了。象繁殖的率(R0 ) 和尚不致命的集中的增加的内在的率那样的繁殖参数与控制相比是显著地更低的,但是在 LC10 集中的粗野繁殖率(GRR ) 被增加,它能是 hormoligosis。另外, hexaflumuron 显著地增加了双倍工资(Dt ) 。我们断定 hexaflumuron 的尚不致命的效果可能在 P 的人口动力学上展出重要效果。xylostella。 | Mohammad Mahmoudvand Habib Abbasipour Aziz Sheikhi Garjan Ali Reza Bandani | 2011 | Insect Science2011，18，6： | 13 |
| 13 | Simultaneous effects of joint spacing and joint orientation on the penetration rate of a single disc cutter显示文摘This paper describes the influence of joint spacing and joint orientation on the penetration rate of a Tunnel Boring Machine(TBM) disc cutter as modeled by the Discrete Element Method(DEM).The input data for the simulations were obtained from the sandstone along the Alborz tunnel that is currently being excavated in Iran using a 5.2 m diameter open TBM.Three joint spacings,150,200,and 300 mm,were modeled together with seven values of joint orientation;0°,15°,30°,45°,60°,75°,and 90°.The results show that the penetration increases when joint orientation increases from 0° to 75°,but it decreases as the joint orientation increases further from 75° to 90°.This is true for each joint spacing.In addition,for a given joint orientation increasing the joint spacing causes the TBM penetration to decrease.The optimum joint orientation,from the viewpoint of TBM penetration,is about 60-75°. | Bejari Hadi Kakaie Reza Ataei Mohammad Khademi-Hamidi Javad | 2011 | Mining Science and Technology2011，21，4： | 13 |
| 14 | Novel cobalt(Ⅱ) complexes of amino acids-Schiff bases catalyzed aerobic oxidation of various alcohols to ketones and aldehyde显示文摘Two cobalt(Ⅱ) complexes 1 and 2 of Schiff bases derived from amino acids were synthesized and used for oxidation of benzyl alcohol with molecular oxygen at different conditions of pH,solvent,temperature and complex/alcohol molar ratio to optimize reaction conditions and to evaluate the catalytic efficiency of new cobalt Schiff base complexes.Under obtained optimum conditions,various alcohols were oxidized to corresponding aldehydes and ketones. | Seyed Mohammad Seyedi Reza Sandaroos Gholam Hossein Zohuri | 2010 | Chinese Chemical Letters2010，21，11： | 13 |
| 15 | Clinical features of hepatopulmonary syndrome in cirrhotic patients显示文摘瞄准:评估频率,临床并且帕拉肝肺症候群(HPS ) 并且到的临床的特征在伊朗在病人在这症候群的诊断决定他们的预兆的价值。方法:54 个肝脏硬化症的病人经历了对比由二位心脏病专家检测肺内、心内的分流的提高的回响心动描记法。动脉的血氧, O (2 ) 坡度(A-a ) 和正统说法被气体(ABG ) 测试的动脉的血测量。为 HPS 的诊断标准积极的病人被定义为表明肺内的动脉的膨胀的临床的 HPS 盒子和那些,但是另外的标准(动脉的血血氧不足) 都没被定义为 lHPS 盒子。HPS 频率,敏感,积极、否定的预兆的价值临床并且帕拉临床的特征被学习。结果:十(18.5%) 并且七(13%) 盒子分别地有临床、无临床症状的 HPS。最普通的病原学是肝炎 B。呼吸困难(100%) 和青紫(90%) 是最流行的临床的特征。呼吸困难并且打分别地是最敏感、特定的临床的特征。没有重要关系被发现在之间 HPS 和脾大,腹水,浮肿,黄疸,尿少,和并行的静脉。HPS 在肝炎 B 是更流行的。PaO (2 )<
70 并且动脉牙槽的坡度在 HPS 病人有最高的敏感。正统说法特性是 100% 。结论:与 75% 的否定预兆的价值(NPV ) 与 75% 的积极预兆的价值(PPV ) 和呼吸困难打是在 HPS 的诊断的最好的临床的因素症候群。PaO (2 )<
70 并且 P (A-a ) O (2 )>
30 并且他们的和,是在 HPS 病人的最珍贵的否定、积极的预兆的价值。 | Amir Houshang MohammadAlizadeh Seyed Reza Fatemi Vahid Mirzaee Manoochehr Khoshbaten Bahman Talebipour Afsaneh Sharifian Ziba Khoram Mohammad Reza Zali Farhad Haj-sheikh-oleslami MasoomehGholamreza-shirazi | 2006 | World Journal of Gastroenterology2006，12，12： | 12 |
| 16 | Computational fluid dynamics(CFD) simulation of effect of baffles on separation in mixer settler显示文摘The main ideas in the development of the solvent extraction mixer settler focused on achieving clean phase separation,minimizing the loss of the reagents and decreasing the surface area of the settlers.The role of baffles in a mechanically agitated vessel is to ensure even distribution,reduce settler turbulence,promote the stability of power drawn by the impeller and to prevent swirling and vortexing of liquid,thus,greatly improving the mixing of liquid.The insertion of the appropriate number of baffles clearly improves the extent of liquid mixing.However,excessive baffling would interrupt liquid mixing and lengthen