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	题名	作者	年代	出处	被引量
1	Liver angiogenesis as a risk factor for hepatocellularcarcinoma development in hepatitis C virus cirrhotic patients显示文摘AIM: To evaluate the predictive value of hepatocyte proliferation and hepatic angiogenesis for the occurrence of Hepatocellular carcinoma (HCC) in hepatitis C virus (HCV) cirrhotic patients. METHODS: One hundred-five patients (69 males, 36 females; age range, 51-90 year; median 66 year) with biopsy proven HCV cirrhosis were prospectively monitored for HCC occurrence for a median time of 64 mo. Angiogenesis was assessed by using microvessel density (MVD), hepatocyte turnover by MIB1 and PCNA indexes at inclusion in liver biopsies. RESULTS: Forty six patients (43.8%) developed HCC after a median time of 55 (6-120) mo while 59 (56.2%) did not. Patients were divided into two groups according to the median value of each index. The difference between patients with low (median MVD = 3; range 0-20) and high (median MVD = 7; range 1-24) MVD was statistically significant (χ2 = 22.06; P < 0.0001) which was not the case for MIB1 or PCNA (MIB-1: χ2 = 1.41; P = 0.2351; PCNA: χ2 = 1.27; P = 0.2589). The median MVD was higher in patients who developed HCC than in those who did not. HCC-free interval was significantly longer in patients with the MVD ≤ 4 (P = 0.0006). No relationship was found between MIB1 or PCNA and MVD (MIB-1 r2 = 0.00007116, P = 0.9281; PCNA: r2 =0.001950; P = 0.6692). MVD only was able to predict the occurrence of HCC in these patients. Among other known risk factors for HCC, only male sex was statistically associated with an increased risk. CONCLUSION: Liver angiogenesis has a role for in HCV- related liver carcinogenesis and for defining patients at higher risk.	Roberto Mazzanti Luca Messerini Camilla E Comin Lorenzo Fedeli Nathalie Gannè-Carrie Michel Beaugrand	2007	World Journal of Gastroenterology2007，13，37：	3
2	Lymph Node Recovery from Colorectal Tumor Specimens:Recommendation for a Minimum Number of Lymph Nodes to be Examined显示文摘	Fabio Cianchi Annarita Palomba Vieri Boddi Luca Messerini Filippo Pucciani Giuliano Perigli Paolo Bechi Camillo Cortesini	2002	World Journal of Surgery2002，，3：	2
3	Pathologic determinants of survival after resection of T3N0 (Stage IIA) colorectal cancer:proposal for a new prognostic model显示文摘	Cianchi F Messerini L Comin CE	2007	Dis Colon Rectum2007，50，9：	1
4	Microvessel density and clinicopathological characteristics in hepatitis C virus and hepatitis B virus related hepatocellular carcinoma显示文摘	Messerini L Novelli L Comin CE	2004	J Clin Pathol2004，57，8：	1
5	Solitary necrotic nodule of the liver: imaging and correlation with pathologic features显示文摘	Colagrande S Politi LS Messerini L	2003	Abdom Imaging2003，28，1：	1
6	Solitary necrotic noldule of the liver:imaging and correlation with pathologic features显示文摘	Colagrande S Politi L S Messerini L	2003	Abdom Imaging2003，28，1：	1
7	Pathologic determinants of survival after resection of T3N0 (Stage Ⅱ A) colorectal cancer: proposal for a new prognostic model显示文摘	Cianchi F Messerini L Comin CE	2007	Dis Colon Rectum2007，50，9：	1
8	Primary signet-ring cell carcinoma of the colon and rectum显示文摘	Dr. Luca Messerini M.D. Annarita Palomba M.D. Giancarlo Zampi M.D	1995	Diseases of the Colon & Rectum1995，，11：	1
9	Natural history of imatinib-naive GISTs : a retrospective analysis of 929 cases with long-term follow-up and development of a survival nomogram based on mitotic index and size as continuous variables显示文摘	Rossi S Miceli R Messerini L	2011	Am J Surg Pathol2011，35，：	1
10	hERG1 channels in human esophagus: evidence for their aberrant expression in the malignant progression of Barrett's esophagus显示文摘	Lastraioli E Taddei A Messerini L et ai	2006	J Cell Physiol2006，209，2：	1
11	Lymph Node Recovery from Colorectal Tumor Specimens:Recommendation for a Minimum Number of Lymph Nodes to be Examined显示文摘	Fabio Cianchi Annarita Palomba Vieri Boddi Luca Messerini Filippo Pucciani Giuliano Perigli Paolo Bechi Camillo Cortesini	2002	World Journal of Surgery2002，，：	1
12	Microvessel density and clinicopathological characteristics in hepatitis C virus and hepatitis Bvirus related hepatocellular carcinoma显示文摘	Messerini L Novelli L Comin CE	2004	J Clin Pathol2004，57，5：	1
13	Incidence and prognostic significance of occult tumor cells in lymph nodes from patients with stage IIA colorectal carcinoma显示文摘	Luca Messerini Fabio Cianchi Camillo Cortesini Camilla E. Comin	2006	Human Pathology2006，，10：	1
14	hERG1 channels in human esophagus~ evidence for their aber rant expression in the malignant progression of Barrett's esophagus显示文摘	Lastraioli E Taddei A Messerini L	2006	J Cell Physiol2006，209，：	1
15	Microvessel density and clinicopathological characteristics in hepatitis C virus and hepatitis B virus related hepatocellular carcinoma 显示文摘	Messerini L Novelli L Comin C E	2004	J Clin Pathol2004，57，8：	1
16	Pathologic determinants of survival after resection of T3 NO (Stage IIA ) colorectal cancer:proposal for a new prognostic model 显示文摘	Cianchi F Messerini L Comin CE	2007	Dis Colon Rectum2007，50，9：	1
17	Adequacy of Lymphadenectomy in Laparoscopic Colorectal Cancer Surgery: A Single-centre, Retrospective Study显示文摘	Fabio Cianchi Camillo Cortesini Giacomo Trallori Luca Messerini Luca Novelli Camilla Eva Comin Etleva Qirici Andrea Bonanomi Giuseppe Macrì Benedetta Badii Aurora Kokomani Giuliano Perigli	2012	Surgical Laparoscopy Endoscopy & Percutaneous Techniques2012，，1：	1
18	Chronic viral hepatitis induced by hepatitis C but not hepatitis B virus infection correlates with increased liver angiagenesis显示文摘	Maszanti R Messerini L Monsacchi L	1997	Hepatology1997，25，1：	1
19	Solitary necrotic nodule of the liver: imaging and correlation with pathologic features 显示文摘	Colagrande S Politi LS Messerini L	2003	Abdom Imaging2003，28，1：	1
20	Character of the invasive margin in colorectal cancer显示文摘	Fabio Cianchi Luca Messerini Annarita Palomba Vieri Boddi Giuliano Perigli Filippo Pucciani Paolo Bechi Camillo Cortesini	1997	Diseases of the Colon & Rectum1997，，10：	1

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