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| 1 | Colorectal cancer diagnosis: Pitfalls and opportunities显示文摘Colorectal cancer(CRC) is a major health problem in the Western world. The diagnostic process is a challenge in all health systems for many reasons: There are often no specific symptoms; lower abdominal symptoms are very common and mostly related to nonneoplastic diseases, not CRC; diagnosis of CRC is mainlybased on colonoscopy, an invasive procedure; and the resource for diagnosis is usually scarce. Furthermore, the available predictive models for CRC are based on the evaluation of symptoms, and their diagnostic accuracy is limited. Moreover, diagnosis is a complex process involving a sequence of events related to the patient, the initial consulting physician and the health system. Understanding this process is the first step in identifying avoidable factors and reducing the effects of diagnostic delay on the prognosis of CRC. In this article, we describe the predictive value of symptoms for CRC detection. We summarize the available evidence concerning the diagnostic process, as well as the factors implicated in its delay and the methods proposed to reduce it. We describe the different prioritization criteria and predictive models for CRC detection, specifically addressing the two-week wait referral guideline from the National Institute of Clinical Excellence in terms of efficacy, efficiency and diagnostic accuracy. Finally, we collected information on the usefulness of biomarkers, specifically the faecal immunochemical test, as non-invasive diagnostic tests for CRC detection in symptomatic patients. | Pablo Vega Fátima Valentín Joaquín Cubiella | 2015 | World Journal of Gastrointestinal Oncology2015，7，12： | 2 |
| 2 | Dielectric and structural studies of a SiO2-Li2O-Nb2O5 glass and glass-ceramic prepared by the sol-gel method显示文摘 | GRACA J M P F FERREIRA da SILVA M G VALENTE M A | 2005 | Journal of Non-crystalline Solids2005，351，33： | 1 |
| 3 | Large-pore apertures in a series of metal-organic frameworks显示文摘 | Deng H Grunder S Cordova K E Valente C Furukawa H Hmadeh M Gandara F Whalley A C Liu Z Asahina S Kazumori H O'Keeffe M Terasaki O Stoddart J F Yaghi O M | 2012 | Science2012，336，： | 1 |
| 4 | Numerical simulation of aluminium stiffened panels subjected to axial compression: sensitivity analyses to initial geometrical imperfections and material properties 显示文摘 | PAULO R M F TEIXEIRA-DIAS F VALENTE R A F | 2013 | Thin-Walled Structures2013，，62： | 1 |
| 5 | Microencapsulated chitosan-dextran sulfate nanoparticles for controlled delivery of bioactive molecules and cells in bone regeneration显示文摘 | Valente J F A Gaspar V M Antunes B P | 2013 | Polymer2013，54，： | 1 |
| 6 | Numerical simulation of aluminium stiffened panels subjected to axial compression: Sensitivity analyses to initial geometrical imperfections and material properties显示文摘 | PAULO R M F TEIXEIRA-DIAS F VALENTE R A F | 2013 | Thin-Walled Structures2013，62，： | 1 |
| 7 | In vivo evidence of apoptesis in arrythmogenic right ventricular cadiomyopathy 显示文摘 | Valente M Calabrese F Thiene G | 1998 | Am J Pathol1998，152，2： | 1 |
| 8 | Multimodal imaging:an evaluation of univariate and multivariate methods for simultaneous EEG/fMRI显示文摘 | de Martino F Valente G de Borst A W | 2010 | Magn Reson Imaging2010，28，8： | 1 |
| 9 | Processing, structural and electric properties of CaCu3 Ti4 012 (CCTO) doped with Ge02显示文摘 | Amaral F Silva C C Valente M A | 2010 | Int J Nanomanufacturing2010，5，12： | 1 |
| 10 | Predictors of morbidity in patients with indwelling ureteric stents:results of a prospective study using the validated Ureteric Stent Symptoms Questionnaire 显示文摘 | Giannarini G Keeley FX Jr Valent F | 2011 | BJU Int2011，107，4： | 1 |
| 11 | Severe infantile hyperkalaemic periodic paralysis and paramyotonia congenita: broadening the clinical spectrum associated with the T704M mutation in SCN4A显示文摘 | Brancati F Valente EM Davies NP | 2003 | J Neurol Neurosurg Psychiatry2003，74，9： | 1 |
| 12 | Efficacy of serum procalci- tonin in evaluating severity of community-acquired pneumonia in childhood显示文摘 | Don M Valent F Korppi M | 2007 | Scand Infect Dis2007，39，2： | 1 |
| 13 | Pruli-floxacin versus levofloxacin in the treatment ofchronic bacterial prostatitis: a prospective ran-domized, double-blind trial显示文摘 | Giannarini G Mogorovich A Valent F | 2007 | Chemother2007，19，3： | 1 |
| 14 | Electromagnetic and mechanical properties of Silica-Aluminosilicates plasma sprayed显示文摘 | Cipri F Bartuli C Valente T | 2007 | Composite Coatings Journal of Thermal Spray Technology2007，16，56： | 1 |
| 15 | Mycoplasma contami nation of Plasmodium cultures a case of parasite parasitism显示文摘 | Turrini F Giribaldi G Valente E | 1997 | Parasitol Today1997，13，10： | 1 |
| 16 | Magnaporthe grisea Genes for Pathogenicity and Virulence Identified Through a Series of Backcrosses显示文摘 | VALENT B FARRALL L CHUMELY F G | 1991 | Genetics1991，127，1： | 1 |
| 17 | Magnaporthe grisea genes for pathogenicity and virulence identified through a se- ries of baekcrosses 显示文摘 | VALENT B FARRALL L CHUMLEY F G | 1991 | Genetics1991，127，： | 1 |
| 18 | A review of rain- fall intereeption modelling 显示文摘 | Muzylo A Llorens P Valente F | 2009 | Journal of Hydrology2009，370，1： | 1 |
| 19 | Isolation of the mating-type genes of the phytopathogenic fungus Magnaporthe grisea using genomic subtraction显示文摘 | Kang S Chumley F G Valent B | 1994 | Genetics1994，138，： | 1 |
| 20 | Predictors of morbidity inpatients with indwelling ureteric stents:results of a prospective studyusing the validated ureteric stent symptoms questionnaire显示文摘 | Giannarini G Keeley FX Jr Valent F | 2011 | BJU Int2011，107，4： | 1 |
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