|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Achieving over 16% efficiency for single-junction organic solar cells显示文摘To achieve high photovoltaic performance of bulk hetero-junction organic solar cells(OSCs), a range of critical factors including absorption profiles, energy level alignment, charge carrier mobility and miscibility of donor and acceptor materials should be carefully considered. For electron-donating materials, the deep highest occupied molecular orbital(HOMO) energy level that is beneficial for high open-circuit voltage is much appreciated. However, a new issue in charge transfer emerges when matching such a donor with an acceptor that has a shallower HOMO energy level. More to this point, the chemical strategies used to enhance the absorption coefficient of acceptors may lead to increased molecular crystallinity, and thus result in less controllable phase-separation of photoactive layer. Therefore, to realize balanced photovoltaic parameters, the donor-acceptor combinations should simultaneously address the absorption spectra, energy levels, and film morphologies. Here, we selected two non-fullerene acceptors, namely BTPT-4F and BTPTT-4F, to match with a wide-bandgap polymer donor P2F-EHp consisting of an imidefunctionalized benzotriazole moiety, as these materials presented complementary absorption and well-matched energy levels. By delicately optimizing the blend film morphology, we demonstrated an unprecedented power conversion efficiency of over 16% for the device based on P2F-EHp:BTPTT-4F, suggesting the great promise of materials matching toward high-performance OSCs. | Baobing Fan Difei Zhang Meijing Li Wenkai Zhong Zhaomiyi Zeng Lei Ying Fei Huang Yong Cao | 2019 | Science China Chemistry2019，62，6： | 38 |
| 2 | IDO1 in cancer: a Gemini of immune checkpoints显示文摘Indoleamine 2,3-dioxygenase 1(IDO1)is a rate-limiting metabolic enzyme that converts the essential amino acid tryptophan(Trp)into downstream catabolites known as kynurenines.Coincidently,numerous studies have demonstrated that IDO1 is highly expressed in multiple types of human cancer.Preclinical studies have further introduced an interesting paradox:while single-agent treatment with IDO1 enzyme inhibitor has a negligible effect on decreasing the established cancer burden,approaches combining select therapies with IDO1 blockade tend to yield a synergistic benefit against tumor growth and/or animal subject survival.Given the high expression of IDO1 among multiple cancer types along with the lack of monotherapeutic efficacy,these data suggest that there is a more complex mechanism of action than previously appreciated.Similar to the dual faces of the astrological Gemini,we highlight the multiple roles of IDO1 and review its canonical association with IDO1-dependent tryptophan metabolism,as well as documented evidence confirming the dispensability of enzyme activity for its immunosuppressive effects.The gene transcript levels for IDO1 highlight its strong association with T-cell infiltration,but the lack of a universal prognostic significance among all cancer subtypes.Finally,ongoing clinical trials are discussed with consideration of IDO1-targeting strategies that enhance the efficacy of immunotherapy for cancer patients。 | Lijie Zhai Erik Ladomersky Alicia Lenzen Brenda Nguyen Ricky Patel Kristen L Lauing Meijing Wu Derek A Wainwright | 2018 | Cellular & Molecular Immunology2018，15，5： | 17 |
| 3 | Mechanisms involved in antineuralgic effects of Paeonia Lactiflora: prediction based on network pharmacology显示文摘目的:白芍的镇痛作用已被广泛应用于中医临床,但对其潜在机制知之甚少.本研究旨在从网络药理学的角度阐明其有效成分和镇痛机制.方法:通过中药系统药理学分析平台(TCMSP)筛选出其可能的活性成分及CAS.从Pubchem 中获得其SMILES,并通过在Swiss Target Prediction 数据库中反向对接获得潜在的靶点.从GeenCards 数据库中提取疼痛相关分子,采用韦恩图筛选出芍药治疗疼痛的预测靶点.机制分析采用String 构建蛋白-蛋白相互作用,运用DAVID 平台进行靶点GO 功能富集和KEGG 信号通路富集.结果:通过GO 和KEGG 分析我们发现疼痛相关的信号通路主要涉及血清素能突触、钙信号通路、调控TRP 通道的炎症介质.利用基于网络的系统生物学和分子对接分析,我们预测了白芍中的11 种活性成分和97 个潜在的治疗靶标.PRKCA、CASP3、ALOX15、SLC6A4、PRKCG、ALOX5、PRKCB、ALOX12、 EGFR、ADRB2、RYR3、RYR1、NOS2、PTAFR、PRKCQ、PRKCD 等基因参与了白芍的镇痛作用.结论:白芍可通过调节TRP 通道炎症介质、钙信号通路和5-羟色胺受体减轻疼痛.PRKCA、PRKCB、PRKCD、 PRKCQ 和PRKCG 可能是疼痛治疗的新靶标. | Di Zhang Shengsuo Ma Jianxin Sun Bing Yang Haoming Lin Meijing Xie Meina Huang Guoping Zhao | 2019 | TMR Clinical Research2019，2，2： | 8 |
