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| 1 | Influence of Ren and Du meridian electro-acupuncture on neural stem cell proliferation and extracellular signal-regulated kinase pathway in a rat model of focal cerebral ischemia injury显示文摘BACKGROUND:Studies have shown that electro-acupuncture at the Ren meridian could improve proliferation of subventricular zone neural stem cells in cerebral-ischemic rats. However,there are few reports on the influence of electro-acupuncture at the Du meridian on neural stem cell proliferation. OBJECTIVE:To observe the influence of electro-acupuncture at Ren and Du meridians on neural stem cell proliferation in the subventricular zone and altered signal transduction in cerebral ischemia rats. DESIGN,TIME AND SETTING:A randomized,controlled,animal experiment was performed at the Laboratory of Human Anatomy,Medical College of Sun Yat-sen University from May 2006 to February 2008. MATERIALS:Mouse anti-rat bromodeoxyuridine (BrdU) monoclonal antibody was provided by Sigma,USA; mouse anti-rat nestin monoclonal antibody and extracellular signal-regulated protein kinase (ERK) specific inhibitor PD98059 were provided by Calbiochem,Germany; acupuncture needle was provided by Suzhou Acupuncture Supplies,China. METHODS:A total of 126 rats were randomly assigned to four groups:model (n = 36),Du meridian (n = 36),Ren/Du meridian (n = 36),and Ren/Du meridian + PD98059 (n = 18). Rats in the Ren /Du meridian + PD98059 group were observed on days 7 (n = 6) and 14 (n = 12) after cerebral ischemia injury. Rats in the model,Du meridian,and Ren/Du meridian groups were observed on days 7,14,and 28 after cerebral ischemia injury,with 12 rats per group at each time point. Thread occlusion was used to establish middle cerebral artery occlusion models. Electro-acupuncture was performed at Renzhong (DU 26) and Baihui (DU 20) acupoints in the Du meridian group,as well as Chengjiang (RN 24),Guanyuan (RN 4),Renzhong,and Baihui acupoints in the Ren/Du meridian and Ren/Du meridian + PD98059 groups 2 days after model establishment. In addition,electro-acupuncture stimulation with disperse-dense waves was performed,with 30 Hz disperse wave,100 Hz dense wave,and 5 V intensity for 20 minutes. Rats in the Ren/Du meridian + PD98059 group were treated with 0.2 μg PD98059 injection into the subventricular zone,2 μL per rat. Rats in the model group were not treated with electro-acupuncture. MAIN OUTCOME MEASURES:BrdU/nestin immunofluorescent staining was used to detect proliferating neural stem cells in the subventricular zone of cerebral ischemia rats; Western blot was used to determine phosphorylated ERK1 and 2 (pERK1/2) expression in the subventricular zone. RESULTS:On days 14 and 28 after cerebral ischemia,there were significantly more BrdU-positive and BrdU/nestin-positive cells in the Ren /Du meridian group compared with the Du meridian group (P < 0.05). PD98059 decreased the number of BrdU-positive and BrdU/nestin-positive cells induced by electro-acupuncture at the Ren and Du meridians (P < 0.05). On days 7,14,and 28 after treatment,pERK1/2 expression was significantly greater in the Du meridian and Ren/Du meridian groups compared with the model group (P < 0.05). The promoting effect of electro-acupuncture at Ren and Du meridians on ERK1/2 phosphorylation was superior to electro-acupuncture at the Du meridian alone on day 14 after model induction (P < 0.05). However,PD98059 completely abolished the promoting effect of electro-acupuncture at Ren/Du meridians on pERK1/2 expression (P < 0.05). CONCLUSION:Electro-acupuncture at Ren and Du meridians increased proliferation of subventricular zone neural stem cells,which was related to activation of the ERK pathway in a rat model of cerebral ischemia injury. | Wenshu Luo Haibo Yu Zhuoxin Yang Min Pi Lihong Diao Xiaodan Rao | 2010 | Neural Regeneration Research2010，5，6： | 14 |
