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| 1 | Endoscopic submucosal dissection for the treatment of neoplastic lesions in the gastrointestinal tract显示文摘AIM: To investigate the indications, resection rate, and safety of endoscopic submucosal dissection (ESD) for neoplastic lesions in the gastrointestinal tract at a European referral center. METHODS: We carried out a retrospective analysis of the ESD procedures performed in our center for mucosal neoplastic and submucosal lesions of the gastrointestinal tract. The duration of the procedure, en bloc and complete (R0) resection rates, and complication rates were evaluated. Variables were reported as mean ± SD or simple proportions. Univariate analysis and comparisons of procedure times and resection rates were performed using Mann-Whitney U tests, or χ2 tests for dichotomous variables.RESULTS: Between 2007 and 2011, ESD was performed in a total of 103 patients (46.7% male, mean age 64.0 ± 12.7 years). The indications for the procedure were epithelial tumor (n = 54), submucosal tumor (n = 42), or other (n = 7). The total en bloc resection rate was 90.3% (93/103) and R0 resection rate 80.6% (83/103). The median speed of the procedure was 15.0 min/cm2 . The complete resection rate was lower for submucosal tumors arising from the muscle layer (68%, 15/22, P < 0.05). Resection speed was quicker for submucosal tumors localized in the submucosal layer than for lesions arising from the muscularis propria layer (8.1 min/cm 2 vs 17.9 min/cm 2 , P < 0.05). The R0 resection rate and speed were better in the last 24 mo (90.1%, 49/54 and 15.3 min/cm 2 ) compared to the first 3 years of treatment (73.5%, 36/49, P < 0.05 and 22.0 min/cm2 , P < 0.05). Complications occurred in 14.6% (n = 15) of patients, including perforation in 5.8% (n = 6), pneumoperitoneum in 3.9% (n = 4), delayed bleeding in 1.9% (n = 2), and other in 2.9% (n = 3). Only one patient with delayed perforation required surgical treatment. During the mean follow-up of 26 ± 15.3 mo, among patients with R0 resection, recurrence occurred in one patient (1.2%).CONCLUSION: ESD is an effective and safe method for resection of neoplastic lesions with low recurrence. Speed and the R0 resection rate increased after 50 procedures. | Andrzej Biaek Anna Wiechowska-Kozowska Jan Pertkiewicz Katarzyna Karpińska Wojciech Marlicz Piotr Milkiewicz Teresa Starzyńska | 2013 | World Journal of Gastroenterology2013，19，12： | 21 |
| 2 | Nodular regenerative hyperplasia:Evolving concepts on underdiagnosed cause of portal hypertension显示文摘Nodular regenerative hyperplasia(NRH)is a rare liver condition characterized by a widespread benign transformation of the hepatic parenchyma into small regenerative nodules.NRH may lead to the development of non-cirrhotic portal hypertension.There are no published systematic population studies on NRH and our current knowledge is limited to case reports and case series.NRH may develop via autoimmune,hematological,infectious,neoplastic,or drug-related causes.The disease is usually asymptomatic,slowly or nonprogressive unless complications of portal hypertension develop.Accurate diagnosis is made by histopathology,which demonstrates diffuse micronodular transformation without fibrous septa.Lack of perinuclear collagen tissue distinguishes NRH from typical regenerative nodules in the cirrhotic liver.While the initial treatment is to address the underlying disease,ultimately the therapy is directed to the management of portal hypertension.The prognosis of NRH depends on both the severity of the underlying illness and the prevention of secondary complications of portal hypertension.In this review we detail the epidemiology,pathogenesis,diagnosis,management,and prognosis of NRH. | Marek Hartleb Krzysztof Gutkowski Piotr Milkiewicz | 2011 | World Journal of Gastroenterology2011，17，11： | 16 |
| 3 | Isolated right posterior bile duct injury following cholecystectomy:Report of two cases显示文摘Anatomic variations of the right biliary system are one of the most common risk factors for sectoral bile duct injury(BDI)during cholecystectomy.Isolated right posterior BDI may in particular be a challenge for both diagnosis and management.Herein we describe two cases of isolated right posterior sectoral BDI that took place during laparoscopic cholecystectomy.Despite effective external biliary drainage from the liver hilum in both cases,there was a persistent biliary leak observed which was not visible on endoscopic retrogradecholangiogram.Careful evaluation of images from both endoscopic and magnetic resonance cholangiograms revealed the diagnosis of an isolated right posterior sectoral BDI.These were treated with a delayed bisegmental(segments 6 and 7)liver resection and a Roux-en-Y hepaticojejunostomy respectively with good outcomes at 24 and 4 mo of follow-up.This paper discusses strategies for prevention of such injuries along with the diagnostic and therapeutic challenges it offers. | Maciej Wojcicki Waldemar Patkowski Tomasz Chmurowicz Andrzej Bialek Anna Wiechowska-Kozlowska Rafal Stankiewicz Piotr Milkiewicz Marek Krawczyk | 2013 | World Journal of Gastroenterology2013，19，36： | 5 |
