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| 1 | Soil Fertility,Microbial Biomass,and Microbial Functional Diversity Responses to Four Years Fertilization in an Apple Orchard in North China显示文摘Soil microbial communities play an essential role in maintaining soil fertility and are considered as ecological indicators to evaluate soil health.In the present study,we examined the influence of almost 4 years of fertilization[no fertilizer(CK),nitrogen alone(N),nitrogen,phosphorus and potassium chemical fertilizer(NPK),organicmanure(M),nitrogen plus organic manure(NM),and NPK plus organic manure(NPKM)]on soil fertility and the functional diversity of soil microbial communities in an apple orchard.Compared to CK,fertilization increased soil organic carbon,total nitrogen,and available nutrients,but reduced soil pH in N and NPK treatments.The highest microbial biomass carbon and nitrogen,most probable number of actinomycetes,bacteria,and fungi occurred in the NPKM treatment.The average well color development(AWCD)values followed the order of NPKM>M>NPK and NM>CK and N.The Shannon index in organic manure treatments were significantly higher than in control and in treatments without organic manure.The principal component analysis showed that manure treatment was significantly separated from other treatments.These results indicated that organic manure applied alone or in combination with chemical fertilizers would increase soil fertility and functional diversity of soil microbial communities.Moreover,applying balanced N,P,K fertilizer in combination with organic manure was found to be superior to the use of a single fertilizer in improving soil microbial community quality. | Zhanling Zhu Yan Bai Minglu Lv Ge Tian Xin Zhang Li Li Yuanmao Jiang Shunfeng Ge | 2020 | Horticultural Plant Journal2020，6，4： | 13 |
| 2 | An epidermal sEMG tattoo-like patch as a new human–machine interface for patients with loss of voice显示文摘Throat cancer treatment involves surgical removal of the tumor,leaving patients with facial disfigurement as well as temporary or permanent loss of voice.Surface electromyography(sEMG)generated from the jaw contains lots of voice information.However,it is difficult to record because of not only the weakness of the signals but also the steep skin curvature.This paper demonstrates the design of an imperceptible,flexible epidermal sEMG tattoo-like patch with the thickness of less than 10μm and peeling strength of larger than 1N cm−1 that exhibits large adhesiveness to complex biological surfaces and is thus capable of sEMG recording for silent speech recognition.When a tester speaks silently,the patch shows excellent performance in recording the sEMG signals from three muscle channels and recognizing those frequently used instructions with high accuracy by using the wavelet decomposition and pattern recognization.The average accuracy of action instructions can reach up to 89.04%,and the average accuracy of emotion instructions is as high as 92.33%.To demonstrate the functionality of tattoo-like patches as a new human–machine interface(HMI)for patients with loss of voice,the intelligent silent speech recognition,voice synthesis,and virtual interaction have been implemented,which are of great importance in helping these patients communicate with people and make life more enjoyable. | Huicong Liu Wei Dong Yunfei Li Fanqi Li Jiangjun Geng Minglu Zhu Tao Chen Hongmiao Zhang Lining Sun Chengkuo Lee | 2020 | Microsystems & Nanoengineering2020，6，1： | 6 |
| 3 | PTEN regulates RPA1 and protects DNA replication forks显示文摘肿瘤 suppressor PTEN 通过多重机制调整细胞的活动和控制染色体稳定性。在这研究,我们报导 PTEN 为对复制应力的 DNA 复制叉的保护是必要的。我们证明 PTEN 的那删除在叉拖延跟随 hydroxyurea 导致的核苷酸弄空之上导致复制叉倒塌和 chromosomal 不稳定性。PTEN 身体上与复制蛋白质 A 被联系 1 (RPA1 ) 经由 RPA1 C 终端领域。暴风雨和 iPOND 表明 PTEN 在复制地点是局部性的并且在复制叉上支持 RPA1 累积。PTEN 成员调停的 deubiquitinase OTUB1 RPA1 deubiquitination。RPA1 删除授与象与复制叉拖延在 PTEN 猛烈房间观察了那一样的显型。PTEN 和 RPA1 的表示在 colorectal 癌症显示出强壮的关联。RPA1 的异质接合的混乱在老鼠支持 tumorigenesis。这些结果证明 PTEN 为 DNA 复制叉保护是必要的。我们建议 RPA1 是在叉保护的 PTEN 功能的一个目标并且 PTEN 通过 DNA 复制的规定维持染色体稳定性。 | Guangxi Wang Yang Li Pan Wang Hui Liang Ming Cui Minglu Zhu Limei Guo Qian Su Yujie Sun Michael A McNut Yuxin Yin | 2015 | Cell Research2015，25，11： | 6 |
