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| 1 | Resveratrol attenuates oxidative stress and histological alterations induced by liver ischemia/reperfusion in rats显示文摘AIM:To investigate the effects of resveratrol on liver ischemia/reperfusion (I/R) injury in rats. METHODS: A total of 40 male Sprague-Dawley rats weighing 240-290 g were randomized into four groups of ten: (1) controls: data from unmanipulated animals; (2) sham group: rats subjected to the surgical procedure, except for liver I/R, and given saline; (3) I/R group: rats underwent liver ischemia for 45 min followed by reperfusion for 45 min; (4) I-R/Resveratrol group: rats pretreat- ed with resveratrol (10 μmol/L,iv). Liver tissues wweerre obtained to determine antioxidant enzyme levels and for biochemical and histological evaluation. RESULTS: Plasma aminotransferase activities were higher in the I/R group than in the I-R/Resveratrol group. Malondialdehyde levels and the hepatic injury score decreased, while superoxide dismutase, catalase ,and glutathione peroxidase levels increased in group 4 compared to group 3. In group 4, histopathological changes were significantly attenuated in resveratrol-treated livers. CONCLUSION: These results suggest that resveratrol has protective effects against hepatic I/R injury, and is a potential therapeutic drug for ischemia reperfusion-related liver injury. | Ercan Gedik Sadullah Girgin Hayrettin Ozturk Basra Deniz Obay Hulya Ozturk Huseyin Buyukbayram | 2008 | World Journal of Gastroenterology2008，14，46： | 14 |
| 2 | Hepatic fibrosis in biliary-obstructed rats is prevented by Ginkgo biloba treatment显示文摘AIM: To assess the antioxidant and antifibrotic effects of long-term Ginkgo biloba administration on liver fibrosis induced by biliary obstruction in rats.METHODS: Liver fibrosis was induced in male Wistar albino rats by bile duct ligation and scission (BDL). Ginkgo administered for 28 d. At the end of the treatment period,all rats were killed. Serum aspartate aminotransferase (AST),alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) levels were determined to assess liver functions and tissue damage, respectively. Tumor necrosis factor-α (TNF-α) was also assayed in serum samples. Liver tissues were taken for determination of the hepatic malondialdehyde (MDA) and glutathione (GSH) levels,myeloperoxidase (MPO) activity and collagen content.Production of reactive oxidants was monitored by chemiluminescence (CL) assay. Serum AST, ALT, LDH, and TNF-α levels were elevated in the BDL group as compared to control group and were significantly decreased by EGb treatment.RESULTS: Hepatic GSH level, depressed by BDL, was elevated back to control level in EGb-treated BDL group.Increase in tissue MDA level, MPO activity and collagen content due to BDL were also attenuated by EGb treatment.Furthermore, luminol and lucigenin CL values in BDL group increased dramatically compared to control and reduced by EGb treatment.CONCLUSION: Our results suggest that Ginkgo biloba protects the liver from oxidative damage following BDL in rats. This effect possibly involves the inhibition of neutrophil infiltration and lipid peroxidation; thus, restoration of oxidant and antioxidant status in the tissue. | Gksel pener Levent Kabasakal Meral Yüksel Nursal Gedik Ynci Alican | 2005 | World Journal of Gastroenterology2005，11，35： | 7 |
| 3 | Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats显示文摘AIM: To investigate whether antioxidants vitamin E and C can retard development of hepatic fibrosis in the bili- ary-obstructed rats. METHODS: Fifty Wistar albino rats were randomly as- signed to 5 groups (10 rats in each). Bile duct was liga- ted in 40 rats and they were treated as follows: group vitC, vitamin C 10 mg/kg sc daily; group vitE, vitamin E 15 mg/kg sc daily; group vitEC, both of the vitamins; bile duct-ligated (BDL, control) group, physiological saline sc. The fifth group was assigned to sham operation. At the end of fourth week, the rats were decapitated, and hepatic tissue biochemical collagen content and collagen surface area were measured. Hepatic tissue specimens were histopathologically evaluated according to Scheuer system. Serum hyaluronate levels were measured by ELISA method. RESULTS: Despite being higher than sham group, he- patic collagen level was significantly decreased in each of the vitC, vitE and vitEC groups (32.7 ± 1.2, 33.8 ± 2.9, 36.7 ± 0.5 μg collagen/mg protein, respectively) compared