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| 1 | Recent advances in the molecular genetics of type 2 diabetes mellitus显示文摘Type 2 diabetes mellitus(T2DM) is a complex disease in which both genetic and environmental factors interact in determining impaired β-cell insulin secretion and peripheral insulin resistance. Insulin resistance in muscle, liver and fat is a prominent feature of most patients with T2DM and obesity, resulting in a reduced response of these tissues to insulin. Considerable evidence has been accumulated to indicate that heredity is a major determinant of insulin resistance and T2DM. It is believed that, among individuals destined to develop T2DM, hyperinsulinemia is the mechanism by which the pancreatic β-cell initially compensates for deteriorating peripheral insulin sensitivity, thus ensuring normal glucose tolerance. Most of these people will develop T2DM when β-cells fail to compensate. Despite the progress achieved in this field in recent years, the genetic causes of insulin resistance and T2DM remain elusive.Candidate gene association, linkage and genome-wide association studies have highlighted the role of genetic factors in the development of T2DM. Using these strategies, a large number of variants have been identified in many of these genes, most of which may influence both hepatic and peripheral insulin resistance, adipogenesis and β-cell mass and function. Recently, a new gene has been identified by our research group, the HMGA1 gene, whose loss of function can greatly raise the risk of developing T2DM in humans and mice. Functional genetic variants of the HMGA1 gene have been associated with insulin resistance syndromes among white Europeans, Chinese individuals and Americans of Hispanic ancestry. These findings may represent new ways to improve or even prevent T2DM. | Antonio Brunetti Eusebio Chiefari Daniela Foti | 2014 | World Journal of Diabetes2014，5，2： | 20 |
| 2 | Living Free Radical Polymerization with Reversible Addition-Fragmentation Chain Transfer (the life of RAFT) 显示文摘 | Moad G Chiefari J Chong Y K | 2000 | Polymer International2000，49，9： | 1 |
| 3 | Living free-radical polymerization by reversible addition-fragmentation chain transfer:The KAFT process 显示文摘 | Chiefari J Chong Y K Ercole F | 1998 | Macromolecules1998，31，16： | 1 |
| 4 | Living free-radical polymerization by reversible addition-fragmentation chain transfer:The RAFT process显示文摘 | Chiefari J Chong Y K Ercolen F | 1998 | Macromolecules1998，31，： | 1 |
| 5 | Living free-radical polymerization by reversible addition-fragmentation chain transfer:The RAFT process显示文摘 | CHIEFARI J | 1998 | Macromolecules1998，31，16： | 1 |
| 6 | 查看详情显示文摘 | Chiefari J Chong Y.K Ercole F Krstina J. Jeffery J. Le T.P.T. Mayadunne R.T.A. Meijs G.F. Moad C.L. Moad G | | 0，，： | 1 |
| 7 | Perspectives on the contribution of genetics to the pathogenesis of type 2 diabetes mellitus 显示文摘 | Brunetti A Chiefari E Foti D | 2011 | Recenti Prog Med2011，102，12： | 1 |
| 8 | Living Free Radical Polymerization With Reversible Addition-Fragmentation Chain Transfer (the Life of RAFT)显示文摘 | Moad G Chiefari J Chong Y K | 2000 | Polym Int2000，49，9： | 1 |
| 9 | Living free-radical polymerization by reversible addition-fragmentation chain transfer:the raft process显示文摘 | Chiefari J Chong Y K Ercole F | 1998 | Macromolecules1998，31，16： | 1 |
| 10 | Synthesis of defined polymers by reversible addition-fragmentation chain transfer 显示文摘 | RIZZARDO E CHIEFARI J | 2000 | ACS Symp Ser2000，768，： | 1 |
| 11 | Living free-radical polymerization by reversible addition-fragmentation chain trarfer: the RAFT process显示文摘 | Chiefari J Rizzardo E Thang H S | 1998 | Maeromolecules1998，31，： | 1 |