| 4 | Determination of metastable zone and induction time of analgin for cooling crystallization显示文摘The solubility, metastable zone width, and induction time of analgin for unseeded batch cooling crystallization in ethanol–aqueous system were experimentally determined. The solubility data could be well described by the van't Hoff equation model. The metastable zone width at various cooling rates was measured, and some parameters of nucleation kinetic were calculated using the Ny'vlt theory. Furthermore, the induction period of various temperatures and supersaturation ratios was also measured. According to classical nucleation theory, some nucleation parameters and interfacial energy was calculated through the induction time(t_(ind)) data. Homogeneous nucleation tended to occur when the supersaturation is high, whereas heterogeneous nucleation was more likely to occur when the supersaturation is low. | Ling Zhou Zhao Wang Meijing Zhang Mingxia Guo Shijie Xu Qiuxiang Yin | 2017 | Chinese Journal of Chemical Engineering2017，25，3： | 7 |
| 5 | Neuropeptide Y and leptin receptor expression in the hypothalamus of rats with chronic immobilization stress显示文摘In this study, Sprague-Dawley rats were immobilized to a frame for 3 hours a day for 21 days to establish a model of chronic immobilization stress. The body weight and food intake of rats subjected to chronic immobilization stress were significantly decreased compared with the control group. Dual-labeling immunofluorescence revealed that the expression of leptin receptor and the co-localization coeffient in these leptic receptor neurons in the arcuate nucleus of the hypothalamus were both upregulated, while the number of neuropeptide Y neurons was decreased. Chronic immobilization stress induced high expression of leptin receptor in the arcuate nucleus and suppressed the synthesis and secretion of neuropeptide Y, thereby disrupting the pathways in the arcuate nucleus that regulate feeding behavior, resulting in diminished food intake and reduced body weight. | Shaoxian Wang Jiaxu Chen Guangxin Yue Minghua Bai Meijing Kou Zhongye Jin | 2013 | Neural Regeneration Research2013，8，18： | 6 |
| 6 | Analysis of heat transfer of loop heat pipe used to cool high power LED显示文摘A novel loop heat pipe(LHP)cooling device for high power LED is developed.The thermal capabilities, including startup performance,temperature uniformity and thermal resistance of the loop heat pipe under different heat loads and incline angles have been investigated experimentally.The obtained results indicate that the thermal resistance of the heat pipe heat sink is in the range of 0.19―3.1 K/W,the temperature uniformity in the evaporator is controlled within 1.5℃,and the junction temperature of high power LED can be controlled steadily under 100℃for a heat load of 100 W. | LU XiangYou HUA ZeZhao LIU MeiJing CHENG YuanXia | 2009 | Science China(Technological Sciences)2009，52，12： | 5 |
| 7 | Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats显示文摘Folic acid participates in the metabolism of homocysteine and lowers plasma homocysteine levels directly or indirectly.To establish a hyperhomocysteinemic pregnant rat model,2 mL of DL-homocysteine was administered daily by intraperitoneal injection at a dose of 200 mg/kg from day 10 to day 19 of gestation.Folic acid was administered by intragastric administration at a dose of 20 mg/kg during the period of preeclampsia induction.Results showed that systolic blood pressure,proteinuria/creatinine ratio,and plasma homocysteine levels in the hyperhomocys-teinemic pregnant rats increased significantly,and that body weight and brain weight of rat pups significantly decreased.Folic acid supplementation markedly reversed the above-mentioned abnormal changes of hyperhomocysteinemic pregnant rats and rat pups.These findings suggest that folic acid can alleviate the symptoms of hyperhomocysteinemia-induced preeclampsia in pregnant rats without influencing brain development of rat pups. | Jun Wang Yan Cui Jing Ge Meijing Ma | 2012 | Neural Regeneration Research2012，7，25： | 4 |
| 8 | New opportunities and challenges of natural products research:When target identification meets single-cell multiomics显示文摘Natural products, and especially the active ingredients found in traditional Chinese medicine(TCM), have a thousand-year-long history of clinical use and a strong theoretical basis in TCM. As such,traditional remedies provide shortcuts for the development of original new drugs in China, and increasing numbers of natural products are showing great therapeutic potential in various diseases. This paper reviews the molecular mechanisms of action of natural products from different sources used in the treatment of inflammatory diseases and cancer, introduces the methods and newly emerging