to BDL (48.3 ± 0.6 mg collagen/g protein) (P < 0.001 for each vitamin group). Each isolated vitamin C, isolated vitamin E and combined vitamin E/C supp-lementation prevented the increase in hepatic collagen surface density (7.0% ± 1.1%, 6.2% ± 1.7%, 12.3% ± 2.0%, respectively) compared to BDL (17.4% ± 5.6%) (P < 0.05 for each). The same beneficial effect of vitamin C, vitamin E and combined vitamin E/C treatment was also observed on the decrease of serum hyaluronate levels compared to BDL group (P < 0.001). The relative liver and spleen weights, serum transaminases, cholestatic enzymes, bilirubins and histopathological inflammation scores were not different between the antioxidant treat- ment groups and the control. However, fibrosis staging scores were obviously reduced only in the vitamin E/C combination group (vit EC: 2.4 ± 0.8 vs BDL: 3.1 ± 0.7; P < 0.05). CONCLUSION: Each antioxidant vitamin E, vitamin C and their combination retard hepatic fibrosis in biliary-obs- tructed rats. Oxidative stress may play a role in the patho- genesis of hepatic fibrosis in secondary biliary cirrhosis. | Ali Riza Soylu Nurettin Aydogdu Umit Nusret Basaran Semsi Altaner Orhan Tarcin Nursal Gedik Hasan Umit Ahmet Tezel Gulbin Dokmeci Huseyin Baloglu Mevlut Ture Kemal Kutlu Kadir Kaymak | 2006 | World Journal of Gastroenterology2006，12，42： | 4 |
| 4 | Single-cell gel electrophoresis applied to the analysis of UV-C damage and its repair in human cells显示文摘 | Gedik CM Ewen SW Collins AR | 1992 | Int J Radiat Biol1992，62，3： | 2 |
| 5 | Serum prolidase and IGF-1 as non-invasive markers of hepatic fibrosis during four different periods after bile-ductligation in rats显示文摘 | Tarcin O Gedik N Karakoyun B | 2008 | Dig Dis Sci2008，53，7： | 1 |
| 6 | Analysis of oxidative DNA damage and HPRT mutations in humans after hyperbaric oxygen treatment 显示文摘 | Dennog C Gedik C Wood S | 1999 | Mutat Res1999，431，2： | 1 |
| 7 | The effect of metformin on leptin in obese patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease显示文摘 | Nar A Gedik O | | 0，，02： | 1 |
| 8 | Oxidative damage to DNA: Do we have a reliable biomarker? 显示文摘 | Collins A R Dusinska M Gedik C M | 1996 | Environmental Health Perspective1996，104，： | 1 |
| 9 | Protecting location privacy with personal- ized k-anonymity: architecture and algorithms 显示文摘 | Gedik B Liu L | 2008 | IEEE Transactions on Mobile Computing2008，7，1： | 1 |
| 10 | Performance investigation of the Afyon geothermal district heating system for building applications:exergy analysis显示文摘 | Kecebas A Kayfeci M Gedik E | | 0，，6： | 1 |
| 11 | A randomized and comparative stady of intravenous immunoglobulin and mega dose methyl prednisolone treatment in children with acute idiopathic thrombo cytopenic purpura显示文摘 | Erduran E Asian Y Gedik Y | 2003 | Turk pediatr2003，45，5： | 1 |
| 12 | Mitochondrial STAT3 activation and cardioprotection by ischemic postconditioning in pigs with regional myocardial ischemia/reperfusion 显示文摘 | Heusch G Musiolik J Gedik N | 2011 | Circ Res2011，109，11： | 1 |
| 13 | Askin' s tumor in an adult: case report and findings on 18 F- FDG PET/CT 显示文摘 | Kara Gedik G Sari O Altinok T | 2009 | Case Rep Med2009，2009，51： | 1 |
| 14 | The evaluation of bacteriology in perianal abscesses of 81 adultpatients显示文摘 | Ulug M Gedik E Girgin S | 2010 | Braz J Infect Dis2010，14，3： | 1 |
| 15 | Protecting location privacy with personalized k-anonymity: architecture and al- gorithms显示文摘 | Gedik Bugra Liu Ling | 2008 | IEEE Transactions on Mobile Compu- ting2008，7，1： | 1 |
| 16 | The evaluation of bacte- riology in perianal abscesses of 81 adult patients 显示文摘 | Ulug M Gedik E Girgin S | 2010 | Braz J Infect Dis2010，14，3： | 1 |
| 17 | Effects of age and dietary restriction on oxidative DNA damage, antiox- idant protection and DNA repair in rats显示文摘 | Gedik C M Grant G Mortice P C | 2005 | European Journal of Nutrition2005，44，5： | 1 |
| 18 | Effects of vitamin D deficincy and repletion on insulin and glucagon secretion in man 显示文摘 | Gedik A Akalin S | 1986 | Diabetogin1986，29，： | 1 |
| 19 | Effects of combination of insulin and acarbosecompared with insulin and gliclazide in type 2 diabetic patients显示文摘 | Giivener N Gedik O | 1999 | Acta Diabeted1999，36，： | 1 |
| 20 | A Distributed Approach to Node Clustering in Decentralized Peer-to-Peer Networks显示文摘 | Ramaswamy L Gedik B Liu L | 2005 | IEEE Trans on Parallel and Distributed System2005，16，9： | 1 |
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