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| 1 | 限制热量摄入6个月对超重者寿命指标、代谢调节及氧化应激的影响——随机对照试验AuthorAffiliations:PenningtonBiomedicalResearchCenter.LouisianaStateUniversity.BatonRouge;andGarvan.InstituteforMedicalResearch.Dadinghurst,AustraIia(DrHeilbronn).显示文摘背景:长期限制热量摄入可延长啮齿类动物的寿命。但是,尚未有研究观测长期限制人体热量是否会影响其寿命及氧化应激指标,降低代谢率。
目的:在超重但不肥胖(体重指数为25—30)的人群中研究限制热量6个月伴/不伴运动对其产生的影响。
设计、地点及参试者:于2002年3月至2004年8月在位于路易斯安娜州首府巴顿鲁治的研究中心对48名不好动的健康人进行随机对照研究。
干预:参试者在6个月内随机分为4个组:对照组(饮食可维持体重);限制热量组(限制基线所需能量的25%);限制热量+运动组(限制12.5%的热量+运动增加12.5%的能耗);极低热量饮食组(每日摄入890keal,直至体重减少15%,随后采用维持体重的饮食)。
主要观测指标:机体组成;硫酸脱氢表雄酮(dehydroepiandrostemne sulfate,DHEAS)、葡萄糖及胰岛素水平;蛋白羰基化合物;DNA损伤;24小时能耗;核心体温。
结果:6个月时各组体重变化的均值(标准误)为:对照组-1.0%(1.1%);限制热量组-10.4%(0.9%);限制热量+运动组-10.0%(0.8%);极低热量饮食组-13.9%(0.7%)。6个月时,各干预组空腹血糖水平较基线明显降低(P均〈0.01),而DHEAS和葡萄糖水平没有改变。限制热量组及限制热量+运动组核心体温有所下降(P均〈0.05)。对机体组成进行校正后发现,对照组24小时静息能耗无变化,但限制热量组(-135kcal/d[42kcal/d])、限制热量+运动组(-117kcal/d[52kcal/d])和极低热量饮食组(-125kcal/d[35kcal/d])24小时静息能耗有所下降(P均〈0.008)。上述“代谢调节”(超出预计值的-6%)与对照组相比存在显著差异(P〈0.05)。6个月时,各组蛋白羰基化合物的浓度较基线时无变化,而各干预组DNA损伤有所减少(P〈0.005)。
结论:我们的研究结果显示,长期限制热量可降低人类寿命的2种指标(即空腹胰岛素水平和体温)。此外,我们的研究结果还支持下述理论,即限制热量能降低代谢率,且超过缩小代谢面积产生的相应效应。我们尚需开展远期研究来评价限制热量能否延缓人类衰老过程。 | Leonie K. Heibronn Lilian de Jonge Madlyn I. Frisard James P. DeLany D. Enette Larson-Meyer Jennifer Rood Tuong Nguyen Corby K. Martin Julia Volaufova Marlene M. Most Frank L. Greenway Steven R. Smith Walter A. Deutsch Donald A. Williamson Eric Ravussin 顾佳(译) | 2006 | 美国医学会杂志(中文版)2006，25，5： | 18 |
| 2 | Lack of Efficacy of Bevacizumab Plus Irinotecan in Children with Recurrent Malignant Glioma and Diffuse Brainstem Glioma:A Pediatric Brain Tumor Consortium Study显示文摘PURPOSE:A phase Ⅱ study of bevacizumab(BVZ) plus irinotecan(CPT-11) was conducted in children with recurrent malignant glioma(MG) and intrinsic brainstem glioma(BSG).PATIENTS AND METHODS:Eligible patients received two doses of BVZ | Gururangan S Chi SN Young Poussaint T Onar-Thomas A Gilbertson RJ Vajapeyam S Friedman HS Packer RJ Rood BN Boyett JM Kun LE | 2010 | 中国神经肿瘤杂志2010，8，2： | 7 |
| 3 | Systematic review: The placebo effect of psychological interventions in the treatment of irritable bowel syndrome显示文摘AIM To determine the placebo response rate associated with different types of placebo interventions used in psychological intervention studies for irritable bowel syndrome. METHODS Randomized controlled trials comparing psychological interventions(stress management/relaxation therapy(cognitive) behavioral therapy, short-term psychodynamic therapy, and hypnotherapy) for the treatment of adult patients with irritable bowel syndrome(IBS) diagnosed with the Manning or Rome criteria with an adequate placebo control treatment and reporting data on IBS symptom severity were identified by searching Pub Med, Embase, the Cochrane Library, CINAHL and Psyc INFO databases. Full-text articles that were written in English and published between 1966 and February 2016 in peer-reviewed journals were selected for the present review. Placebo interventions were considered to be adequate if the number of sessions and the amount of time spent with the therapist were the same as in the active treatment. The placebo response rate(PRR) was computed for IBS symptom severity(primary outcome measure) as well as for anxiety, depression and quality of life(secondary outcome measures). RESULTS Six studies, with a total of 555 patients met the inclusion criteria. Four studies used an educational intervention, whereas two studies used a form of supportive therapy as the placebo intervention. The PRR for IBS symptom severity ranged from 25% to 59%, with a pooled mean of 41.4%. The relative PRR for the secondary outcome measures