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| 1 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 2 | Supernumerary teeth in a Turkish population显示文摘 | Esenlik E Sayin MO Atilla AO | 2009 | Am J Orthod Dentofacial Orthop2009，136，6： | 1 |
| 3 | Medical Additive Manufacturing: From a Frontier Technology to the Research and Development of Products显示文摘1.Research and development(R&D)and the challenges of raw materials for medical additive manufacturing Raw materials for medical additive manufacturing have a wide range of commonalities that are also seen in many other fields,making them an important basis in the field of three-dimensional(3D)printing.Problems and challenges related to material types,powder properties,formability,viscoelasticity,and so forth also share common features.For example,many metal materials are used in the field of aviation,while metals,polymers,and inorganic materials are used in the field of biomedicine.The most widely used materials in biomedicine are biocompatible.Various homogeneous and non-homogeneous composites are also available for 3D printing,and impose an additional challenge in additive manufacturing;the use of heterogeneous composites in 3D printing is particularly challenging. | Guixing Qiu Wenjiang Ding Wei Tian Ling Qin Yu Zhao Lianmeng Zhang Jian Lu Daijie Chen Guangyi Yuan Chengtie Wu Bingheng Lu Ruxu Du Jimin Chen Mo Elbestawi Zhongwei Gu Dichen Li Wei Sun Yuanjin Zhao Jie He Dadi Jin Bin Liu Kai Zhang Jianmo Li Kam WLeong Dewei Zhao Dingjun Hao Yingfang Ao Xuliang Deng Huilin Yang ShaoKeh Hsu Yingqi Chen Long Li Jianping Fan Guohui Nie Yun Chen Hui Zeng Wei Chen Yuxiao Lai | 2020 | Engineering2020，6，11： | 1 |
| 4 | Relatlonship between depression and quality of iife in persons with HIV infection in Nigeria显示文摘 | Adewuya AO hfoiabi MO Ola BA ct al | 2008 | Int J Psychiatry Med2008，38，1： | 1 |
| 5 | Flow cytometric assessment of the effects of chlorine, chloramine, and UV on bacteria by using nucleic acid stains and 5-cyano-2,3-ditolyltetrazolium chloride显示文摘 | Xuebiao Nie Wenjun Liu Mo Chen Minmin Liu Lu Ao | 2016 | Frontiers of Environmental Science & Engineering2016，10，6： | 1 |
| 6 | Effect of sublingual misoprostol versus intravenous oxytocin on reducing blood loss at cesarean section in nigeria:a randomized controlled trial显示文摘 | Kola MO Ayodele OA Michael AO | 2011 | Journal of Obstetrics and Gynaecology Research2011，37，7： | 1 |
| 7 | MYC translocation partner gene determines survival of patients with large B-cell lymphoma with MYC- or double-hit MYC/BCL2 translocations 显示文摘 | Pedersen MO Gang AO Poulsen TS | 2014 | Eur J Haemato12014，92，1： | 1 |
| 8 | Reciprocal relations of subcutaneous and visceral fat to bone structure and strength 显示文摘 | Gilsanz V Chalfant J Mo AO | 2009 | J Clin Endocrinol Metab2009，94，： | 1 |
| 9 | Supernumeraryteeth in a Turkish population显示文摘 | Esenlik E Sayin MO Atilla AO | 2009 | Am J Orthod Dento-facial Orthop2009，136，6： | 1 |
| 10 | Reciprocal relations of subcu- taneous and visceral fat to bone structure and strength 显示文摘 | Gilsanz V Chalfant J Mo AO | 2009 | J Clin Endocrinol Metab2009，94，9： | 1 |
| 11 | Knowledge about childhood autism among health workers (KCAHW) questionnaire:description,reliability and internal consistency显示文摘 | Bakare MO Ebigbo PO Agomoh AO | 2008 | Clin Pract Epidemiol Ment Health2008，6，4： | 1 |
| 12 | Cell of origin predicts outcome to treatment with etoposide-containing chemotherapy in young patients with high-risk diffuse large B-cell lymphoma显示文摘 | Gang AO Pedersen MO Knudsen H | 2015 | Leuk Lymphoma2015，21，： | 1 |
| 13 | Reciprocal relations of subcutaneous and visceral fat to bone structure and strength 显示文摘 | Gilsanz V Chalfant J Mo AO | 2009 | J Clin Endocrinol Metab2009，94，9： | 1 |
| 14 | Cross-cultural adaptation and initial validation of the Stroke-Specific Quality of Life Scale into the Yoruba language显示文摘 | Akinpelu AO Odetunde MO Odole AC | 2012 | Int J Rehabil Res2012，35，4： | 1 |
| 15 | Radiological evaluation of head trauma by computer tomography in Ibadan,Nigeria显示文摘 | Ogunseyinde AO Obnjimi MO Ogundare SM | | 0，，01： | 1 |
| 16 | Characterization ofpatients treated by rehabilitation service after establishing of an acute strokeunit in a Brazilian hospital显示文摘 | Luvizutto GJ Gameiro MO Schelp AO | 2015 | J Phys Ther Sci2015，27，： | 1 |
| 17 | Physicians' Knowledge of the Glasgow Coma Scale in a Nigerian University Hospital :is the simple GCS still too complex显示文摘 | Adeleye AO Owolabi MO Rabiu TB | 2012 | Front Neurol2012，3，： | 1 |
| 18 | Heavy trace metals and macronutrients status in herbal plants of Nigeria 显示文摘 | AJASA AMO BELLO MO IBRAHIM AO | 2004 | Food Chem2004，85，1： | 1 |
| 19 | Reciprocal rela- tions of subcutaneous and visceral fat to bone structure and strength 显示文摘 | Gilsanz V Chalfant J Mo AO | 2009 | J Clini Endocrinol Metab2009，94，： | 1 |
| 20 | Presentation of primary mediastinal masses in Ibadan 显示文摘 | Adegboye VO Ogunseyinde AO Obajimi MO | 2003 | East Afr Med J2003，80，9： | 1 |
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