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| 1 | Ultrafast epitaxial growth of metre-sized single-crystal graphene on industrial Cu foil显示文摘A foundation of the modern technology that uses single-crystal silicon has been the growth of highquality single-crystal Si ingots with diameters up to 12 inches or larger. For many applications of graphene, large-area high-quality(ideally of single-crystal) material will be enabling. Since the first growth on copper foil a decade ago, inch-sized single-crystal graphene has been achieved. We present here the growth, in 20 min, of a graphene film of(5 ×50) cm^2 dimension with >99% ultra-highly oriented grains.This growth was achieved by:(1) synthesis of metre-sized single-crystal Cu(1 1 1) foil as substrate;(2)epitaxial growth of graphene islands on the Cu(1 1 1) surface;(3) seamless merging of such graphene islands into a graphene film with high single crystallinity and(4) the ultrafast growth of graphene film.These achievements were realized by a temperature-gradient-driven annealing technique to produce single-crystal Cu(1 1 1) from industrial polycrystalline Cu foil and the marvellous effects of a continuous oxygen supply from an adjacent oxide. The as-synthesized graphene film, with very few misoriented grains(if any), has a mobility up to ~23,000 cm^2 V^(-1)s^(-1)at 4 K and room temperature sheet resistance of ~230 Ω/□. It is very likely that this approach can be scaled up to achieve exceptionally large and high-quality graphene films with single crystallinity, and thus realize various industrial-level applications at a low cost. | Xiaozhi Xu Zhihong Zhang Jichen Dong Ding Yi Jingjing Niu Muhong Wu Li Lin Rongkang Yin Mingqiang Li Jingyuan Zhou Shaoxin Wang Junliang Sun Xiaojie Duan Peng Gao Ying Jiang Xiaosong Wu Hailin Peng Rodney S. Ruoff Zhongfan Liu Dapeng Yu Enge Wang Feng Ding Kaihui Liu | 2017 | Science Bulletin2017，62，15： | 40 |
| 2 | miR-210 over-expression enhances mesenchymal stem cell survival in an oxidative stress environment through antioxidation and c-Met pathway activation显示文摘microRNA-210(miR-210)has generally been reported to be associated with cell survival under hypoxia.However,there are few data regarding the role of miR-210 in the survival of mesenchymal stem cells(MSCs)under oxidative stress conditions.Thus,we sought to investigate whether miR-210 over-expression could protect MSCs against oxidative stress injury and what the primary mechanisms involved are.The results showed that over-expression of miR-210 significantly reduced the apoptosis of MSCs under oxidative stress,accompanied by obvious increases in cell viability and superoxide dismutase activity and remarkable decreases in malonaldehyde content and reactive oxygen species production,resulting in a noticeable reduction of apoptotic indices when compared with the control.Moreover,the above beneficial effects of miR-210 could be significantly reduced by c-Met pathway repression.Collectively,these results showed that miR-210 over-expression improved MSC survival under oxidative stress through antioxidation and c-Met pathway activation,indicating the potential development of a novel approach to enhance the efficacy of MSC-based therapy for injured myocardium. | XU JianFeng HUANG ZheYong LIN Li FU MingQiang GAO YanHua SHEN YunLi ZOU YunZeng SUN AiJun QIAN JuYing GE JunBo | 2014 | Science China(Life Sciences)2014，57，10： | 10 |
| 3 | A space power system of free piston Stirling generator based on potassium heat pipe显示文摘The power system of a free piston Stirling generator(FPSG)based on potassium heat pipes has been developed in this paper.Thanks to the advantages of long life,high reliability,and high overall thermal efficiency,the FPSG is a promising candidate for nuclear energy,especially in space exploration.In this paper,the recent progress of FPSG based on nuclear reactor for space use was briefly reviewed.A novel FPSG weighted only 4.2 kg was designed,and one dimensional thermodynamic modeling of the FPSG using Sage software was performed to estimate its performance.The experiment results indicated that this FPSG could provide 142.4 W at a thermal-to-electric efficiency of nearly 17.4%.Besides,the power system integrated with four FPSGs and potassium heat pipes was performed and the single machine failure test was conducted.The results show that this system could provide an electrical power of 300 W at an overall thermal efficiency of 7.3%.Thus,it is concluded that this power system is feasible and will have a great prospect for future applications. | Mingqiang LIN Jian MOU Chunyun CHI Guotong HONG Panhe GE Gu HU | 2020 | Frontiers in Energy2020，14，1： | 5 |
