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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Transcriptome profile of human neuroblastoma cells in the hypomagnetic field显示文摘Research has shown that the hypomagnetic field(HMF)can affect embryo development,cell proliferation,learning and memory,and in vitro tubulin assembly.In the present study,we aimed to elucidate the molecular mechanism by which the HMF exerts its effect,by comparing the transcriptome profiles of human neuroblastoma cells exposed to either the HMF or the geomagnetic field.A total of 2464 differentially expressed genes(DEGs)were identified,216 of which were up-regulated and2248 of which were down-regulated after exposure to the HMF.These DEGs were found to be significantly clustered into several key processes,namely macromolecule localization,protein transport,RNA processing,and brain function.Seventeen DEGs were verified by real-time quantitative PCR,and the expression levels of nine of these DEGs were measured every 6 h.Most notably,MAPK1 and CRY2,showed significant up-and down-regulation,respectively,during the first 6 h of HMF exposure,which suggests involvement of the MAPK pathway and cryptochrome in the early bio-HMF response.Our results provide insights into the molecular mechanisms underlying the observed biological effects of the HMF. | MO WeiChuan LIU Ying BARTLETT Perry F HE RongQiao | 2014 | Science China(Life Sciences)2014，57，4： | 8 |
| 3 | Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomised, phase 2 trial显示文摘 | Eric Lawitz Fred F Poordad Phillip S Pang Robert H Hyland Xiao Ding Hongmei Mo William T Symonds John G McHutchison Fernando E Membreno | 2013 | The Lancet2013，，： | 5 |
| 4 | Atomic bonding of precipitate and phase transformation of Al-Cu-Mg alloy 显示文摘 | CAO Y J HOU X H MO Q F | 2007 | J Alloys Compd2007，441，： | 1 |
| 5 | Combining mapping and citation analysis for evaluative bibliometric purposes:A bibliometric study 显示文摘 | Noyons E C M Moed H F Luwel M | 1999 | Journal of the American Society for Information Science1999，50，2： | 1 |
| 6 | Spatiotemporal evolution of China's railway network in the 20th century=An accessibility approach显示文摘 | WANG J E JINA F J MO H H | 2009 | Transportation Research Part A2009，，43： | 1 |
| 7 | Statistical Relationships Between Downloads and Ci- tations at the Level of Individual Documents Within a Single Journal显示文摘 | Moed H F | 2005 | Journal of the American Society for Information Sci- ence and Technology2005，56，10： | 1 |
| 8 | Effect of the Woods-Saxon nuclear distribution on the chiral magnetic field in Relativ- istic Heavy-ion Collisions显示文摘 | Mo Y J Feng S Q Shi Y F | 2013 | Physical Review C2013，88，88： | 1 |
| 9 | Integrating research performance analysis and science mapping 显示文摘 | Noyons E C M Moed H F Van Raan A F J | 1999 | Scientometfics1999，46，3： | 1 |
| 10 | Modeling the Buildup and Washoff of Pollutants on Urban Watersheds显示文摘 | BARBE D E CRUISE J F MO X | 1996 | Water Resources Bulletin-AWRA1996，32，3： | 1 |
| 11 | Publication delays in the science field and their relationship to the aging of scientific literature显示文摘 | Luwel M Moed H F | 1998 | Scientometrics1998，41，12： | 1 |
| 12 | Biological marker compounds as indicators of depositional history of the Maoming oil shale显示文摘 | Brassell S C Eglinton G Mo F J | 1986 | Organic Geochemistry1986，10，： | 1 |
| 13 | Identification, charact terization, and immunogenicity of the lactoferrin-binding protein from Helicobacter pylori显示文摘 | Dhaenens L Szczebara F Husson MO | 1997 | Infect Immun1997，85，2： | 1 |
| 14 | Polyphasic study of the spatial distribution of microorganisms in Mexican pozol, a fermented maize dough demonsWates the need for cultivation-independent methods to investigate traditional fermentations 显示文摘 | AMPE F OMAR B N MO IZAN C | 1999 | Applied Environmental Microbiology1999，65，： | 1 |
| 15 | Cyr61,a product of a growth factor-inducible immediate-early gene,promotes cell proliferation migration and adhesion显示文摘 | Kireeva M L Mo F E Yang J P | 1996 | Mol Cell Biol1996，16，4： | 1 |
| 16 | Geochemical investigation of Early Cretaceous igneous rocks along an east-west traverse throughout the central Lhasa Terrane, Tibet显示文摘 | Zhu D C Mo X X Niu Y L Zhao Z D Wang L Q Liu Y S Wu F Y | 2009 | Chem Geol2009，268，34： | 1 |
| 17 | Presence of asymmetric dimethylarginine gradients across high-grade lesions in patients with coronary artery disease显示文摘 | Joyal D Leya F Obada-Al-Chekakie MO | 2007 | Coron Artery Dis2007，18，6： | 1 |
| 18 | Donor heart preservation in anempty beating state under mild hypothermia显示文摘 | Lin H Mo A Zhang F | 2010 | The Annalsof thoracic surgery2010，89，5： | 1 |
| 19 | Symptoms of posttraumatic stress disorder,depression,and anxiety among adolescents following the 2008 Wenchuan earthquake in China显示文摘 | Fan F Zhang Y Yang Y Mo L & Liu X | | 0，，01： | 1 |
| 20 | Golgi phosphoprotein 2 (GOLPH2) expression in liver tumors and its value as a serum marker in hepatocellular carcinomas显示文摘 | Riener MO Stenner F Liewen H | | 0，，： | 1 |
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