| 2 | Real-time fault detection method based on belief rule base for aircraft navigation system显示文摘Real-time and accurate fault detection is essential to enhance the aircraft navigation system's reliability and safety. The existent detection methods based on analytical model draws back at simultaneously detecting gradual and sudden faults. On account of this reason, we propose an online detection solution based on non-analytical model. In this article, the navigation system fault detection model is established based on belief rule base (BRB), where the system measuring residual and its changing rate are used as the inputs of BRB model and the fault detection function as the output. To overcome the drawbacks of current parameter optimization algorithms for BRB and achieve online update, a parameter recursive estimation algorithm is presented for online BRB detection model based on expectation maximization (EM) algorithm. Furthermore, the proposed method is verified by navigation experiment. Experimental results show that the proposed method is able to effectively realize online parameter evaluation in navigation system fault detection model. The output of the detection model can track the fault state very well, and the faults can be diagnosed in real time and accurately. In addition, the detection ability, especially in the probability of false detection, is superior to offline optimization method, and thus the system reliability has great improvement. | Zhao Xin Wang Shicheng Zhang Jinsheng Fan Zhiliang Min Haibo | 2013 | Chinese Journal of Aeronautics2013，26，3： | 13 |
| 3 | Electro-acupuncture at Conception and Governor vessels and transplantation of umbilical cord bloodderived mesenchymal stem cells for treating cerebral ischemia/reperfusion injury显示文摘Mesenchymal stem cell transplantation is a novel means of treating cerebral ischemia/reperfusion,and can promote angiogenesis and neurological functional recovery.Acupuncture at Conception and Governor vessels also has positive effects as a treatment for cerebral ischemia/reperfusion.Therefore,we hypothesized that electro-acupuncture at Conception and Governor vessels plus mesenchymal stem cell transplantation may have better therapeutic effects on the promotion of angiogenesis and recovery of neurological function than either treatment alone.In the present study,human umbilical cord blood-derived mesenchymal stem cells were isolated,cultured,identified and intracranially transplanted into the striatum and subcortex of rats at24 hours following cerebral ischemia/reperfusion.Subsequently,rats were electro-acupunctured at Conception and Governor vessels at 24 hours after transplantation.Modified neurological severity scores and immunohistochemistry findings revealed that the combined interventions of electro-acupuncture and mesenchymal stem cell transplantation clearly improved neurological impairment and up-regulated vascular endothelial growth factor expression around the ischemic focus.The combined intervention provided a better outcome than mesenchymal stem cell transplantation alone.These findings demonstrate that electro-acupuncture at Conception and Governor vessels and mesenchymal stem cell transplantation have synergetic effects on promoting neurological function recovery and angiogenesis in rats after cerebral ischemia/reperfusion. | Haibo Yu Pengdian Chen Zhuoxin Yang Wenshu Luo Min Pi Yonggang Wu Ling Wang | 2014 | Neural Regeneration Research2014，9，1： | 13 |
| 4 | Study on formation of non-metallic inclusions with lower melting temperatures in extra low oxygen special steels显示文摘Investigations were made both in laboratorial and industrial scales on formation of non-metallic inclusions with relatively lower melting temperatures to improve the fatigue property of the special steels which contained extra low oxygen.It was found in laboratory studies that steel/slag reaction time largely affected non-metallic inclusions in steel.With the slag/steel reaction time increasing from 30 to 90 min,inclusions of MgO-Al2O3 spinel were gradually changed into CaO-MgO-Al2O3 system inclusions which were surrounded by lower melting temperature softer CaO-Al2O3 surface layers.By using high basicity and as much as 41 mass% Al2O3 refining slag,the ratio of the lower melting temperature CaO-MgO-Al2O3 system inclusions was remarkably increased to above 80%.In the industrial experiments,it was found that the inclusions changed in the order of 'Al2O3 →MgO-Al2O3 system→CaO-MgO-Al2O3 system' in the secondary refining,and the change from MgO-Al2O3 system to CaO-MgO-Al2O3 system took place from the outside to the inside.The diffusion of CaO and MgO inside the layer of CaO-MgO-Al2O3 was considered as the controlling step of the inclusion transfer.Through LF and RH refining,most inclusions could be transferred to lower melting temperature CaO-Al2O3 and CaO-MgO-Al2O3 system inclusions. | WANG XinHua JIANG Min CHEN Bing LI HaiBo | 2012 | Science China(Technological Sciences)2012，55，7： | 12 |