| 4 | Characterization of bacterial community dynamics in a full-scale drinking water treatment plant显示文摘Understanding the spatial and temporal dynamics of microbial communities in drinking water systems is vital to securing the microbial safety of drinking water.The objective of this study was to comprehensively characterize the dynamics of microbial biomass and bacterial communities at each step of a full-scale drinking water treatment plant in Beijing,China.Both bulk water and biofilm samples on granular activated carbon(GAC) were collected over 9 months.The proportion of cultivable cells decreased during the treatment processes,and this proportion was higher in warm season than cool season,suggesting that treatment processes and water temperature probably had considerable impact on the R2 A cultivability of total bacteria.16 s rRNA gene based 454 pyrosequencing analysis of the bacterial community revealed that Proteobacteria predominated in all samples.The GAC biofilm harbored a distinct population with a much higher relative abundance of Acidobactena than water samples.Principle coordinate analysis and one-way analysis of similarity indicated that the dynamics of the microbial communities in bulk water and biofilm samples were better explained by the treatment processes rather than by sampling time,and distinctive changes of the microbial communities in water occurred after GAC filtration.Furthermore,20 distinct OTUs contributing most to the dissimilarity among samples of different sampling locations and 6 persistent OTUs present in the entire treatment process flow were identified.Overall,our findings demonstrate the significant effects that treatment processes have on the microbial biomass and community fluctuation and provide implications for further targeted investigation on particular bacteria populations. | Cuiping Li Fangqiong Ling Minglu Zhang Wen-Tso Liu Yuxian Li Wenjun Liu | 2017 | Journal of Environmental Sciences2017，29，1： | 5 |
| 5 | The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection显示文摘Epigenetic modifications to histones dictate the differentiation of naïve CD4^(+) T cells into different subsets of effector T helper(TH)cells.The histone methyltransferase enhancer of zeste homolog 2(EZH2)has been implicated in the mechanism regulating the differentiation of TH1,TH2 and regulatory T(Treg)cells.However,whether and how EZH2 regulates follicular helper T(TFH)cell differentiation remain unknown.Using a mouse model of acute lymphocytic choriomeningitis virus(LCMV)infection,we observed abundant EZH2 expression and associated H3K27me3 modifications preferentially in the early committed virus-specific TFH cells compared to those in TH1 cells.Ablation of EZH2 in LCMV-specific CD4^(+) T cells leads to a selective impairment of early TFH cell fate commitment,but not late TFH differentiation or memory TFH maintenance.Mechanistically,EZH2 specifically stabilizes the chromatin accessibility of a cluster of genes that are important for TFH fate commitment,particularly B cell lymphoma 6(Bcl6),and thus directs TFH cell commitment.Therefore,we identified the chromatin-modifying enzyme EZH2 as a novel regulator of early TFH differentiation during acute viral infection. | Xiangyu Chen Guoshuai Cao Jialin Wu Xinxin Wang Zhiwei Pan Jianbao Gao Qin Tian Lifan Xu Zhirong Li Yaxing Hao Qizhao Huang Pengcheng Wang Minglu Xiao Luoyingzi Xie Shupei Tang Zhenyu Liu Li Hu Jianfang Tang Ran He Li Wang Xinyuan Zhou Yuzhang Wu Mengjie Chen Beicheng Sun Bo Zhu Jun Huang Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，3： | 4 |
| 6 | Genome Analysis of Dasineura jujubifolia Toursvirus 2,A Novel Ascovirus显示文摘So far,ascoviruses have only been identified from Lepidoptera host insects and their transmission vectors-endoparasitic wasps.Here,we reported the first finding of a complete novel ascovirus genome from a Diptera insect,Dasineura jujubifolia.Initially,sequence fragments with homology to ascoviruses were incidentally identified during metagenomic sequencing of the mitochondria of D.jujubifolia(Cecidomyiidae,Diptera)which is a major pest on Ziziphus jujuba.Then a full circular viral genome was assembled from the metagenomic data,which has an A+T percentage of 74%and contains 142,600 bp with 141 open reading frames(ORFs).Among the 141 ORFs,37 were conserved in all sequenced ascoviruses(core genes)including proteins predicted to participate in DNA replication,gene transcription,protein modification,virus assembly,lipid metabolism and apoptosis.Multi-gene families including those encode for baculovirus repeated open reading frames(BROs),myristylated membrane proteins,RING/U-box E3 ubiquitin ligases,and ATP-binding cassette(ABC)transporters were found in the virus genome.Phylogenetic analysis showed that the newly identified virus belongs to genus Toursvirus of Ascoviridae,and is therefore named as Dasineura jujubifolia toursvirus 2(DjTV-2a).The virus becomes the second reported species of the genus after Diadromus pulchellus toursvirus 1(DpTV-1a).The genome arrangement of DjTV-2a is quite different from that of DpTV-1a,suggesting these two viruses separated in an early time of evolution.The results suggest that the ascoviruses may infect a much broader range of hosts than our previous knowledge,and shed lights on the evolution of ascoviruses and particularly on that of the toursviruses. | Jun Wang Minglu Yang Haibing Xiao Guo-Hua Huang Fei Deng Zhihong Hu | 2020 | Virologica Sinica2020，35，2： | 4 |