technologies used to identify and validate the targets of natural active ingredients, enumerates the expansive list of TCM used to treat inflammatory diseases and cancer, and summarizes the patterns of action of emerging technologies such as single-cell multiomics, network pharmacology, and artificial intelligence in the pharmacological studies of natural products to provide insights for the development of innovative natural product-based drugs. Our hope is that we can make use of advances in target identification and singlecell multiomics to obtain a deeper understanding of actions of mechanisms of natural products that will allow innovation and revitalization of TCM and its swift industrialization and internationalization. | Yuyu Zhu Zijun Ouyang Haojie Du Meijing Wang Jiaojiao Wang Haiyan Sun Lingdong Kong Qiang Xu Hongyue Ma Yang Sun | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 3 |
| 9 | Thermodynamic properties of metamizol monohydrate in pure and binary solvents at temperatures from(283.15 to 313.15) K显示文摘The thermodynamic properties of metamizol monohydrate in pure solvents(methanol,ethanol,n-propanol and isopropanol) and two binary mixed solvent systems including(methanol+ethanol) and(methanol+isopropanol) were measured from 283.15 K to 313.15 K by gravimetric method under atmospheric pressure thought as 0.1 MPa.The modi fied Apelblat equation,the CNIBS/R-K equation,the Hybrid model and the NRTL model were used to correlate the solubility of metamizol monohydrate,respectively.The results show that the solubility of metamizol monohydrate in all the tested solvents increases with the rising temperature which means that it has temperature dependence.What's more,the effects of solvent components of the binary solvent mixtures on solubility were discussed,it illustrates that the increasing of the molar fraction of methanol gives the system a greater dissolving power.Furthermore,according to the NRTL model,the enthalpy,the Gibbs energy and the entropy of the mixing process were also obtained and discussed. | Mingxia Guo Qiuxiang Yin Chang Wang Yaohui Huang Yang Li Zaixiang Zhang Xia Zhang Zhao Wang Meijing Zhang Ling Zhou | 2017 | Chinese Journal of Chemical Engineering2017，25，10： | 3 |
| 10 | Long‐term follow‐up of children exposed intrauterine to maternal thiopurine therapy during pregnancy in females with inflammatory bowel disease显示文摘 | T. G. J. Meij B. Jharap C. M. F. Kneepkens A. A. Bodegraven N. K. H. Boer | 2013 | Aliment Pharmacol Ther2013，，1： | 2 |
| 11 | Codeswitching in English Courses in Chinese Universities显示文摘 | HANSVAN DER MEIJ XIAOGUANGZHAO | 2010 | The Modern Language Journal2010，，3： | 2 |
| 12 | Diagnostic accuracy of 64- slice computed tomography coronary angiography: A prospective, multicenter, multivendor study显示文摘 | Meijboom WB Meijs MR Schuijf JD | 2008 | Journal of the American College of Cardiology2008，52，25： | 1 |
| 13 | Bone volume after secondary bone grafting in unilateral and bilateral clefts determined by computed tomography scans显示文摘 | Van der Meij AJ Baart JA Prahl-Andersen B | 2001 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2001，92，2： | 1 |
| 14 | The fate of mercury in coal-fired power plants and the influence of wet flue-gas desulphurization 显示文摘 | Meij R | 1991 | Water Air and Soil Pollution1991，11，： | 1 |
| 15 | The long-term significance of microscopic dural invasion in 354 patients with pituitary adenomas treated with transsphenoidal surgery显示文摘 | Lopes MB Ellegala DB | 2002 | J Neurosurg2002，96，2： | 1 |
| 16 | The fate of mercury in coal-fired power plants and the influence of wet flue-gas desulphurization 显示文摘 | R Meij | 1991 | Water Air and Soil Pollution1991，56，： | 1 |
| 17 | The effect of ambient cal- cium on prolactin cell activity and plasma electrolytes in Sarother- odon mossambicus (Tilapia mossambica) 显示文摘 | Wendelaar B S E Van der Meij J C A | 1980 | Gen Comp Endoeri- nol1980，40，： | 1 |
| 18 | Preoperative computed tomography coronary angiography to detect significant coronary artery disease in patients referred for cardiac valve surgery显示文摘 | Meijboom WB Meijs MR van Mieghem CA | 2006 | Journal of the hmerican College of Cardiology2006，48，： | 1 |
| 19 | The fight against stigma:an overview of stigma- reduction strategies and interventions显示文摘 | Heijnders M Van Der Meij S | 2006 | Psychol Health Med2006，11，3： | 1 |
| 20 | Effect of Exercise-induced ischemia on QT interval dispersion 显示文摘 | Singh JP Meijs M | 1998 | Am Heart J1998，235，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员