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| 1 | Inhibiting effect of antisense oligonucleotides phosphorthioate on gene expression of TIMP-1 in rat liver fibrosis显示文摘AIM To observe the inhibition of antisenseoligonucleotides (asON) phosphorthioate to thetissue inhibitors metalloproteinase-1 (TIMP-1)gene and protein expression in the liver tissue ofimmunologically induced hepatic fibrosis rats.The possibility of reversing hepatic fibrosisthrough gene therapy was observed.METHODS Human serum albumin (HSA) wasused to attack rats, as hepatic fibrosis model, inwhich asONs were used to block the gene andprotein expressing TIMP-1. According to theanalysis of modulator, structure protein, codingseries of TIMP-1 genome, we designed fourdifferent asONs. These asONs were injected intothe hepatic fibrosis models through coccygealvein. The results was observed by RT-PCR formeasuring TIMP-1 mRNA expression,immunohistochemistry and in situ hybridizationfor collagen Ⅰ, Ⅲ, special staining of collagenfiber, and electron microscopic examination.RESULTS Hepatic fibrosis could last within 363days in our modified model. The expressinglevel of TIMP-1 was high during hepatic fibrosisprocess. It has been proved by theimmunohistochemical and the electronmicroscopic examination that the asONphosphorthioate of TIMP-1 could exactly expressin vivo. The effect of colchicine wasdemonstrated to inhibit the expressing level ofmRNA and the content of collagen Ⅰ, Ⅲ in theliver of experimental hepatic fibrosis rats.However, the electron microscopy research andthe pathologic grading of hepatic fibrosisshowed that there was no significant differencebetween the treatment group and the modelgroup (P>0.05).CONCLUSION The experimental rat model ofhepatic fibrosis is one of the preferable modelsto estimate the curative effect of anti-hepaticfibrosis drugs. The asON phosphorthioate ofTIMP-1 could block the gene and proteinexpression of TIMP-1 in the liver of experimentalhepatic fibrosis rats at the mRNA level. It ispossible to reverse hepatic fibrosis, and it isexpected to study a new drug of anti-hepaticfibrosis on the genetic level. Colchicine has verylimited therapeutic effect on hepatic fibrosis,furthermore, its toxicity and side effects areobvious. | Qing He Nie Yong Qian Cheng Yu Mei Xie Yong Xing Zhou Yi Zhan Cao The Center of Infectious Disease Diagnosis and Treatment of PLA,Tangdu Hospital,Forth Military Medical University,Xi’an 710038,Shaanxi Province,ChinaDr,Qing He Nie graduated from Qinghai Medical College as a doctor in 1983,got master degree at Beijing 302 Army Hospital in 1993,got doctor degree at the Third Military Medical University in 1998,engaged in postdoctoral research at the Fourth Military Medical University from 1998 to 2000,now an associate professor,specialized in clinical and experimental research of infectious diseases,had more than 90 papers published,coauthor of ten books,first author of one book. | 2001 | World Journal of Gastroenterology2001，7，3： | 73 |
| 2 | Gait Recognition by Cross Wavelet Transform and Graph Model显示文摘In this paper, a multi-view gait based human recognition system using the fusion of two kinds of features is proposed.We use cross wavelet transform to extract dynamic feature and bipartite graph model to extract static feature which are coefficients of quadrature mirror filter(QMF)-graph wavelet filter bank. Feature fusion is done after normalization. For normalization of features, min-max rule is used and mean-variance method is used to find weights for normalized features. Euclidean distance between each feature vector and center of the cluster which is obtained by k-means clustering is used as similarity measure in Bayesian framework. Experiments performed on widely used CASIA B gait database show that, the fusion of these two feature sets preserve discriminant information. We report 99.90 % average recognition rate. | Sagar Arun More Pramod Jagan Deore | 2018 | IEEE/CAA Journal of Automatica Sinica2018，5，3： | 8 |
