|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Telbivudine vs tenofovir in hepatitis B e antigen-negative chronic hepatitis B patients: OPTIMA roadmap study显示文摘AIM To make efficacy and safety comparison of telbivudineraodmap and tenofovir-roadmap in hepatitis B e antigen(HBe Ag)-negative chronic hepatitis B(CHB) patients.METHODS This was the first prospective, randomised, two-arm, open-label, non-inferiority study in HBe Ag-negative CHB patients that compared telbivudine and tenofovir administered as per roadmap concept. Patients were treated up to 24 wk and, depending on virologic response, continued the same therapy or received addon therapy up to 104 wk. Eligible patients received an additional 52 wk of treatment in the extension period(i.e., up to 156 wk). Patients who developed virologic breakthrough(VB) while on monotherapy also received add-on therapy. The primary efficacy endpoint was the rate of patients achieving hepatitis B virus(HBV) DNA < 300 copies/m L at week 52. Secondary efficacy endpoints included the rates of HBV DNA < 300 and < 169 copies/m L, HBV DNA change from baseline, alanine aminotransferase normalisation, hepatitis B surface antigen(HBs Ag) loss, HBs Ag seroconversion, VB, and emergence of resistance at various timepoints throughout the study. Safety and estimated glomerular filtration rate(e GFR) were also analysed.RESULTS A total of 241 patients were randomised. Non-inferiority of telbivudine arm to tenofovir arm was demonstrated at week 52(± 7 d window), with over 91% of patients in each treatment arm achieving HBV DNA level < 300 copies/m L. Both arms were similar in terms of key secondary efficacy variables at weeks 104 and 156. The percentage of patients achieving HBV DNA < 300 copies/m L remained high and was similar in the telbivudine and tenofovir arms at both weeks 104 and 156. Over 82% of patients in both arms achieved alanine aminotransferase normalisation at week 52, and this percentage remained high at weeks 104 and 156. Telbivudine treatment progressively reduced serum HBs Ag levels from baseline while no change was reported in quantitative HBs Ag during therapy with tenofovir. Both treaments showed acceptable safety profiles. The telbivudine arm showed e GFR improvement unlike the tenofovir arm.CONCLUSION Efficacy was shown for both telbivudine-roadmap and tenofovir-roadmap regimens in HBe Ag-negative CHB patients over 156 wk. Telbivudine arm was associated with renal improvement. | Zahari Krastev Diana Petrova Iskren Kotzev Mustafa Kemal Celen Meryl Mendelson Richa Chandra Priti Pandey Kamal Hamed | 2016 | World Journal of Hepatology2016，8，32： | 9 |
| 2 | 沿海和海洋生态系统与人类人口系统间的相互作用:关于消费如何调解这种相互作用的看法显示文摘人口、环境及可持续发展的困境 20世纪的80和90年代,环境工作者和普通公众普遍认为,不加控制的人口增长是造成各类环境退化的根本原因。这种新马尔萨斯人口论的观点最初出现在20世纪60年代Ehrlich所著的《人口炸弹》的文章中,该文以危言耸听的语气解释了那十年空前高的人口增长率。在随后的几年中,这种观点,连同关于承载能力的工作以及不断发展的环境运动,导致产生一种表面上看起来是通情达理的结论,即:人口的高增长率,特别是高出生率,对环境有破坏作用。这种夸张的语言往往是无法控制的(见20世纪90年代世界观察研究所的各种出版物),并已扩散到超出学术界和非政府组织部门的范围。 | Sara Curran Anuradha Kumar Wolfgang Lutz Meryl Williams 林宝法 | 2002 | AMBIO-人类环境杂志2002，31，4： | 3 |
| 3 | KDOQI US Commentary on the 2012 KDIGO Clinical Practice Guideline for Glomerulonephritis显示文摘 | Laurence Beck Andrew S. Bomback Michael J. Choi Larry B. Holzman Carol Langford Laura H. Mariani Michael J. Somers Howard Trachtman Meryl Waldman | 2013 | American Journal of Kidney Diseases2013，，： | 2 |