| 5 | Multi-objective robust control based on fuzzy singularly perturbed models for hypersonic vehicles显示文摘In this paper, we propose a multi-objective robust controller based on fuzzy singularly perturbed models (FSPM) for the longitudinal motion of an air-breathing hypersonic vehicle. The control objective is to provide velocity and altitude tracking in the presence of the uncertainties and unknown nonlinearities in the model caused by variations in flight conditions. By approximating the multi-time-scale model with FSPM, ill-posed matrix calculations are circumvented. Under this framework, a fuzzy multi-objective robust controller is developed, and the linear matrix inequalities (LMI) condition is derived. Numerical simulation using the longitudinal model of a hypersonic aircraft is provided to demonstrate the effectiveness of the proposed strategy. | HU YeNan YUAN Yuan MIN HaiBo SUN FuChun | 2011 | Science China(Information Sciences)2011，54，3： | 11 |
| 6 | Fuzzy dynamic characteristic modeling and adaptive control of nonlinear systems and its application to hypersonic vehicles显示文摘In this paper, a fuzzy dynamic characteristic modeling and adaptive control method is proposed for a class of nonlinear systems. By employing fuzzy dynamic characteristic model, the controlled plant is described as a slowly time-varying fuzzy system, wherein the parameters are estimated online by using recursive Least-Squares algorithm. Under this framework, a fuzzy adaptive controller is constructed, and the stability condition of the closed-loop system is also derived. The main advantage of the proposed method lies in no requirement for the prior knowledge of system model and less parameters to tune, which allows engineers to operate it in a simple, straightforward manner. The proposed method is applied to the control of hypersonic vehicle, and simulation results are given to demonstrate the effectiveness of the obtained results. | LI HongBo SUN ZengQi MIN HaiBo DENG JianQiu | 2011 | Science China(Information Sciences)2011，54，3： | 10 |
| 7 | Satellite-observed trends in the Arctic sea ice concentration for the period 1979–2016显示文摘Arctic sea ice cover has decreased dramatically over the last three decades. This study quanti?es the sea ice concentration(SIC) trends in the Arctic Ocean over the period of 1979–2016 and analyzes their spatial and temporal variations. During each month the SIC trends are negative over the Arctic Ocean, wherein the largest(smallest) rate of decline found in September(March) is-0.48%/a(-0.10%/a).The summer(-0.42%/a) and autumn(-0.31%/a) seasons show faster decrease rates than those of winter(-0.12%/a) and spring(-0.20%/a) seasons. Regional variability is large in the annual SIC trend. The largest SIC trends are observed for the Kara(-0.60%/a) and Barents Seas(-0.54%/a), followed by the Chukchi Sea(-0.48%/a), East Siberian Sea(-0.43%/a), Laptev Sea(-0.38%/a), and Beaufort Sea(-0.36%/a). The annual SIC trend for the whole Arctic Ocean is-0.26%/a over the same period. Furthermore, the in?uences and feedbacks between the SIC and three climate indexes and three climatic parameters, including the Arctic Oscillation(AO), North Atlantic Oscillation(NAO), Dipole anomaly(DA), sea surface temperature(SST), surface air temperature(SAT), and surface wind(SW), are investigated. Statistically, sea ice provides memory for the Arctic climate system so that changes in SIC driven by the climate indices(AO, NAO and DA) can be felt during the ensuing seasons. Positive SST trends can cause greater SIC reductions, which is observed in the Greenland and Barents Seas during the autumn and winter. In contrast, the removal of sea ice(i.e., loss of the insulating layer) likely contributes to a colder sea surface(i.e., decreased SST), as is observed in northern Barents Sea. Decreasing SIC trends can lead to an in-phase enhancement of SAT, while SAT variations seem to have a lagged in?uence on SIC trends. SW plays an important role in the modulating SIC trends in two ways: by transporting moist and warm air that melts sea ice in peripheral seas(typically evident inthe Barents Sea) and by exporting sea ice out of the Arctic Ocean via passages into the Greenland and Barents Seas, including the Fram Strait, the passage between Svalbard and Franz Josef Land(S-FJL),and the passage between Franz Josef Land and Severnaya Zemlya(FJL-SZ). | WANG Yunhe BI Haibo HUANG Haijun LIU Yanxia LIU Yilin LIANG Xi FU Min ZHANG Zehua | 2019 | Journal of Oceanology and Limnology2019，37，1： | 7 |
