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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Gasvolumetrische bestimmung der amidosulfons(a)ure,H2NSO3H显示文摘 | MEUWESEN A MERKEL H | 1940 | Zeitschrift für anorganische und allgemeine Chemie1940，244，1： | 1 |
| 3 | 查看详情显示文摘 | Mlynek A Reich M Giannone L Treutterer W Behler K Blank H Buhler A Cole R Eixenberger H Fischer R Lohs A Lüddecke K Merkel R Neu G Ryter F Zasche D the ASDEX Upgrade Team | | 0，，： | 1 |
| 4 | Stereoscopic skiagrams of the coronary arteries of the human heart under normal and pathological conditions 显示文摘 | Jamin F Merkel H | 1907 | Arch Roentgen Ray1907，11，： | 1 |
| 5 | 查看详情显示文摘 | S· Merkel H · R· Wenk J.F Shu P Gillet H.K.Mao and R.J.Hemley G} Y 5hen | | 0，，： | 1 |
| 6 | Finite-Element Modeling of Diamond Deformation at Multimegabar Pressures 显示文摘 | Merkel S Hemley R J Mao H K | 1999 | Appl Phys Lett1999，74，5： | 1 |
| 7 | 查看详情显示文摘 | Mlynek A Reich M Giannone L Treutterer W Behler K Blank H Buhler A Cole R Eixenberger H Fischer R Lohs A Lü uddecke K Merkel R Neu G Ryter F Zasche D the ASDEX Upgrade Team | | 0，，： | 1 |
| 8 | A diseasespecific activity index for Wegener' s granulomatosis : modification of the Birmingham Vasculitis Activity Score Inter national Network for the study of the systemic vassulitides (INSSYS) 显示文摘 | Stone J H Hoffman G S Merkel P A | 2001 | Arthritis Rheum2001，44，： | 1 |
| 9 | Changes in parameters of oxi-dative stress and free iron biomarkers during treatment with defera-sirox in iron-overloaded patients with myelodysplastic syndromes显示文摘 | Ghoti H Fibach E Merkel D | 2010 | Haematologica2010，95，8： | 1 |
| 10 | FLACC Behavioral Pain Assessment Scale:a Comparison with the Child's Self-report显示文摘 | Willis M H Merkel S I Voepel-Lewis T | | 0，，03： | 1 |
| 11 | The sitting position in neuro- surgery:indications, complications and results, a single institution ex- perience of 600 cases 显示文摘 | Ganslandt O Merkel A Sehmitt H | 2013 | Acta Neurochir ( Wien )2013，155，10： | 1 |
| 12 | The effect of ci nacalcet on bone remodeling and renal function in transplant pa tients with persistent hyperparathyroidism 显示文摘 | SCHWARZ A MERKEL S LEITOLF H | 2011 | Transplantation2011，91，5： | 1 |
| 13 | Power plant post-combustion carbon dioxide capture : An opportunity for membranes 显示文摘 | MERKEL T C LIN H WEI X BAKER R | 2010 | JMembrSci2010，359，1： | 1 |
| 14 | FLACC behavioral pain assessment scale: A comparison with the child' s self-report 显示文摘 | Willis M H Merkel S I Voepel-Lewis T | 2003 | Pediatr Nurs2003，29，3： | 1 |
| 15 | Power plant post-combustion car- bon dioxide capture: An opportunity for membranes 显示文摘 | Merkel T C Lin H Wei X | 2010 | Journal of Membrane Science2010，359，12： | 1 |
| 16 | Assessment of disease activity and progTession in Takayasu's arteritis显示文摘 | Direskeneli H Aydin SZ Merkel PA | 2011 | Clin Exp Rheumatol2011，29，11064： | 1 |
| 17 | Resistivity analysis for plane-layer half- space models with buried current sources显示文摘 | Merkel R H | 1971 | Geophysical Prospecting1971，19，4： | 1 |
| 18 | Performance of commercial layers when fed diets with four levels of corn oil or poultry fat显示文摘 | BOHNSACK C R HARMS R H MERKEL W D | 2002 | Journal of Applied Poultry Research2002，11，1： | 1 |
| 19 | Power plant post-com- bustion carbon dioxide capture: an opportunity for membranes显示文摘 | Merkel T Lin H Wei X | 2010 | J Membr Sci2010，359，12： | 1 |
| 20 | The effect of cinacalcet on bone remodeling and renal function in transplant patients with persistent hyperparathyroidism显示文摘 | Schwarz A Merkel S Leitolf H | 2011 | Transplantation2011，91，： | 1 |
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