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| 1 | Homocysteine-mediated cholesterol efflux via ABCA1 and ACAT1 DNA methylation in THP-1 monocyte-derived foam cells显示文摘Homocysteine (Hcy ) 为心血管的事件作为一个流行风险因素被认出了。装载胆固醇的泡沫房间是动脉粥样硬化患者损害的一个中央部件。ATP 有约束力的盒子 transporter A1 (ABCA1 ) 它调停细胞的胆固醇和 phospholipids 的流出,是在类脂化合物的限制率的步新陈代谢。酰辅酶 A:cholesterol acyltransferase-1 (ACAT1 ) 在巨噬细胞支持胆固醇酉旨的累积,从而导致泡沫房间形成,在动脉粥样硬化的早舞台的一个特点。在这研究,有教养的导出单核白血球的泡沫房间为 24 h 与 Hcy 的临床的相关集中被孵化。胆固醇的房间和累积被发现的泡沫的两个都增加的数字,和 ABCA1 的 mRNA 和蛋白质表示层次被减少,当 ACAT1 表示面对 Hcy 被增加时。而且,而 ACAT1 DNA methylation 被使用 Hcy 的不同集中减少, ABCA1 基因的 DNA methylation 水平被增加。而且,我们的结果显示出那项 DNA methyltransferase (DNMT ) 活动和 DNA methyltransferase 1 (DNMT1 ) mRNA 表示被 Hcy 增加。DNA methylation 有功能经由 DNMT 调整 ABCA1 和 ACAT1 的表示,这被显示。在结论,这些结果建议 Hcy 导致的 ABCA1 和 ACAT1 DNA methylation 可以在导出单核白血球的泡沫房间在 ABCA1 和 ACAT1 表示和胆固醇的累积起一个潜在的作用。 | Yu Liang Xiaoling Yang Linna Ma Xin Cai Lei Wang Cheng Yang Guizhong Li Minghao Zhang Weiwei Sun Yideng Jiang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，3： | 26 |
| 2 | Estimating In-pulse Characteristics of Radar Signal Based on Multi-index显示文摘 | HAN Jun HE Minghao TANG Zhikai WANG Jie | 2011 | Chinese Journal of Electronics2011，20，1： | 23 |
| 3 | A Strigolactone Biosynthesis Gene Contributed to the Green Revolution in Rice显示文摘Plant architecture is a complex agronomic trait and a major factor of crop yield,which is affected by several important hormones.Strigolactones(SLs)are identified as a new class hormoneinhibiting branching in many plant species and have been shown to be involved in various developmental processes.Genetical and chemical modulation of the SL pathway is recognized as a promising approach to modify plant architecture.However,whether and how the genes involved in the SL pathway could be utilized in breeding still remain elusive.Here,we demonstrate that a partial loss-of-function allele of the SL biosynthesis gene,HIGH TILLERING AND DWARF 1/DWARF17(HTD1/D17),which encodes CAROTENOID CLEAVAGE DIOXYGENASE 7(CCD7),increases tiller number and improves grain yield in rice.We found that the HTD1 gene had been widely utilized and co-selected with Semidwarf 1(SD1),both contributing to the improvement of plant architecture in modern rice varieties since the Green Revolution in the 1960s.Understanding how phytohormone pathway genes regulate plant architecture and how they have been utilized and selected in breeding will lay the foundation for developing the rational approaches toward improving crop yield. | Yuexing Wang Lianguang Shang Hong Yu Longjun Zeng Jiang Hu Shen Ni Yuchun Rao Sanfeng Li Jinfang Chu Xiangbing Meng Lei Wang Ping Hu Jijun Yan Shujing Kang Minghao Qu Hai Lin Tao Wang Quan Wang Xingming Hu Hongqi Chen Bing Wang Zhenyu Gao Longbiao Guo Dali Zeng Xudong Zhu Guosheng Xiong Jiayang Li Qian Qian | 2020 | Molecular Plant2020，13，6： | 23 |
| 4 | Ecosystem Health Assessment of Honghu Lake Wetland of China Using Artificial Neural Network Approach显示文摘Honghu Lake,located in the southeast of Hubei Province,China,has suffered a severe disturbance during the past few decades.To restore the ecosystem,the Honghu Lake Wetland Protection and Restoration Demonstration Project(HLWPRDP) has been implemented since 2004.A back propagation(BP) artificial neural network(ANN) approach was applied to evaluatinig the ecosystem health of the Honghu Lake wetland.And the effectiveness of the HLWPRDP was also assessed by comparing the ecosystem health before and after the project.Particularly,12 ecosystem health indices were used as evaluation parameters to establish a set of three-layer BP ANNs.The output is one layer of ecosystem health index.After training and testing the BP ANNs,an optimal model of BP ANNs was selected to assess the ecosystem health of the Honghu Lake wetland.The result indicates that four stages can be identified based on the change of the ecosystem health from 1990 to 2008 and the ecosystem health index ranges from morbidity before the implementation of HLWPRDP(in 2002) to middle health after the implementation of the HLWPRDP(in 2005).It demonstrates that the HLWPRDP is effective and the BP ANN could be used as a tool for the assessment of ecosystem health. | MO Minghao WANG Xuelei WU Houjian CAI Shuming Xiaoyang ZHANG WANG Huiliang | 2009 | Chinese Geographical Science2009，19，4： | 21 |
