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| 1 | Simultaneous optimal estimates of fixed effects and variance components in the mixed model显示文摘For a general linear mixed model with two variance components, a set of simple conditions is obtained, under which, (i) the least squares estimate of the fixed effects and the analysis of variance (ANOVA) estimates of variance components are proved to be uniformly minimum variance unbiased estimates simultaneously; (ii) the exact confidence intervals of the fixed effects and uniformly optimal unbiased tests on variance components are given; (iii) the exact probability expression of ANOVA estimates of variance components taking negative value is obtained. | WU Mixia WANG Songgui | 2004 | Science China Mathematics2004，47，5： | 6 |
| 2 | A new method of spectral decomposition of covariance matrix in mixed effects models and its applications显示文摘For the mixed effects models with balanced data, a new ordering of design matrices of random effects is defined, and then a simple formula of the spectral decomposition of covariance matrix is obtained. To compare with the two methods in literature,the decomposition can not only give the actual number of all distinct eigenvalues and their expression, but also show clearly the relationship between the design matrices of random effects and the decomposition. These results can be applied to the problems for testifying the analysis of the variance estimate being a minimum variance unbiased under all random effects models and some mixed effects models with balanced data, for finding the explicit solution of maximum likelihood equations for the general mixed effects model and for showing the relationship between the spectral decomposition estimate and the analysis of variance estimate. | WU Mixia WANG Songgui | 2005 | Science China Mathematics2005，48，11： | 4 |
| 3 | Real-time simultaneous recording of electrophysiological activities and dopamine overflow in the deep brain nuclei of a non-human primate with Parkinson’s disease using nano-based microelectrode arrays显示文摘Parkinson’s disease(PD)is characterized by a progressive degeneration of nigrostriatal dopaminergic neurons.The precise mechanisms are still unknown.Since the neuronal communications are inherently electrical and chemical in nature,dual-mode detection of PD-related neuroelectrical and neurochemical information is essential for PD research.Subthalamic nucleus(STN)highfrequency stimulation(HFS)can improve most symptoms of PD patients and decrease the dosage of antiparkinsonian drugs.The mechanism of STN-HFS for PD still remains elusive.In this study,a silicon-based dual-mode microelectrode array(MEA)probe was designed and fabricated,and systematic dual-mode detection methods were established.The recording sites were modified using Pt nanoparticles and Nafion to improve the signal-to-noise(SNR)ratio.To evaluate its applicability to PD research,in vivo electrophysiological and electrochemical detection was performed in normal and hemiparkinsonian models,respectively.Through comparison of the dual-mode signals,we demonstrated the following in a PD monkey:(1)the maximum dopamine concentration in the striatum decreased by 90%;(2)the spike firing frequency increased significantly,especially in the region of the cortex;(3)the spectrogram analysis showed that much power existed in the 0–10 Hz frequency band;and(4)following repeated subthalamic nucleus high-frequency stimulation trials,the level of DA in the striatum increased by 16.5μM,which led to a better elucidation of the mechanism of HFS.The dual-mode MEA probe was demonstrated to be an effective tool for the study of neurological disorders. | Song Zhang Yilin Song Mixia Wang Guihua Xiao Fei Gao Ziyue Li Guoxian Tao Ping Zhuang Feng Yue Piu Chan Xinxia Cai | 2018 | Microsystems & Nanoengineering2018，4，1： | 2 |