the mixing time.Computational fluid dynamics(CFD) provides a tool for determining detailed information on fluid flow(hydrodynamics) which is necessary for modeling subprocesses in mixer settler.A total of 54 final CFD runs were carried out representing different combinations of variables like number of baffles,density and impeller speed.CFD data shows that amount of separation increases with increasing baffles number and decreasing impeller speed. | Mohsen Ostad Shabani Ali Mazahery Mehdi Alizadeh Ali Asghar Tofigh Mohammad Reza Rahimipour Mansour Razavi Alireza Kolahi | 2012 | International Journal of Mining Science and Technology2012，22，5： | 12 |
| 17 | Rare earth elements distribution in marine sediments of Malaysia coasts显示文摘In the east coast Peninsular Malaysia region,sediments are transported by several rivers from the east Malaysia into the South China Sea estuary.In the vicinity of the five river estuaries core sediments were collected in order to investigate rare earth elements(REEs) profile.Core sediments were divided into strata of between 2 to 4 cm intervals and prepared for analyzing by ICP-AES.REE concentrations of 54.3 μg/gr at 24-26 cm in EC4 increased to 114.1 μg/gr at 20-22 cm in EC5.The measured concentration of LREEs and Fe normalized enrichment factors indicated that sediments were not enriched with light rare earth elements derived from effluents of anthropogenic activities.Results of the total concentration were used to establish baseline data in environmental pollution assessment and to develop the correlations between the Ce/Ce and Eu/Eu anomalies and the distribution patterns of some light rare earth elements(LREEs) and the heavy rare earth elements(HREEs).The chondrite-normalized ratios of REEs showed LREEs enrichment and flat HREE depletion. | Rezaee Ebrahim Saraee Khadijeh Saion B.Elias Abdul Khalik Wood Abdi Mohammad Reza | 2009 | Journal of Rare Earths2009，27，6： | 11 |
| 18 | Predictive value and main determinants of abnormal features of intraoperative cholangiography during cholecystectomy显示文摘BACKGROUND:The major issue with intraoperative cholangiography (IOC) is whether its diagnostic accuracy for common bile duct (CBD) stones matches that of other diagnostic procedures,and thus,whether it will become a routine diagnostic procedure.The current study aimed to address the main determinants of CBD stone diagnosis in IOC among an Iranian population.METHODS:In a retrospective review database-based study conducted in Taleghani Hospital in Tehran between 2006 and 2008,baseline data and perioperative information of 2060 patients (male to female ratio 542:1518,mean age 53.7 years) who were candidates for cholecystectomy and underwent concomitant IOC for confirming CBD stones were reviewed.The predictive power of this procedure for diagnosis of abnormal biliary ducts with the focus on biliary stones was determined.RESULTS:Overall mortality and morbidity following cholecystectomy in the study population were 0.6% and 2.6%,respectively.Both early mortality and morbidity due to cholecystectomy were higher in male than female.The prevalence of CBD stones in IOC was 3.4% (5.2% in male and 2.8% in female,P=0.008).Among those without gallstones,8.7% had CBD stones and only 3.1% had concomitant gallstones and CBD stones.The main predictors of stone appearance as an abnormal feature of IOC during cholecystectomy were:advanced age (OR=1.022,P=0.001),male gender (OR=1.498,P=0.050),history of abdominal surgery (OR=1.543,P=0.040) and preoperative endoscopic retrograde cholangiopancreatography (OR=5.400,P<0.001).CONCLUSIONS:IOC is a safe and accurate method for the assessment of bile duct anatomy and stones.Therefore,the routine use of IOC within cholecystectomy seems reasonable and is recommended. | Shahram Yousefpour Azary Heshmat Kalbasi Ali Setayesh Mirhadi Mousavi Asad Hashemi Mahsa Khodadoostan Mohammad Reza Zali Amir Houshang Mohammad Alizadeh | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 11 |