| 5 | A New Method for Sorting Unknown Radar Emitter Signal显示文摘Sorting rate of common method is not high and it is sensitive to the Signal noise ratio(SNR), in order to solve these problems, bispectrum two dimensions characteristics complexity is applied to sort unknown complicated radar signal and a high sorting rate would be got. The bispectrum of received signal is extracted and it is predigested to two dimensions characteristic, the box dimension and information dimension are extracted from the two dimensions characteristic and used as the sorting characteristics, and the last sorting is accomplished by using KFCM algorithm. For the bispectrum of different signal is distinguishing and it is not sensitive to SNR, the box dimension and information dimension are divisible and steady, the advantage of this new method is validated by simulation results, and the lowest sorting rate is 90% at SNR equals to 10 dB. | CHEN Changxiao HE Minghao XU Jing HAN Jun | 2014 | Chinese Journal of Electronics2014，23，3： | 19 |
| 6 | SUPERCONVERGENCE ANALYSIS OF THE STABLE CONFORMING RECTANGULAR MIXED FINITE ELEMENTS FOR THE LINEAR ELASTICITY PROBLEM显示文摘在这份报纸,我们基于 Hellinger-Reissner 变化原则考虑线性弹性问题。为压力和排水量和排水量的全球 superconvergence 结果的一个 O (h2 ) 顺序 superclose 性质被采用 Cl 茅 m ent 插值,不可分的身份和适当 postprocessing 技术建立。[从作者抽象] | Dongyang Shi Minghao Li | 2014 | Journal of Computational Mathematics2014，32，2： | 15 |
| 7 | Endoplasmic reticulum oxidoreductin 1α mediates hepatic endoplasmic reticulum stress in homocysteine-induced atherosclerosis显示文摘Endoplasmic 蜂窝胃(嗯) 应力作为不同病理学的过程的一个重要调节的人并且作为贡献导致的 homocysteine (Hcy ) 的机制正在出现 hepar 损害。然而,分子的事件导致 Hcy 嗯在在动脉粥样硬化背景下面的 hepar 的应力当前是未知的。Endoplasmic 蜂窝胃 oxidoreductin (ERO1 ) 1 在维持起一个关键作用嗯压力功能。在这研究,我们在 hepacytes 在 hyperhomocysteinemia 和 ERO1 的效果在 hepar 决定了 ERO1 的表示嗯应力面对 Hcy。HHcy 模型被在 apolipoprotein-E-deficient (ApoE-/-) 喂蛋氨酸食谱建立老鼠,和 hepatocytes 与 Hcy 的叶酸、不同的集中被孵化。我们的结果证明 Hcy 被触发嗯应力描绘了由一调整葡萄糖的蛋白质的增加的内容 78 (GRP78 ) ,蛋白质 kinase 象 RNA 一样嗯 kinase (津贴) ,激活抄写因素(ATF ) 6 并且 X 盒子有约束力的 protein-1 (XBP-1 ) 。在 HHcy 老鼠和对待 Hcy 的 hepatocytes 的 ERO1 表情在 ApoE-/- 组和控制 hepacytes 与那些相比被减少(P < 0.05 ) 分别地。有小介入的 RNA 的 ERO1 的表示显著地扩充了的敲门下面导致 Hcy 嗯应力。同时,表情嗯压力相关的因素包括 GRP78,津贴, ATF6 和 XBP-1,当 ERO1 基因在 hepacytes 是过去表示的时,显著地被减少。我们的结果建议 ERO1 可以涉及导致 Hcy 的 hepar 嗯 ERO1 表示的应力,和抑制能加速这进程。 | Xiaoling Yang Hua Xu Yinju Hao Li Zhao Xin Cai Jue Tian Minghao Zhang Xuebo Han Shengchao Ma Jun Cao Yideng Jiang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，10： | 14 |
| 8 | Long-term thermal regimes of the Qinghai-Tibet Railway embankments in plateau permafrost regions显示文摘Ten years of ground temperature data(2003–2013) indicate that the long-term thermal regimes within embankments of the Qinghai-Tibet Railway(QTR) vary significantly with different embankment structures. Obvious asymmetries exist in the ground temperature fields within the traditional embankment(TE) and the crushed-rock basement embankment(CRBE). Measurements indicate that the TE and CRBE are not conducive to maintaining thermal stability. In contrast, the ground temperature fields of both the crushed-rock sloped embankment(CRSE) and the U-shaped crushed-rock embankment(UCRE) were symmetrical. However, the UCRE gave better thermal stability than the CRSE because slow warming of deep permafrost was observed under the CRSE. Therefore, the UCRE has the best long-term effect of decreasing ground temperature and improving the symmetry of the temperature field. More generally, it is concluded that construction using the cooling-roadbed principle meets the design requirements for long-term stability of the railway and for train transport speeds of 100 km h?1. However, temperature differences between the two shoulders, which exist in all embankments shoulders, may cause potential uneven settlement and might require maintenance. | NIU Fu un LIU MingHao CHENG GuoDong LIN ZhanJu LUO Jing YIN GuoAn | 2015 | Science China Earth Sciences2015，58，9： | 14 |
