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| 1 | TGF-β and BMP signaling in osteoblast,skeletal development,and bone formation,homeostasis and disease显示文摘Transforming growth factor-beta(TGF-β) and bone morphogenic protein(BMP) signaling has fundamental roles in both embryonic skeletal development and postnatal bone homeostasis.TGF-βs and BMPs,acting on a tetrameric receptor complex,transduce signals to both the canonical Smad-dependent signaling pathway(that is,TGF-β/BMP ligands,receptors,and Smads) and the non-canonical-Smad-independent signaling pathway(that is,p38 mitogen-activated protein kinase/p38 MAPK) to regulate mesenchymal stem cell differentiation during skeletal development,bone formation and bone homeostasis.Both the Smad and p38 MAPK signaling pathways converge at transcription factors,for example,Runx2 to promote osteoblast differentiation and chondrocyte differentiation from mesenchymal precursor cells.TGF-β and BMP signaling is controlled by multiple factors,including the ubiquitin–proteasome system,epigenetic factors,and micro RNA.Dysregulated TGF-β and BMP signaling result in a number of bone disorders in humans.Knockout or mutation of TGF-β and BMP signaling-related genes in mice leads to bone abnormalities of varying severity,which enable a better understanding of TGF-β/BMP signaling in bone and the signaling networks underlying osteoblast differentiation and bone formation.There is also crosstalk between TGF-β/BMP signaling and several critical cytokines' signaling pathways(for example,Wnt,Hedgehog,Notch,PTHr P,and FGF) to coordinate osteogenesis,skeletal development,and bone homeostasis.This review summarizes the recent advances in our understanding of TGF-β/BMP signaling in osteoblast differentiation,chondrocyte differentiation,skeletal development,cartilage formation,bone formation,bone homeostasis,and related human bone diseases caused by the disruption of TGF-β/BMP signaling. | Mengrui Wu Guiqian Chen Yi-Ping Li | 2016 | Bone Research2016，4，1： | 123 |
| 2 | Flexible N-Doped reduced graphene oxide/carbon Nanotube-MnO_(2) film as a Multifunctional Material for High-Performance supercapacitors, catalysts and sensors显示文摘A flexible 3D N-doped reduced graphene oxide(N-RGO)/carbon nanotube(CNT)eMnO_(2) hybrid film was constructed with outstanding supercapacitor,excellent oxygen reduction reaction(ORR)and good sensing performances.The resultant hybrid film possessed large specific capacitances of 418 F g^(-1) and 209 mF cm^(-2) in aqueous and solid electrolytes,and outstanding capacitance retentions of 95% and 94% were obtained for both electrolytes after experiencing 5000 cycles.A simple supercapacitor based on the resultant flexible hybrid film was further fabricated with a much smaller time constant τ0(0.38 s)than that of typical activated-carbon supercapacitors,suggesting a quick response frequency.Moreover,the assembled supercapacitor device showed high energy densities of 45.72 and 92.13 Wh kg^(-1) and simultaneously sustained large power densities of 12,526 and 15873 W kg^(-1) under a scan rate of 50 mV s^(-1) in aqueous and solid electrolytes,respectively.Furthermore,the resultant flexible film showed excellent performance in the ORR and can also be used to assemble a strain sensor with an excellent sensing performance for bending strain. | Chuanyin Xiong Mengrui Li Wei Zhao Chao Duan Yonghao Ni | 2020 | Journal of Materiomics2020，6，3： | 6 |
| 3 | Tomato SlPUB24 enhances resistance to Xanthomonas euvesicatoria pv. perforans race T3显示文摘Solanum lycopersicum var.cerasiforme accession PI 114490 has broad-spectrum resistance to bacterial spot caused by several species of Xanthomonas.Resistance is quantitatively inherited,and a common quantitative trait locus QTL-11B on chromosome 11 has been identified previously.In this study,the SlPub24 gene was characterized in QTL-11B.SlPub24 in PI 114490 was upregulated by infection with X.euvesicatoria pv.perforans race T3,but its transcription was low in the susceptible line OH 88119 whether or not it was infected by the pathogen.The differential