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| 1 | Prognostic factors and time-related changes influence results of colorectal liver metastases surgical treatment:A single-center analysis显示文摘AIM:To analyze the prognostic factors involved in survival and cancer recurrence in patients undergoing surgical treatment for colorectal liver metastases(CLM) and to describe the effects of time-related changes on survival and recurrence in these patients.METHODS:From January 1994 to January 2006,236 patients with CLM underwent surgery with the aim of performing curative resection of neoplastic disease at our institution and 189(80%) of these patients underwent resection of CLM with curative intention.Preoperative,intraoperative and postoperative data,including primary tumor and CLM pathology results,were retrospectively reviewed.Patients were divided into two time periods:a first period from January 1994 to January 2000(n = 93),and a second period from February 2000 to January 2006(n = 143).RESULTS:Global survival at 1,3 and 5 years in patients undergoing hepatic resection was 91%,54% and 47%,respectively.Patients with preoperative extrahepatic disease,carcinoembryonic antigen(CEA) levels over 20 ng/dL,more than four nodules or extrahepatic invasion at pathological analysis had worse survival.Tumor recurrence rate at 1 year was 48.3%,being more frequent in patients with preoperative and pathological extrahepatic disease and CEA levels over 20 ng/dL.Although patients in the second time period had more adverse prognostic factors,no differences in overall survival and recurrence were observed between the two periods.CONCLUSION:Despite advances in surgical technique and better adjuvant treatments and preoperative imaging,careful patient staging and selection is crucial to continue offering a chance of cure to patients with CLM. | Josep Martí María Marta Modolo Josep Fuster Jaume Comas Rebeca Cosa Joana Ferrer Victor Molina Juan Romero Constantino Fondevila Ramón Charco Juan Carlos García-Valdecasas | 2009 | World Journal of Gastroenterology2009，15，21： | 9 |
| 2 | Tonic and phasic descend- ing dopaminergic controls of nociceptive transmission in the me- dullary dorsal horn显示文摘 | Lapirot O Melin C Modolo A | 2011 | Pain2011，152，8： | 1 |
| 3 | Pulp and paper plant wastes valorisation in bituminous mixes 显示文摘 | Modolo R Benta A Ferreira V M | 2010 | Waste Manage2010，30，4： | 1 |
| 4 | Cytotoxicity of goniothalamin enantiomers in renal cancer cells: involvement of nitric oxide, apoptosis and autophagy 显示文摘 | De Fatima A Zambuzz W F Modolo L V | 2008 | Chem Biol Interact2008，176，23： | 1 |
| 5 | 6,6'-bis(5,5,5,8-tetramethyl-5,6,7,8-tetrahydro-benzo[1,2,4]triazin-3-yl)[2,2']bipyridine,an effective extracting agent for the separation of americium(III) and curium(III) from the lanthanides显示文摘 | Geist A Hil C Modolo G | | 0，，04： | 1 |
| 6 | Genomic and coexpression analyses predict multiple genes involved in triterpene saponin biosynthesis in Medicago truncatula 显示文摘 | Naoumkina M A Modolo L V Huhman D V | 2010 | Plant Cell2010，22，3： | 1 |
| 7 | Influence of red mud addition on rheological behavior and hardened properties of mortars 显示文摘 | Senff L Modolo R C E Santos Silva A | 2014 | Construction and Building Materials2014，65，： | 1 |
| 8 | Intrave- nous versus inhalation anaesthesia for one - lung ventilation 显示文摘 | MODOLO N S P MODOLO M P MARTON M A et at | 2013 | Cochrane Database Syst Rev2013，7，00： | 1 |
| 9 | Resistant or re- fractory hypertension:are they different 显示文摘 | Modolo R de Faria AP Almeida A | 2014 | Curr Hyper- tens Rep2014，16，10： | 1 |
| 10 | Genomic and coexpression analyses predict multiple genes involved in triterpene saponin biosynthesis in Medicago truncatula 显示文摘 | Naournkina M A Modolo L V Huhman D V | 2010 | Plant Cell2010，22，： | 1 |
| 11 | Single amino acid mutations of Medicago glycosyltransferase UGT85H2 enhance activity and impart reversibility显示文摘 | Modolo L V Escamilla-Trevino L L Dixon R A | 2009 | Febs Lett2009，583，12： | 1 |
| 12 | Generation of interface states by ionizing radiation in very thin MOS oxides 显示文摘 | SAKS N S ANCONA M G MODOLO J A | 1986 | IEEE Transactions on Nuclear Science1986，33，6： | 1 |
| 13 | Wound healing agents : the role of natural and non-natural products in drug development显示文摘 | de-Fatima A Modolo L V Sanches A C | 2008 | MiniRevMedChem2008，8，9： | 1 |
| 14 | Genomic and coexpression analyses predict multiple genes involved in triterpene saponin biosynthesis in Medicago truncatula 显示文摘 | Naoumkina M A Modolo L V Huhman D V | 2010 | Plant Cell2010，22，： | 1 |
| 15 | Crystal structure of Medicago truncatula UGT85H2-insights into the structural basis of a multifunctional (iso)flavonoid glycosyltransferase显示文摘 | Li L Modolo L V Escamilla-Trevino L L Achinine L Dixon R A Wang X Q | 2007 | Journal of Molecular Biology2007，370，5： | 1 |
| 16 | Crystal structures of glycosyltransferase UGT78G1 reveal the molecular basis for glycosylation and deglycosylation of (iso)flavonoids显示文摘 | Modolo L V Li L Pan H Blount J W Dixon R A Wang X Q | 2009 | Journal of Molecular Biology2009，392，5： | 1 |
| 17 | Generation of interface states by ionizing radiation in very thin MOS oxides 显示文摘 | SAKS N S ANCONA M G MODOLO J A | 1986 | IEEE Trans Nucl Sci1986，33，6： | 1 |
| 18 | Genomic and coexpression analyses predict multiple genes involved in trit-erpene saponin biosynthesis in Medicago truncatula显示文摘 | Naoumkina M A Modolo L V Huhman D V | 2010 | Plant Cell2010，22，： | 1 |
| 19 | Immunolocalization of bone morphogenetic protein 2 during the early healing events after guided bone regeneration显示文摘 | Andréa Carvalho De Marco Maria Aparecida Neves Jardini Filipe Modolo Fábio Daumas Nunes Luiz Antonio Pugliesi Alves de Lima | 2012 | Oral Surgery Oral Medicine Oral Pathology and Oral Radiology2012，，4： | 1 |
| 20 | Closed-loop cortical neuromodulation in Parkinson's disease: An alternative to deep brain stimulation ? 显示文摘 | Beuter A Lefaucheur J P Modolo J | 2014 | Clin Neurophysiol2014，125，5： | 1 |
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