| 19 | A review of the efficacy of traditional Iranian medicine forinflammatory bowel disease显示文摘The etiology of inflammatory bowel disease(IBD) is not yet known,but many factors such as defects in the immune system,oxidative stress,microbial content in the gastrointestinal tract,nuclear factor(NF)-κB,nitric oxide(NO),cyclooxygenase-2(Cox-2),and leukotriene B4(LB4) are thought to play a role in its pathogenesis.In traditional Iranian medicine(TIM),several medicinal plants are thought to be effective for the treatment of IBD.In this study,information on all of these remedies were derived from all available old sources such as documents or notes and books and were added to the information derived from modern medical databases covering all in vitro,in vivo and clinical trials.For some of these plants,only one or two mechanisms of action have been found such as in Cassia fistula,Lepidium sativum,and Bunium persicum.However,for some plants various mechanisms of action are known.For example,Commiphora mukul is effective in IBD due to its immunomodulatory,antioxidant,and antibacterial properties and it decreases NF-κB,NO and Cox-2.Another herb,Plantago ovata,has immunomodulatory,antioxidant,anti-inflammatory and wound healing activities and decreases NO and LB4.Considering the mechanisms of action of these plants,the combination of some of them may be useful because of their many mechanisms of action such as Pistacia lentiscus,Bunium persicum,Solanum nigrum,Plantago ovata,Boswellia,Solanum nigrum,Plantago ovata and Commiphora mukul.For some of the herbal products used in TIM such as oleogum resin from Commiphora myrrha,seeds of Ocimum basilicum,seeds of Linum usitatissimum,gum resin of Dracaena cinnabari,seeds of Plantago major,seeds of Lallementia royleana,and seeds of Allium porrum,there is no or not enough studies to confirm their benefits in IBD.It is suggested that an evaluation of the effects of these plants on different aspects of IBD should be performed. | Roja Rahimi Mohammad Abdollahi Mohammad Reza Shams-Ardekani | 2010 | World Journal of Gastroenterology2010，16，36： | 10 |
| 20 | Association of p53/p21 expression with cigarette smoking and prognosis in esophageal squamous cell carcinoma patients显示文摘factors,such as cigarette smoking,in esophageal squamous cell carcinoma(ESCC)in northeastern Iran,a region with a high incidence of ESCC.METHODS:The expression of p53 and p21 proteins was investigated immunohistochemically in tumor tissue from 80 ESCC patients and in 60 available paraffinembedded blocks of adjacent normal specimens from the cases,along with normal esophageal tissue from 80 healthy subjects.RESULTS:Positive expression of p53 protein was detected in 56.2%(45/80)of ESCC cases,and in none of the normal esophageal tissue of the control group(P<0.001).Furthermore,73.8%(59/80)of ESCC cases and 43.8%(35/80)of controls had positive expression of p21 protein(P<0.001).Cigarette smoking was significantly associated with p53 over-expression in ESCC cases(P=0.010,OR=3.64;95%CI:1.32-10.02).p21 over-expression was associated with poorer clinical outcome among the ESCC patients(P=0.009).CONCLUSION:Over-expression of p53 in association with cigarette smoking may play a critical role in ESCC carcinogenesis among this high-risk population of northeastern Iran.Furthermore,p21 over-expression was found to be associated with poor prognosis,specifically in the operable ESCC patients. | Noushin Taghavi Firouzeh Biramijamal Masoud Sotoudeh Omeed Moaven Hooman Khademi Mohammad Reza Abbaszadegan Reza Malekzadeh | 2010 | World Journal of Gastroenterology2010，16，39： | 10 |
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