| 8 | Combinatorial effects of conception and governor vessel electroacu-puncture and human umbilical cord blood-derived mesenchymal stem cells on pathomorphologic lesion and cellular apoptosis in rats with cerebral ischemia/reperfusion显示文摘OBJECTIVE: To investigate the combinatorial effects of conception and governor vessel electroacupuncture(EA) and human umbilical cord blood-derived mesenchymal stem cells(HUCB-MSCs) on pathomorphologic lesion and cellular apoptosis in rats with cerebral ischemia/reperfusion. METHODS: With the HUCB-MSCs isolated, cultured and identified and the models of cerebral ischemia-reperfusion established, the HUCB-MSCs of passage three were intracranially transplanted and the EA at conception and governor vessels was applied. The pathomorphologic lesion by hematoxylin-eosin staining and the cellular apoptosis by terminal deoxynucleotidyl transferase-mediated nick-end labeling method around the ischemic focus were observed. RESULTS: The cultured adherent HUCB-MSCs exhibited a spindle shape and expressed MSC-specific markers, with the cell purity and proliferation rate significantly increasing after the primary passage. HE staining showed that there were no pathological changes observed in the sham surgery group. However, in the PBS transplantation group, degeneration and necrosis of a great number of nerve cells were seen. In both the HUCB-MSCs transplantation group and the HUCB-MSCs transplantation + EA group, reparative changes of the pathomorphism of the tissue were found. Both combination treatment and simple MSCs treatment were able to improve the pathomorphorlogic lesion following cerebral ischemia and reduce the abnormal TUNEL-positive numbers, with former better than latter. CONCLUSION: HUCB-MSCs improve pathological lesions and inhibit the cellular apoptosis around the cerebral ischemic area. EA at conception and governor vessels also improve pathological lesion and inhibit the cellular apoptosis in rats treated with HUCB-MSCs transplantation, which effects were superior to that of simple HUCB-MSCs transplantation. | Zhuoxin Yang Pengdian Chen Haibo Yu Wenshu Luo Min Pi Yonggang Wu Ling Wang Fuxia Yang Yanhua Gou | 2013 | Journal of Traditional Chinese Medicine2013，33，6： | 5 |
| 9 | Tunable synthesis solid or hollow Au-Ag nanostructure, assembled with GO and comparative study of their catalytic properties显示文摘在这个工作,我们由调整 pH 作为种子与 Ag nanoparticles ( AgNPs )为 Ag@Au 核心壳 nanoparticles ( Ag@AuNPs )和 Ag/Au 空 nanocages ( Ag/AuNCs )的合成表明了一个简单、有效的二拍子的圆舞方法,并且混合 Ag@AuNPs-graphene 或 Ag/AuNCs-graphene 氧化物 nanocomposites (Ag@AuNPs去或 Ag/AuNCs-GO )的准备基于自己组装。它从静电的集会实验被注意 Ag/AuNCs 在上的装载数量去 nanosheet 多于 Ag@AuNPs 的。同样综合的混合材料被传播电子显微镜学描绘,原子力量显微镜学, -potential, 高角度的环形的黑暗地的扫描传播电子显微镜学, thermogravimetric 分析器和 X 光检查衍射。Ag@AuNPs, Ag/AuNCs 和 Ag/AuNCs-GO nanostructures 的催化活动在 4- , 3-nitrophenol 或 2-nitrophenol 的减小被调查到 4- , 3-aminophenol, 或 2-aminophenol,并且根据比较运动研究,下列趋势为相关催化活动被获得:Ag/AuNCs-GO ?>? Ag/AuNCs ?>? Ag@AuNPs。这些观察被归因于为混合 nanostructures 的催化反应和作文可得到的表面区域的同时的效果。 | Lidan Xu Min Hong Yongliang Wang Ming Li Haibo Li Madhavan P. N. Nair Chen-Zhong Li | 2016 | Science Bulletin2016，61，19： | 4 |
| 10 | Dependence of magnetic properties on microstructure and composition of Ce-Fe-B sintered magnets显示文摘In this paper,dependence of magnetic properties on microstructure and composition of Ce-Fe-B sintered magnets with Cu-doped Ce-rich alloy addition was investigated.It shows that the maximum energy product(BH)(max)and coercivity H(cj)of Ce-Fe-B sintered magnet are improved from 6.76 to 9.13 MGOe by 35.1%,and from 1.44 to 1.67 kOe by 16.0%,respectively,via adding 5 wt%liquid phase alloy of Ce(35.58)Fe(57.47)Cu6 B(0.95)(at%).Compared with the magnet without Cerich alloy addition,the volume fraction of the grain-boundary phase with low melting point increases in the magnet with Ce-rich alloy additio n,which is be ne ficial to imp roving the microstructure and promoting the coercivity enhancement of the magnet.In the Ce-Fe-B magnet with Ce-rich alloy addition,Cu and Ce enrich in the grain boundaries of the magnet after annealing,therefore the as-annealed magnet has a higher coercivity than the as-sintered magnet.A distinct Fe-rich layer with the average thickness of 60 nm is found in the grain boundaries in the magnet without Ce-rich alloy addition,but it seems that Fe-rich phase disappears in the magnet with Ce-rich alloy addition.The present work suggests that the further improvement of coercivity in the Ce-Fe-B sintered magnets is expectable by designing the composition and structure of added liquid phase alloys. | Longlong Xi Anhua Li Haibo Feng Min Tan Wei Sun Minggang Zhu Wei Li | 2019 | Journal of Rare Earths2019，37，8： | 4 |