| 4 | Empirical Likelihood Inference for the Semiparametric Varying-Coefficient Spatial Autoregressive Model显示文摘In this paper empirical likelihood(EL)-based inference for a semiparametric varyingcoefficient spatial autoregressive model is investigated.The maximum EL estimators for the parametric component and the nonparametric component are established.Furthermore,asymptotic properties of the proposed estimators and EL ratios are derived,and the corresponding confidence regions/bands are constructed.Their finite sample performances are studied via simulation and an example. | LUO Guowang WU Mixia PANG Zhen | 2021 | Journal of Systems Science & Complexity2021，34，6： | 1 |
| 5 | The ANOVA-Type Inference in Linear Mixed Model with Skew-Normal Error显示文摘Linear mixed effect models with skew-normal errors and distribution-free random effects are considered. The ANOVA-type F-tests are proposed to test the significance of random effects and the hypothesis on fixed effects of interest, respectively. Both tests are proved to be exact F-tests under this model, and the exact confidence interval for fixed effects of interest is derived. Simulation results are given to study the powers of ANOVA-type tests. | WU Mixia ZHAO Jing WANG Tonghui ZHAO Yan | 2017 | Journal of Systems Science & Complexity2017，30，3： | 1 |
| 6 | The toxic effects of ionic liquids on the activities of acetylcholinesterase and cellulase in earthworms显示文摘 | LUO Yanrui WANG Sanhu YUN Mixia | 2009 | Chemosphere2009，77，： | 1 |
| 7 | The efficacy of Jing Wan Hong Ointment for nerve injury diabetic foot ulcer and its mecha- nisms显示文摘 | Jin Shumei Zhang Mixia Gao Yah Zhang Xuebin Cui Guangzhi Zhang Yanjun | 2014 | J Diabetes Res2014，11，： | 1 |
| 8 | Regulated deficit irrigation improved fruit quality and water use efficiency of pear-jujube trees显示文摘 | Ningbo Cui Taisheng Du Shaozhong Kang Fusheng Li Jianhua Zhang Mixia Wang Zhijun Li | 2007 | Agricultural Water Management2007，，4： | 1 |
| 9 | Robust inference in linear mixed model with skew normal-symmetric error显示文摘 | Mixia WU Ye TIAN Aiyi LIU | 2017 | Frontiers of Mathematics in China2017，12，6： | 1 |
| 10 | Protective effects of berberine against amyloid beta-induced toxicity in cultured rat cortical neurons显示文摘Berberine,a major constituent of Coptidis rhizoma,exhibits neural protective effects.The present study analyzed the potential protective effect of berberine against amyloid β-induced cytotoxicity in rat cerebral cortical neurons.Alzheimer's disease cell models were treated with 0.5 and 2 μmol/L berberine for 36 hours to inhibit amyloid β-induced toxicity.Methyl thiazolyl tetrazolium assay and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling staining results showed that berberine significantly increased cell viability and reduced cell apoptosis in primary cultured rat cortical neurons.In addition,western blot analysis revealed a protective effect of berberine against amyloid β-induced toxicity in cultured cortical neurons,which coincided with significantly decreased abnormal up-regulation of activated caspase-3.These results showed that berberine exhibited a protective effect against amyloid β-induced cytotoxicity in cultured rat cortical neurons. | Wang, Jing Zhang, Yanjun Du, Shuai Zhang, Mixia | 2011 | Neural Regeneration Research2011，6，3： | 1 |
| 11 | Effect of ethanol treatment on physiological and quality at- tributes of fresh-cut eggplant显示文摘 | Hu Wenzhong Jiang Aili Tian Mixia | 2010 | JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE2010，90，8： | 1 |
| 12 | Software sharing technology based on grid 显示文摘 | Zhao Hong Wo Xur Liu Mixia | 2007 | Engineering and Science2007，，8： | 1 |
| 13 | Grid cell remapping under three-dimensional object and social landmarks detected by implantable microelectrode arrays for the medial entorhinal cortex显示文摘Grid cells with stable hexagonal firing patterns in the medial entorhinal cortex(MEC)carry the vital function of serving as a metric for the surrounding environment.Whether this mechanism processes only spatial information or involves nonspatial information remains elusive.Here,we fabricated an MEC-shaped microelectrode array(MEA)to detect the variation in neural spikes and local field potentials of the MEC when rats forage in a square enclosure with a planar,three-dimensional object and social landmarks in sequence.The results showed that grid cells exhibited rate remapping under social conditions in which spike firing fields closer to the social landmark had a higher firing rate.Furthermore,global