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| 1 | Effect of burden and origin sites of premature ventricular contractions on left ventricular function by 7-day Holter monitor显示文摘Recent studies have shown that premature ventricular contractions(PVCs) could enlarge the heart,but its risk factors are incompletely understood as a single 24-hour recording cannot reflect the true PVC burden due to day-to-day variability.Our purpose was to investigate the effect of burden and origin sites on left ventricular(LV) function in patients with PVCs by 7-day Holter electrocardiography(ECG).From May 2012 to August2013,112 consecutive patients with PVCs were recruited from the authors' affiliated hospital.All patients received2-dimensional transthoracic echocardiography,12-lead routing ECG and 7-days Holter ECG.Serum N-terminal probrain natriuretic peptide(NT-proBNP) levels were measured.A total of 102 participants with PVCs were included in the final analysis.Origin of PVCs from the tricuspid annulus had the highest burden and NT-proBNP level.LV papillary muscle had a higher LV ejection fraction(EF) level and a lower LV end-systolic dimension(ESD) than other PVC foci(P<0.05).The high burden group had a higher LV end-diastolic dimension(EDD) and LVESD but lower LVEF than the other two groups(P<0.05).Female,older age,physical work,and history of PVCs had a significantly positive correlation with symptoms.Male,older age,physical work,and high burden were positive predictors of enlarged LVEDD,LVESD and higher serum NT-proBNP level,but lower LVEF.Seven-day dynamic ECG Holter monitor showed the true PVC burden on patients with PVCs.PVCs with a lower burden or origin from the LV papillary muscle and the fascicle were relatively benign,while PVCs with a higher burden or origin from the tricuspid annulus may lead to cardiac dysfunction. | Wenhua Xu Mingfang Li Minglong Chen Bing Yang Daowu Wang Xiangqing Kong Hongwu Chen Weizhu Ju Kai Gu Kejiang Cao Hailei Liu Qi Jiang Jiaojiao Shi Yan Cui Hong Wang | 2015 | The Journal of Biomedical Research2015，29，6： | 4 |
| 2 | Molecularphylogeny of Chinese vegetable mustard (Brassica juncea) basedon the internal transcribed spacers (ITS) of nuclear ribosomalDNA显示文摘 | Xiaoming Wu Xiaohua Qi Mingfang Zhang | 2007 | Genet Resour Crop Evol2007，54，： | 1 |
| 3 | Temporal and Spatial Distribution of Auxin Response Factor Genes During Tomato Flower Abscission显示文摘 | Xiaoxi Guan Tao Xu Song Gao Mingfang Qi Yanling Wang Xin Liu Tianlai Li | 2014 | Journal of Plant Growth Regulation2014，，2： | 1 |
| 4 | Calcium Requirement for Ethylene-Induced Abscission显示文摘 | Tao Xu Tianlai Li Mingfang Qi | 2009 | Journal of Plant Nutrition2009，，3： | 1 |
| 5 | Light quality regulates plant biomass and fruit quality through a photoreceptor-dependent HY5-LHC/CYCB module in tomato显示文摘Increasing photosynthesis and light capture offers possibilities for improving crop yield and provides a sustainable way to meet the increasing global demand for food.However,the poor light transmittance of transparent plastic films and shade avoidance at high planting density seriously reduce photosynthesis and alter fruit quality in vegetable crops,and therefore it is important to investigate the mechanisms of light signaling regulation of photosynthesis and metabolism in tomato(Solanum lycopersicum).Here,a combination of red,blue,and white(R1W1B0.5)light promoted the accumulation of chlorophyll,carotenoid,and anthocyanin,and enhanced photosynthesis and electron transport rates by increasing the density of active reaction centers and the expression of the genes LIGHT-HARVESTING COMPLEX B(SlLHCB)and A(SlLHCA),resulting in increased plant biomass.In addition,R1W1B0.5 light induced carotenoid accumulation and fruit ripening by decreasing the expression of LYCOPENEβ-CYCLASE(SlCYCB).Disruption of SlCYCB largely induced fruit lycopene accumulation,and reduced chlorophyll content and photosynthesis in leaves under red,blue,and white light.Molecular studies showed that ELONGATED HYPOCOTYL 5(SlHY5)directly activated SlCYCB,SlLHCB,and SlLHCA expression to enhance chlorophyll accumulation and photosynthesis.Furthermore,R1W1B0.5 