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| 1 | Clinical research linking Traditional Chinese Medicine constitution types with diseases:a literature review of 1639 observational studies显示文摘OBJECTIVE:To analyze clinical studies on correlations between Traditional Chinese Medicine(TCM)body constitution types and diseases published in the past 10 years,and to provide an evidence base to support the use of such correlations for health maintenance and disease prevention.METHODS:We searched five databases for the period April 2009 to December 2019:China National Knowledge Infrastructure Database,Wanfang Database,China Science and Technology Journal Database,PubMed and Embase.Three types of observational studies on correlation between constitution types and diseases were included:cross-sectional,case-control and cohort studies.Descriptive statistical methods were employed for data analysis.RESULTS:A total of 1639 clinical studies were identified:1452(88.59%)cross-sectional studies,115(7.02%)case-control studies and 72(4.39%)cohort studies covering 30 regions of China and five other countries(Malaysia,South Korea,Singapore,Thailand and France).The collection of studies comprised 19 disease categories and 333 different diseases.The 10 most commonly studied diseases were hypertension,diabetes,stroke,coronary atherosclerotic heart disease(CAHD),sleep disorders,neoplasm of the breast,dysmenorrhea,fatty liver disease,chronic viral hepatitis B and dyslipidemia.We found high distributions for each biased constitution type in different patient populations as follows:Qi-deficiency constitution in stroke,diabetes,chronic obstructive pulmonary disease,acquired immunodeficiency syndrome and hypertension;Yang-deficiency constitution in female infertility,osteoporosis,irritable bowel syndrome,gonarthrosis and dysmenorrhea;Yin-deficiency constitution in hypertension,diabetes,constipation,female climacteric states and osteoporosis;phlegm-dampness constitution in hypertension,stroke,fatty liver disease,diabetes and metabolic syndrome;damp-heat constitution in acne,chronic gastritis,chronic viral hepatitis B,human papillomavirus infection and hyperuricemia;blood-stasis constitution in CAHD,endometriosis and stroke;Qi-stagnation constitution in hyperplasia and neoplasms of the breast,insomnia,depression and thyroid nodules;and inherited-special constitution in asthma and allergic rhinitis.CONCLUSION:Eight biased TCM constitutions were closely related to specific diseases,and could be used to guide individualized prevention and treatment.More rigorously designed studies are recommended to further verify the constitution-disease relationship. | Liang Xue Wang Qi Jiang Zeqiang Li Zhuqing Zhang Mengxing Yang Peiying Wang Xin Wang Yanqiu Qin Yuehua Li Tianxing Zhang Tianyi Wang Yi Sun Jianxiang Li Yusi Luo Hui Li Lingru | 2020 | Journal of Traditional Chinese Medicine2020，40，4： | 29 |
| 2 | Application of chemical vapor-deposited monolayer ReSe2 in the electrocatalytic hydrogen evolution reaction显示文摘 | Shaolong Jiang Zhepeng Zhang Na Zhang Yahuan Huan Yue Gong Mengxing Sun Jianping Shi Chunyu Xie Pengfei Yang Qiyi Fang He Li Lianming Tong Dan Xie Lin Gu Porun Liu Yanfeng Zhang | 2018 | Nano Research2018，11，4： | 6 |
| 3 | Heterostructured graphene quantum dot/WSe2/Si photo-detector with suppressed dark current and improved detectivity显示文摘 | Mengxing Sun Qiyi Fang Dan Xie Yilin Sun Liu Qian Jianlong Xu Peng Xiao Changjiu Teng Weiwei Li Tianling Ren Yanfeng Zhang | 2018 | Nano Research2018，11，6： | 5 |
| 4 | Recommending Authors and Papers Based on ACTTM Community and Bilayer Citation Network显示文摘Citation network is often used for academic recommendation. However, it is difficult to achieve high recommendation accuracy and low time complexity because it is often very large and sparse and different citations have different purposes. What's more, some citations include unreasonable information, such as in case of intentional self-citation. To improve the accuracy of citation network-based academic recommendation and reduce the time complexity, we propose an academic recommendation method for recommending authors and papers. In which, an author-paper bilayer citation network is built, then an enhanced topic model, Author Community Topic Time Model(ACTTM) is proposed to detect high quality author communities in the author layer, and a set of attributes are proposed to comprehensively depict the author/paper nodes in the bilayer citation network. Experimental results prove that the proposed ACTTM can detect high quality author communities and facilitate low time complexity, and the proposed academic recommendation method can effectively improve the recommendation accuracy. | Meilian Lu Zhihe Qu Mengxing Wang Zhen Qin | 2018 | China Communications2018，15，7： | 4 |