| 9 | Exosomes-the enigmatic regulators of bone homeostasis显示文摘Exosomes are a heterogeneous group of cell-derived membranous structures, which mediate crosstalk interaction between cells.Recent studies have revealed a close relationship between exosomes and bone homeostasis. It is suggested that bone cells can spontaneously secret exosomes containing proteins, lipids and nucleic acids, which then to regulate osteoclastogenesis and osteogenesis. However, the network of regulatory activities of exosomes in bone homeostasis as well as their therapeutic potential in bone injury remain largely unknown. This review will detail and discuss the characteristics of exosomes, the regulatory activities of exosomes in bone homeostasis as well as the clinical potential of exosomes in bone injury. | Minhao Gao Weiyang Gao J. M. Papadimitriou Changqing Zhang Junjie Gao Minghao Zheng | 2018 | Bone Research2018，6，4： | 13 |
| 10 | Molecular mechanism of SCARB2-mediatec attachment and uncoating of EV71显示文摘 | Minghao Dang Xiangxi Wang Quan Wang Yaxin Wang Jianping Lin Yuna Sun Xuemei Li Liguo Zhang Zhiyong Lou Junzhi Wang Zihe Rao | 2014 | Protein & Cell2014，5，9： | 13 |
| 11 | Recent development of a refined multiple air pollutant emission inventory of vehicles in the Central Plains of China显示文摘Central Plains region of China,represented by Henan Province,is facing serious air pollution problems.Vehicular exhaust emissions had adverse impacts on the atmospheric environment.The first comprehensive and novel vehicle emission inventory for Henan Province using vehicle kilometers traveled,localized emission factors,and activity data at city-level was developed.Furthermore,3 km×3 km gridded emission and temporal variations were determined by using localized information.Results show that the total emissions of sulfur dioxide(SO2),nitrogen oxides(NOx),carbon monoxide(CO),particular matter with aerodynamic diameter<10μm(PM10),aerodynamic diameter<2.5μm(PM2.5),volatile organic compounds(VOCs),VOCs-evaporation and ammonia in 2015 were 9.1,533.4,1190.7,23.7,21.6,150.8,31.5 and 10.4 Gg,respectively,and the emission intensities of the above pollutants were 0.05,2.7,6.0,0.1,0.1,0.8,0.2 and 0.05 g/km,respectively.Vehicles meeting the Primary China 1,China 3 and China 4 contributed 89.1%,82.7%,75.3%,75.5%,75.5%,68.2%,68.4%and 82.3%for SO2,NOx,CO,PM10,PM2.5,VOCs,VOCs-evaporation and ammonia emissions,respectively.Zhengzhou,Zhoukou,Nanyang,Luoyang,Shangqiu and Xinyang showed relatively higher emissions and contributed more than 50%of each pollutant.The spatial distribution indicated obvious characteristics of the road network,and high-level emission was concentrated in the downtown areas.Additionally,the ozone formation potential(OFP)based on the estimated speciated VOC emissions was 569.6 Gg in Henan Province.Aliphatic and aromatic hydrocarbons were the main species of VOCs,whereas olefins contributed the largest proportion of OFP,with 42.2%. | Xingke Gu Shasha Yin Xuan Lu Huan Zhang Lingling Wang Ling Bai Chen Wang Ruiqin Zhang Minghao Yuan | 2019 | Journal of Environmental Sciences2019，31，10： | 11 |
