|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Child-Pugh-Turcott versus Meld score for predicting survival in a retrospective cohort of black African cirrhotic patients显示文摘AIM: To compare the performance of the Child-Pugh-Turcott (CPT) score to that of the model for end-stage liver disease (MELD) score in predicting survival of a retrospective cohort of 172 Black African patients with cirrhosis on a short and mid-term basis.METHODS: Univariate and multivariate (Cox model) analyses were used to identify factors related to mortality. Relationship between the two scores was appreciated by calculating the correlation coefficient. The Kaplan Meier method and the log rank test were used to elaborate and compare survival respectively. The Areas Under the Curves were used to compare the performance between scores at 3, 6 and 12 mo.RESULTS: The study population comprised 172 patients, of which 68.9% were male. The mean age of the patient was 47.5 ± 13 years. Hepatitis B virus infection was the cause of cirrhosis in 70% of the cases. The overall mortality was 31.4% over 11 years of follow up. Independent factors significantly associated with mortality were: CPT score (HR = 3.3, 95% CI [1.7-6.2]) (P < 0.001) (stage C vs stage A-B); Serum creatine (HR = 2.5, 95% CI [1.4-4.3]) (P = 0.001) (Serum creatine > 1.5 mg/dL versus serum creatine < 1.5 mg/dL); MELD score (HR = 2.9, 95% CI [1.63-5.21]) (P < 0.001) (MELD > 21 vs MELD < 21). The area under the curves (AUC) that predict survival was 0.72 and 0.75 at 3 mo (P = 0.68), 0.64 and 0.62 at 6 mo (P = 0.67), 0.69 and 0.64 at 12 mo (P = 0.38) respectively for the CPT score and the MELD score.CONCLUSION: The CPT score displays the sameprognostic significance as does the MELD score in black African patients with cirrhosis. Moreover, its handling appears less cumbersome in clinical practice as compared to the latter. | KA Attia KC Ackoundou-N'guessan AT N’dri-yoman AK Mahassadi E Messou YF Bathaix YH Kissi | 2008 | World Journal of Gastroenterology2008，14，2： | 5 |
| 2 | Prevalence and virological profiles of hepatitis B infection in human immunodeficiency virus patients显示文摘AIM: To determine the prevalence of hepatitis B virus (HBV) in adult human immunodeficiency virus (HIV) patients with CD4+ T-cell count less than 500/mm 3 and without antiretroviral therapy; to describe different HBV-HIV coinfection virological profiles; and to search for factors associated with HBs antigen (HBsAg) presence in these HIV positive patients.METHODS: During four months (June through September 2006), 491 patients were received in four HIV positive monitoring clinical centers in Abidjan. Inclusion criteria: HIV-1 or HIV-1 and 2 positive patients, age ≥ 18 years, CD4+ T-cell count < 500/mL and formal and signed consent of the patient. Realized blood tests included HIV serology, CD4+ T-cell count, quantitative HIV RNA load and HBV serological markers, such as HBsAg and HBc antibody (anti-HBcAb). We performed HBeAg, anti-HBe antibody (anti-HBeAb), anti-HBc IgM and quantitative HBV DNA load in HBsAg positive patients. Anti-HBsAb had been tested in HIV patients with HBsAg negative and anti-HBcAb-positive. HBV DNA was also tested in 188 anti-HBcAb positive patients with HBsAg negative status and without anti-HBsAb. Univariate analysis (Pearsonχ 2 test or Fischer exact test) and multivariate analysis (backward step-wise selection logistic regression) were performed as statistical analysis. RESULTS: Mean age of 491 patients was 36 ± 8.68 years and 73.3% were female. Type-1 HIV was found in 97% and dual-type HIV (type 1 plus type 2) in 3%. World Health Organization (WHO) clinical stage was 1, 2, 3 and 4 respectively in 61 (12.4%), 233 (47.5%), 172 (35%) and 25 patients (5.1%). Median CD4+ T-cell count was 341/mm 3 (interquartile range: 221-470). One hundred and twelve patients had less than 200 CD4+ T-cell/mm 3 . Plasma HIV-1 RNA load was elevated (≥ 5 log 10 copies/mL) in 221 patients (45%). HBsAg and anti-HBcAb prevalence was respectively 13.4% and 72.9%. Of the 66 HBsAg positive patients, 22 were inactive HBV carriers (33.3%), 21 had HBeAg positive hepatitis (31.8%) and 20 had HBeAg negative hepatitis (30.3%). HBeAg and anti-HBeAb were indeterminate in 3 of them. Occult B infection prevalence (HBsAg negative, anti-HBcAb positive, anti-HBsAb negative and detectable HBV DNA) was 21.3%. Three parameters were significantly