|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins显示文摘The Omicron BA.2 variant has become a dominant infective strain worldwide.Receptor binding studies show that the Omicron BA.2 spike trimer exhibits 11-fold and 2-fold higher potency in binding to human ACE2 than the spike trimer from the wildtype(WT)and Omicron BA.1 strains.The structure of the BA.2 spike trimer complexed with human ACE2 reveals that all three receptor-binding domains(RBDs)in the spike trimer are in open conformation,ready for ACE2 binding,thus providing a basis for the increased infectivity of the BA.2 strain.JMB2002,a therapeutic antibody that was shown to efficiently inhibit Omicron BA.1,also shows potent neutralization activities against Omicron BA.2.In addition,both BA.1 and BA.2 spike trimers are able to bind to mouse ACE2 with high potency.In contrast,the WT spike trimer binds well to cat ACE2 but not to mouse ACE2.The structures of both BA.1 and BA.2 spike trimer bound to mouse ACE2 reveal the basis for their high affinity interactions.Together,these results suggest a possible evolution pathway for Omicron BA.1 and BA.2 variants via a human-cat-mouse-human circle,which could have important implications in establishing an effective strategy for combating SARS-CoV-2 viral infections. | Youwei Xu Canrong Wu Xiaodan Cao Chunyin Gu Heng Liu Meriting Jiang Xiaoxi Wang Qingning Yuan Kai Wu Jia Liu Deyi Wang Xianqing He Xueping Wang Su-Jun Deng H.Eric Xu Wanchao Yin | 2022 | Cell Research2022，32，7： | 6 |
| 2 | Probiotics for childhood functional gastrointestinal disorders: a systematic review and meta‐analysis显示文摘 | Judith J Korterink Lize Ockeloen Marc A Benninga Merit M Tabbers Mirrian Hilbink Judith M Deckers‐Kocken | 2014 | Acta Paediatr2014，，4： | 2 |
| 3 | Effect of metoprolol CR/CL in chronic heart failure:Metoprolol CR/CL randomly intervention trial in congestive heart failure显示文摘 | | 1999 | Lancet1999，353，9169： | 1 |
| 4 | Therapeutics and vaccines against chikungunya virus 显示文摘 | Ahola T Couderc T Courderc T Ng LF Halleng/ird D Powers A Leeuit M Esteban M Merits A Roques P Liljestr6m P | 2015 | Vector Borne Zoonotic Dis2015，15，4： | 1 |
| 5 | Acute toxicity removal in textile finishing wastewater by Fenton's oxidation, ozone and coagulation- floceulation processes显示文摘 | Merit S Selquk H Belgiorno V | 2005 | Water Res2005，39，6： | 1 |
| 6 | Novel attenuated chikungunya vaccine candidates elicit protective immunity in C57BL/6 mice 显示文摘 | Halleng/ird D Kakoulidou M Lulla A Kfimmerer BM Johansson DX Mutso M Lulla V Fazakerley JK Roques P Le Grand R Merits A Liljestr6m P | 2014 | J Viroh2014，88，5： | 1 |
| 7 | Evaluation of 28 years of surgical treatment of children and young adults with familial adenomatous polyposis显示文摘 | Klaske A.C. Booij Elisabeht M.H. Mathus-Vliegen Jan A.J.M. Taminiau Fibo J.W. Ten Kate J. Frederick M. Slors Merit M. Tabbers Daniel C. Aronson | 2010 | Journal of Pediatric Surgery2010，，3： | 1 |
| 8 | Therapeutic targents for amyotrophic lateral scerosis:current treaments and prospects for more effective therapies显示文摘 | Lucie B Merit C | 2006 | Neurotlierapeutics2006，6，： | 1 |
| 9 | Effect of metoprolol, CR/XL in chronic heart failure:Metoprolol CX/XL Randomised Intervention Trial in congestive Heart Failure (MERIT - HF) 显示文摘 | MERIT - HF Study Group | 1999 | Lancet1999，353，： | 1 |
| 10 | The effect of pre-ozone oxidation on acute toxicity and inert soluble COD fractions of a textile finishing industry wastewater显示文摘 | Selcuk H Eremektar G MeritS | 2006 | J Hazard Mater2006，137，1： | 1 |
| 11 | Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL randomized intervention trial in congestive heart failure(MERIT - HF)显示文摘 | MERIT - HF Study Group | 1999 | Lancet1999，353，6： | 1 |
| 12 | Endocrine profile in serum and follicular fluid differs after ovarian stimulation with HP-HMG or recombinant FSH in IVF patients显示文摘 | Smitz J MERIT Group | 2007 | Hum Reprod2007，22，： | 1 |
| 13 | Effect of metoprolol CR/XL in chronic heart hailure:Metopmlol CR/XL randomised intervention trial in congestive heart failure (MERIT- HF)显示文摘 | Merit Study Group | 1999 | Lancet1999，353，9169： | 1 |
| 14 | Displaced acetabular fractures 显示文摘 | Mata JM Merit PO | 1988 | Clin Or- thop Relat Res1988，，230： | 1 |
| 15 | Effect of metoprolol CR/XL in chronic heart failure: Metroprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT- HF)显示文摘 | MERIT - HF Study Group | 1999 | Lancet1999，353，9169： | 1 |
| 16 | Anti-tumor necrosis factor modulates anti-CD3-triggered T cell cytokine gene expression in vivo显示文摘 | Ferran C Dautry F Merite S | 1994 | J Clin Invest1994，93，5： | 1 |
| 17 | Self-association and mapping of interaction domains of helper component-proteinase of potato A potyvirus显示文摘 | Merits A Saarma M | 1999 | Journal of General Virology1999，80，： | 1 |
| 18 | Ecological and low intensity agriculture as contributors to landscape and biological diversity显示文摘 | Ulo Mander Merit Mikk Mart Kulvik | 1999 | Landscape and Urban Planning1999，46，4： | 1 |
| 19 | Effect Of metoprolol CPcXL in chronic heart hailure:Metopmlol CP/XL Randomised Intervention Trial in Congestive Heart Failure(MERIT-HF)显示文摘 | | 1999 | Lancet1999，353，9169： | 1 |
| 20 | Polymorphisms in MMP-2 and MMP-9 promoter regions are associated with endometriosis显示文摘 | Merli Saare Merit Lamp Tanel Kaart Helle Karro ülle Kadastik Andres Metspalu Maire Peters Andres Salumets | 2010 | Fertility and Sterility2010，，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员