expression of SlPub24 between PI 114490 and OH 88119 was due to great sequence variation in the promoter region.The promoter of SlPub24 in OH 88119 had very low activity and did not respond to pathogen infection.Transgenic lines of OH 88119 overexpressing SlPub24 isolated from PI 114490 showed significantly enhanced resistance,while mutants of Slpub24 generated by CRISPR/Cas9 editing showed more susceptibility to race T3 and to other races.The mutants also showed spontaneous cell death in leaves.The expression of the salicylic acid(SA)pathway gene phenylalanine ammonia-lyase(PAL)and signaling-related genes pathogenesis-related(PR1)and nonexpresser of PR1(NPR1)were influenced by SlPub24.The content of SA in tomato plants was consistent with the level of SlPub24 expression.Furthermore,SlPUB24 interacted with the cell wall protein SlCWP and could regulate the degradation of SlCWP.The expression levels of SlCWP and SlCWINV1,a cell wall invertase gene,showed opposite patterns during pathogen infection.The activity of SlCWINV1 was lower in mutants than in PI 114490.The results are discussed in terms of the roles of the abovementioned genes,and a potential model for SlPUB24-mediated resistance to bacterial spot is proposed. | Xin Liu Ge Meng Mengrui Wang Zilin Qian Yaxian Zhang Wencai Yang | 2021 | Horticulture Research2021，8，1： | 4 |
| 4 | Hierarchically porous, ultrathin N–doped carbon nanosheets embedded with highly dispersed cobalt nanoparticles as efficient sulfur host for stable lithium–sulfur batteries显示文摘The sluggish redox kinetics and shuttle effect of soluble polysulfides intermediate primarily restrict the electrochemical performance of lithium–sulfur(Li–S) batteries. To address this issue, rational design of high–efficiency sulfur host is increasingly demanded to accelerate the polysulfides conversion during charge/discharge process. Herein, we propose a macro–mesoporous sulfur host(Co@NC), which comprises highly dispersed cobalt nanoparticles embedding in N–doped ultrathin carbon nanosheets. Co@NC is simply synthesized via a carbon nitride–derived pyrolysis approach. Owing to the highly conductive graphene–like matrix and well defined porous structure, the designed multifunctional Co@NC host enables rapid electron/ion transport, electrolyte penetration and effective sulfur trapping. More significantly,N heteroatoms and homogeneous Co nanocatalysts in the graphitic carbon nanosheets could serve as chemisorption sites as well as electrocatalytic centers for sulfur species. These Co–N active sites can synergistically facilitate the redox conversion kinetics and mitigate the shuttling of polysulfides, thus leading to improved electrochemical cycling performance of Li–S batteries. As a consequence, the S/Co@NC cathode demonstrates high initial specific capacity(1505 mA h g-1 at 0.1 C) and excellent cycling stability at 1 C over 300 cycles, giving rise to a capacity retention of 91.7% and an average capacity decline of 0.03%cycle-1. | Mengrui Wang Xunfu Zhou Xin Cai Hongqiang Wang Yueping Fang Xinhua Zhong | 2020 | Journal of Energy Chemistry2020，29，11： | 3 |
| 5 | Screen printing fabricating patterned and customized full paper-based energy storage devices with excellent photothermal,self-healing,high energy density and good electromagnetic shielding performances显示文摘Supercapacitors are favored by researchers because of their high power density,especially with the acceleration of people’s life rhythm.However,their energy density,especially from the point of view of the whole energy storage device,is far lower than that of commercial batteries.In this work,a kind of customizable full paper-based supercapacitor device with excellent self-healing ability is fabricated by simple and low-cost screen printing,electropolymerization and dip coating methods.The resultant separatorfree supercapacitor device exhibits both ultrahigh gravimetric and areal specific energy(power)densities of 39 Wh kg^(-1)(69 k W kg^(-1))and 692μWh cm^(-2)(236 m W cm^(-2)),achieving excellent supercapacitor performance.Notably,the addition of vitrimers endows the whole device with outstanding self-healing properties,which is helpful for enhancing the adaptability of the device to the environment.In addition,this kind of paper-based device also displays good photothermal and electromagnetic shielding performances.These striking features make paper matrix composites attractive in the fields of supercapacitors,medical photothermal treatment and electromagnetic shielding. | Chuanyin Xiong Mengrui Li Qing Han Wei Zhao Lei Dai Yonghao Ni | 2022 | Journal of Materials Science & Technology2022，，2： | 2 |