| 7 | Kinematic Analysis of Mobile Manipulator for Measurement and Maintenance in Dangerous Environment显示文摘This paper studies the kinematic modeling of a mobile manipulator that consists of 5-DOF manipulator and an autonomous wheeled mobile platform.Then an artificial neural network to realize the coordination motion between manipulator and mobile platform is developed.On the basis of the task specifications,the algorithm determines the appropriate control variables to respond to the well tracking trajectory.The control strategy employed for either subsystem is achieved by using a robust supervised controller.A learning paradigm is used to produce the required reference variables for an overall cooperative behavior of the sys- tem.Simulation results are presented to show the effectiveness of this approach. | CUI Genqun LI Chunshu ZHANG Minglu School of Mechanical Engineering,Hebei University of Technology,Tianjin 300062,China, | 2006 | 武汉理工大学学报2006，28，S3： | 4 |
| 8 | Deep learning-enabled triboelectric smart socks for IoT-based gait analysis and VR applications显示文摘The era of artificial intelligence and internet of things is rapidly developed by recent advances in wearable electronics.Gait reveals sensory information in daily life containing personal information,regarding identification and healthcare.Current wearable electronics of gait analysis are mainly limited by high fabrication cost,operation energy consumption,or inferior analysis methods,which barely involve machine learning or implement nonoptimal models that require massive datasets for training.Herein,we developed low-cost triboelectric intelligent socks for harvesting waste energy from low-frequency body motions to transmit wireless sensory data.The sock equipped with self-powered functionality also can be used as wearable sensors to deliver information,regarding the identity,health status,and activity of the users.To further address the issue of ineffective analysis methods,an optimized deep learning model with an end-to-end structure on the socks signals for the gait analysis is proposed,which produces a 93.54%identification accuracy of 13 participants and detects five different human activities with 96.67%accuracy.Toward practical application,we map the physical signals collected through the socks in the virtual space to establish a digital human system for sports monitoring,healthcare,identification,and future smart home applications. | Zixuan Zhang Tianyiyi He Minglu Zhu Zhongda Sun Qiongfeng Shi Jianxiong Zhu Bowei Dong Mehmet Rasit Yuce Chengkuo Lee | 2020 | npj Flexible Electronics2020，4，1： | 4 |
| 9 | FRFT Based Parameter Estimation of the Quadratic FM Signal显示文摘 | QU Qiang JIN Minglu KIM Jae Moung | 2010 | Chinese Journal of Electronics2010，19，3： | 3 |
| 10 | Random walk search in unstructured P2P显示文摘Unstructured P2P has power-law link distribution, and the random walk in power-law networks is analyzed. The analysis results show that the probability that a random walker walks through the high degree nodes is high in the power-law network, and the information on the high degree nodes can be easily found through random walk. Random walk spread and random walk search method (RWSS) is proposed based on the analysis result. Simulation results show that RWSS achieves high success rates at low cost and is robust to high degree node failure. | Jia Zhaoqing You Jinyuan Rao Ruonan Li Minglu | 2006 | Journal of Systems Engineering and Electronics2006，17，3： | 3 |
| 11 | Overcoming chemotherapy resistance via simultaneous drug-efflux circumvention and mitochondrial targeting显示文摘Multidrug resistance(MDR) has been considered as a huge challenge to the effective chemotherapy. Therefore, it is necessary to develop new strategies to effectively overcome MDR. Here,based on the previous research of N-(2-hydroxypropyl)methacrylamide(HPMA) polymer–drug conjugates, we designed an effective system that combined drug-efflux circumvention and mitochondria targeting of anticancer drug doxorubicin(Dox). Briefly, Dox was modified with mitochondrial membrane penetrating peptide(MPP) and then attached to(HPMA) copolymers(P-M-Dox). Our study showed that macromolecular HPMA copolymers successfully bypassed drug efflux pumps and escorted Dox into resistant MCF-7/ADR cells via