| 11 | Effect of electro-acupuncture on basic fibroblast growth factor protein and mRNA expression in hippocampal dentate gyrus of spleen deficiency rats显示文摘BACKGROUND: Spleen deficiency in traditional Chinese medicine refers to the functional disorder of spleen,pancreas,intestines,and nervous system in modern medicine.OBJECTIVE: To test whether electro-acupuncture could alter basic fibroblast growth factor (bFGF) protein and mRNA expression in the hippocampal dentate gyrus of spleen deficiency rats.DESIGN,TIME AND SETTING: The randomized,controlled,in vivo animal experiment was performed at the National Level-B Laboratory of Clinical Cell Molecule and Biology in Shenzhen Hospital of Traditional Chinese Medicine,between March and November in 2008.MATERIALS: Reserpine injection was produced by Guangdong Bangmin Pharmaceutical Co.Rhubarb extract granule preparation was produced by Guangdong Yifang Pharmaceutical.Huanqiu Brand sterile acupuncture pin was provided by Suzhou Acupuncture Supplies,China.Huatuo Brand electroacupuncture instrument (type SDZ-II) was purchased from Suzhou Medical Appliance Factory,China.METHODS: A total of 96 male Sprague Dawley rats were randomly assigned to control (n = 32) and induction (n = 64) groups.Spleen deficiency was induced via intraperitoneal injection of reserpine and intragastric administration of rhubarb.The successful models were randomized into two groups: model and electro-acupuncture,with 32 rats in each group.Elec-tro-acupuncture was administered at Zusanli (ST 36) and Sanyinjiao (SP 6) acupoints using a condensation wave and rarefaction (condensation wave 15 Hz) at a strength of 6–15 V for 20 minutes,once per day.The appearance of a slight shiver in the corresponding locus was taken as the standard.According to electro-acupuncture time points,each group was assigned to four subgroups at 7,14,28,and 49 days,respectively,with eight rats in each subgroup.Immunohistochemical staining,image analysis,and reverse-transcription polymerase chain reaction were performed at different time points.MAIN OUTCOME MEASURES: bFGF protein and mRNA expression in the hippocampal dentate gyrus of spleen deficiency rats.RESULTS: After 7 days of electro-acupuncture therapy,bFGF protein and mRNA expression significantly increased compared with the model and control groups (P < 0.05).After 14 days,bFGF protein and mRNA expression decreased until 28 days,where levels were then equal to the model group and greater than the control group (P < 0.05).After 49 days,the above indices remained increased in the electro-acupuncture group compared to the model and control groups (P < 0.05).CONCLUSION: Continuous electro-acupuncture maintained a high level of bFGF protein and mRNA expression in the hippocampal dentate gyrus of spleen deficiency rats. | Zhuoxin Yang Yuanyuan Zhuo Haibo Yu Min Pi Mumin Shao | 2010 | Neural Regeneration Research2010，5，2： | 4 |
| 12 | Distributed Containment Control of Networked Nonlinear Second-order Systems With Unknown Parameters显示文摘In this paper, we study the containment control problem for nonlinear second-order systems with unknown parameters and multiple stationary/dynamic leaders. The topologies that characterize the interaction among the leaders and the followers are directed graphs. Necessary and sufficient criteria which guarantee the control objectives are established for both stationary leaders(regulation case) and dynamic leaders(dynamic tracking case) based protocols. The final states of all the followers are exclusively determined by the initial values of the leaders and the topology structures. In the regulation case, all the followers converge into the convex hull spanned by the leaders,while in the dynamic tracking case, not only the positions of the followers converge into the convex hull but also the velocities of the followers converge into the velocity convex hull of the leaders.Finally, all the theoretical results are illustrated by numerical simulations. | Long Ma Haibo Min Shicheng Wang Yuan Liu Zhiguo Liu | 2018 | IEEE/CAA Journal of Automatica Sinica2018，5，1： | 3 |