| 12 | Expression of matrix metalloproteinase-11 is increased under conditions of insulin resistance显示文摘AIM To investigate matrix metalloproteinase-11(MMP-11) expression in adipose tissue dysfunction, using in vitro and in vivo models of insulin resistance.METHODS Culture of mouse 3T3-L1 preadipocytes were induced to differentiation into mature 3T3-L1 adipocytes. Cellular insulin resistance was induced by treating differentiated cultured adipocytes with hypoxia and/or tumor necrosis factor(TNF)-α, and transcriptional changes were analyzed in each condition thereafter. For the in vivo studies, MMP-11 expression levels were measured in white adipose tissue(WAT) from C57BL/6J mice that underwent low fat diet or high-fat feeding in order to induce obesity and obesity-related insulin resistance. Statistical analysis was carried out with GraphP ad Prism Software.RESULTS MMP-11 m RNA expression levels were significantly higher in insulin resistant 3T3-L1 adipocytes compared to control cells(1.46±0.49vs0.83±0.21, respectively;P<0.00036). The increase in MMP-11 expression was observed even in the presence of TNF-α alone(3.79±1.11vs1±0.17, P<0.01) or hypoxia alone(1.79±0.7vs0.88±0.1, P<0.00023). The results obtained in in vitro experiments were confirmed in the in vivo model of insulin resistance. In particular, MMP-11 m RNA was upregulated in WAT from obese mice compared to lean mice(5.5±2.8vs1.1±0.7, respectively; P<3.72E-08). The increase in MMP-11 levels in obese mice was accompanied by the increase in typical markers of fibrosis, such as collagen type Ⅵ alpha 3(Col6_α3), and fibroblast-specific protein 1.CONCLUSION Our results indicate that dysregulation of MMP-11 expression is an early process in the adipose tissue dysfunction, which leads to obesity and obesity-related insulin resistance. | Biagio Arcidiacono Eusebio Chiefari Anna Elisa Laria Sebastiano Messineo Francesco Luciano Bilotta Domenico Britti Daniela Patrizia Foti Anna Foryst-Ludwig Ulrich Kintscher Antonio Brunetti | 2017 | World Journal of Diabetes2017，8，9： | 1 |
| 13 | Living free-radical polymerization by reversible addition-fragmentation chain transfer:The RAFT process显示文摘 | Chiefari J Chong Y K Ercole F | 1998 | Macromolecules1998，31，： | 1 |
| 14 | Living Free-Radical Polymerization by Reversible Addition-Fragmentation Chain Transfer: The RAF Process 显示文摘 | Chiefari J Chong Y K Ercole F | 1998 | Macromolecules1998，31，16： | 1 |
| 15 | Living freeradical polymerization by reversible addition - fragmentation chain transfer: the RAFT process显示文摘 | Chiefari J Rizzardo E Thang S H | 1998 | Macromolecules1998，31，： | 1 |
| 16 | Living free-radical polymeriza- tion by reversible addition-fragmentation chain transfer: the RAFT process 显示文摘 | Chiefari J Chong YK Ereole F Krstina J Jeffery J Le TPT Mayadunne RTA Meijs GF Moad CL Moad G Rizzardo E Thang SH | 1998 | Macromolecules1998，31，： | 1 |
| 17 | Living freeradical polymerization by reversible addition-fragmentation chain transfer:the RAFT process显示文摘 | Chiefari J Chong Y K Ercole F | 1998 | Macromolecules1998，31，16： | 1 |
| 18 | Living free-radical polymerization by reversible addition-fragmentation chain transfer: The RAFT process显示文摘 | Chiefari J Chong Y K Ercole F | 1998 | Macromolecules1998，31，： | 1 |
| 19 | Living free radical polymerization with reversible addition-fragmentation chain transfer ( the life of RAFT) 显示文摘 | Moad G Chiefari J Chong Y K | 2000 | Polymer International2000，49，： | 1 |
| 20 | Pseudogene-mediatedposttranscriptional silencing of HMGA1 can result in insulin resist- ance and type 2 diabetes显示文摘 | Chiefari E Iiritano S Paonessa F | 2010 | Nat Commun2010，1，： | 1 |
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