endocytic pathway. Subsequently, the mitochondria accumulation of drugs was significantly enhanced with 11.6-fold increase by MPP modification. The excellent mitochondria targeting then resulted in significant enhancement of reactive oxygen species(ROS) as well as reduction of adenosine triphosphate(ATP)production, which could further inhibit drug efflux and resistant cancer cell growth. By reversing Dox resistance, P-M-Dox achieved much better suppression in the growth of 3D MCF-7/ADR tumor spheroids compared with free Dox. Hence, our study provides a promising approach to treat drug-resistant cancer through simultaneous drug efflux circumvention and direct mitochondria delivery. | Minglu Zhou Lijia Li Lian Li Xi Lin Fengling Wang Qiuyi Li Yuan Huang | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 3 |
| 12 | Spatial continuity incorporated multi-attribute fuzzy clustering algorithm for blood vessels segmentation显示文摘A three-dimensional representation of vasculature can be extremely important in image-guided neurosurgery, pre-surgical planning. In this paper, a spatial continuity incorporated multi-attribute fuzzy clustering algorithm (MAFCM S) is proposed to segment entire blood vessels from TOF MRA images. This clustering method takes both the intensity information and the geometrical information into account, while most of the cur- rent clustering methods only deal with the former. In this method, a new dissimilarity measure, which integrates the intensity and the geometry shape dissimilarity, is introduced. Because of the presence of the geometrical information, the new measure is able to differentiate the pixels with similar intensity values within different geometrical shape structures. Experimental results show that the new algorithm can get better segmentation. | HAO JuTao ZHAO JingJing LI MingLu | 2010 | Science China(Information Sciences)2010，53，4： | 3 |
| 13 | Modulating Sand’s time by ion-transport-enhancement toward dendrite-free lithium metal anode显示文摘Metallic lithium is deemed as the“Holy Grail”anode in high-energy-density secondary batteries.Uncontrollable lithium dendrite growth and related issues originated from uneven concentration distribution of Li+in the vicinity of the anode,however,induce severe safety concerns and poor cycling efficiency,dragging lithium metal anode out of practical application.Herein we address these issues by using cross-linked lithiophilic amino phosphonic acid resin as the effective host with the ion-transportenhancement feature.Based on theoretical calculations and multiphysics simulation,it is found that this ion-transportenhancement feature is capable of facilitating the self-concentration kinetics of Li+and accelerating Li^(+)transfer at the electrolyte/electrode interface,leading to uniform bulk lithium deposition.Experimental results show that the proposed lithiumhosting resin decreases the irreversible lithium capacity and improves lithium utilization(with the Coulombic efficiency(CE)of 98.8%over 130 cycles).Our work demonstrates that inducing the self-concentrating distribution of Li+at the interface can be an effective strategy for improving the interfacial ion concentration gradient and optimizing lithium deposition,which opens a new avenue for the practical development of next-generation lithium metal batteries. | Yu Yan Chaozhu Shu Ruixin Zheng Minglu Li Zhiqun Ran Miao He Anjun Hu Ting Zeng Haoyang Xu Ying Zeng | 2022 | Nano Research2022，15，4： | 2 |
| 14 | Detection and quantification of enteroviruses in coastal seawaters from Bohai Bay,Tianjin,China显示文摘An 8-month survey was conducted to detect and quantify enteroviruses in Tianjin coastal seawaters of Bohai Bay to assess coastal water quality. Ten water samples were collected from Bohai Bay for the detection and quantification of enteroviruses by conventional reverse transcription polymerase chain reaction (RT-PCR) and SYBR Green real-time quantitative RT-PCR (qRT-PCR). Total viral nucleic acid was extracted from 500 mL of seawater samples concentrated by Centricon plus-70 centrifugal filter devices. The viral recovery rate was 29.1% based on viral seeding study. The centrifugal ultrafiltration method applied is effective for viral recovery from small volume of polluted water, which may have broader applications to monitoring human virus in aquatic environment. Our results indicated that there was a severe viral contamination in seawater of Bohai Bay. Enteroviruses were detected at concentrations ranging from 1.7×106 to 6.3×107 copies/L by qRT-PCR. Sequencing analyses identified that all of the twenty clones as poliovirus type 2. This is the first quantitative report of human viruses in coastal waters of a metropolitan city in China. This study emphasized the importance for the local and central governments to monitor and assess the water quality. | Minglu Zhang Huabing Zhao Jian Yang Sunny Jiang Baoli Cai | 2010 | Journal of Environmental Sciences2010，22，1： | 2 |