| 5 | Trends and predictors of myocardial infarction or vascular death after ischaemic stroke or TIA in China, 2007-2018: insights from China National Stroke Registries显示文摘Background Although stroke management,primary and secondary preventions have been improved in China last decades,the trends and predictors of major vascular events after ischaemic stroke or transient ischaemic attack(TIA)at national scale are less known.Methods Data were obtained from the three phases of China National Stroke Registry(CNSR),including CNSR-Ⅰ(years 2007-2008),CNSR-Ⅱ(years 2012-2013)and CNSR-III(years 2015-2018).For comparison,patients who were diagnosed as ischaemic stroke or TIA were included.Kaplan-Meier estimates of myocardial infarction(MI)or vascular death were calculated at 1 year.Independent predictors were further assessed with a Cox proportional hazards regression.Results From 2007 to 2018,a total of 50284 patients with ischaemic stroke or TIA were enrolled in this study.A declining trend was found in 1-year MI or vascular death(p for trend<0.001),while recurrent stroke depicted a U-shape curve with a nadir in 2012-2013 cohort.A similar trend was also observed in patients who were admitted to 26 hospitals in all three CNSRs.In 2015-2018 cohort,only 251(1.7%;95%CI 1.5%to 1.9%)MI or vascular death had occurred at 1 year.Older age,previous stroke or TIA,history of coronary artery disease and the National Institutes of Health Stroke Scale>6 were associated with both an increased risk of MI or vascular death and recurrent stroke.While early antiplatelet therapy and lipid-lowering agents at discharge predicted a reduced risk.Conclusion A declining trend and current low incidence of MI or vascular death,rather than recurrent stroke,after ischaemic stroke or TIA were observed in China.Traditional factors were found as independent predictors.These findings suggested there is still much room to improve for stroke management. | Long Li Yuesong Pan Mengxing Wang Jing Jing Xia Meng Yong Jiang Caixia Guo Zening Jin Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 4 |
| 6 | Microfluidic actuators based on temperature-responsive hydrogels显示文摘The concept of using stimuli-responsive hydrogels to actuate fluids in microfluidic devices is particularly attractive,but limitations,in terms of spatial resolution,speed,reliability and integration,have hindered its development during the past two decades.By patterning and grafting poly(N-isopropylacrylamide)PNIPAM hydrogel films on plane substrates with a 2μm horizontal resolution and closing the system afterward,we have succeeded in unblocking bottlenecks that thermo-sensitive hydrogel technology has been challenged with until now.In this paper,we demonstrate,for the first time with this technology,devices with up to 7800 actuated micro-cages that sequester and release solutes,along with valves actuated individually with closing and opening switching times of 0.6±0.1 and 0.25±0.15 s,respectively.Two applications of this technology are illustrated in the domain of single cell handling and the nuclear acid amplification test(NAAT)for the Human Synaptojanin 1 gene,which is suspected to be involved in several neurodegenerative diseases such as Parkinson’s disease.The performance of the temperature-responsive hydrogels we demonstrate here suggests that in association with their moderate costs,hydrogels may represent an alternative to the actuation or handling techniques currently used in microfluidics,that are,pressure actuated polydimethylsiloxane(PDMS)valves and droplets. | Loïc D'Eramo Benjamin Chollet Marie Leman Ekkachai Martwong Mengxing Li Hubert Geisler Jules Dupire Margaux Kerdraon Clémence Vergne Fabrice Monti Yvette Tran Patrick