associated with the presence of HBsAg: male [odds ratio (OR): 2.2;P = 0.005; 95% confidence interval (CI): 1.3-3.8]; WHO stage 4 (OR: 3.2;P = 0.01;95% CI: 1.3-7.9); and aspartate aminotransferase (AST) level higher than the standard (OR: 1.9;P = 0.04; 95% CI: 1.02-3.8). CONCLUSION: HBV infection prevalence is high in HIV-positive patients. HBeAg positive chronic hepatitis and occult HBV infection are more frequent in HIVpositive patients than in HIV negative ones. Parameters associated with HBsAg positivity were male gender, AIDS status and increased AST level. | Koffi Alain Attia Serge Eholié Eugène Messou Christine Danel Sandrine Polneau Henri Chenal Thomas Toni Myreille Mbamy Catherine Seyler Naomi Wakasugi Thérèse N'dri-Yoman Xavier Anglaret | 2012 | World Journal of Hepatology2012，4，7： | 4 |
| 3 | Association between lep tin,metabolic factors and liver histology in patients with chronic hepatitis C显示文摘 | Myers RP Messous D Poynard T | 2007 | Can J Gastroenterol2007，21，5： | 1 |
| 4 | Vaginal douching: association with lower genital tract infections in African pregnantwomen显示文摘 | La Ruche Messou N Ali - Napo L | 1999 | Sex Transm Dis1999，26，： | 1 |
| 5 | Vaginal douching:association with lower genital tract infections in African pregnant women显示文摘 | La Ruche Messou N Ali-Napo L | 1999 | Sex Transm Dis1999，26，4： | 1 |
| 6 | Vaginal douching : association with lower genital tract infections in African pregnant women 显示文摘 | La Ruche Messou N All - Napo L | 1999 | Sex Transm Dis1999，26，4： | 1 |
| 7 | Incidenceanddeterminantsofmor-talityandmorbidityfollowingearlyARTinitiationinHIV-infecteda-dultsinWestAfrica显示文摘 | MohR DanelC MessouE | | 0，，： | 1 |
| 8 | Association betweenmedication possession ratio,virologic failure and drug resis-tance in HIV-1 infected adults on antiretroviral therapy inCote d’Ivoire显示文摘 | Messou EEN Chaix M Gabillard D | 2011 | J Acquir Immune Defic Syndr2011，56，4： | 1 |
| 9 | The effect of cotrimoxazole coadministrated with antituberculous drugs on serum transaminases in HIV-infected adults from the Ivory Coast 显示文摘 | Messou E Anglaret X Bonard D | 2001 | Br J Clin Pharmacol2001，52，5： | 1 |
| 10 | Association between leptin,metabolic factors and liver histology in patients with chronic hepatitis C显示文摘 | Myers RP Messous D Poynard T | 2007 | Can J Gastroenterol2007，21，5： | 1 |
| 11 | Biomarkers for the prediction of liver fibrosis in patients with chronic alcoholic liver disease显示文摘 | Sylvie Naveau Bruno Raynard Vlad Ratziu Annie Abella Fran?oise Imbert–bismut Djamila Messous Fabienne Beuzen Frédérique Capron Dominique Thabut Mona Munteanu Jean Claude Chaput Thierry Poynard | 2005 | Clinical Gastroenterology and Hepatology2005，，2： | 1 |
| 12 | Incidence and determinants of mortality and morbidity following early antiretroviral therapy initiation in HIV-infected adults in West Africa 显示文摘 | Moh R Danel C Messou E | 2007 | AIDS2007，21，18： | 1 |
| 13 | Vaginal douching: association with lower genital tract infections in African pregnant women显示文摘 | La Ruche Messou N Ali-Napo L | 1999 | Sex Transm Dis1999，26，4： | 1 |
| 14 | A prospective assess- ment of the inter-laboratory variability of biochemical markers of fi- brosis (FibroTest) and activity (ActiTest) in patients with chronic liver disease 显示文摘 | Halfon P Imbert-Bismut F Messous D | 2002 | Comp Hepatol2002，1，1： | 1 |
| 15 | Association between leptin, metabolic factors and liver histology in patients with chronic hepatitis C 显示文摘 | Myers R P Messous D Poynard T | 2007 | Can J Gastroenterol2007，21，： | 1 |
| 16 | Biomarkers for the prediction of liver fibrosis in patients with chronic alcoholic liver disease显示文摘 | Sylvie Naveau Bruno Raynard Vlad Ratziu Annie Abella Fran?oise Imbert–bismut Djamila Messous Fabienne Beuzen Frédérique Capron Dominique Thabut Mona Munteanu Jean Claude Chaput Thierry Poynard | 2005 | Clinical Gastroenterology and Hepatology2005，，2： | 1 |
| 17 | A prospective assessment of the inter laboratory variability of biochemical markers of fibrosis (Fibro Test) and activity (Aeti Test) in patients with chronic liver disease显示文摘 | Halfon P Imbert-Bismut F Messous D | 2002 | Comp Hepatol2002，1，3： | 1 |
| 18 | Impact of genotypic drug resistance mutations on clinical and immunological out comes in HIV infected adults on HAART in West Africa显示文摘 | Seyler C Adje-Toure C Messou E | 2007 | AIDS2007，21，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员