| 12 | Osteoarthritis:pathogenic signaling pathways and therapeutic targets显示文摘Osteoarthritis(OA)is a chronic degenerative joint disorder that leads to disability and affects more than 500 million population worldwide.OA was believed to be caused by the wearing and tearing of articular cartilage,but it is now more commonly referred to as a chronic whole-joint disorder that is initiated with biochemical and cellular alterations in the synovial joint tissues,which leads to the histological and structural changes of the joint and ends up with the whole tissue dysfunction.Currently,there is no cure for OA,partly due to a lack of comprehensive understanding of the pathological mechanism of the initiation and progression of the disease.Therefore,a better understanding of pathological signaling pathways and key molecules involved in OA pathogenesis is crucial for therapeutic target design and drug development.In this review,we first summarize the epidemiology of OA,including its prevalence,incidence and burdens,and OA risk factors.We then focus on the roles and regulation of the pathological signaling pathways,such as Wnt/β-catenin,NF-κB,focal adhesion,HIFs,TGFβ/ΒΜP and FGF signaling pathways,and key regulators AMPK,mTOR,and RUNX2 in the onset and development of OA.In addition,the roles of factors associated with OA,including MMPs,ADAMTS/ADAMs,and PRG4,are discussed in detail.Finally,we provide updates on the current clinical therapies and clinical trials of biological treatments and drugs for OA.Research advances in basic knowledge of articular cartilage biology and OA pathogenesis will have a significant impact and translational value in developing OA therapeutic strategies. | Qing Yao Xiaohao Wu Chu Tao Weiyuan Gong Mingjue Chen Minghao Qu Yiming Zhong Tailin He Sheng Chen Guozhi Xiao | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 11 |
| 13 | Characteristics,sources and health risks assessment of VOCs in Zhengzhou,China during haze pollution season显示文摘Zhengzhou is one of the most haze-polluted cities in Central China with high organic carbon emission,which accounts for 15%-20%of particulate matter(PM_(2.5))in winter and causes significantly adverse health effects.Volatile organic compounds(VOCs)are the precursors of secondary PM_(2.5)and O_(3)formation.An investigation of characteristics,sources and health risks assessment of VOCs was carried out at the urban area of Zhengzhou from 1^(st) to 31^(st) December,2019.The mean concentrations of total detected VOCs were 48.8±23.0 ppbv.Alkanes(22.0±10.4 ppbv),halocarbons(8.1±3.9 ppbv)and aromatics(6.5±3.9 ppbv)were the predominant VOC species,followed by alkenes(5.1±3.3 ppbv),oxygenated VOCs(3.6±1.8 ppbv),alkyne(3.5±1.9,ppbv)and sulfide(0.5±0.9 ppbv).The Positive Matrix Factorization model was used to identify and apportion VOCs sources.Five major sources of VOCs were identified as vehicular exhaust,industrial processes,combustion,fuel evaporation,and solvent use.The carcinogenic and non-carcinogenic risk values of species were calculated.The carcinogenic and non-carcinogenic risks of almost all air toxics increased during haze days.The total non-carcinogenic risks exceeded the acceptable ranges.Most VOC species posed no non-carcinogenic risk during three haze events.The carcinogenic risks of chloroform,1,2-dichloroethane,1,2-dibromoethane,benzyl chloride,hexachloro-1,3-butadiene,benzene and naphthalene were above the acceptable level(1.0×10^(-6))but below the tolerable risk level(1.0×10^(-4)).Industrial emission was the major contributor to non-carcinogenic,and solvent use was the major contributor to carcinogenic risks. | Dong Zhang Bing He Minghao Yuan Shijie Yu Shasha Yin Ruiqin Zhang | 2021 | Journal of Environmental Sciences2021，33，10： | 10 |