Tabeling | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 7 | Hymecromone:a clinical prescription hyaluronan inhibitor for efficiently blocking COVID-19 progression显示文摘Currently,there is no effective drugs for treating clinically COVID-19 except dexamethasone.We previously revealed that human identical sequences of SARS-CoV-2 promote the COVID-19 progression by upregulating hyaluronic acid(HA).As the inhibitor of HA synthesis,hymecromone is an approved prescription drug used for treating biliary spasm.Here,we aimed to investigate the relation between HA and COVID-19,and evaluate the therapeutic effects of hymecromone on COVID-19.Firstly,HA was closely relevant to clinical parameters,including lymphocytes(n=158;r=−0.50;P<0.0001),C-reactive protein(n=156;r=0.55;P<0.0001),D-dimer(n=154;r=0.38;P<0.0001),and fibrinogen(n=152;r=0.37;P<0.0001),as well as the mass(n=78;r=0.43;P<0.0001)and volume(n=78;r=0.41;P=0.0002)of ground-glass opacity,the mass(n=78;r=0.48;P<0.0001)and volume(n=78;r=0.47;P<0.0001)of consolidation in patient with low level of hyaluronan(HA<48.43 ng/mL).Furthermore,hyaluronan could directly cause mouse pulmonary lesions.Besides,hymecromone remarkably reduced HA via downregulating HAS2/HAS3 expression.Moreover,89%patients with hymecromone treatment had pulmonary lesion absorption while only 42%patients in control group had pulmonary lesion absorption(P<0.0001).In addition,lymphocytes recovered more quickly in hymecromone-treated patients(n=8)than control group(n=5)(P<0.05).These findings suggest that hymecromone is a promising drug for COVID-19 and deserves our further efforts to determine its effect in a larger cohort. | Shuai Yang Yun Ling Fang Zhao Wei Li Zhigang Song Lu Wang Qiuting Li Mengxing Liu Ying Tong Lu Chen Daoping Ru Tongsheng Zhang Kaicheng Zhou Baolong Zhang Peng Xu Zhicong Yang Wenxuan Li Yuanlin Song Jianqing Xu Tongyu Zhu Fei Shan Wenqiang Yu Hongzhou Lu | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 2 |
| 8 | Global existence and stability of solutions for reaction diffusion functional differential equations显示文摘 | He Mengxing | 1996 | J Math Anal Appl1996，199，3： | 1 |
| 9 | Combined effects of anions on arsenic removalby iron hydroxides 显示文摘 | MengX Korfiatis G P Bang S | 2002 | Toxicology Letters2002，133，1： | 1 |
| 10 | Tissue distribution and expression of signaling lymphocyte activation molecule receptor to peste des petits ruminant virus in goats detected by real-time PCR 显示文摘 | MengX Dou Y Zhai J | 2011 | Mol Hist2011，42，： | 1 |
| 11 | Both low and high temperature may increase the risk of stroke mortality显示文摘 | ChenR WangC MengX | 2013 | Neurology2013，81，10： | 1 |
| 12 | Alpine tundra soil in Changbai Mountain显示文摘 | MengX X 1982 | 1982 | Scientia Geographica Sinica1982，2，1： | 1 |
| 13 | The oscillations of hyperbolic functional differential equations 显示文摘 | Anping Liu | | Applied Mathematics and Computation0，142，： | 1 |
| 14 | Influence of needlegauge on in vivo ultrasound and microbubble-mediated genetransfection显示文摘 | Richard JB Helen M Mengxing T | 2011 | Ultrasound Med Biol2011，37，9： | 1 |
| 15 | Effects of applied voltages on hydroxyapatite coating of titanium by electrophoretic deposition显示文摘 | MengX Kwon TY YangY | | 0，，02： | 1 |
| 16 | Stability for large systems of partial functional differential equations : iterative analysis method 显示文摘 | Mengxing He Anping Liu Zhuoling Ou | 2002 | Appl Math Comput2002，132，： | 1 |
| 17 | Global Existence and Stability of Solutions for Reaction Diffusion Functional Differential Equations显示文摘 | Mengxing He | 1996 | J Math Anal Appl1996，199，： | 1 |
| 18 | Asymptotic Behavior and Convergence of Solutions of a Semili-near Transport Equation with Delay 显示文摘 | Mengxing He Ronggui Luo | 2001 | Journal of Mathematical Analysis and Applications2001，254，： | 1 |
| 19 | A novel tomato MYC-type ICEl-like transcription factor, SIICEla, confers cold, osmotic and salt tolerance in transgenic tobacco 显示文摘 | FengHL MANN MengX etal | 2013 | Plant Physiology and Biochemistry2013，73，： | 1 |
| 20 | Involved-fieldirradiationindefini-tivechemoradiotherapyforlocallyadvancedesophagealsquamouscellcarcinoma显示文摘 | ZhangX LiM MengX etal | 2014 | RadiationOncology2014，9，： | 1 |
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