| 3 | A novel synthetic compound MCAP suppresses LPS- induced murine microglial activation in vitro via inhibiting NF-kB and p38 MAPK pathways显示文摘目的:调查新奇合成混合物的 anti-neuroinflammatory 活动,对在 vitro.Methods 的 导致LPS 的 microglial 激活的 7-methylchroman-2-carboxylic 酸N-( 2-trifluoromethyl ) phenylamide ( MCAP ):主要老鼠 microglia 和 BV2 microglia 房间暴露于 LPS ( 50 或 100 ng/mL )。iNOS 和 COX-2 的表示, proinflammatory cytokines, NF-κ B 和 p38 MAPK 发信号分子被 RT-PCR,西方的污点和 ELISA 分析。microglia 的词法变化和 NF-ĸ 的原子 translocation; B 用阶段对比和荧光显微镜学被设想, respectively.Results : 有 MCAP 的预告的处理(0.1, 1, 10 μ mol/L ) 在 BV2 microglia 房间的 iNOS 和 COX-2 的 dose-dependently 禁止的导致 LPS 的表示。类似的结果与 MCAP 在主要 microglia pretreated 被获得(0.1, 0.5 μ mol/L ) 。MCAP dose-dependently 消除了 TNF-α 的导致 LPS 的版本;, IL-6 和 IL-1β,并且 NF-κ 的减轻的导致 LPS 的激活;由减少 Iκ 的 phosphorylation 的 B; Bα在 BV2 microglia 房间。而且, MCAP 稀释了 p38 MAPK 的 导致LPS 的 phosphorylation SB203580 ,一个 p38 MAPK 禁止者, MEF-2 ( p38 MAPK 下游的一个抄写因素)的表示上的显著地加强的 引起MCAP 的抑制 .Conclusion : MCAP 由禁止 p38 MAPK 和 NF-κ 在 vitro 在鼠科的 microglia 施加反煽动性的效果; B 发信号小径和 proinflammatory 回答。MCAP 可以为治疗包含激活的 microglial 房间的疾病作为一个新奇代理人被开发。 | Byung-Wook KIM Sandeep Vasant MORE Yo-Sep YUN Hyun-Myung KO Jae-Hwan KWAK Heesoon LEE Kyoungho SUK In-Su KIM Dong-Kug CHOI | 2016 | Acta Pharmacologica Sinica2016，37，3： | 8 |
| 4 | Scientific development of smart farming technologies and their application in Brazil显示文摘Smart farming(SF)involves the incorporation of information and communication technologies into machinery,equipment,and sensors for use in agricultural production systems.New technologies such as the internet of things and cloud computing are expected to advance this development,introducing more robots and artificial intelligence into farming.Therefore,the aims of this paper are twofold:(i)to characterize the scientific knowledge about SF that is available in the worldwide scientific literature based on the main factors of development by country and over time and(ii)to describe current SF prospects in Brazil from the perspective of experts in this field.The research involved conducting semi-structured interviews with market and researcher experts in Brazil and using a bibliometric survey by means of data mining software.Integration between the different available systems on the market was identified as one of the main limiting factors to SF evolution.Another limiting factor is the education,ability,and skills of farmers to understand and handle SF tools.These limitations revealed a market opportunity for enterprises to explore and help solve these problems,and science can contribute to this process.China,the United States,South Korea,Germany,and Japan contribute the largest number of scientific studies to the field.Countries that invest more in R&D generate the most publications;this could indicate which countries will be leaders in smart farming.The use of both research methods in a complementary manner allowed to understand how science frame the SF and the mains barriers to adopt it in Brazil. | Dieisson Pivoto Paulo Dabdab Waquil Edson Talamini Caroline Pauletto Spanhol Finocchio Vitor Francisco Dalla Corte Giana de Vargas Mores | 2018 | Information Processing in Agriculture2018，5，1： | 5 |