| 6 | 4.1N suppresses hypoxia-induced epithelial-mesenchymal transition inepithelial ovarian cancer cells显示文摘 | Letian Zhang Ajin Hu Mengrui Li Hongquan Zhang Caixia Ren Xiuli An Congrong Liu | 2016 | Molecular Medicine Reports2016，，： | 1 |
| 7 | Wnt signaling:Essential roles in osteoblast differentiation,bone metabolism and therapeutic implications for bone and skeletal disorders显示文摘Wnt signaling executes an indispensable performance in osteoblast differentiation,bone development,homeostasis,and remodeling.Wnt signals trigger the intracellular Wnt signaling cascade to initiate regulating the implication of b-catenin in the bone environment.Going through the novel discoveries done via high-throughput sequencing technologies on ge-netic mouse models,we highlighted the significant contribution of Wnt ligands,co-receptors,inhibitors,their related skeletal phenotypes in mouse models and the similar bone disorders clinically observed in human beings.Moreover,the crosstalk between Wnt signaling pathway and BMP,TGF-b,FGF,Hippo,Hedgehog,Notch and PDGF signaling pathways is thoroughly demonstrated to be the underlying gene regulatory network that orchestrates osteoblast dif-ferentiation and bone development.We also introspected the significance of Wnt signaling transduction in the reorganization of cellular metabolism by stimulating glycolysis,glutamine catabolism,and fatty acid oxidation in osteoblast-lineage cells that display an important reg-ulatory arbor in the cellular bioenergetics of the bone.Throughout this evaluation,most to date therapeutical approaches towards osteoporosis and other bone maladies found in human beings,are formulated with an aspiration to holistically revamp the present clinical applica-tions involving various monoclonal antibodies therapies that lack specificity,efficacy,and safety into more requisite advanced therapeutics that satisfy these three requirements for further clinical considerations.Conclusively,our review provides comprehensive scientific findings related to the fundamental significance of Wnt signaling cascades in skeletal system and the underlying gene regulatory network with other signaling pathways enlightening re-searchers with the possibility to further integrate the identified target molecules into thera-peutic strategies for skeletal disorders treatment in the clinic. | Rexhina Vlashi Xingen Zhang Mengrui Wu Guiqian Chen | 2023 | Genes & Diseases2023，10，4： | 1 |
| 8 | Coactivator-associated arginine methyltransferase 1: A versatile player in cell differentiation and development显示文摘Protein arginine methylation is a common post-translational modification involved in the regulation of various cellular functions. Coactivator-associated arginine methyltransferase 1 (CARM1) is a protein arginine methyltransferase that asymmetrically dimethylates histone H3 and non-histone proteins to regulate gene transcription. CARM1 has been found to play important roles in cell differentiation and development, cell cycle progression, autophagy, metabolism, pre-mRNA splicing and transportation, and DNA replication. In this review, we describe the molecular characteristics of CARM1 and summarize its roles in the regulation of cell differentiation and development in mammals. | Zhongrui Ma Xinxing Lyu Ning Qin Haoyu Liu Mengrui Zhang Yongchao Lai Bo Dong Peiyuan Lu | 2023 | Genes & Diseases2023，10，6： | 0 |