| 13 | Three-Dimensional Direct Laser Writing of PEGda Hydrogel Microstructures with Low Threshold Power using a Green Laser Beam显示文摘Three-dimensional(3D)direct laser writing(DLW)based on two-photon polymerisation(TPP)is an advanced technology for fabricating precise 3D hydrogel micro-and nanostructures for applications in biomedical engineering.Particularly,the use of visible lasers for the 3D DLW of hydrogels is advantageous because it enables high fabrication resolution and promotes wound healing.Polyethylene glycol diacrylate(PEGda)has been widely used in TPP fabrication owing to its high biocompatibility.However,the high laser power required in the 3D DLW of PEGda microstructures using a visible laser in a high-water-content environment limits its applications to only those below the biological laser power safety level.In this study,a formula for a TPP hydrogel based on 2-hydroxy-2-methylpropiophenone(HMPP)and PEGda was developed for the fabrication of 3D DLW microstructures at a low threshold power(0.1 nJ per laser pulse at a writing speed of 10μm·s^(−1))in a high-water-content environment(up to 79%)using a green laser beam(535 nm).This formula enables the fabrication of microstructures with micrometre fabrication resolution and high mechanical strength(megapascal level)and is suitable for the fabrication of waterresponsive,shape-changing microstructures.These results will promote the utilisation of low-power 3D DLW for fabricating hydrogel microstructures using visible lasers in high-water-content environments. | Haoyi Yu Haibo Ding Qiming Zhang Zhongze Gu Min Gu | 2021 | Light(Advanced Manufacturing)2021，2，1： | 3 |
| 14 | Forming limit of sheet metals based on mixed hardening model显示文摘The calculation method of forming limit of sheet metals based on M-K instability theory is proposed,and the method is applicable to different yield criterions and hardening models.The forming limit dia-grams of AA5754-O,AA6111-T4 aluminum alloy sheet and DP steel sheet under combined loading paths are obtained based on mixed hardening model with YLD2000-2D yield criterion proposed by Barlat in 2003 and L-C nonlinear kinematic hardening model proposed by Lemaitre and Chaboche.The results show that the forming limit diagram made up of limit strain(FLD-strain) is evidently influenced by the loading path.The forming limit diagram made up of limit stress(FLD-stress) is also influenced by loading path and it is not an only curve,which differs from the conventional view.The degree of the influence of loading path on FLD-stress is related with pre-strain.The larger the pre-strain is,the greater the influence of loading path on FLD-stress will be.The change of FLD-stress is small only when pre-strain is small.In addition,the hardening behavior of the material will influence the path-dependence of FLD-stress:The larger the proportion of kinematic hardening in the whole hard-ening is,namely the more obvious Bauschinger effect of the material,the greater the influence of loading path on FLD-stress will be. | HaiBo Wang Min Wan | 2009 | Science China(Technological Sciences)2009，52，5： | 3 |
| 15 | Electroacupuncture at Du channel and meridian of foot-Taiyang for hippocampal neurons in rats with depression显示文摘BACKGROUND: Long-term anti-depression treatment can promote the regeneration of hippocampal regeneration. Up-regulation of hippocampal regeneration can reverse or prevent against the injury of stress to cerebrum,especially to hippocampal structure and function. Therefore,promoting hippocampal neuronal regeneration may be a new strategy for treating depression and anxiety. OBJECTIVE: To observe the effect of electro-acupuncture at Du channel and meridian of foot-Taiyang on hippocampal neurons from model rats of depression. DESIGN: A randomized controlled animal experiment. SETTING: Department of Acupuncture and Moxibustion,Shenzhen Affiliated Hospital,Guangzhou University of Traditional Chinese Medicine. MATERIALS: Twenty-four Wistar rats,of either gender,aged 2 months old,weighing 200-220 g,were provided by the Animal Experimental Center,Guangzhou University of Traditional Chinese Medicine. METHODS: This experiment was carried out in the Clinical Molecular Biochemical Laboratory,Shenzhen Affiliated Hospital,Guangzhou University of Traditional Chinese Medicine between October 2006 and