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| 1 | Incidental gallbladder cancer during laparoscopic cholecystectomy:Managing an unexpected finding显示文摘AIM:To evaluate the impact of incidental gallbladder cancer on surgical experience.METHODS:Between 1998 and 2008 all cases of cholecystectomy at two divisions of general surgery,one university based and one at a public hospital,were retrospectively reviewed.Gallbladder pathology was diagnosed by history,physical examination,and laboratory and imaging studies [ultrasonography and computed tomography(CT)].Patients with gallbladder cancer(GBC) were further analyzed for demographic data,and type of operation,surgical morbidity and mortality,histopathological classification,and survival.Incidental GBC was compared with suspected or preoperatively diagnosed GBC.The primary endpoint was diseasefree survival(DFS).The secondary endpoint was the difference in DFS between patients previously treated with laparoscopic cholecystectomy and those who had oncological resection as first intervention.RESULTS:Nineteen patients(11 women and eight men) were found to have GBC.The male to female ratio was 1:1.4 and the mean age was 68 years(range:45-82 years).Preoperative diagnosis was made in 10 cases,and eight were diagnosed postoperatively.One was suspected intraoperatively and confirmed by frozen sections.The ratio between incidental and nonincidental cases was 9/19.The tumor node metastasis stage was:pTis(1),pT1a(2),pT1b(4),pT2(6),pT3(4),pT4(2);five cases with stageⅠa(T1 a-b);two with stageⅠb(T2 N0);one with stage Ⅱa(T3 N0);six with stage Ⅱb(T1-T3 N1);two with stage Ⅲ(T4 Nx Nx);and one with stage Ⅳ(Tx Nx Mx).Eighty-eight percent of the incidental cases were discovered at an early stage(≤Ⅱ).Preoperative diagnosis of the 19 patients with GBC was:GBC with liver invasion diagnosed by preoperative CT(nine cases),gallbladder abscess perforated into hepatic parenchyma and involving the transversal mesocolon and hepatic hilum(one case),porcelain gallbladder(one case),gallbladder adenoma(one case),and chronic cholelithiasis(eight cases).Every case,except one,with a T1b or more advanced invasion underwent Ⅳb + Ⅴ wedge liver resection and pericholedochic/hepatoduodenal lymphadenectomy.One patient with stage T1b GBC refused further surgery.Cases with Tis and T1a involvement were treated with cholecystectomy alone.One incidental case was diagnosed by intraoperative frozen section and treated with cholecystectomy alone.Six of the nine patients with incidental diagnosis reached 5-year DFS.One patient reached 38 mo survival despite a port-site recurrence 2 years after original surgery.Cases with non incidental diagnosis were more locally advanced and only two patients experienced 5-year DFS.CONCLUSION:Laparoscopic cholecystectomy does not affect survival if implemented properly.Reoperation should have two objectives:R0 resection and clearance of the lymph nodes. | Andrea Cavallaro Gaetano Piccolo Vincenzo Panebianco Emanuele Lo Menzo Massimiliano Berretta Antonio Zanghì Maria Di Vita Alessandro Cappellani | 2012 | World Journal of Gastroenterology2012，18，30： | 33 |
