|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Durability of neutralizing antibodies and T-cell response post SARS-CoV-2 infection显示文摘The ongoing pandemic of coronavirus disease 19(COVID-19)is caused by a newly discoveredβcoronavirus named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).How long the adaptive immunity triggered by SARS-CoV-2 can last is of critical clinical relevance in assessing the probability of second infection and efficacy of vaccination.Here we examined,using ELISA,the IgG antibodies in serum specimens collected from 17 COVID-19 patients at 6–7 months after diagnosis and the results were compared to those from cases investigated 2 weeks to 2 months post-infection.All samples were positive for IgGs against the S-and N-proteins of SARS-CoV-2.Notably,14 samples available at 6–7 months post-infection all showed significant neutralizing activities in a pseudovirus assay,with no difference in blocking the cell-entry of the 614D and 614G variants of SARS-CoV-2.Furthermore,in 10 blood samples from cases at 6–7 months post-infection used for memory T-cell tests,we found that interferonγ-producing CD4+and CD8+cells were increased upon SARS-CoV-2 antigen stimulation.Together,these results indicate that durable anti-SARS-CoV-2 immunity is common in convalescent population,and vaccines developed from 614D variant may offer protection from the currently predominant 614D variant of SARS-CoV-2. | Yun Tan Feng Liu Xiaoguang Xu Yun Ling Weijin Huang Zhaoqin Zhu Mingquan Guo Yixiao Lin Ziyu Fu Dongguo Liang Tengfei Zhang Jian Fan Miao Xu Hongzhou Lu Saijuan Chen | 2020 | Frontiers of Medicine2020，14，6： | 6 |
| 2 | An electrodeposition approach to metal/metal oxide heterostructures for active hydrogen evolution catalysts in near-neutral electrolytes显示文摘Neutral water splitting is attractive for its use of non-corrosive and environmentally friendly electrolytes.However,catalyst development for hydrogen and oxygen evolution remains a challenge under neutral conditions.Here we report a simple electrodeposition and reductive annealing procedure to produce a highly active Ni-Co-Cr metal/metal oxide heterostructured catalyst directly on Ni foam.The resulting electrocatalyst for hydrogen evolution reaction (HER) requires only 198 mV of overpotential to reach 100 mNcm2 in 1 M potassium phosphate (pH =7.4) and can operate for at least two days without significant performance decay.Scanning transmission electron microscopy coupled with electron energy loss spectroscopy (STEM-EELS) imaging reveals a Ni-Co alloy core decorated with blended oxides layers of NiO,CoO and Cr2O3.The metal/metal oxide interfaces are suggested to be responsible for the high HER activity. | Michael J.Kenney Jianan Erick Huang Yong Zhu Yongtao Meng Mingquan Xu Guanzhou Zhu Wei-Hsuan Hung Yun Kuang Mengchang Lin Xiaoming Sun Wu Zhou Hongjie Dai | 2019 | Nano Research2019，12，6： | 4 |
| 3 | Efficacy and safety of high-dose esomeprazole–amoxicillin dual therapy for Helicobacter pylori rescue treatment:a multicenter,prospective,randomized,controlled trial显示文摘Background:High-dose dual therapy(HDDT)with proton pump inhibitors(PPIs)and amoxicillin has attracted widespread attention due to its favorable efficacy in eradicating Helicobacter pylori(H.pylori).This study aimed to compare the efficacy and safety of high-dose PPI-amoxicillin dual therapy and bismuth-containing quadruple therapy for H.pylori rescue treatment.Methods:This was a prospective,randomized,multicenter,non-inferiority trial.Patients recruited from eight centers who had failed previous treatment were randomly(1:1)allocated to two eradication groups:HDDT(esomeprazole 40 mg and amoxicillin 1000 mg three times daily;theHDDTgroup)and bismuth-containing quadruple therapy(esomeprazole 40 mg,bismuth potassium citrate 220 mg,and furazolidone 100 mg twice daily,combined with tetracycline 500 mg three times daily;the tetracycline,furazolidone,esomeprazole,and bismuth[TFEB]group)for 14 days.The primary endpoint was the H.pylori eradication rate.The