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	题名	作者	年代	出处	被引量
1	热带水蛭Hirudinaria manillensis睡液提取物的体内降糖作用(英文)显示文摘The anticoagulant effect of leech saliva was traditionally employed in the treatment of diabetes mellitus complications such as peripheral vascular complications.This study was carried out to examine the effect of leech saliva extract(LSE)on blood glucose levels in alloxan-induced diabetic rats.First,LSE was collected from leeches which were fed on a phagostimulatory solution.Second,total protein concentration was estimated using the Bradford assay.Third,diabetic rats were injected subcutaneously(sc)with LSE at doses of 500 and 1 000μg·kg 1body weight(bw).Other diabetic rats were injected sc with insulin at doses of 10 and 20 U·kg 1bw.Another group was injected simultaneously with LSE(250μg·kg 1bw)and insulin(10 U·kg 1bw).Fasting blood glucose(FBG)concentrations were monitored during a study period of eight hours at regular intervals.Findings showed that both doses of LSE resulted in a significant and gradual decrease in FBG starting from 10%18%downfall after two hours of injection reaching the maximal reduction activity of 58%after eight hours.Remarkably,LSE was sufficient to bring the rats to a near norm-glycemic state.The high dose of insulin induced a severe hypoglycemic condition after 2 4 h of injection.The lower dose was able to decline FBG for 2 6 h in rats which became diabetic again after 8 h.On the other hand,the concurrent injection of low doses of LSE and insulin produced a hypoglycemic effect with all rats showing normal FBG levels.Taken together,these findings indicated that the subcutaneous injection of LSE of the medicinal Malaysian leech was able to provide better glycemic control compared with insulin.Moreover,the synergism between LSE and insulin suggests that LSE could be utilized as an adjuvant medication in order to reduce insulin dosage or to achieve better control of blood glucose.	Abdualkader Abdualrahman Mohammed Ghawi Abbas Mohammad Alaama Mohamed Awang Mohamed Merzouk Ahmed	2013	中国天然药物2013，11，5：	3
2	Antioxidant status and levels of different vitamins determined by high performance liquid chromatography in diabetes subjects with multiple complications显示文摘	Merzouk S Hichami A Madanis S	2003	Gen Physiol Biophys2003，22，：	1
3	Removal turbidity and separation of heavy metals using electrocoagulation- electroflotation technique: A case study 显示文摘	Merzouk B Gourich B Sekki A	2009	Journal of Hazardous Materials2009，164，1：	1
4	Anticancer effects of medical Malaysian leech saliva extract LSE 显示文摘	Merzouk A Ghawi AM Abdualkader AM	2012	Pharm Anal Acta2012，，15：	1
5	Removal of a disperse red dye from synthetic wastewater by chemical coagulation and continuous electrocoagulation显示文摘	MERZOUK B GOURICH B MADANI K	2011	A comparative Study Desalination2011，272，13：	1
6	Derivation of a tube solar collector transmittance for beam and diffuse radiation显示文摘	Mustapha Merzouk Poubaby Ramany Bala Michel Feidt etal	2003	International Journal of Thermal Sciences2003，42，：	1
7	l Maternal and fetalserum lipid and lipoprotein concentrations and compositionsin type 1 diabetic pregnancy:relationshipwithmaternal glycemic contro显示文摘	Merzouk H Madani S Korso N et a	2000	J Lab ClinMed2000，136，6：	1
8	Free radical scavenging activity of the medicinal Malaysian leech saliva extract, Hirudinaria manillensis 显示文摘	Ghawi AM Abdualkader AM Merzouk A	2012	J Bioequiv Bioavail2012，14，：	1
9	Physico-chemical and Microbiological Analysis of Algerian Raw Camel's Milk and Identification of Predominating Thermophilic Lactic Acid Bacteria显示文摘	Merzouk Yamina Chahrour Wassila Zarour Kenza Zergui Amina Saidi Noureddine Henni Jamal Eddine Kihal Mebrouk	2013	Journal of Food Science and Engineering2013，3，2：	1
10	Fetal maeroso- miarelated to maternal poorly controlled type 1 diabet- esstrongly impairs serum lipoprote in oncentrations and composition显示文摘	Merzouk H Bouchenak Loukidi	2000	J Clin athol2000，53，12：	1
11	Effects of mancozeb and metfibuzin on in vitro proliferative responses and oxidative stress of human and rat spleen lymphocytes stimulated by mitogens 显示文摘	Medjdoub a merzouk s a merzouk h	2011	Pesticide biochemistry and physiology2011，101，1：	1
12	On the use of silylated nucleophiles in the palladium catalysed deprotection of allylic carboxylates and carbamates 显示文摘	Merzouk A Guibe F Loffe A	1992	Tetrahedron Lett1992，33，：	1
13	Clinical evaluation of lipids, lipoproteins and red blood eells sodium and potassium in patients with different grades of hypertension显示文摘	Aribi M Merzouk H~ Haddouche M	2010	Clinieal Biochemistry2010，43，12：	1
14	Changes in lipid and lipoprotein concentrations and compositions at birth and after 1 month of life in macrosomic infants of insulin - dependent diabetic mothers显示文摘	Merzouk H Madani S Prost J	1999	Eur J Pedatr1999，158，9：	1
15	Fetal macrosomia related to matermal poorly controlled type 1 dibetes strongly impairs serum lipoprotein concentrations and composition显示文摘	Merzouk H Bouchenak M Loukidi B	2000	J Clin Pathol2000，53，12：	1
16	Low SOD activity is associated with overproduction of peroxynitrite and hi-tfic oxide in patients with acute coronary syndrome 显示文摘	Gheddouchi S Mokhtari-soulimane N Merzouk H	2015	Nitric Ox- ide2015，3，49：	1
17	Allylic protection of thiols and cysteine:Ⅰ:The allyloxycarbonylaminomethyl group显示文摘	Kimbonguila A M Merzouk A GuibéF	1999	Tetrahedron1999，55，22：	1
18	N-3polyunsaturated fatty acidsmodulate in-vitro Tcell function in TypeⅠdiabetic patients显示文摘	Merzouk SA Saker M Repuip KB	2008	Lipids2008，43，6：	1
19	N-3 fatty acids modulate antioxidant status in diabetic rats and their macrosomic offspring显示文摘	Yessoufou A Soulaimann N Merzouk S A	2006	International Journal Obes(Lond)2006，30，5：	1
20	Antioxidant status and levels of different vitamins determined by high performance liquid chromatography in diabetic subjects with multiple complications 显示文摘	Merzouk S Hicbami A Madani S	2003	Gen Physiol Biophys2003，22，1：	1

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