| 4 | Health-related quality of life in autoimmune hepatitis显示文摘Autoimmune hepatitis(AIH)is a severe chronic autoimmune disease and has a significant impact on the patient’s quality of life,in particular regarding psychological problems such as anxiety and depression.Consistent evidence on which patient-related,disease-related or physician-related factors cause health-related quality of life(HRQoL)impairment in patients with AIH is lacking.Current studies on HRQoL in AIH are mainly single-centered,comprising small numbers of patients,and difficult to compare because of the use of different questionnaires,patient populations,and cutoff values.Literature in the pediatric field is sparse,but suggests that children/adolescents with AIH have a lower HRQoL.Knowledge of HRQoL and cohesive factors in AIH are important to improve healthcare for AIH patients,for example by developing an AIH-specific chronic healthcare model.By recognizing the importance of quality of life beyond the concept of biochemical and histological remission,clinicians allow us to seek enhancements and possible interventions in the management of AIH,aiming at improved health. | Romée JALM Snijders Piotr Milkiewicz Christoph Schramm Tom JG Gevers | 2021 | World Journal of Hepatology2021，13，11： | 1 |
| 5 | Biliary tract complications after liver transplantation: a review 显示文摘 | WOJCICKI M MILKIEWICZ P SILVA M | 2008 | Dig Surg2008，25，4： | 1 |
| 6 | Obstetric cholestasis显示文摘 | Milkiewicz P Elias E Williams C | 2002 | BMI2002，324，7330： | 1 |
| 7 | Pathobiolo-gy and experimental therapeutics in hepatocelluarcholestasis : lessons from the hepatocyte coupletModel 显示文摘 | Milkiewicz P Roma M Elias E | 2002 | Clin Sci2002，102，6： | 1 |
| 8 | Obstetric cholestasis显示文摘 | Milkiewicz P Elias E Williamson C | 2002 | BMJ2002，324，12： | 1 |
| 9 | p38 MAPK activity is stimulated by vascular endothelial growth factor receptor 2 activation and is essential for shear stress-induced angiogenesis显示文摘 | Gee E Milkiewicz M Haas TL | 2010 | J Cell Physiol2010，222，1： | 1 |
| 10 | Regulators of angiogenesis and strategies for their therapeutic manipulation显示文摘 | Malgorzata Milkiewicz Eric Ispanovic Jennifer L. Doyle Tara L. Haas | 2005 | International Journal of Biochemistry and Cell Biology2005，，3： | 1 |
| 11 | Nitric oxide, VEGF, and VEGFR-2 : interactions in activity-induced angiogenesis in rat skeletal muscle 显示文摘 | Milkiewicz M Hudlicka O Brown MD | 2005 | Am J Physiol Heart Circ Physiol2005，289，1： | 1 |
| 12 | Obstetric cholestasis显示文摘 | Milkiewicz P Elias E Williamson C | 2002 | Br Med J2002，324，： | 1 |
| 13 | Regulators of angiogenesis and strategies for their therapeutic manipulation 显示文摘 | Milkiewicz M Ispanovic E Doyle JL | 2006 | Int J Biochem Cell Biol2006，38，3： | 1 |
| 14 | Differential ex- pression of Flk- 1 and Flt- 1 in rat skeletal muscle in response to chronic ischaemia, favourable effect of muscle activity 显示文摘 | Milkiewicz M Hudlieka O Verhaeg J | 2003 | Clin Sci (Lond)2003，105，4： | 1 |
| 15 | Rapid correction of prothrombin time after low-dose recombinant factor VIIA in patients undergoing orthotopic liver transplantation.显示文摘 | Surudo T Wojcicki M Milkiewicz P | | 0，，： | 1 |
| 16 | Regulators of angiogernesis and strategies for their therapeutic ma2 nipulation显示文摘 | Milkiewicz M Ispanovic E Doyle JL | 2006 | Int J B iochem Cell Biol2006，38，3： | 1 |
| 17 | Value of autoantibody analysis in the differential diag- nosis of chronic cholestatic liver disease显示文摘 | Milkiewicz P Buwaneswaran H Coltescu C | 2009 | Clin Gas- troenterol Hepatol2009，7，12： | 1 |
| 18 | Obstetric cholestasis显示文摘 | Milkiewicz P Elias E Williamson C | 2002 | Br Med2002，324，： | 1 |
| 19 | Value of autoantibody analysis in the differential diagnosis of chronic cholestatic liver disease显示文摘 | Milkiewicz P Buwaneswaran H Coltescu C | 2009 | Clin Gastroenterol Hepatol2009，7，12： | 1 |
| 20 | Nitric oxide, VEGF, and VEGFR-2: interactions in activity-induced angiogenesis in rat skeletal muscle 显示文摘 | Milkiewicz M Hudlicka O Brown MD | 2005 | Am J Physiol Heart Cite Physiol2005，289，1： | 1 |
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