| 4 | Interstitial copper-doped edge contact for n-type carrier transport in black phosphorus显示文摘Black phosphorus(BP)has been shown as a promising two-dimensional(2D)material for electronic devices owing to its high carrier mobility.To realize complementary electronic circuits with 2D materials,it is important to fabricate both n-type and p-type transistors with the same channel material.By engineering the contact region with copper(Cu)-doped BP,here we demonstrate an n-type carrier transport in BP field-effect transistors(FETs),which usually exhibit strongly p-type characteristics.Cu metal atoms are found to severely penetrate into the BP flakes,which forms interstitial Cu(Cuint)-doped edge contact and facilitates the electron transport in BP.Our BP FETs in backgated configuration exhibit n-type dominant characteristics with a high electron mobility of^138 cm^2 V^−1 s^−1 at room temperature.The Schottky barrier height for electrons is relatively low because of the edge contact between Cuint-doped BP and pristine BP channel.The contact doping of BP by highly mobile Cu atoms gives rise to n-type transport property of BP FETs.Furthermore,we demonstrate a p-n junction on the same BP flake with asymmetric contact.This strategy on contact engineering can be further extended to other 2D materials. | Ziyuan Lin Jingli Wang Xuyun Guo Jiewei Chen Chao Xu Mingqiang Liu Bilu Liu Ye Zhu Yang Chai | 2019 | InfoMat2019，1，2： | 2 |
| 5 | Extensively Drug-Resistant(XDR)Salmonella Typhi Outbreak by Waterborne Infection——Beijing Municipality,China,January-February 2022显示文摘Summary What is already known about this topic?Typhoid fever remains a major public health problem in developing countries.Waterborne typhoid fever affects an estimated 27 million people worldwide each year.Decades of indiscriminate antibiotic usage has driven the emergence and spread of multidrug-resistant(MDR)and even extensively drug-resistant(XDR)Salmonella Typhi(S.Typhi)strains. | Yu Wang Dan Lu Yingying Jin Huanxin Wang Bing Lyu Xin Zhang Ying Huang Gaolin Shu Baiwei Liu Changying Lin Hao Zhao Mingqiang Zhao Lingyu Shen Zhiyong Gao Daitao Zhang Quanyi Wang Mei Qu Lei Jia | 2022 | China CDC weekly2022，4，12： | 1 |
| 6 | 白细胞介素-18抑制Lewis肺癌小鼠移植瘤生长与诱导移植瘤细胞凋亡的研究(英文)显示文摘Objective:The aim of our study was to investigate the effects of interleukin-18(IL-18) on implanted Lewis lung cancer in suppressing tumor growth and inducing tumor cells apoptosis.Methods:One week after hypodermic inoculation of Lewis cells, sixteen tumor-bearing syngeneic mice were randomly divided into two groups.The mice in the treatment group were intraperitoneal injected with the IL-18, in the control group were intraperitoneal injected with normal saline.The health conditions of the mice were measured, the morphology of the tumors was studied and the apoptosis of implanted lung cancer cells was detected by TUNEL to evaluated the effects of IL-18.Results:IL-18 had no significant effects on the health conditions of the mice, but it could suppress the implanted tumor growth(inhibition rate was 75%) and induce tumor cells apoptosis.Conclusion:IL-18 can suppress the implanted Lewis lung cancer cells by way of inducing tumor cells apoptosis.It could be used as a new strategy for lung cancer. | Sheng Yang Huishan Lu Xiangqi Chen Tingyan Lin Zhiying Li Mingqiang Kang | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，3： | 1 |
| 7 | High-speed graphene transistors with a self-aligned nanowire gate显示文摘 | Liao Lei Lin Yungchen Bao Mingqiang | 2010 | Nature2010，467，7313： | 1 |
| 8 | High-speed graphene transistors with a self-aligned nanowire gate 显示文摘 | Liao Lei Lin Yungchen Bao Mingqiang | 2010 | Nature2010，467，7313： | 1 |
| 9 | State of health estimation for lithium-ion batteries in real-world electric vehicles显示文摘The state of health(SOH) plays a significant role in the mileage and safety of an electric vehicle(EV). In recent years, many methods based on data-driven analysis and laboratory measurements have been developed for SOH estimation. However, most of these proposed methods cannot be applied to real-world EVs. Here, we present a method for SOH estimation based on realworld EV data. A battery-aging evaluation health index(HI) with a strong correlation to the SOH is retrieved from battery-aging data and then modified with thermal factors to depict the former SOH. Afterward, a local weighted linear-regression algorithm is used to qualitatively characterize the declining trend of the HI, which eliminates the local HI fluctuation caused by data noise.Subsequently, a series of features-of-interest(FOIs) is extracted according to the battery consistency, cell-voltage extrema, and cumulative mileage, and validated using the grey relational analysis. Finally, a battery-degradation model is built using the extreme gradient-boosting algorithm with the selected FOIs. The experimental results from real-world data indicate that the proposed method has high estimation accuracy and generalization, and the maximum error is around 2% for batteries in realworld EVs. | WU Ji FANG LeiChao DONG GuangZhong LIN MingQiang | 2023 | Science China(Technological Sciences)2023，66，1： | 0 |