| 9 | The roles and regulatory mechanisms of TGF-β and BMP signaling in bone and cartilage development, homeostasis and disease显示文摘Transforming growth factor-βs (TGF-βs) and bone morphometric proteins (BMPs) belong to the TGF-β superfamily and perform essential functions during osteoblast and chondrocyte lineage commitment and differentiation, skeletal development, and homeostasis. TGF-βs and BMPs transduce signals through SMAD-dependent and -independent pathways;specifically, they recruit different receptor heterotetramers and R-Smad complexes, resulting in unique biological readouts. BMPs promote osteogenesis, osteoclastogenesis, and chondrogenesis at all differentiation stages, while TGF-βs play different roles in a stage-dependent manner. BMPs and TGF-β have opposite functions in articular cartilage homeostasis. Moreover, TGF-β has a specific role in maintaining the osteocyte network. The precise activation of BMP and TGF-β signaling requires regulatory machinery at multiple levels, including latency control in the matrix, extracellular antagonists, ubiquitination and phosphorylation in the cytoplasm, nucleus-cytoplasm transportation, and transcriptional co-regulation in the nuclei. This review weaves the background information with the latest advances in the signaling facilitated by TGF-βs and BMPs, and the advanced understanding of their diverse physiological functions and regulations. This review also summarizes the human diseases and mouse models associated with disordered TGF-β and BMP signaling. A more precise understanding of the BMP and TGF-β signaling could facilitate the development of bona fide clinical applications in treating bone and cartilage disorders. | Mengrui Wu Shali Wu Wei Chen Yi-Ping Li | 2024 | Cell Research2024，34，2： | 0 |
| 10 | High Spin States in A≈50 Region显示文摘The present experiment was carried out at HI-13 tandem accelerator of the China Institute of Atomic Energy in Beijing. High spin states in ^52Mn, ^53Mn and ^54Mn were populated via ^12C+^48Ti fusion evaporation reactions at beam energy of 55-85 MeV. The target was a ^48Ti foil with a thickness of 1.5mg/cm^2, backed with a lead laver of about 20mg/cm^2 to stop the recoils. | WUXiao-guang ZHULi-hua WENShu-xian LIGuang-sheng ZHANGZhen-long MENGRui CUIXing-zhu HEChuang-ye WANGZhi-min MARui-gang YANGChun-xiang | 2003 | Annual Report of China Institute of Atomic Energy2003，，1： | 0 |
| 11 | The haplotype-resolved T2T genome of teinturier cultivar Yan73 reveals the genetic basis of anthocyanin biosynthesis in grapes显示文摘Teinturier grapes are characterized by the typical accumulation of anthocyanins in grape skin,flesh,and vegetative tissues,endowing them with high utility value in red wine blending and nutrient-enriched foods developing.However,due to the lack of genome information,the mechanism involved in regulating teinturier grape coloring has not yet been elucidated and their genetic utilization research is still insufficient.Here,the cultivar‘Yan73’was used for assembling the telomere-to-telomere(T2T)genome of teinturier grapes by combining the High Fidelity(HiFi),Hi-C and ultralong Oxford Nanopore Technologies(ONT)reads.Two haplotype genomes were assembled,at the sizes of 501.68 Mb and 493.38 Mb,respectively.In the haplotype 1 genome,the transposable elements(TEs)contained 32.77%of long terminal repeats(LTRs),while in the haplotype 2 genome,31.53%of LTRs were detected in TEs.Furthermore,obvious inversions were identified in chromosome 18 between the two haplotypes.Transcriptome profiling suggested that the gene expression patterns in‘Cabernet Sauvignon’and‘Yan73’were diverse depending on tissues,developmental stages,and varieties.The transcription program of genes in the anthocyanins biosynthesis pathway between the two cultivars exhibited high similarity in different tissues and developmental stages,whereas the expression levels of numerous genes showed significant differences.Compared with other genes,the expression levels of VvMYBA1 and VvUFGT4 in all samples,VvCHS2 except in young shoots and VvPAL9 except in the E-L23 stage of‘Yan73’were higher than those of‘Cabernet Sauvignon’.Further sequence alignments revealed potential variant gene loci and structure variations of anthocyanins biosynthesis related genes and a 816 bp sequence insertion was found in the promoter of VvMYBA1 of‘Yan73’haplotype 2 genome.The‘Yan73’T2T genome assembly and comparative analysis provided valuable foundations for further revealing the coloring mechanism of teinturier grapes and the genetic improvement of grape coloring traits. | Kekun Zhang Mengrui Du Hongyan Zhang Xiaoqian Zhang Shuo Cao Xu Wang Wenrui Wang Xueqiang Guan Penghui Zhou Jin Li Wenguang Jiang Meiling Tang Qiuling Zheng Muming Cao Yongfeng Zhou Keqin Chen Zhongjie Liu Yulin Fang | 2023 | Horticulture Research2023，10，11： | 0 |