| 4 | 中国糖尿病患者胰岛素用药行为和记忆问题网络调查显示文摘目的探讨中国糖尿病患者胰岛素使用相关记忆问题(MPs)及其对患者生理和心理机能、工作和糖尿病管理的影响。方法对3个国家64例采用胰岛素治疗的患者进行焦点小组访谈和电话访问,根据结果设计网络调查问卷,在5个国家中开展网络调查,近1个月内与胰岛素使用相关的3种MPs,即忘记注射胰岛素(UF)、忘记是否注射胰岛素(QT)和忘记注射胰岛素剂量(QD)的发生频次、原因和后果。结果 354例完成调查的中国糖尿病患者中,74.6%患者报告有UF,83.1%患者报告有QT,65.8%患者报告有QD,42.9%患者报告3种均发生过。MPs对患者的生理和心理机能、工作时间均有负面影响,增加额外的血糖监测和医疗服务。结果在不同人口学特征、疾病特点和胰岛素治疗方案的患者中比较差异无统计学意义。结论与胰岛素使用相关MPs在中国糖尿病患者中非常普遍。MPs降低患者的总体健康状况和各项机能,占用额外的医疗服务资源,导致患者损失劳动时间,增加经济负担。 | Meryl Brod Jens Kongso Donald Bushnell 于忱非 杨莉 许樟荣 | 2014 | 中国糖尿病杂志2014，22，5： | 2 |
| 5 | Diisocyanate asthma:clinical aspects and immunopathogenesis显示文摘 | CARRIE A MERYL H | 2002 | International immunopharmacology2002，，2： | 1 |
| 6 | Carbonbased supercapacitors produced by activation of graphene显示文摘 | Yanwu Zhu Shanthi Murali Meryl D Stoller | 2011 | Science2011，332，6037： | 1 |
| 7 | Phloretin enhances adipocyte differentiation and adiponectin expression in 3T3-L1cells显示文摘 | Meryl H Claire E Y Jean-Fran ois L | 2007 | Biochem Biophys Res Commun2007，361，1： | 1 |
| 8 | Gene expression profiling of 3T3-L1 adipocytes exposed to phloretin显示文摘 | Meryl H Claire E Y Christiane M D | 2010 | J Nutr Biochem2010，21，7： | 1 |
| 9 | A Cultural Perspective on Organizations: The Need for and Consequences of Viewing Organizations as Culture-Bearing Milieux 显示文摘 | Meryl L | 1981 | Human Systems Manag-meat1981，2，： | 1 |
| 10 | Sponsorship:An Important Component of the Promotions Mix显示文摘 | Gardner Meryl Paula and Philip Joel Shuman | 1987 | Journal of Advertising1987，，16： | 1 |
| 11 | Early Microbio- logical Response to Linezolid vs Vancomycin in Ventilator- Associated Pneumonia Due to Methieillin-Resistant staphylo- coccus aureus显示文摘 | Richard GW Meryl HM Michael SS | 2008 | Chest2008，134，6： | 1 |
| 12 | Graphene based ultracapaeitors 显示文摘 | Meryl D S Park S J Zhu Y W | 2008 | Nano Letters2008，8，10： | 1 |
| 13 | The Migration of Organizational Functions to the Work Unit Level: Buffering, Spanning, and Bringing Up Boundaries显示文摘 | Aimin Yan Meryl Reis Louis | | Human Relations0，，： | 1 |
| 14 | Early microbiological response to linezolid vs vancomycin in ventilator-associated pneumonia due to methicillin-resistant staphylococcus aureus 显示文摘 | Meryl H Somero Michael S | 2008 | Chest2008，134，6： | 1 |
| 15 | Graphene-based ultraeapaeitors显示文摘 | Meryl D S Park S J Zhu Y W | 2008 | Nano Lett2008，8，10： | 1 |
| 16 | Energy Production from Biomass Pyrolysis: A New Coefficient of Pyrolytic Valorisation 显示文摘 | Gaelle G Patrick B Meryl B | 2005 | Fuel2005，84，6： | 1 |
| 17 | Diisocyanate asthma: clinical aspects and immunopathogenesis显示文摘 | Can'ie AR Meryl HK | 2002 | Int Immunopharmacol2002，，2： | 1 |
| 18 | Graphene-based ultracapacitors 显示文摘 | Meryl D S Sung J P Yan W Z | 2008 | Nano letter2008，8，10： | 1 |
| 19 | A fully automated method for quantifying and localizing white matter hyperlntensities on MR images 显示文摘 | Minjie W Caterina R Meryl B | 2006 | Psychiatry Research Neuroimaging2006，148，： | 1 |
| 20 | Gene expression profiling of 333-L1 adipocytes exposed to phloretin 显示文摘 | Meryl H Claire E Y Christiane M D | 2010 | J Nutr Biochem2010，21，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员