ranged from 0% to 267% for anxiety, 6% to 52% for depression 20% to 125% for quality of life. The PRR associated with pharmacological treatments, treatment with dietary bran and complementary medicine ranged from 37.5% to 47%. Contrary to our expectations, the PRR in studies on psychological interventions was comparable to that in studies on pharmacological, dietary and alternative medical interventions.CONCLUSION The PRR is probably determined to a larger extent by patient-related factors, such as expectations and desire for the treatment to be effective, than the content of the placebo intervention. | Carla E Flik Laura Bakker Wijnand Laan Yanda R van Rood André JPM Smout Niek J de Wit | 2017 | World Journal of Gastroenterology2017，23，12： | 7 |
| 4 | Formation Principles of Similar Systems | ZHOU Meili(Department of Mechanical Engineering, Anhui Institute of Technology 111 Lu An Rood, Hefei 230069, Anhui, People’s Republic of China) | 1996 | Systems Science and Systems Engineering1996，6，3： | 2 |
| 5 | Molecular genetics and pathogenesis of Clostridium perfringens 显示文摘 | COLE S T | 1991 | Microbiol Rev1991，55，： | 1 |
| 6 | Adhesion molecules involved in transendothelial migration of human hematopoietic progenitor cells显示文摘 | VOERMANSA C ROOD P M HORDIJK P L | 2000 | Stem Cells2000，18，6： | 1 |
| 7 | Mercury adsorption properties of sulfur-impregnated adsorbents 显示文摘 | Hsi H Rood M J Abadi M R | 2002 | Journal of Environmental Engineering2002，128，11： | 1 |
| 8 | Highly conserved alphatoxin sequences of avian isolates of Clostridium perfringens显示文摘 | Sheedy SA Ingham AB Rood JI | 2004 | J Clin Microbiol2004，42，3： | 1 |
| 9 | Sasonal changes in 14CO2 assimilation and 14C translocation in oilseed rape显示文摘 | ROOD S B MAJOR D J CHARNETSKI W A | 1984 | Field Crops Research1984，8，： | 1 |
| 10 | Central venous catheter sepsis in surgical newborns显示文摘 | Klein MD Rood K Graham P | 2003 | Pediatr Surg 1nt2003，19，7： | 1 |
| 11 | Hypermethyla- tion of HIC-! and 17p allelic loss in medulloblastoma显示文摘 | Rood BR Zhang H Weitman DM | 2002 | Cancer Res2002，62，13： | 1 |
| 12 | Genetic causes of fo- cal segmental glomerulosclerosis: implications for clinical practice显示文摘 | Rood IM Deegens JK Wetzels JF | 2012 | Nephrol Dial Transplant2012，27，3： | 1 |
| 13 | The 5'non-translated region of Varroa destructor virus 1 ( genus Iflavirus ) : structure prediction and IRES activity in Lymantria dispar cells 显示文摘 | Ongus R Roode C Pleij A | 2006 | J Gen Virol2006，87，11： | 1 |
| 14 | Adsorption and electrothermal desorption of organic vapors using activated carbon adsorbents with novel morphologies显示文摘 | LUO L RAMIREZ D ROOD M J | 2006 | Carbon2006，44，13： | 1 |
| 15 | Falsely elevated lactate in se-vere ethylene glycol intoxication 显示文摘 | Sandberg Y Rood PP Russcher H | 2010 | Neth J Med2010，68，1： | 1 |
| 16 | Inflammation and peripheral nerve sensitization 显示文摘 | Rood JP Pateromichelakis S | 1981 | BrJ Oral Surg1981，19，1： | 1 |
| 17 | Abrupt downstream forest decline following river damming in southern Alberta显示文摘 | Rood S B Heinze-Milne S 1989 | 1989 | Can J Bot1989，67，： | 1 |
| 18 | Mixtures of pollution,dust, sea salt, and volcanic aerosol during ACE-Asia: radiative proper- ties as a function of relative humidity显示文摘 | CARRICO C M KUS P ROOD M J | 2003 | Journal of Geophysical Re- search2003，108，23： | 1 |
| 19 | Cognitive functioning during long-term tamoxifen treatment in postmenopausal women with breast cancer显示文摘 | Boele FW Schilder CM de Roode ML | 2015 | Menopause2015，22，1： | 1 |
| 20 | Activated carbon fiber cloth electrothermal swing adsorption system显示文摘 | SULLIVAN P ROOD M GREVILLOT G | | 0，，18： | 1 |
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