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| 1 | Guanylyl cyclase C signaling axis and colon cancer prevention显示文摘Colorectal cancer(CRC) is a major cause of cancerrelated mortality and morbidity worldwide. While improved treatments have enhanced overall patient outcome, disease burden encompassing quality of life, cost of care, and patient survival has seen little benefit. Consequently, additional advances in CRC treatments remain important, with an emphasis on preventative measures. Guanylyl cyclase C(GUCY2C), a transmembrane receptor expressed on intestinal epithelial cells, plays an important role in orchestrating intestinal homeostatic mechanisms. These effects are mediated by the endogenous hormones guanylin(GUCA2A) and uroguanylin(GUCA2B), which bind and activate GUCY2 C to regulate proliferation, metabolism and barrier function in intestine. Recent studies have demonstrated a link between GUCY2 C silencing and intestinal dysfunction, including tumorigenesis. Indeed, GUCY2 C silencing by the near universal loss of its paracrine hormone ligands increases colon cancer susceptibility in animals and humans. GUCY2C's role as a tumor suppressor has opened the door to a new paradigm for CRC prevention by hormone replacement therapy using synthetic hormone analogs, such as the FDA-approved oral GUCY2 C ligand linaclotide(Linzess^(TM)). Here we review the known contributions of the GUCY2 C signaling axis to CRC, and relate them to a novel clinical strategy targeting tumor chemoprevention. | Amanda M Pattison Dante J Merlino Erik S Blomain Scott A Waldman | 2016 | World Journal of Gastroenterology2016，22，36： | 2 |
| 2 | Proteomic analysis of amphiphilic proteins of hexaploid wheat kernel显示文摘 | Amiour N Merlino M Leroy P | 2002 | Proteomics2002，2，： | 1 |
| 3 | hCMV pp67-mRNA detection by nucleic acid sequence-based amplification in renal transplant patients显示文摘 | Merlino C Bergallo M Gregori G | 2002 | New Microbiol2002，25，1： | 1 |
| 4 | Electrocardiographic score and short-term outcomes of acute pulmonary embolism显示文摘 | TOOSI M S MERLINO J D LEEPER K V | 2007 | Am J Cardiol2007，100，： | 1 |
| 5 | Association of rest-less legs syndrome in type 2 diabetes:a case-control study显示文摘 | Merlino G Fratticci L Valente M | | 0，，07： | 1 |
| 6 | Epstein Barr viral load monitoring by quantitative PCR in renal transplant patients显示文摘 | Merlino C Cavallo R Bergallo M | 2003 | New Microbiol2003，26，2： | 1 |
| 7 | HCMV pp67-mRNA detection by nucleic acid sequence-based amplification in renal transplant patients显示文摘 | Merlino C Bergallo M Gregori G | 2002 | New Microbiol2002，25，1： | 1 |
| 8 | HCMV pp67-mRNA detection by nucleic acid sequence-based amplification in renal transplant patients显示文摘 | MERLINO C BERGALLO M GREGORI G | 2002 | New Microbiol2002，25，1： | 1 |
| 9 | Proteomieanalysis of amphiphilic proteins of hexaploid wheat kernels 显示文摘 | Amiour N Merlino M Leroy P | 2002 | Proteomics2002，2，： | 1 |
| 10 | A proposed protocol for the surgical treatment of pressure sores based on a study of 337 cases 显示文摘 | Margara A Merlino G Borsetti M | 2003 | European J Plastic Surgery2003，26，2： | 1 |
| 11 | Evaluation of a DNA pool-sampling strategy for estimating the RFLP diversity of maize populations显示文摘 | Dubreuil P Rebourg C Merlino M | 1999 | Plant Mol Biol Rep1999，17，： | 1 |
| 12 | Epstein barr viral load monitoring by quantitative PCR in renal transplant patients显示文摘 | Merlino C Cavallo R Bergallo M | 2003 | New Microbiol2003，26，2： | 1 |
| 13 | Sleep disturbances in dialysis pa- tients显示文摘 | Merlino G Gig li G L Valente M | 2008 | Nephrol2008，21，13： | 1 |
| 14 | TRAP bind-ing to the Bacillus subtilis trp leader region RNA causes effi-cient transcription termination at a weak intrinsic terminator显示文摘 | POTTER K D MERLINO N M JACOBS T | 2011 | Nucleic Acids Research2011，39，6： | 1 |
| 15 | Restless legs syndrome:diagnosis,epidemiology,classification and consequences显示文摘 | Merlino G Valente M Serafini A | 2007 | Neurol Sci2007，28，1： | 1 |
| 16 | Sleep Disturbances in Dialysis Patients显示文摘 | Merlino G Gigli G L Valente M | 2008 | J Nephrol2008，21，13： | 1 |
| 17 | Association of restless legs syndrome in type 2 diabetes: a case-control study显示文摘 | Merlino G Fratticci L Valente M | 2007 | Sleep2007，30，7： | 1 |
| 18 | HCMV pp67-mRNA detection by nucleic acid sequence-based amplification in renal transplant patients显示文摘 | Merlino C Bergallo M | 2002 | New Microbiol2002，25，1： | 1 |
| 19 | Prospective randomized trials affect the outcomes of intraabdominal infection显示文摘 | Malangoni M A Smith C M | 2001 | Ann Surg2001，233，6： | 1 |
| 20 | c-Met autocrine activation induces development of malignant melanoma and acquisition of the metastatic phenotype显示文摘 | Otsuka T Takayama H Sharp R Celli G LaRochelle WJ Bottaro DP Ellmore B Vieira W Owens JW Anver M and Merlino G | | 0，，： | 1 |
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