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| 1 | Effects of aminoguanidine on nitric oxide production induced by inflammatory cytokines and endotoxin in cultured rat hepatocytes显示文摘AIM To study the effects of aminoguanidine(AG) and two L-arginine analogues Nω-nitro-L-arginine methyl ester (L-NAME) and Nω-nitro-L-arginine (L-NNA) on nitric oxide (NO) productioninduced by cytokines (TNF-α, IL-11β, and IFN-γ)and bacterial lipopolysaccharide (LPS) mixture(CM) in the cultured rat hepatocytes, andexamine their mechanisms action.METHODS Rat hepatocytes were incubatedwith AG, L-NAME, L-NNA, Actinomycin D (ActD)and dexamethasene in a medium containing CM(LPS plus TNF-α, IL-1β, and IFN-γ) for 24 h. NOproduction in the cultured supernatant wasmeasured with the Griese reaction. IntracellularcGMP level was detected with radioimmunoasey.RESULTS NO production was markedlyblocked by AG and L-NAME in a dose-dependentmanner under inflammatory stimuli conditiontriggered by CM in vitro. The rate of themaximum inhibitory effects of L-NAME (38.9%)was less potent than that obtained with AG(53.7%, P<0.05). There was no significantdifference between the inhibitory effects of AGand two L-arginine analogues on intracellularcGMP accumulation in rat cultured hepatocytes.Non-specific NOS expression inhibitordexamethasone ( DEX ) and iNOS mRNAtranscriptional inhibitor ActD also significantlyinhibited CM-induced NO production. AG(0.1mmol.L-1) and ActD (0.2ng@Lt) wereequipotent in decreasing NO production inducedby inflammatory stimuli in vitro, and botheffects were more potent than that induced bynon-selectivity NOS activity inhibitor L-NAME(0. 1 mmol@ L- 1) under similar stimuli conditions(P | Guo Liang Zhang Ye Hong Wang Hui Ling Teng Zhi Bin Lin Department of Pharmacology,School of Basic Medical Sciences,Beijing University,Beijiog 100083,ChinaDr.Guo Liang Zhang graduated from Xinxiang Medical College in 1982,got Ph.D.at Nagoya City University Medical School,Japan in 1994,finished postdoctoral research at Beijing Medical Univcrsity in 1996,now an associate professor of pharmacology,specialized in hepatic pharmacology,having 15 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 20 |
| 2 | Carcinogenicity testing of phthalate esters and related compounds by NTP显示文摘 | 1982 | 1982 | Environ Health Persp1982，45，： | 1 |
| 3 | Vesicular-arbuscular mycorrhizae of southern Ontario ferns and fern-allies 显示文摘 | Berch SM Kendrick B 1982 | 1982 | Mycologia1982，74，： | 1 |
| 4 | Theoretical study of the effect of soil surfaceshape upon the soil temperature profile显示文摘 | Mahrer Y A 1982 | 1982 | J Soil Sci1982，134，6： | 1 |
| 5 | Hepatic effects of phthalate esters显示文摘 | 1982 | 1982 | Environ Health Perspectives1982，45，： | 1 |
| 6 | Adsorption of phthalic acid esters from sea water显示文摘 | Atlas E L Giam C S 1982 | 1982 | Environ Sci Technol1982，16，： | 1 |
| 7 | Determining the concentration of easily assimilable organic carbon in drinking water显示文摘 | Van der Kooij D Visser A Hijnen W A M 1982 | 1982 | J AWWA1982，74，10： | 1 |
| 8 | Sound velocity andrelated properties of marine sediments显示文摘 | HAMILTON E L BACHMAN R T 1982 | 1904 | The Journal of theAcoustical Society of America1904，72，6： | 1 |
| 9 | 显示文摘 | 吴宗济.? 普通话语句中的声调变化(J)中国语文. 1982 (06) | 1982 | 中国语文1982，，06： | 1 |
| 10 | Partitioning of organic compounds in octanol-water system显示文摘 | Chiou C T Schmedding D W Manes M 1982 | 1982 | Environ Sci Technol1982，16，： | 1 |
| 11 | Alpine tundra soil in Changbai Mountain显示文摘 | MengX X 1982 | 1982 | Scientia Geographica Sinica1982，2，1： | 1 |
| 12 | In chromosome number reports LXXⅦ显示文摘 | Baker M Parfitt B 1982 | 1982 | Taxon1982，31，： | 1 |
| 13 | Problems of application of the ecological model, SALMO, to lakes and reservoir having various trophic states 显示文摘 | Benndorf J Recknagel F 1982 | 1982 | Ecol Model1982，17，： | 1 |
| 14 | Strouhal numbers of rectangular cylinders显示文摘 | Okajima A 1982 | 1982 | Journal of Fluid Mechanics1982，123，： | 1 |
| 15 | Plant mimicry:evolutionary constraints显示文摘 | WilliamsonGB 1982 | 1982 | Biol J Linn Soc1982，18，： | 1 |
| 16 | Adsorption of arsenite and arsenate on amorphous iron hydroxide显示文摘 | Pierce M L Moore C B 1982 | 1982 | Water Research1982，16，7： | 1 |
| 17 | Transitivity in a Czech folk tale 显示文摘 | Kalmdr L 1982 | 1982 | Syntax and Semantics1982，，15： | 1 |
| 18 | 显示文摘 | 李政文.? 苏联杂志介绍加西亚·马尔克斯及其创作(J)外国文学动态. 1982 (12) | 1982 | 外国文学动态1982，，12： | 1 |
| 19 | The use of ecological terms in parasitology显示文摘 | Margolis L Esch G W Holmes J C 1982 | 1982 | The Journal of Parasitology1982，68，： | 1 |
| 20 | Generic evaluation of the wheatgrass显示文摘 | L(o)ve A 1982 | 1982 | Biologisches Zentralblatt1982，101，： | 1 |
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