| 2 | Use of biological meshes for abdominal wall reconstruction in highly contaminated fields显示文摘Abdominal wall defects and incisional hernias represent a challenging problem. In particular, when a synthetic mesh is applied to contaminated wounds, its removal is required in 50%-90% of cases. Biosynthetic meshes are the newest tool available to surgeons and they could have a role in ventral hernia repair in a potential-ly contaminated field. We describe the use of a sheet of bovine pericardium graft in the reconstruction of abdominal wall defect in two patients. Bovine pericardium graft was placed in the retrorectus space and secured to the anterior abdominal wall using polypropylene sutures in a tension-free manner. We experienced no evidence of recurrence at 4 and 5 years follow-up. | Andrea Cavallaro Emanuele Lo Menzo Maria Di Vita Antonio Zanghì Vincenzo Cavallaro Pier Francesco Veroux Alessandro Cappellani | 2010 | World Journal of Gastroenterology2010，16，15： | 9 |
| 3 | Laparoscopic lysis of adhesions 显示文摘 | Szomstein S Lo Menzo E Simpfendorfer C | 2006 | World J Surg2006，30，4： | 1 |
| 4 | The recurrent goiter:prevention and management显示文摘 | Cappel ani A Di Vita M Zanghì A Lo Menzo E Caval aro A Alfano G Giuffrida D | | 0，，04： | 1 |
| 5 | Quantitative molecular methods in virology 显示文摘 | Menzo S Manzin A Bagnarelli P | 1995 | Arch Virol1995，140，9： | 1 |
| 6 | Quantitative PCR and RT-PCR in virology 显示文摘 | Menzo S Bagnarelli P Manzin A Valenza A Varaldo PE | 1993 | PCR Methods Appl1993，2，3： | 1 |
| 7 | Omental reinforcement for intraoperative leak repairs during laparoscopic Roux-en-Y gastric bypass显示文摘 | Madan AK Martinez JM Lo Menzo E | 2009 | Am Surg2009，75，9： | 1 |
| 8 | Quantitation of hepatitis C virus geneome molecules in plasma sample 显示文摘 | Manzin A Bagnarelli P Menzo S | 2002 | J Clin Microbiol2002，32，8： | 1 |
| 9 | Laparoscopic Lysis of Adhesions显示文摘 | Samuel Szomstein MD Emanuele Lo Menzo MD PhD Conrad Simpfendorfer MD Nathan Zundel MD Raul J. Rosenthal MD | 2006 | World Journal of Surgery2006，，4： | 1 |
| 10 | Management of recurrent inguinal hernias after total extraperitoneal (TEP) hemiorrhaphies 显示文摘 | Menzo Emanuele Lo Spector Seth A Iglesias Alberto | 2009 | J Laparoendosc Adv Surg Tech A2009，19，4： | 1 |
| 11 | Management of recur- rent inguinal hernias after total extraperitoneal(TEP)hemiorrha- phies显示文摘 | Lo Menzo E Spector SA Iglesias A | 2009 | J Laparoendosc Adv Surg Tech A2009，19，4： | 1 |
| 12 | TRAP molecularmarkers as a system for saturation of the genetic map of durumwheat 显示文摘 | MENZO V GIANCASPRO A GIOVE S | 2013 | Euphytica2013，194，： | 1 |
| 13 | Laparoscopic lysis of adhesions显示文摘 | Szomstein S Lo Menzo E Simpfendoffer C | 2006 | World J Surg2006，30，4： | 1 |
| 14 | Laparoscopic lysis of adhesions显示文摘 | Szomstein S Menzo EL Simpfendorfer C | 2006 | World J Surg2006，30，4： | 1 |
| 15 | Colorectal Cancer in Elderly Patients: From Best Supportive Care to Cure显示文摘 | Massimiliano Berretta Fabrizio Di Benedetto Raffaele Di Francia Emanuele Lo Menzo Sergio Palmeri Umberto Tirelli Paolo De Paoli | 2013 | Anti-Cancer Agents in Medicinal Chemistry2013，，9： | 1 |
| 16 | Resistance and replicative capacity of HIV-1 strains selected in vivo by long-term enfuvirtide treatment显示文摘 | Menzo S Castagna A Monachetti A | 2004 | New Microbiol2004，27，21： | 1 |
| 17 | Lamivudine monotherapy in HIV-l-infected patients harbouring a lamivudine-resistant virus: a randomized pilot study (E-184V study) 显示文摘 | Castagna A Danise A Menzo S | 2006 | AIDS2006，20，6： | 1 |
| 18 | Studies in subjects with long- term nonprogressive human immunodeficiency virus infection显示文摘 | Menzo S Vaccarezza M | 1995 | N Engl J Med1995，332，： | 1 |
| 19 | Laparoscopic Lysis of Adhesions显示文摘 | Samuel Szomstein Emanuele Lo Menzo Conrad Simpfendorfer Nathan Zundel Raul J. Rosenthal | 2006 | World Journal of Surgery2006，，4： | 1 |
| 20 | Studies in subjects with long-term non-progressive human immunodeficiency virus infection显示文摘 | Menzo S Vaccarezza M | 1995 | N Engl J Med1995，332，4： | 1 |
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