April 2007. ①The involved rats were randomized into 4 groups according to body mass: blank control group,model group,electroacupuncture A group and electroacupuncture B group,with 6 in each. Rats in the blank control group were free to access to water,and were not given any intervention. Rats in the latter 3 groups were developed into rat depression models by chronic stress combined with feeding alone,and received 21-day unpredictable various stresses. Rats in the model group were euthanized at 14 days after modeling,and their brain tissues were harvested. Rats in the electroacupuncture A group were modeled,then points 'Baihui' and 'Shenting' were chosen,and given electroacupuncture,once a day,20 minutes once. Rats in the electroacupuncture B group were modeled,then points 'Baihui','Shenting','Xinshu'and 'Ganshu' were chosen,and frequency and therapeutic time were the same as those of electroacupuncture A group. Rats in the latter 2 groups were also given electroacupuncture,and their brain tissues were harvested 14 days later. ②Index evaluation: Neurons in hippocampal CA1 and CA3 regions as well as dentate gyrus neuron specific enolase (NSE)-positive cells were counted by immunofluorescent technique. Each rat was weighted on the day of grouping and before execution at 35 days. MAIN OUTCOME MEASURES: Neuron amount in each hippocampal region and body mass of rats in each group. RESULTS: Twenty-four rats were involved in the final analysis. ①Neuronal amount in each region of hippocampus: Neurons in the hippocampal CA1 and CA3 regions as well as dentate gyrus of rats in the model group were significantly less than those in the blank control group (P < 0.01). Neurons in hippocampal CA1and CA3 regions as well as dentate gyrus of rats in the electroacupuncture A and B groups were more than those in the model group (P < 0.05). ② Change in body mass of rats: Body mass increase of rats in the model group was less than that in the blank control group (P < 0.05),and body mass increase of electroacupuncture A and B groups was significantly more than that in the model group,respectively (P < 0.01). CONCLUSION: Electroacupuncture at Du channel and meridian of foot-Taiyang alleviates hippocampal neuronal injury of rats,and thereby,improves depression and promotes the increase of body mass of rats. | Min Pi Wenshu Luo Lihong Diao Xiaodan Rao Haibo Yu Zhuoxin Yang | 2007 | Neural Regeneration Research2007，2，6： | 2 |
| 16 | Recent satellite-derived sea ice volume flux through the Fram Strait: 2011–2015显示文摘The Fram Strait(FS) is the primary region of sea ice export from the Arctic Ocean and thus plays an important role in regulating the amount of sea ice and fresh water entering the North Atlantic seas. A 5 a(2011–2015) sea ice thickness record retrieved from Cryo Sat-2 observations is used to derive a sea ice volume flux via the FS. Over this period, a mean winter accumulative volume flux(WAVF) based on sea ice drift data derived from passivemicrowave measurements, which are provided by the National Snow and Ice Data Center(NSIDC) and the Institut Francais de Recherche pour d'Exploitation de la Mer(IFREMER), amounts to 1 029 km^3(NSIDC) and1 463 km^3(IFREMER), respectively. For this period, a mean monthly volume flux(area flux) difference between the estimates derived from the NSIDC and IFREMER drift data is –62 km^3 per month(–18×10~6 km^2 per month).Analysis reveals that this negative bias is mainly attributable to faster IFREMER drift speeds in comparison with slower NSIDC drift data. NSIDC-based sea ice volume flux estimates are compared with the results from the University of Bremen(UB), and the two products agree relatively well with a mean monthly bias of(5.7±45.9) km^3 per month for the period from January 2011 to August 2013. IFREMER-based volume flux is also in good agreement with previous results of the 1990 s. Compared with P1(1990/1991–1993/1994) and P2(2003/2004–2007/2008), the WAVF estimates indicate a decline of more than 600 km^3 in P3(2011/2012–2014/2015). Over the three periods, the variability and the decline in the sea ice volume flux are mainly attributable to sea ice motion changes, and second to sea ice thickness changes, and the least to sea ice concentration variations. | BI Haibo WANG Yunhe ZHANG Wenfeng ZHANG Zehua LIANG Yu ZHANG Yi HU Wenmin FU Min HUANG Haijun | 2018 | Acta Oceanologica Sinica2018，37，9： | 2 |
