|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Comparison of magnetic resonance spectroscopy, proton density fat fraction and histological analysis in the quantification of liver steatosis in children and adolescents显示文摘AIM To establish a threshold value for liver fat content between healthy children and those with nonalcoholic fatty liver disease(NAFLD) by using magnetic resonance imaging(MRI), with liver biopsy serving as a reference standard. METHODS The study was approved by the local ethics committee, and written informed consent was obtained from all participants and their legal guardians before the study began. Twenty-seven children with NAFLD underwent liver biopsy to assess the presence of nonalcoholic steatohepatitis. The assessment of liver fat fraction was performed using MRI, with a high field magnet and 2D gradient-echo and multiple-echo T1-weighted sequence with low flip angle and single-voxel pointresolved 1H MR-Spectroscopy(1H-MRS), corrected for T1 and T2* decays. Receiver operating characteristic curve analysis was used to determine the best cutoff value. Lin coefficient test was used to evaluate thecorrelation between histology, MRS and MRI-PDFF. A Mann-Whitney U-test and multivariate analysis were performed to analyze the continuous variables. RESULTS According to MRS, the threshold value between healthy children and those with NAFLD is 6%; using MRI-PDFF, a cut-off value of 3.5% is suggested. The Lin analysis revealed a good fit between the histology and MRS as well as MRI-PDFF.CONCLUSION MRS is an accurate and precise method for detecting NAFLD in children. | Michele Di Martino Lucia Pacifico Mario Bezzi Rossella Di Miscio Beatrice Sacconi Claudio Chiesa Carlo Catalano | 2016 | World Journal of Gastroenterology2016，22，39： | 16 |
| 2 | Subclinical hypothyroidism in early childhood ,, a frequent outcome of transient neonatal hyperthyrotropinemia 显示文摘 | Calaciura F Notta Rll Miscio G | 2002 | Clin Endocrinol Metab2002，87，7： | 1 |
| 3 | sympathetic skin responsein amyotrophic lateral Sclerosis显示文摘 | Miscio G Pisano F | 1998 | Acta Neurol Scand1998，98，4： | 1 |
| 4 | Media bias in financial newspapers: Evidence from early twentieth-century France显示文摘 | Bignon V Miscio A | 2010 | European Review of Economic History2010，14，3： | 1 |
| 5 | Quantitative evalua- tion of normal muscle tone显示文摘 | Pisano F Miscio G Colombo R | 1996 | Journal of the Neurological Science1996，135，2： | 1 |
| 6 | A variation in 3' UTR of hPTP1B increases specific gene expression and associates with insulin resistance显示文摘 | Di Paola R Frittitta L Miscio G | 2002 | Am J Hum Genet2002，70，3： | 1 |
| 7 | A variation in 3'UTR of hPTP1B increases specific gene expression and associates with insulin resistance 显示文摘 | Di P R Frittitta L Miscio G | 2002 | Am J Hum Genet2002，70，3： | 1 |
| 8 | A Variation in 3′ UTR of hPTP1B Increases Specific Gene Expression and Associates with Insulin Resistance显示文摘 | Rosa Di Paola Lucia Frittitta Giuseppe Miscio Maura Bozzali Roberto Baratta Marta Centra Daniela Spampinato Maria Grazia Santagati Tonino Ercolino Carmela Cisternino Teresa Soccio Sandra Mastroianno Vittorio Tassi Peter Almgren Antonio Pizzuti Riccardo Vi | 2002 | The American Journal of Human Genetics2002，，3： | 1 |
| 9 | A functional variant inthe gene 3,untranslated region regulates HSP70 expression and isa potential candidate for insulin resistance-related abnormalities显示文摘 | Marucci A Miscio G Padovano L | 2010 | J Intern Med2010，267，2： | 1 |
| 10 | A variation in 3' UTR of hPTP1B increases specific gene expression and associates with insulin resistance显示文摘 | Di Paola R Frittitta L Miscio G | | 0，，： | 1 |
| 11 | Motor neuron disease:usefulness of transeranial magnetic stimulation in improving the diagnosis显示文摘 | Miscio G Pisano F Mora G | 1999 | Clin Neurophysiol1999，110，5： | 1 |
| 12 | The allelic variant of LAR gene promoter -127 bp T→A is associated with reduced risk of obesity and other features related to insulin resistance 显示文摘 | Miscio G Tassi V Coco A | 2004 | J Mol Med2004，82，7： | 1 |
| 13 | Sympathetic skin response in amyotrophic lateral sclerosis 显示文摘 | Miscio G Pisano F | 1998 | Acta Neurol Scand1998，98，4： | 1 |
| 14 | A PC- 1 amino acid variant (K121Q) is associated with faster progression of renal disease in patients with type 1 diabetes and albuminuria 显示文摘 | DE COSMO S ARGIOLAS A MISCIO G | 2000 | Diabetes2000，49，： | 1 |
| 15 | Functionalinvolvement of central nervous system at high altitude显示文摘 | MISCIO G MILANO E AGUILAR J | 2009 | Exp Brain Res2009，194，1： | 1 |
| 16 | Subclinical hypothyroidism in early childhood: a frequent outcome of Iransient neonatal hyperthyrolropinemia显示文摘 | Calaciura F Motta RM Miscio G | 2002 | J Clin Endocrinol Metab2002，87，7： | 1 |
| 17 | A variation in 3' UTR of hPTPIB increases gene expression and associates with insulin resistance显示文摘 | Di Paola R Frittitta L Miscio G | 2002 | Am J HumGenet2002，70，3： | 1 |
| 18 | Subclinical hypothyroid- ism in early childhood: a frequent outcome of transient neonatal hyperthyrotropinemia 显示文摘 | Calaciura F Motta RM Miscio G | 2002 | J Clin Endocrinol Metab2002，87，： | 1 |
| 19 | The role of PC-1 and ACE genes in diabetic nephropathy in type 1 diabetic patients: evidence for a polygenie Control of kidney disease progression 显示文摘 | de Cosmo S Miscio G Zucaro L | 2002 | Nephrol Dial Transplant2002，17，8： | 1 |
| 20 | Quantitative measures of spasticity in post-stroke patients 显示文摘 | PISANO F MISCIO G DEL CONTE C | 2000 | Clin Neuro- phys2000，111，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员