| 14 | Aqueous-phase catalytic hydrogenation of furfural to cyclopentanol over Cu-Mg-Al hydrotalcites derived catalysts:Model reaction for upgrading of bio-oil显示文摘A series of Cu-Mg-Al hydrotalcites derived oxides with a(Cu+Mg)/Al mole ratio of 3 and varied Cu/Mg mole ratio(from 0.07 to 0.30) were prepared by co-precipitation and calcination methods, then they were introduced to the hydrogenation of furfural in aqueous-phase. Effects of Cu/Mg mole ratio, reaction temperature, initial hydrogen pressure, reaction time and catalyst amount on the conversion rate of furfural as well as the selectivity toward desired product cyclopentanol were systematically investigated. The conversion of furfural over calcined hydrotalcite catalyst with a Cu/Mg mole ratio of 0.2 was up to 98.5% when the reaction was carried out under 140 ?C and the initial hydrogen pressure of 4 MPa for 10 h, while the selectivity toward cyclopentanol was up to 94.8%. The catalysts were characterized by XRD and SEM. XRD diffraction of all the samples showed characteristic pattern of hydrotalcite with varied peak intensity as a result of different Cu content. The catalytic activity was improved gradually with the increase of Cu component in the hydrotalcite. | Minghao Zhou Zuo Zeng Hongyan Zhu Guomin Xiao Rui Xiao | 2014 | Journal of Energy Chemistry2014，23，1： | 9 |
| 15 | Risk assessment on the epidemics of human infection with a novel avian influenza A (H7N9) virus in Jiangsu Province, China显示文摘A novel avian influenza A (H7N9) virus was discovered in February 2013 in China and has resulted in more than 100 comfirmed human infections including 26 fatal cases as of May 2, 2013. The situation raises many urgent questions and global public health concerns. In this study, epidemiologic characteristics of infected human cases in Jiangsu province were analyzed and risk assessment was undertaken based on the information available. Briefly, it is highly unlikely that a pandemic of human infection with avian influenza A (H7N9) virus will happen in Jiangsu Province in the near future. In the end, some measures are recommended to prevent the situation from becoming worse. | Wendong Liu Yefei Zhu Xian Qi Ke Xu Aihua Ge Hong Ji Jing Ai Changjun Bao Fenyang Tang Minghao Zhou | 2013 | The Journal of Biomedical Research2013，27，3： | 9 |
| 16 | Degradation of bisphenol-A using ultrasonic irradiation assisted by low-concentration hydrogen peroxide显示文摘This study investigated the degradation of bisphenol-A (BPA) by ultrasonic irradiation in the presence of different additives (H2O2,air bubbles and humic acid) under various operating conditions,i.e.,ultrasonic frequency,power intensity and power density.The results demonstrated that the BPA degradation followed pseudo first-order kinetics under different experimental conditions.The optimum power intensities were 0.9,1.8,and 3.0W/cm 2 at the frequencies of 400,670,and 800 kHz,respectively.At the fixed frequency (800 kHz),the degradation rate of BPA was shown proportional to the increase of power density applied.With this manner,the BPA sonolysis could be facilitated at H2O2 dosage being lower than 0.1 mmol/L;while BPA degradation was hindered at H2O2 concentration in excess of 1 mmol/L.Additionally,BPA removal was shown to be inhibited by the presence of aeration and humic acid during ultrasonic irradiation.The present study suggested that the degradation rate of BPA assisted by ultrasonic irradiation was influenced by a variety of factors,and high BPA removal rate could be achieved under appropriate conditions. | Kejia Zhang Naiyun Gao Yang Deng Tsair Fuh Lin Yan Ma Lei Li Minghao Sui | 2011 | Journal of Environmental Sciences2011，23，1： | 9 |
| 17 | Dual-Mode Induction of Tunable Circularly Polarized Luminescence from Chiral Metal-Organic Frameworks显示文摘The general approach for fabricating solid-state materials showing circularly polarized luminescence(CPL)is still in its challenge.In this work,chiral metal-organic frameworks(MOFs)with full-color and white-color circularly polarized light emission are firstly achieved through a host-guest emitter-loading strategy.Chiral zeolitic imidazolate frameworks(ZIFs,a class of MOFs)are fabricated by a facile and simple mixed-ligand coassembly pathway.Meantime,achiral dyes,quantum dots(QDs),and upconversion nanoparticles(UCNPs)are easily loaded into the chiral ZIFs during the synthetic process.Size-matched dyes can be solely encapsulated into the chiral