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| 1 | Prognostic factors and time-related changes influence results of colorectal liver metastases surgical treatment:A single-center analysis显示文摘AIM:To analyze the prognostic factors involved in survival and cancer recurrence in patients undergoing surgical treatment for colorectal liver metastases(CLM) and to describe the effects of time-related changes on survival and recurrence in these patients.METHODS:From January 1994 to January 2006,236 patients with CLM underwent surgery with the aim of performing curative resection of neoplastic disease at our institution and 189(80%) of these patients underwent resection of CLM with curative intention.Preoperative,intraoperative and postoperative data,including primary tumor and CLM pathology results,were retrospectively reviewed.Patients were divided into two time periods:a first period from January 1994 to January 2000(n = 93),and a second period from February 2000 to January 2006(n = 143).RESULTS:Global survival at 1,3 and 5 years in patients undergoing hepatic resection was 91%,54% and 47%,respectively.Patients with preoperative extrahepatic disease,carcinoembryonic antigen(CEA) levels over 20 ng/dL,more than four nodules or extrahepatic invasion at pathological analysis had worse survival.Tumor recurrence rate at 1 year was 48.3%,being more frequent in patients with preoperative and pathological extrahepatic disease and CEA levels over 20 ng/dL.Although patients in the second time period had more adverse prognostic factors,no differences in overall survival and recurrence were observed between the two periods.CONCLUSION:Despite advances in surgical technique and better adjuvant treatments and preoperative imaging,careful patient staging and selection is crucial to continue offering a chance of cure to patients with CLM. | Josep Martí María Marta Modolo Josep Fuster Jaume Comas Rebeca Cosa Joana Ferrer Victor Molina Juan Romero Constantino Fondevila Ramón Charco Juan Carlos García-Valdecasas | 2009 | World Journal of Gastroenterology2009，15，21： | 9 |
| 2 | Tonic and phasic descend- ing dopaminergic controls of nociceptive transmission in the me- dullary dorsal horn显示文摘 | Lapirot O Melin C Modolo A | 2011 | Pain2011，152，8： | 1 |
| 3 | Decreased arginine and nitrite levels in nitrate reductasedeficient Arabidopsis thaliana plants impair nitric oxide synthesis and the hypersensitive response to Pseudomonas syringae显示文摘 | Modolo L V Augusto O Almeida I M G | 2006 | Plant Science2006，171，1： | 1 |
| 4 | Expression of extracellular matrix proteins in adenomatoid odontogenic tumor显示文摘 | Modolo F Biz MT Martins MT | | J Oral Pathol Med0，39，3： | 1 |
| 5 | Heat transfer in a mechanical face seal 显示文摘 | Brunetibre N Modolo B | 2009 | International Journal of Thermal Sciences2009，48，4： | 1 |
| 6 | Preoperative combined with intraoperative skin-surface warming avoids hypothemia caused by general anesthesia and surgery显示文摘 | Vanni SM Braz JR Modolo NS | 2003 | J Clin Anesth2003，15，2： | 1 |
| 7 | Pulp and paper plant wastes valorisation in bituminous mixes 显示文摘 | Modolo R Benta A Ferreira V M | 2010 | Waste Manage2010，30，4： | 1 |
| 8 | Resistant hyper- tension revisited: definition and true prevalence显示文摘 | Modolo R de Faria AP Sahbatini AR | 2014 | J Hyper tens2014，32，7： | 1 |
| 9 | The separation of trivalent actinides from lanthanides by dithiophosphinic acids from HNO3 medium显示文摘 | G Modolo R Odoj | 1998 | Journal of Alloys and Compounds1998，，： | 1 |
| 10 | Synergistic selective extraction of actinides ( Ⅲ) over lanthanides from nitric acid using new aromatic diorganyldithiophosphinie acids and neutral organophosphorus compounds 显示文摘 | G Modolo R Odoj | 1999 | Solvent Extraction and Ion Exchange1999，17，1： | 1 |
| 11 | A short review of their antimicrobial activities显示文摘 | Da Silva C M Da Silva D L Modolo L V | | 0，，01： | 1 |
| 12 | Cytotoxicity of goniothalamin enantiomers in renal cancer cells: involvement of nitric oxide, apoptosis and autophagy 显示文摘 | De Fatima A Zambuzz W F Modolo L V | 2008 | Chem Biol Interact2008，176，23： | 1 |
| 13 | , 2006 Decreased arginine and nitrite levels in nitrate reductase-deficient Arabidopsis thaliana plants impair nitric oxide synthesis and the hypersensitive response to Pseudomonas syringae 显示文摘 | Modolo LV Augusto O Almeida IMG | 2006 | Plant Science2006，171，： | 1 |
| 14 | 6,6'-bis(5,5,5,8-tetramethyl-5,6,7,8-tetrahydro-benzo[1,2,4]triazin-3-yl)[2,2']bipyridine,an effective extracting agent for the separation of americium(III) and curium(III) from the lanthanides显示文摘 | Geist A Hil C Modolo G | | 0，，04： | 1 |
| 15 | Construction materials as a waste managementsolution for cellulose sludge显示文摘 | MODOLO R FERREIRA V M MACHADO L M etal | 2011 | Waste Management2011，31，2： | 1 |
| 16 | Increased arterial stiff- ness in resistant hypertension is associated with inflammatory bio- markers显示文摘 | Barbaro NR Fontana V Modolo R | 2015 | Blood Press2015，24，1： | 1 |
| 17 | Heat transfer in a mechanical face seal 显示文摘 | Noel Brunetiere Benoit Modolo | 2009 | International Journal of Thermal Sciences2009，48，： | 1 |
| 18 | Construction materials as a waste management solution for cellulose sludge显示文摘 | Modolo FZ Ferreira V M Machado L M | 2011 | Waste Management2011，31，2： | 1 |
| 19 | Emergence agitation in pediatric anesthesia: current features显示文摘 | Silva LM Braz LG Modolo NS | 2008 | J Pediatr ( Rio J)2008，84，2： | 1 |
| 20 | Schiff bases: A short review of their antimlcrobial activities 显示文摘 | DaSilva C M DaSilva D L Modolo L V | 2011 | Journal of Advanced Research2011，2，1： | 1 |
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