| 12 | Effects of fiber orientation on tool wear evolution and wear mechanism when cutting carbon fiber reinforced plastics显示文摘The aim of the present paper is to reveal the influence of different fiber orientations on the tool wear evolution and wear mechanism. Side-milling experiments with large-diameter milling tools are conducted. A finite element(FE) cutting model of carbon fiber reinforced plastics(CFRP)is established to get insight into the cutting stress status at different wear stages. The results show that different fiber orientations bring about distinct differences in the extent, profile and mechanism of tool wear. Severer wear occurs when cutting 45° and 90° plies, followed by 0°, correspondingly,the least wear is obtained when θ = 135°(θ represents the orientation of fibers). Moreover, the worn profiles of cutting tools when θ = 0° and 45° are waterfall edge, while round edge occurs whenθ = 135° and a combined shape of waterfall and round edge is obtained when θ = 90°. The wear mechanisms under different fiber orientations are strongly dependent on the cutting stress distributions. The evolution of tool wear profile is basically consistent with the stress distribution on the tool surface at different wear stages, and the extent of tool wear is determined by the magnitude of stress on the tool surface. Besides, the worn edges produce an actual negative clearance angle,which decreases the actual cutting thickness and leads to compressing and bending failure of fibers beneath the cutting region as well as low surface qualities. | Weizhou WU Shipeng LI Xuda QIN Wentao LIU Xin CUI Hao LI Mengrui SHI Haibao LIU | 2023 | Chinese Journal of Aeronautics2023，36，5： | 0 |
| 13 | Regulatory Effects of Xylooligosaccharides on Intestinal Microbial Flora Proliferation and Defecation of BALB/c Mice显示文摘[Objective] This study aimed to investigate the regulatory effects of xylooligosaccharides on intestinal microbial flora proliferation and defecation of BALB/c mice.[Method] In the intestinal microbial flora proliferation regulation experiment, microflora quantities of Bifidobacterium, Lactobacillus, Enterobacter and Enterococci in excrements of BALB/c mice were determined after continuous administration of high-dose[1.0 g/(kg·bw)] and low-dose[0.5 g/(kg·bw)] xylooligosaccharides for 14 d.In the defecation regulation experiment, constipation model of BALB/c mice was established with compound diphenoxylate after continuous administration of high-dose and low-dose xylooligosaccharides for 21 d, to determine the first defecation time of black excrement, weight of black excrements within 6 h and rate of intestinal propulsion of constipation mice.[Result] Compared with the control group, after continuous administration of xylooligosaccharides for 14 d, microflora quantities of Lactobacillus and Bifidobacterium in excrements of BALB/c mice in low-dose and high-dose groups both increased significantly (P<0.05).After continuous administration of xylooligosaccharides, microflora quantities of Enterococci and Lactobacillus in control group were significantly raised (P<0.05 and P<0.01, respectively) compared with those before administration; microflora quantities of Enterococci in high-dose and low-dose groups were significantly reduced (P<0.05), while microflora quantities of Lactobacillus and Bifidobacterium and the B/E value increased significantly (P<0.05, P<0.01 and P<0.01, respectively).After continuous administration of xylooligosaccharides for 21 d, compared with the model group, the first defecation time of black excrement in high-dose and low-dose groups was significantly shortened (P<0.05), the total weight of black excrements within 6 h increased significantly (P<0.05) and the rate of intestinal propulsion was significantly enhanced (P<0.01).[Conclusion] Low-dose (0.5 g/Kg.bw) and high-dose (1 g/Kg.bw) xylooligosaccharides can improve the proliferation of intestinal microbial flora and prevent mice from constipation. | Tao WEI Hongtao SHANG Zhaolan GAO Li WANG Siyu LI Xue HUANG Mengrui ZHENG | 2013 | Agricultural Biotechnology2013，2，3： | 0 |