cages of ZIF,resulting in induced CPL and enhanced luminescence efficiency in solid-state ZIF⊃dye composites.Large-sized QDs,after embedding into the gap of the ZIF particles,also exhibited intense CPL activity.Furthermore,through modulating the blending ratio of colored dyes or QDs in chiral ZIFs,white light-emitting ZIFs with circular polarization could be constructed in a solid state.In addition,through loading rare earth element-based upconversion nanoparticles(UCNPs)into chiral ZIFs,upconverted CPL(UC-CPL)could be achieved with a high dissymmetry factor(glum).Thus,various achiral luminophores were endowed with CPL upon coupling with chiral ZIFs,which significantly deepened and enlarged the research scope of the chiroptical materials in a solid state. | Tonghan Zhao Jianlei Han Xue Jin Minghao Zhou Yan Liu Pengfei Duan Minghua Liu | 2020 | Research2020，，1： | 8 |
| 18 | Development Status and Trend of Electric Vehicles in China显示文摘Due to pressures from both energy and environment,electric vehicles(EVs)and their related technologies have experienced considerable achievements in China in recent years.This paper firstly presents the EV development status in China with key statistics including EV market status,mainstream technical indicators,charging infrastructure,and key components(battery,motor drive systems).Then,the developmental driving forces of EVs in China are reviewed and analyzed with an emphasis on government policies such as subsidy rules,research investment,and standards.Finally,the development trend of EVs in China is prospected from aspects of industry,technology and policy,opportunities and challenges,with an expectation that more attention from academia,industry and government will be attracted into the area of EVs. | Ming Cheng Minghao Tong | 2017 | Chinese Journal of Electrical Engineering2017，3，2： | 7 |
| 19 | Review and Development of Electric Motor Systems and Electric Powertrains for New Energy Vehicles显示文摘This paper presents a review on the recent research and technical progress of electric motor systems and electric powertrains for new energy vehicles.Through the analysis and comparison of direct current motor,induction motor,and synchronous motor,it is found that permanent magnet synchronous motor has better overall performance;by comparison with converters with Si-based IGBTs,it is found converters with SiC MOSFETs show significantly higher efficiency and increase driving mileage per charge.In addition,the pros and cons of different control strategies and algorithms are demonstrated.Next,by comparing series,parallel,and power split hybrid powertrains,the series-parallel compound hybrid powertrains are found to provide better fuel economy.Different electric powertrains,hybrid powertrains,and range-extended electric systems are also detailed,and their advantages and disadvantages are described.Finally,the technology roadmap over the next 15 years is proposed regarding traction motor,power electronic converter and electric powertrain as well as the key materials and components at each time frame. | William Cai Xiaogang Wu Minghao Zhou Yafei Liang Yujin Wang | 2021 | Automotive Innovation2021，4，1： | 7 |
| 20 | An Improved Radar Emitter Recognition Method Based on Dezert-Smarandache Theory显示文摘The parameters of radar emitter are fast changing in the current complicated electromagnetic environment, and the radar emitter recognition rate which used single sensor method cannot satisfied. To solve the problem, an improved radar emitter recognition method based on Dezert-Smarandache theory is proposed, which can improve proportional conflict redistribution rule to solve fuzzy and conflicting information from radar emitter. Some examples are given to show the validity of the improved method. | CHEN Changxiao HE Minghao LI Hongfei | 2015 | Chinese Journal of Electronics2015，24，3： | 7 |
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