secondary endpoints were adverse effects,symptom improvement rates,and patient compliance.Results:A total of 658 patients who met the criteria were enrolled in this study.The HDDT group achieved eradication rates of 75.4%(248/329),81.0%(248/306),and 81.3%(248/305)asdetermined by the intention-to-treat(ITT),modified intention-totreat(MITT),and per-protocol(PP)analyses,respectively.The eradication rates were similar to those in the TFEB group:78.1%(257/329),84.2%(257/305),and 85.1%(257/302).The lower 95%confidence interval boundary(9.19%in the ITT analysis,9.21%in the MITT analysis,and9.73%in the PP analysis)was greater than the predefined non-inferiority margin of10%,establishing a non-inferiority of the HDDT group vs.the TFEB group.The incidence of adverse events in the HDDT group was significantly lower than that in the TFEB group(11.1%vs.26.8%,P<0.001).Symptom improvement rates and patients’compliance were similar between the two groups.Conclusions:Fourteen-day HDDT is non-inferior to bismuth-containing quadruple therapy,with fewer adverse effects and good treatment compliance,suggesting HDDT as an alternative for H.pylori rescue treatment in the local region.Trial registration:Clinicaltrials.gov,NCT04678492. | Hanxin Bi Xingxing Chen Yuxin Chen Xin Zhao Shasha Wang Jiehong Wang Ting Lyu Shuang Han Tao Lin Mingquan Li Donghong Yuan Junye Liu Yongquan Shi | 2022 | Chinese Medical Journal2022，，14： | 3 |
| 4 | Multi-element analysis of Baijiu(Chinese liquors)by ICP-MS and their classification according to geographical origin显示文摘Objectives:Investigating the element profiles of Be,Al,V,Cr,Mn,Fe,Co,Ni,Cu,Zn,As,Se,Rb,Sr,Ag,Cd,Cs,La,Pr,Nd,Sm,Eu,Gd,Pb,Th,and U of Baijiu(Chinese liquors),and setting up their classification according to geographical origin.Materials and Methods:Twenty-eight Chinese liquors from Shandong,Guizhou,and Sichuan provinces were analyzed by inductively coupled plasma mass spectrometry with the aid of matrix matching,online internal calibration,and direct injection to determine the concentrations of the aforementioned 26 elements.Multivariate statistical analysis,based on the contents of elements in the liquors,was applied to differentiate the liquors from different origins.Results:Both the cluster analysis based on 11 elements and the discriminant analysis based on 5 elements can separate the liquors of Shandong Province from others.A leave-one-out cross test of the discriminant analysis data resulted in 100 per cent accuracy regarding the recognition ability and prediction ability for the liquors from Shandong Province,and an overall 75.0 per cent accuracy of its prediction for all the 28 total liquors.Limitations:The liquors of Guizhou and Sichuan provinces can not be differentiated successfully.Conclusions:The liquors produced in Shandong Province can be differentiated in a great extent from Guizhou and Sichuan provinces based on the multivariate statistical analysis of the concentration of elements in liquors,while those of Guizhou and Sichuan provinces can not be differentiated successfully due to their geographical adjacency. | Xuebo Song Min Hou Zhi Li Lin Zhu Fuping Zheng Mingquan Huang Xiaotao Sun Hehe Li Feng Chen Baoguo Sun | 2018 | Food Quality and Safety2018，2，1： | 3 |
| 5 | Characterization of terpenoids and norisoprenoids from base and retail Qingke Baijiu by GC×GC-TOFMS and multivariate statistical analysis显示文摘Qingke(highland barley)Baijiu is a special Chinese Baijiu which is mainly produced from Qinghai-Tibet Plateau.Since the pine board is used as the bottom of the fermentation pit,we deduced that the terpenoids and norisoprenoids in pine board might be introduced into Qingke Baijiu.Thus,the terpenoids and norisoprenoids in Qingke Baijiu were investigated by headspace solid phase microextraction(HS-SPME)combined with comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry(GC×GC-TOFMS).The results showed thatγ-terpinene(0.70-530.72μg/L),α-phellandrene(0.34-256.66μg/L),longicyclene(0-38.55μg/L),α-pinene(1.21-35.54μg/L)and limonene(0.93-23.69μg/L)were