| 14 | A Novel Tuning Method for Predictive Control of VAV Air Conditioning System Based on Machine Learning and Improved PSO显示文摘The variable air volume(VAV)air conditioning system is with strong coupling and large time delay,for which model predictive control(MPC)is normally used to pursue performance improvement.Aiming at the difficulty of the parameter selection of VAV MPC controller which is difficult to make the system have a desired response,a novel tuning method based on machine learning and improved particle swarm optimization(PSO)is proposed.In this method,the relationship between MPC controller parameters and time domain performance indices is established via machine learning.Then the PSO is used to optimize MPC controller parameters to get better performance in terms of time domain indices.In addition,the PSO algorithm is further modified under the principle of population attenuation and event triggering to tune parameters of MPC and reduce the computation time of tuning method.Finally,the effectiveness of the proposed method is validated via a hardware-in-the-loop VAV system. | Ning He Kun Xi Mengrui Zhang Shang Li | 2022 | Journal of Beijing Institute of Technology2022，31，4： | 0 |
| 15 | Total Synthesis and High Performance Liquid Chromatography Analysis of Phenylethanolamine A显示文摘 | WANG Tongtong SONG Yinqing WANG Min TANG Xiaoyan ZHOU Jian YANG Mengrui | 2017 | Chemical Research in Chinese Universities2017，33，4： | 0 |
| 16 | Existence of Boundary Value Problems for Impulsive Fractional Differential Equations with a Parameter显示文摘We investigate a class of boundary value problems for nonlinear impulsive fractional differential equations with a parameter.By the deduction of Altman’s theorem and Krasno-selskii’s fixed point theorem,the existence of this problem is proved.Examples are given to illustrate the effectiveness of our results. | Jin You Mengrui Xu Shurong Sun | 2021 | Communications on Applied Mathematics and Computation2021，3，4： | 0 |
| 17 | Osteoarthritis versus psoriasis arthritis: Physiopathology, cellular signaling, and therapeutic strategies显示文摘Osteoarthritis and psoriasis arthritis are two degenerative forms of arthritis that share similar yet also different manifestations at the histological,cellular,and clinical levels.Rheumatologists have marked them as two entirely distinct arthropathies.Given recent dis-coveries in disease initiation and progression,potential mechanisms,cellular signaling path-ways,and ongoing clinical therapeutics,there are now more opportunities for discovering osteoarthritis drugs.This review summarized the osteoarthritis and psoriasis arthritis signaling pathways,crosstalk between BMP,WNT,TGF-β,VEGF,TLR,and FGF signaling pathways,bio-markers,and anatomical pathologies.Through bench research,we demonstrated that regen-erative medicine is a promising alternative for treating osteoarthritis by highlighting significant scientific discoveries on entheses,multiple signaling blockers,and novel molecules such as immunoglobulin new antigen receptors targeted for potential drug evaluation.Furthermore,we offered valuable therapeutic approaches with a multidisciplinary strategy to treat patients with osteoarthritis or psoriasis arthritis in the coming future in the clinic. | Salma Nassor Juma Junguang Liao Yuping Huang Rexhina Vlashi Qingwan Wang Bocong Wu Dan Wang Mengrui Wu Guiqian Chen | 2024 | Genes & Diseases2024，11，3： | 0 |
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