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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Computed tomographic assessment of fractures of the posterior wall of the acetabulum after operative treatment显示文摘 | Moed B R Willson Carr S E Gruson K I | 2007 | J Bone Joint Surg Am2007，85，3： | 1 |
| 3 | Kimuras disease:the CT and MRI characteristics in fifteen cases显示文摘 | Zhang R Ban X H Mo Y X | 2011 | Eur J Radioi2011，80，2： | 1 |
| 4 | Role of complement activation in atherosclerosis显示文摘 | Oksjoki R Kovanen PT Pentikainen MO | 2003 | Curr Opin Lipidol2003，14，5： | 1 |
| 5 | New mouse models of congenital anorectal malformations显示文摘 | Kimmel SG Mo R Hui CC | 2000 | J Pediatr Surg2000，35，2： | 1 |
| 6 | Biomechanical effects of polyaxial pedicle screw fixation on the lumbosacral segments with an anterior interbody cage support显示文摘 | Chen SH Mo Lin R Chen HH | 2007 | BMC Musculoskelet Disord2007，8，： | 1 |
| 7 | DNA damage in the nucleosome core is refractory to repair by human excision nuclease显示文摘 | HARA R MO J SANCAR A | 2000 | Mol Cell Biol2000，20，24： | 1 |
| 8 | Appropriate BMI levels for PCOS patients in Southern China显示文摘 | Chen X Ni R Mo Y | 2010 | Hum Reprod2010，25，5： | 1 |
| 9 | Moleeular evolution ~ff CXC chemokines: extant CXC chemokines originate from the CNS 显示文摘 | Huising MO Stet R J Kruiswijk CP | 2003 | Trends Immunol2003，6，： | 1 |
| 10 | Two-kidney,two clip renalvascular hypertensive rats can be used as stroke-prone rats显示文摘 | Zeng J Zhang Y Mo J Su Z Huang R | 1998 | Stroke1998，29，8： | 1 |
| 11 | 显示文摘 | Mo Y G Dillon R O Snyder P G | 1999 | Thin Solid Films1999，355，： | 1 |
| 12 | The impact of UGT1A8, UGT1A9, and UGT2B7 genetic polymorphisms on the pharmacokinetic profile of mycophenolic acid after a single oral dose in healthy volunteers显示文摘 | Levesque E Delage R Benoit-Biancamano MO | 2007 | Clin PharmacolIher2007，81，3： | 1 |
| 13 | Pilon fractures:treatment protocol based on severity of soft tissue injury显示文摘 | Watson J T Moed B R Karges D E | 2000 | Clin Orthop Relat Res2000，375，6： | 1 |
| 14 | 查看详情显示文摘 | MO Y R BAO P GAO J L | | 0，，： | 1 |
| 15 | Silibinin improves palmitate-induced insulin resistance in C2C12 myotubes by attenuating IRS-1/PI3K/Akt pathway inhibition显示文摘 | LI H B YANG Y R MO Z J | 2015 | Braz J Med Biol Res2015，48，5： | 1 |
| 16 | The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants显示文摘 | Mo R Hui CC | 1998 | Development1998，125，15： | 1 |
| 17 | New mouse models of congenital anoreetal malformations 显示文摘 | Kimmel SG Mo R Hui CC | 2000 | J Pediatr Surg2000，35，2： | 1 |
| 18 | Late salvage of failed open reduction and internal fixation of posterior wall fractures of the acetabulum显示文摘 | Dean D B Moed B R | 2009 | J Orthop Trauma2009，23，3： | 1 |
| 19 | Time-domain parameter estimation algorithm for structures,Ⅱ:numerical simulation studies显示文摘 | Banan Mo R Banan Ma R Hjelmstad K D | 1995 | Journal of Engineering Mechanics1995，121，3： | 1 |
| 20 | The role of coping strategies in quality of life of adolescents with asthma显示文摘 | Van De Ven MO Engels RC Sawyer SM Otten R Van Den Eijnden RJ | 2007 | Qual Life Res2007，，2： | 1 |
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