| 17 | Biochemical properties of skin collagens isolated from black carp ( Mylopharyngodon piceus )显示文摘 | Yuanjun Jia Haibo Wang Haiyin Wang Yunyan Li Min Wang Jian Zhou | 2012 | Food Science and Biotechnology2012，，6： | 2 |
| 18 | An Overview of Research in Distributed Attitude Coordination Control显示文摘This paper provides an overview of attitude coordination problems of multi-rigid-body with the goal of promoting research in this area. Theoretical results regarding consensus seeking with different system models, different communication topologies, different control goals and different techniques are summarized. And applications of consensus protocols to multirigid-body coordination are investigated. Finally, some future research directions and open problems are also proposed. | Long Ma Haibo Min Shicheng Wang Yuan Liu Shouyi Liao | 2015 | IEEE/CAA Journal of Automatica Sinica2015，2，2： | 2 |
| 19 | Elevation gradient distribution of indices of tree population in a montane forest:The role of leaf traits and the environment显示文摘Background:To disentangle the controls on species distribution in the context of climate change is a central element in proposed strategies to maintain species diversity.However,previous studies have focused mainly on the roles of abiotic factors(e.g.,climate and soil properties),with much less attention given to the roles of biotic factors such as functional traits.Here,we measured eight leaf traits for 240 individual trees of 53 species and analyzed the variation in traits and population composition indices and their relationships with soil properties,climate factors,and leaf traits.Results:The tree density,frequency and species importance values of the overall species and saplings significantly increased with increasing elevation,while the same indices(except for species frequency)of adults did not significantly change.The largest percentage of variation of species importance value(greater than 50%)was explained by climate,but leaf traits played a critical role in driving elevation distribution patterns of both saplings and adults;the abundance of saplings significantly increased with elevation,with increased leaf carbon contents,while the abundance of adults did not change in accordance with a nutrient conservation strategy associated with the leaf economic spectrum.Conclusions:Our results suggest that the elevation gradient distribution of woody plant species is dependent on tree size and that local atmospheric humidity and leaf traits cause considerable variation in species distribution along subtropical mountain elevations.We provide evidence of which leaf traits play a key role in the elevation gradient distribution of different sizes of woody tree species. | Zuhua Wang Rong Zheng Lilin Yang Tinghong Tan Haibo Li Min Liu | 2022 | Forest Ecosystems2022，9，1： | 1 |
| 20 | Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis,prognosis and drug target discovery显示文摘Disease progression prediction and therapeutic drug target discovery for Coronavirus disease 2019(COVID-19)are particularly important,as there is still no effective strategy for severe COVID-19 patient treatment.Herein,we performed multi-platform omics analysis of serial plasma and urine samples collected from patients during the course of COVID-19.Integrative analyses of these omics data revealed several potential therapeutic targets,such as ANXA1 and CLEC3B.Molecular changes in plasma indicated dysregulation of macrophage and suppression of T cell functions in severe patients compared to those in non-severe patients.Further,we chose 25 important molecular signatures as potential biomarkers for the prediction of disease severity.The prediction power was validated using corresponding urine samples and plasma samples from new COVID-19 patient cohort,with AUC reached to 0.904 and 0.988,respectively.In conclusion,our omics data proposed not only potential therapeutic targets,but also biomarkers for understanding the pathogenesis of severe COVID-19. | Yuming Li Guixue Hou Haibo Zhou Yanqun Wang Hein Min Tun Airu Zhu Jingxian Zhao Fei Xiao Shanwen Lin Dongdong Liu Dunrong Zhou Lang Mai Lu Zhang Zhaoyong Zhang Lijun Kuang Jiao Guan Qiushi Chen Liyan Wen Yanjun Zhang Jianfen Zhuo Fang Li Zhen Zhuang Zhao Chen Ling Luo Donglan Liu Chunke Chen Mian Gan Nanshan Zhong Jincun Zhao Yan Ren Yonghao Xu | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 1 |
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