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| 1 | Aging:A mitochondrial DNA perspective,critical analysis and an update显示文摘The mitochondrial theory of aging, a mainstream theory of aging which once included accumulation of mitochondrial DNA(mt DNA) damage by reactive oxygen species(ROS) as its cornerstone, has been increasingly losing ground and is undergoing extensive revision due to its inability to explain a growing body of emerging data. Concurrently, the notion of the central role for mtDNA in the aging process is being met with increased skepticism. Our progress in understanding the processes of mtDNA maintenance, repair, damage, and degradation in response to damage has largely refuted the view of mt DNA as being particularly susceptible to ROS-mediated mutagenesis due to its lack of 'protective' histones and reduced complement of available DNA repair pathways. Recent research on mitochondrial ROS production has led to the appreciation that mitochondria, even in vitro, produce much less ROS than previously thought, automatically leading to a decreased expectation of physiologically achievable levels of mtDNA damage. New evidence suggests that both experimentally induced oxidative stress and radiation therapy result in very low levels of mtDNA mutagenesis. Recent advances provide evidence against the existence of the 'vicious' cycle of mtDNA damage and ROS production. Meta-studies reveal no longevity benefit of increased antioxidant defenses. Simultaneously, exciting new observations from both comparative biology and experimental systems indicate that increased ROS production and oxidative damage to cellular macromolecules, including mtDNA, can be associated with extended longevity. A novel paradigm suggests that increased ROS production in aging may be the result of adaptive signaling rather than a detrimental byproduct of normal respiration that drives aging. Here, we review issues pertaining to the role of mtDNA in aging. | Inna N Shokolenko Glenn L Wilson Mikhail F Alexeyev | 2014 | World Journal of Experimental Medicine2014，4，4： | 6 |
| 2 | Adipose tissue-derived progenitor cells and cancer显示文摘Recruitment of stem cells and partially differentiated progenitor cells is a process which accompanies and facilitates the progression of cancer.One of the factors complicating the clinical course of cancer is obesity,a progressively widespread medical condition resulting from overgrowth of white adipose tissue(WAT),com-monly known as white fat.The mechanisms by which obesity in uences cancer risk and progression are not completely understood.Cells of WAT secret soluble molecules(adipokines) that could stimulate tumor growth,although there is no consensus on which cell populations and which adipokines are important.Recent reports suggest that WAT-derived mesenchymal stem(stromal) cells,termed adipose stem cells(ASC),may represent a cell population linking obesity and cancer.Studies in animal models demonstrate that adipokines secreted by ASC can promote tumor growth by assisting in formation of new blood vessels,a process necessary for expansion of tumor mass.Importantly,migration of ASC from WAT to tumors has been demonstrated,indicating that the tumor microenvironment in cancer may be modulated by ASC-derived trophic factors in a paracrine rather than in an endocrine manner.Here,we review possible positive and adverse implications of progenitor cell recruitment into the diseased sites with a particular emphasis on the role in cancer progression of progenitors that are expanded in obesity. | Charles F Bellows Mikhail G Kolonin | 2010 | World Journal of Stem Cells2010，2，5： | 2 |
| 3 | Risk of pneumothorax in CT-guided transthoracic needle aspiration biopsy of the lung显示文摘 | KAZEROONI E A LIM F T MIKHAIL A | 1996 | Radiology1996，198，： | 1 |
| 4 | Digital Communication Using Chaotic-Pulse-Position Modulation显示文摘 | Nikolai F Rulkov Mikhail M Sushchik Lev S Tsimring | 2001 | IEEE Trans on Circuits and Systems -I :Fundamental Theory and Applications2001，48，12： | 1 |
| 5 | Generalized synchronization of chaos in directionally coupled chaotic system显示文摘 | Nikolai F Rulkov Mikhail M Sushchik Lev S Tsimring | 1995 | Phys Rev E1995，51，： | 1 |
| 6 | Generalized synchronization of chaos:the auxiliary system approach 显示文摘 | Henr D I Abarbanel Nikolai F Rulkov Mikhail M Sushchik | 1996 | Physical Review E1996，53，5： | 1 |
| 7 | A kinetic model of the choline chloride synthesis显示文摘 | Roman A K Valery F S Mikhail G M | 1999 | Organic Process Research Development1999，3，5： | 1 |
| 8 | Preferential formation of benzopyrene adducts at lung cancer mutational hotspots in P53显示文摘 | Denissenko Mikhail F Pao Annie Tang Moon-shong | 1996 | Science1996，274，5286： | 1 |
| 9 | Risk of pneumothorax in CT-guided transthoracic needle aspiration of the lung显示文摘 | Kazerooni EA Lim F Mikhail A | 1996 | Radiology1996，198，2： | 1 |
| 10 | Use of array comparative genome hybridization in orofacial clefting显示文摘 | Gallego C J Grant J Mikhail F M | 2010 | J Craniofac Surg2010，21，5： | 1 |
| 11 | Growth enhancement and muscle structure of striped mullet, Mugil cephalus L, fingerlings by feeding algal meal- based diets 显示文摘 | WASSEF E A MASRY E L MIKHAIL F R | 2001 | Aquaculture Research2001，，： | 1 |
| 12 | Risks of pneumothorax in CT,guided transthoracic needle aspiration of the lung显示文摘 | Kazerooni EA Lim F Mikhail A | 1996 | Radiology1996，198，： | 1 |
| 13 | The effect of auxins, time exposure to auxin and genotypes on somatic from mature embryos of embryogenesis wheat显示文摘 | MIKHAIL F DMITRY M DARYA V | 2006 | Plant Cell Tissue and Organ Culture2006，84，2： | 1 |
| 14 | The use of drug eluting stents in single and multivessel disease:results from a single centre experience显示文摘 | Mikhail GW Airoldi F Tavano D | 2004 | Heart2004，90，9： | 1 |
| 15 | Generalized synchronization of chaos in directional coupled chaotic systems显示文摘 | RULKOV N F MIKHAIL M S | 1995 | Physical Review E1995，51，2： | 1 |
| 16 | Surface oxidation of cellulose fibers by vacuum ultraviolet irradiation显示文摘 | Koichi K Victor V N Mikhail F N | 1999 | J Polym Sei Part A:Polym Chem1999，37，3： | 1 |
| 17 | Using comparative genomics to reorder the human genome sequence into a virtual sheep genome显示文摘 | Brian P Dalrymple Ewen F Kirkness Mikhail Nefedov | 2007 | Genome Biology2007，8，： | 1 |
| 18 | The effect of auxins, time ex- posure to auxin and genotypes on somatic embryogenesis from ma- ture embryos of wheat显示文摘 | Mikhail F Dmitry M Darya V | 2006 | Plant Cell Tissue and Organ Culture2006，84，： | 1 |
| 19 | Generalized synchronization of chaos: the auxiliary system approach 显示文摘 | Henry D I A Nikolai F R Mikhail M S | 1996 | Physical Review E1996，53，5： | 1 |
| 20 | Oryopreservation of Arabi dopsis thaliana seedlings by vitrification 显示文摘 | Liu Y Mikhail Nasrallah Gao R F | 1999 | Forestry Studies in China1999，1，2： | 1 |
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