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| 1 | 与在人的疾病的糖尿病 mellitus 和肥胖有关的肾的 hyperfiltration显示文摘 High intraglomerular pressure is associated with renal hyperf iltration, leading to the initiation and progression of kidney disease in experimental models of diabetes mellitus (DM). In humans, hyperf iltration is observed in patients with type 1 and type 2 DM, and is also seen in patients with pre-diabetic conditions, such as the metabolic syndrome. From a mechanistic perspective, both vascular and tubular factors likely contribute to the pathogenesis of hyperf iltration. Until now, human studies have primarily focused on the use of medications that inhibit the renin angiotensin system to reduce efferent vasoconstriction and thereby improve hyperfiltration. More recent advances in the development of investigational adenosine antagonists and inhibitors of sodium glucose cotransport may help to elucidate tubular factors that contribute to afferent vasodilatation. In this review, we summarize available data from experimental and human studies of type 1 and type 2 DM and obesity to provide an overview of factors that contribute to the hyperf iltration state. We have focused on the renin angiotensin system, cyclooxygenase-2 system, nitric oxide, protein kinase C and endothelin as vascular determinants of hyperfiltration. We also dis-cuss relevant tubular factors, since experimental models have suggested that inhibition of sodium-glucose cotransport may be renoprotective. | Alexa N Sasson David ZI Cherney | 2012 | World Journal of Diabetes2012，3，1： | 11 |
| 2 | Conglomeration versus Strategic Focus:Evidence from the Insurance Industry显示文摘 | Berger A N Cummins J D Weiss M A and Zi H | 2000 | Journal of Financial Intermediation2000，9，4： | 1 |
| 3 | Gene expression profiles analysis of the growing rat liver in response to different zinc status by cDNA microarray analysis显示文摘 | SUN J Y WANG J F ZI N T | 2007 | Biological Trace Element Research2007，115，2： | 1 |
| 4 | Conglom- eration versus strategic focus: Evidence from the insur- ance industry 显示文摘 | Berger A N Cummins J D Weiss M A Zi H | 2000 | Journal of Financial Intermediation2000，9，： | 1 |
| 5 | Backward stochastic nonlinear Volterra integral equations with local Lipschitz drift显示文摘 | AMAN A N'ZI M | 2005 | Probab Math Stat2005，25，： | 1 |
| 6 | Corrosion behavior of copper with minor alloying addition in chloride solution 显示文摘 | Zhang Y N Zi J L Zheng M S | 2008 | Alloy and Compound2008，426，12： | 1 |
| 7 | Does preoperative administration of allopurinol protect the lungs from ischemia- reperfusion injury occuring during cardiopulmonary bypass? 显示文摘 | GORMUS ZI CELIK JB ERGENE N | 2013 | Bratisl Lek Listy2013，114，10： | 1 |
| 8 | Comparison of the antioxidant enzymes of broccoli after cold or heat shock treatment at different storage temperatures显示文摘 | Zhang Zi Kohei N Shigenori M | 2009 | Postharvest Biology and Technology2009，54，2： | 1 |
| 9 | A method for multiple crack growth in brittle materials without remeshing显示文摘 | BUDYN E ZI G MO S N | 2004 | International Journal for Numerical Methods in Engineering2004，61，10： | 1 |
| 10 | Developmental competence of embryos derived from reciprocalin vitrofertilization between yak(Bos grunniens)and cattle(Bos taurus)显示文摘 | Zi X D Yin R H Chen S W Liang G N Zhang D W Guo C H | | 0，，： | 1 |
| 11 | A finite element approach for solution of Burgers' equation显示文摘 | (O)zi(s) T Aksan E N (O)zde(s) A | 2003 | Appl Math Comput2003，139，： | 1 |
| 12 | Vascular dysfunction in aging: Po- tential effects of resveratrol, an anti-inflammatory phytoestrogen显示文摘 | Labinskyy N Csiszar A Veress G Stef G Pacher P Oros- zi G Wu J Ungvari Z | 2006 | Current Medicinal Chemistry2006，13，9： | 1 |
| 13 | Enhanced polyphenolic nature of flavonoid antioxidant plays a detrimental role in the activation of survival factor Akt and apoptosis in prostate cancer DU145 cells:A comparison of silymarin,genistein and EGCG显示文摘 | Bhatia N Zi X Agaral R | 1999 | Proc Am Assoc Cancer Res1999，40，： | 1 |
| 14 | Experiment&l studies of ischemicbr&in edem&:A new experiment model of cerebrzlem bolism in r&ts in which recircul&tion c&n be introduced in the ischemic &re&显示文摘 | Koizumi J Yoshid& Y N&kzz&wa T et zI | 1986 | Stroke1986，8，1： | 1 |
| 15 | Serum paraoxonase activity changes in patients with Alzheimer’s disease and vascular dementia显示文摘 | Gy?rgy Paragh Petra Balla Evelin Katona Ildikó Seres Anikó égerházi István Degrell | 2002 | European Archives of Psychiatry and Clinical Neurosciences2002，，2： | 1 |
| 16 | Cloning,sequencing and characterization of a novel DNA repair gene ppr A from the radio resistant bacterium deinococcus radiodurans显示文摘 | DU Zi TIAN H L ISSAY N | 1988 | Radiate Research and Radiate Process1988，16，4： | 1 |
| 17 | Preclini- cal evaluation of two human anti-hepatitis B virus (HBV) monoclonal antibodies in the HBV-trimera mouse model and in HBV chronic carrier chimpanzees 显示文摘 | Eren R Ilan E Nussbaum O Lubin I Terkieltaub D Ara- zi Y Ben-Moshe O Kitchinzky A Berr S Gopher J Zauberman A Galun E Shouval D Daudi N Eid A Jurim O Magnius LO Hammas B Reisner Y Dagan S | 2000 | Hepatology2000，32，3： | 1 |
| 18 | Does preoperative administration of allopurinol protect the lungs from ischemia- repeffusion injury occuring during cardiopulmonary bypass? 显示文摘 | GORMUS ZI CELIK JB ERGENE N | 2013 | Bratisl Lek Listy2013，114，10： | 1 |
| 19 | Carcinoma arising in enterocutan fistulae of Crohn’s disease patients: description of two cases显示文摘 | Tamás Zágoni Zoltán Péter Ferenc Sipos Csaba Dicházi Zsolt Tarján István Dobó Ilona Kaszás Zsolt Tulassay | 2006 | International Journal of Colorectal Disease2006，，5： | 1 |
| 20 | Visualization framework for inter-domain access control policy integration显示文摘 | Pan L Liu N Zi X | 2013 | Communications China2013，10，3： | 1 |
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