remapping showed that hexagonal firing patterns were rotated and scaled when the planar landmark was replaced with object and social landmarks.In addition,when grid cells were activated,the local field potentials were dominated by the theta band(5–8 Hz),and spike phase locking was observed at troughs of theta oscillations.Our results suggest the pattern separation mechanism of grid cells in which the spatial firing structure and firing rate respond to spatial and social information,respectively,which may provide new insights into how the brain creates a cognitive map. | Zhaojie Xu Fan Mo Gucheng Yang Penghui Fan Yiding Wang Botao Lu Jingyu Xie Yuchuan Dai Yilin Song Enhui He Shihong Xu Juntao Liu Mixia Wang Xinxia Cai | 2022 | Microsystems & Nanoengineering2022，8，5： | 0 |
| 14 | A NEW QUANTITATIVE DETECTION METHOD OF RECOMBINANT CFP10-ESAT6 AMALGAMATION PROTEINS FROM MYCOBACTERIUM TUBERCULOSIS BASED ON MICRO-MAGNETIC PROBES STRATEGY显示文摘A new rapid,specific and sensitive method for assay of recombinant CFP10-ESAT6 amalgamation proteins from Mycobacterium tuberculosis was proposed.The method used streptavidincoated magnetic beads to enrich the specific biotinylated anti-CFP10 antibody,then adopted a sandwich-type enzyme linked immunosorbent assay technology with two kinds of monoclonal antibodies:biotinylated anti-CFP10 antibody and HRP-labeled anti-CFP10 antibody to identify the target CFP10-ESAT6 proteins,and finally detected chemiluminescence intensity by a small home-made optical sensor.It was shown that,the corresponding chemiluminescence intensity had a good logarithmic linear response to the concentration of CFP10-ESAT6 proteins when ranging at 1~1000 ng/mL,and the correlation coefficient is 0.9937.The proposed method could detect the CFP10-ESAT6 proteins with low detection limit(1 ng/mL)and the detection time could be controlled within 45 min.Compared with commonly used detection methods of M.tuberculosis,this method was easy to operate,faster,and of higher sensitivity.The achievement of the quantitative detection of CFP10-ESAT6 proteins has important scientific significance and wide application prospects in tuberculosis control. | YIQING HUANG JINPING LUO MIXIA WANG JUNTAO LIU XINXIA CAI | 2012 | Journal of Innovative Optical Health Sciences2012，5，1： | 0 |
| 15 | Recent advances and research progress on microsystems and bioeffects of terahertz neuromodulation显示文摘Terahertz waves can interact with the nervous system of organisms under certain conditions.Compared to common optical modulation methods,terahertz waves have the advantages of low photon energy and low risk;therefore,the use of terahertz waves to regulate the nervous system is a promising new method of neuromodulation.However,most of the research has focused on the use of terahertz technology for biodetection,while relatively little research has been carried out on the biological effects of terahertz radiation on the nervous system,and there are almost no review papers on this topic.In the present article,we begin by reviewing principles and objects of research regarding the biological effects of terahertz radiation and summarizing the current state of related research from a variety of aspects,including the bioeffects of terahertz radiation on neurons in vivo and in vitro,novel regulation and detection methods with terahertz radiation devices and neural microelectrode arrays,and theoretical simulations of neural information encoding and decoding.In addition,we discuss the main problems and their possible causes and give some recommendations on possible future breakthroughs.This paper will provide insight and assistance to researchers in the fields of neuroscience,terahertz technology and biomedicine. | Meiting Liu Juntao Liu Wei Liang Botao Lu Penghui Fan Yilin Song Mixia Wang Yirong Wu Xinxia Cai | 2023 | Microsystems & Nanoengineering2023，9，6： | 0 |
| 16 | Effects of 2,5-Norbornadiene (NBD) on Physiological and Biochemical Responses of Fresh-cut Winter Squash显示文摘 | Wenzhong Hu Aili Jiang Chen Chen Mixia Tian Chenghui Liu Jia Liu | 2013 | Journal of Food Science and Engineering2013，3，3： | 0 |
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