| 5 | Preparation and investigation of Pd doped Cu catalysts for selective hydrogenation of acetylene显示文摘A series of PdCu bimetallic catalysts with low Cu and Pd loadings and different Cu:Pd atomic ratios were prepared by conventionally sequential impregnation(CSD)and modified sequential impregnation(MSI)of Cu and Pd for selective hydrogenation of acetylene.Characterization indicates that the supported copper(I)nitrate in the PdCu bimetallic catalysts prepared by MSI can be directly reduced to Cu metal particles due to the hydrogen spillover from Pd to Cu(NO3)2 crystals.In addition,for the catalysts prepared by MSI,Pd atoms can form PdCu alloy on the surface of metal particles,however,for the catalysts prepared by CSI,Pd tends to migrate and exist below the surface layer of Cu.Reaction results indicate that compared with CSI,the MSI method enables samples to possess preferable stability as well as comparable reaction activity.This should be due to the MSI method in favor of the formation of PdCu alloy on the surface of metal particles.Moreover,even Pd loading is super low,<0.045 wt-%in this study,by through adjusting Cu loading to an appropriate value,attractive reactivity and selectivity still can be achieved. | Xinxiang Cao Tengteng Lyu Wentao Xie Arash Mirjalili Adelaide Bradicich Ricky Huitema Ben W.-L.Jang Jong K.Keum Karren More Changjun Liu Xiaoliang Yan | 2020 | Frontiers of Chemical Science and Engineering2020，14，4： | 4 |
| 6 | Effect of aqueous extract of Solanum xanthocarpum Schrad. & Wendl. on postmenopausal syndrome in ovariectomized rats显示文摘OBJECTIVE: Solanum xanthocarpum Schrad. & Wendl.(Solanaceae) is present in many Ayurveda compound formulations including Chavanaprasha and Dasamoolarishta. The whole plant is used in conditions such as inflammation, constipation and promoting conception in females. In the present study, we carried out different tests to evaluate the effect of aqueous extract of Solanum xanthocarpum(SXE) in postmenopausal syndrome. METHODS: The study was carried out in bilaterally ovariectomized one-month-old Wistar rats(40–50 g). Bilaterally ovariectomized(OVX) Wistar rats were divided into four groups(n=6) receiving different treatments, consisting of a vehicle(distilled water), aqueous extract of Solanum xanthocarpum at two different doses(200 and 400 mg/kg) administered orally daily for 90 d and standard drug β estradiol at a dose of 1 mg/kg administered subcutaneously biweekly for 90 d. Estrogenic activity was assessed by vaginal cornifi cation, sexual behavior, serum estradiol and uterine weight to body weight ratio. Antiosteoporotic activity was assessed on the basis of biomechanical and biochemical parameters followed by histopathological studies, and antidepressant activity was assessed by forced swim test. RESULTS: SXE showed presence of steroids. At the dose of 200 mg/kg, it signifi cantly improved all the parameters of sexual behavior(P<0.01), caused vaginal cornifi cation, and increased serum estradiol and uterine weight(P<0.01). It also significantly improved all the parameters of bone strength as well as depression(P<0.01). Histopathology of bones confi rmed the above fi ndings. CONCLUSION: The study indicated that SXE may provide an effective treatment in the prevention of postmenopausal symptoms. | Urmila Aswar Mayuri Gurav Ganesh More Khaled Rashed Manoj Aswar | 2014 | Journal of Integrative Medicine2014，12，5： | 3 |