the top 5 terpenoids/norisoprenoids in Qingke Baijiu.Pulegone was detected and reported for the first time in Baijiu,and the concentrations in Qingke Baijiu were 0.78μg/L(fresh)and 3.90μg/L(7 years old).According to the principal component analysis(PCA)plot,young,aged,and retail Qingke Baijiu could be differentiated clearly.Fold change(FC)and t-tests analysis indicated thatβ-pinene,γ-terpinene,andα-selinene were the most different terpenoids/norisoprenoids between young and aged Qingke Baijiu,and longifolene was the most different terpenoids/norisoprenoids between base and retail Qingke Baijiu.The terpenoids and norisoprenoids,such as(E)-β-ionone,isoborneol andβ-cyclocitral,could be potential markers indicating the ageing process of Qingke Baijiu. | Xinlei Wang Lin Zhu Xuebo Song Si Jing Fuping Zheng Mingquan Huang Shengbao Feng Luzhong La | 2023 | Food Science and Human Wellness2023，12，1： | 2 |
| 6 | Knowledge Graph Applications in Medical Imaging Analysis:A Scoping Review显示文摘Background. There is an increasing trend to represent domain knowledge in structured graphs, which provide efficient knowledgerepresentations for many downstream tasks. Knowledge graphs are widely used to model prior knowledge in the form of nodesand edges to represent semantically connected knowledge entities, which several works have adopted into different medicalimaging applications. Methods. We systematically searched over five databases to find relevant articles that applied knowledgegraphs to medical imaging analysis. After screening, evaluating, and reviewing the selected articles, we performed a systematicanalysis. Results. We looked at four applications in medical imaging analysis, including disease classification, diseaselocalization and segmentation, report generation, and image retrieval. We also identified limitations of current work, such asthe limited amount of available annotated data and weak generalizability to other tasks. We further identified the potentialfuture directions according to the identified limitations, including employing semisupervised frameworks to alleviate the needfor annotated data and exploring task-agnostic models to provide better generalizability. Conclusions. We hope that our articlewill provide the readers with aggregated documentation of the state-of-the-art knowledge graph applications for medicalimaging to encourage future research. | Song Wang Mingquan Lin Tirthankar Ghosal Ying Ding Yifan Peng | 2022 | Health Data Science2022，，1： | 0 |
| 7 | Atomically dispersed lr/α-MoC catalyst with high metal loading and thermal stability for water-promoted hydrogenation reaction显示文摘Synthesis of atomically dispersed catalysts with high metal loading and thermal stability is challenging but particularly valuable for industrial application in heterogeneous catalysis.Here,we report a facile synthesis of a thermally stable atomically dispersed Ir/α-MoC catalyst with metal loading as high as 4 wt%,an unusually high value for carbide supported metal catalysts.The strong interaction between Ir and theα-MoC substrate enables high dispersion of Ir on the α-MoC surface,and modulates the electronic structure of the supported Ir species.Using quinoline hydrogenation as a model reaction,we demonstrate that this atomically dispersed Ir/α-MoC catalyst exhibits remarkable reactivity,selectivity and stability,for which the presence of high-density isolated Ir atoms is the key to achieving high metal-normalized activity and mass-specific activity.We also show that the water-promoted quinoline hydrogenation mechanism is preferred over the Ir/α-MoC,and contributes to high sele ctivity towards 1,2,3,4-tetrahydroquinoline.The present work demonstrates a new strategy in constructing a high-loading atomically dispersed catalyst for the hydrogenation reaction. | Siwei Li Ruochen Cao Mingquan Xu Yuchen Deng Lili Lin Siyu Yao Xuan Liang Mi Peng Zirui Gao Yuzhen Ge Jin-Xun Liu Wei-Xue Li Wu Zhou Ding Ma | 2022 | National Science Review2022，9，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员