| 10 | Multi-Feature Fusion-Based Instantaneous Energy Consumption Estimation for Electric Buses显示文摘Dear Editor, This letter presents a multi-feature fusion-based method for estimating the instantaneous energy consumption of electric buses. More specifically, to improve the accuracy of instantaneous energy consumption estimation of electric buses, we propose a new energy consumption estimation method based on random forest regression(RFR) with multi-feature fusion. The multi-feature includes driving behavior, vehicle status, and external environment. | Mingqiang Lin Shouxin Chen Wei Wang Ji Wu | 2023 | IEEE/CAA Journal of Automatica Sinica2023，10，10： | 0 |
| 11 | Lithium-ion battery degradation trajectory early prediction with synthetic dataset and deep learning显示文摘Knowing the long-term degradation trajectory of Lithium-ion(Li-ion) battery in its early usage stage is critical for the maintenance of the battery energy storage system(BESS) in reality. Previous battery health diagnosis methods focus on capacity and state of health(SOH) estimation which can receive only the short-term health status of the cell. This paper proposes a novel degradation trajectory prediction method with synthetic dataset and deep learning, which enables to grasp the characterization of the cell's health at a very early stage of Li-ion battery usage. A transferred convolutional neural network(CNN) is chosen to finalize the early prediction target, and the polynomial function based synthetic dataset generation strategy is designed to reduce the costly data collection procedure in real application. In this thread, the proposed method needs one full lifespan data to predict the overall degradation trajectories of other cells. With only the full lifespan cycling data from 4 cells and 100 cycling data from each cell in experimental validation, the proposed method shows a good prediction accuracy on a dataset with more than 100 commercial Li-ion batteries. | Mingqiang Lin Yuqiang You Jinhao Meng Wei Wang Ji Wu Daniel-Ioan Stroe | 2023 | Journal of Energy Chemistry2023，，10： | 0 |
| 12 | Quantitative monitoring and mutations of ctDNA before and after non-small cell lung cancer radical surgery显示文摘Objective The aim of this study was to study the quantitative expression of circulating tumour DNA(ctDNA) in patients with non-small cell lung cancer(NSCLC) before and after radical operation and to explore the correlation between gene mutations in non-small cell lung cancer tissues and those in ctDNA.Methods We randomly assigned 5 NSCLC patients from the Department of Thoracic Surgery of Fujian Medical University Union Hospital. All the patients had undergone radical surgery. Venous blood samples were collected from the 5 NSCLC patients at two time points(before the operation and 21–37 days after the operation) for monitoring ctDNA levels. This was done by isolating plasma from venous blood using high velocity centrifugation, extracting DNA from the plasma using the QIAamp Circulating Nucleic Acid kit, and then quantifying the ctDNA levels. The results were analyzed using the Wilcoxon Rank Sum Test. Moreover, the ctDNA levels were compared with those of carcinoembryonic antigen(CEA), which was detected simultaneously with the ctDNA. Then, DNA samples from the tumor tissues and peripheral blood cells and ctDNA were sequenced using the Hiseq2000 sequencing platform(Illumina) and the mutant genes were screened out. Mutations that occurred within the tumor tissues were used as positive control, whereas those found in the pre-operative blood cells were used as a negative control. Based on the mutational analysis of ctDNA genes, a total of 508 cancer-related genes were screened. Results The median values of the pre-and post-operative ctDNA levels in the 5 patients with NSCLC were 0.612(0.518–0.876) and 0.430(0.372–0.612) ng/μL, respectively. There was a significant difference between the two groups(P < 0.05). The pre-operative CEA level was slightly higher than the post-operative level(P > 0.05). In one of the cases, LC tissues showed multiple mutations, consistent with pre-operative ctDNA. Moreover, isogenic mutations of the same type were not detected in post-operative ctDNA or peripheral blood cells. Conclusion Mutations found in the lung cancer(LC) ctDNA gene were consistent with the mutation type of LC tissue. Hence, the quantitative and qualitative analysis of ctDNA is a promising novel molecular biomarker for the evaluation of tumor burden changes in NSCLC. | Xiangqi Chen Tingyan Lin Zhisen Gao Jiangjiang Xu Rui Feng Sheng Yang Shuchen Chen Mingqiang Kang | 2019 | Oncology and Translational Medicine2019，5，3： | 0 |
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