| 15 | Near-zero-dispersion soliton and broadband modulational instability Kerr microcombs in anomalous dispersion显示文摘The developing advances of microresonator-based Ker cavity solitons have enabled versatile applications ranging from communication,signal processing to high-precision measurements.Resonator dispersion is the key factor determining the Kerr comb dynamics.Near the zero group-velocity-dispersion(GVD)regime,low-noise and broadband microcomb sources are achievable,which is crucial to the application of the Kerr soliton.When the GVD is almost vanished,higher-order dispersion can significantly affect the Kerr comb dynamics.Although many studies have investigated the Kerr comb dynamics near the zero-dispersion regime in microresonator or fiber ring system,limited by dispersion profles and dispersion perturbations,the near-zero-dispersion soliton structure pumped in the anomalous dispersion side is still elusive so far.Here,we theoretically and experimentally investigate the microcomb dynamics in fiber-based Fabry-Perot microresonator with ultra-small anomalous GVD.We obtain 2/3-octave-spaning microcombs with~10 GHz spacing,>84 THz span,and>8400 comb lines in the modulational instability(MI)state,without any external nonlinear spectral broadening.Such widely-spanned Ml combs are also able to enter the soliton state.Moreover,we report the first observation of anomalous-dispersion based near-zero-dispersion solitons,which exhibits a local repetition rate up to 8.6 THz,an individual pulse duration<100 fs,a span>32 THz and>3200 comb lines.These two distinct comb states have their own advantages.The broadband MI combs possess high conversion efficiency and wide existing range,while the near-zero-dispersion soliton exhibits relatively low phase noise and ultra-high local repetition rate.This work complements the dynamics of Kerr cavity soliton near the zero-dispersion regime,and may stimulate cross-disciplinary inspirations ranging from dispersion-controlled microresonators to broadband coherent comb devices. | Zeyu Xiao Tieying Li Minglu Cai Hongyi Zhang Yi Huang Chao Li Baicheng Yao Kan Wu Jianping Chen | 2023 | Light(Science & Applications)2023，12，2： | 2 |
| 16 | Optimal Control of a Universal Rotating Magnetic Vector for Petal-shaped Capsule Robot in Curve Environment显示文摘Steering control of a capsule robot in curve environment by magnetic navigation is not yet solved completely.A petal-shaped capsule robot with less steering resistance based on multiple wedge effects is presented,and an optimization method with two processes for determining the orientation of a pre-applied universal magnetic spin vector is proposed.To realize quick and non-contact steering swimming,a fuzzy comprehensive evaluation method for optimizing the steering driving angle is presented based on two evaluation indexes including the average steering speed and the average steering trajectory deviation,achieving the initial optimal orientation of a universal magnetic spin vector.To further reduce robotic magnetic vibration,a main target method for optimizing its final orientation,which is used for fine adjustment,is employed under the constrains of the magnetic moments.Swimming experimental results in curve pipe verified the effectiveness of the optimization method,which can be effectively used to realize non-contact steering swimming of the petal-shaped robot and reduce its vibration. | ZHANG Yongshun BAI Jianwei CHI Minglu CHENG Cunxin WANG Dianlong | 2014 | Chinese Journal of Mechanical Engineering2014，27，5： | 2 |
| 17 | Performance evaluation of SUVnet with real-time traffic data显示文摘 | HUANG Hongyu LUO Peien LI Minglu | | 0，，6： | 1 |
| 18 | Competencies and Responsibilities of Social Science Data librarians: An Analysis of Job Descriptions显示文摘 | Xia Jingfeng Wang Minglu | 2014 | College & Research Libraries2014，，3： | 1 |
| 19 | Parametric analysis of mechanical behavior of steel planer tubular truss under fire 显示文摘 | Jin Meng Zhao Jincheng Liu Minglu | 2011 | Journal of Constructional Steel Research2011，67，1： | 1 |
| 20 | Detection of glutathione within single mice hepatocytes using microfluidic chips coupled with a laser-induced fluorescence system显示文摘 | MINGLU H RUTAO L HAO Z | 2014 | Spectrochimica Acta Part A:Molecular and Biomolecular Spectroscopy2014，125，1： | 1 |
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