light-induced chlorophyll accumulation,photosynthesis,and SlHY5 expression were largely decreased in the slphyb1cry1 mutant.Collectively,R1W1B0.5 light noticeably promoted photosynthesis,biomass,and fruit quality through the photoreceptor(SlPHYB1 and SlCRY1)-SlHY5-SlLHCA/B/SlCYCB module in tomato.Thus,the manipulation of light environments in protected agriculture is a crucial tool to regulate the two vital agronomic traits related to crop production efficiency and fruit nutritional quality in tomato. | Jiarong Yan Juan Liu Shengdie Yang Chenghao Jiang Yanan Liu Nan Zhang Xin Sun Ying Zhang Kangyou Zhu Yinxia Peng Xin Bu Xiujie Wang Golam Jalal Ahammed Sida Meng Changhua Tan Yufeng Liu Zhouping Sun Mingfang Qi Feng Wang Tianlai Li | 2023 | Horticulture Research2023，10，12： | 0 |
| 6 | PRKCDBP Methylation is a Potential and Promising Candidate Biomarker for Non-small Cell Lung Cancer显示文摘Background and objectives:The occurrence and development of lung cancer are closely linked to epigenetic modification.Abnormal DNA methylation in the CpG island region of genes has been found in many cancers.Protein kinase C delta binding protein(PRKCDBP) is a potential tumor suppressor and its epigenetic changes are found in many human malignancies.This study investigated the possibility of PRKCDBP methylation as a potential biomarker for non-small cell lung cancer(NSCLC).Methods:We measured the methylation levels of PRKCDBP in the three groups of NSCLC tissues.Promoter activity was measured by the dual luciferase assay,with S’-aza-deoxycytidine to examine the effect of demethylation on the expression level of PRKCDBP.Results:The methylation levels of PRKCDBP in tumor tissues and 3 cm para-tumor were higher than those of distant(>10 cm)non-tumor tissues.Receiver operating characteristic(ROC) curve analysis between tumor tissues and distant non-tumor tissues showed that the area under the line(AUC) was 0.717.Dual luciferase experiment confirmed that the promoter region was able to promote gene expression.Meanwhile,in vitro methylation of the fragment(PRKCDBP;e) could significantly reduce the promoter activity of the fragment.Demethylation of 5’-aza-deoxycytidine in lung cancer cell lines A549 and H1299 showed a significant up-regulation of PRKCDBP mRNA levels.Conclusion:PRKCDBP methylation is a potential and promising candidate biomarker for non-small cell lung cancer. | Jing LI Lin QI Mingfang ZHANG Caiyun YAO Jinan FENG Zhonghua ZHENG Chujia CHEN Shiwei DUAN Yuanlin QI | 2022 | 中国肺癌杂志2022，25，2： | 0 |
| 7 | PROTECTIVE ROLES OF D1 PROTEIN TURNOVER AND THE XANTHOPHYLL CYCLE IN TOMATO(SOLANUM LYCOPERSICUM)UNDER SUB-HIGH TEMPERATURE AND HIGH LIGHT STRESS显示文摘D1 protein turnover and the xanthophyll cycle(XC)are important photo-protective mechanisms in plants that operate under adverse conditions.Here,streptomycin sulfate(SM)and dithiothreitol(DTT)were used in tomato plants as inhibitors of D1 protein turnover and XC to elucidate their photoprotec-tive impacts under sub-high temperature and high light conditions(HH,35°C,1000 limol m 2.S1).SM and DTT treatments significantly reduced the net photosynthetic rate,apparent quantum efficiency,maximum photochemical efficiency,and potential activity of photosystem II,leading to photoinhibition and a decline in plant biomass under HH.The increase in reactive oxygen species levels resulted in thylakoid membrane lipid peroxidation.In addition,there were increased non-photochemical quenching and decreased chlorophyll pigments in SM and DTT application,causing an inhibition of D1 protein production at both transcriptional and translational levels.Overall,inhibition of D1 turnover caused greater photoinhibition than XC inhibition.Additionally,the recovery levels of most photosynthesis indicators in DTT-treated plants were higher than in SM-treated plants.These findings support the view that D1 turnover has a more important role than XC in photoprotection in tomato under HH conditions. | Tao LUA Jiazhi LU Mingfang QI Zhouping SUN Yufeng LIU Tianlai LI | 2021 | Frontiers of Agricultural Science and Engineering2021，8，2： | 0 |
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