| 7 | 加速量热仪对锂离子蓄电池安全性能的评估显示文摘在国外,加速量热仪(ARC)已被广泛应用于锂离子蓄电池的研究。使用该设备,在绝热条件下记录电池内的温度、压力及自放热速率和时间的函数关系。使用英国THT公司生产的加速绝热量热仪及附加设备(KSUTM)和(BSUTM)检测电池使用过程中充放电、滥用以及短路和高温下的热分解,并利用这些数据来量化电池储存和放置等条件下的热稳定特性。 | 陈俊燕 Martyn Ottaway Stelios More | 2007 | 电源技术2007，31，1： | 3 |
| 8 | GREEN MESSENGER──WOMEN'S MOUNTAIN PRODUCTION BRIGADE IN YOUXI VILLAGE | (For more information, please contact:Mrs.Xie Jingxiang,Beijing Forestry University,Beijing,100083,china.) | 1995 | Forestry and Society Newsletter1995，，1： | 2 |
| 9 | Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db / db Mice显示文摘 | Hong Chen Olga Charlat Louis A Tartaglia Elizabeth A Woolf Xun Weng Stephen J Ellis Nathan D Lakey Janice Culpepper Karen J More Roger E Breitbart Geoffrey M Duyk Robert I Tepper Jay P Morgenstern | 1996 | Cell1996，，3： | 2 |
| 10 | The expression of proteins involved in digestion and detoxification are regulated in Helicoverpa armigera to cope up with chlorpyrifos insecticide显示文摘Helicoverpa armigera 是在许多重要庄稼的一个关键害虫,它被化学策略主要控制。为了设法,这个害虫对杀虫药剂由于它抵抗的能力和进化正在变得挑战性。进一步,它 nonhost 植物上的随后的传播在最近的时间是显著的。因此,对 phytochemicals 和合成杀虫药剂译码抵抗机制是主要挑战。现在的工作描述消化,辩护和豁免联系了酶,这在 H 与 chlorpyrifos 抵抗被联系。armigera。H 的 Proteomic 分析。在在用 nano 液体层析团 spectrometry 包含饮食(CH ) 和人工的饮食(广告) 的 chlorpyrifos 上喂之上的 armigera 内脏织物鉴别在 CH 的 upregulated 23 蛋白质喂了幼虫。与基因本体论分析相结合的数据库搜索表明识别内脏蛋白质在消化,为免疫关键的蛋白质,强调的适应回答,和 detoxification 占去。候选人蛋白质的生物化学、量的即时聚合酶链反应分析显示昆虫正在努力在 CH 的存在得到营养素和精力,当同时努力使 chlorpyrifos 产生代射变化时。而且,我们在 H 建议了 chlorpyrifos 的一条潜在的处理小径。由用煤气的层析团 spectrometry 检验代谢物的 armigera 勇气。H。到由调整蛋白质的表示的杀虫药剂的吸引人的行为的、词法改编和电阻的一个范围在消化和 detoxification 机制包含了处理在上面的 armigera 展览与 chlorpyrifos。在这些上下文,作为内脏是生物信息的一个富有的仓库;内脏纸巾的深刻分析能在昆虫给 detoxification 和抵抗机制的线索。 | Vishal V. Dawkar Yojana R. Chikate Tushar H. More Vidya S. Gupta Ashok P. Giri | 2016 | Insect Science2016，23，1： | 2 |
| 11 | Peroxisome proliferator-activated receptor alpha-isoform deficient leads to progressive dyslipidemia with sexuallly dimorphic obesity and steatosis显示文摘 | COSTET P LEGENDRE C MORE J | 1998 | J Biol Chem1998，273，29： | 2 |
| 12 | Systematic design of adaptive controllers for feedback linearizable systems 显示文摘 | KANELLAKOPOULOS I KOKOTOVIC P V MORE A S | 1991 | IEEE Transactions on Automatic Control1991，36，： | 1 |
| 13 | Fatal anaphy laxis to indoornative fire ant stings in an infant显示文摘 | More D Kohlmeier RE Hoffma N | 2008 | Am J Forensic Med Pathol2008，29，1： | 1 |
| 14 | Decentralized control of linear multivariable systems显示文摘 | Corfmat J P Mores A S | 1976 | Automatica1976，12，3： | 1 |
| 15 | Quasi-Newton methods, motivation and theory显示文摘 | Dennis J J More J J | 1977 | SIAM REIEW1977，19，： | 1 |
| 16 | Low temperature growth of aligned ZnO nanowires and their application as ? eld emission cathodes显示文摘 | SHEINI F J JOAG D S MORE M A | 2010 | Materials Chemistry and Physics2010，210，： | 1 |
| 17 | Smoking reduces surfactant protein D and phospholipids in patients with and without chronic obstructive pulmonary disease显示文摘 | More JM Voelker DR Silveira LJ | 2010 | Pulm Med2010，，10： | 1 |
| 18 | Trans- fusion of the injured patient:proceed with caution显示文摘 | Silliman C More E Johnson J | 2004 | Shock2004，21，4： | 1 |
| 19 | Delayed recovery from anaesthesia in a patient with optimised hypothyroidism and incidental hypokalemia 显示文摘 | More P Laheri VV Waigankar T | 2015 | J Clin Diagn Res2015，9，1： | 1 |
| 20 | Academic autocracy显示文摘 | More P E | 1913 | Nation1913，，5： | 1 |
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