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| 1 | Nd-doped structurally disordered YSr_(3)(PO_(4))_(3) single crystal:Growth and laser performances显示文摘Disordered-structure crystals have drawn increasing attention as promising ultrashort laser material hosts owing to their broad linewidth.Herein,a novel disordered Nd:YSr_(3)(PO_(4))_(3)(Nd:YSP)crystal with good quality was successfully grown via the Czochralski pulling technique.The absorption and fluorescence spectra of the Nd:YSP single crystal were recorded at ambient temperature.The maximum absorption cross section for Nd:YSP single crystal is found to be approximately 3.89×10^(-20) cm^(2).The stimulated emission cross section for Nd:YSP crystal at~1060 nm was determined to be 7.64×10^(20) cm^(2) with the full width half maximum value of 22 nm.The fluorescence lifetime of the Nd3+ions in the Nd:YSP crystal is fitted to be 288μs.Diode-pumped continuous-wave laser operation is firstly realized at approximately 1060 nm.The maximum output power value from the Nd:YSP crystal is 714 mW,corresponding to a slope efficiency of-12.8%.The results indicate that the Nd:YSP crystal with a disordered structure may be a promising disordered laser host. | Guangda Wu Xiaoqin Yin Mengdi Fan Fapeng Yu Shuzhen Fan Zhengping Wang Xian Zhao | 2021 | Journal of Rare Earths2021，39，12： | 2 |
| 2 | Electro-elastic features of YBa3(PO_(4))3 and YbBa3(PO_(4))3 crystals with pure face-shear mode for acoustic wave sensor applications显示文摘The fundamental shear horizontal(SH0)waves have been proved to be a very useful method for nondestructive testing due to their non-dispersive characteristics.Currently,although several methods have been proposed to generate SH0 waves,it is still a challenge to obtain pure SH0 wave mode efficiently.Herein,in this study,non-centrosymmetric YBa3(PO_(4))3(YBP)and YbBa3(PO_(4))3(YbBP)crystals with pure face-shear mode were grown via the traditional Czochralski pulling method at temperatures above 1800℃.High resolution X-ray diffraction was carried out to evaluate the crystalline quality.Results showed that the YBP and YbBP crystals were of good quality,with the full width at half-maxima being on the order of 42.500 and 52.300,respectively.Moreover,the full set of electro-elastic constants for the YBP and YbBP crystals were determined and collated using a combination of impedance and pulse-echo methods.The piezoelectric coefficient(d14)of the YBP and YbBP crystals were determined to be 10.6 pC/N and 11.4 pC/N,respectively,corresponding to the electromechanical coupling coefficient(k14)equal to 15.4%and 15.9%,exhibiting large and pure face-shear vibration mode.Collectively,these results indicate that the YBP and YbBP crystals are promising for acoustic wave sensing application. | Guangda Wu Lingkai Kong Mengdi Fan Fapeng Yu Chao Jiang Xiufeng Cheng Xian Zhao | 2021 | Journal of Materiomics2021，7，4： | 0 |
| 3 | Patent Applications of Pharmaceutical Industry in Liaoning: Current Situation and Suggestions显示文摘Objective To analyze the current situation of pharmaceutical patents in Liaoning Province with the background of increasing emphasis on intellectual property rights in the pharmaceutical industry and the application of pharmaceutical-related patents having taken shape in Liaoning Province.Methods The invention patent information applied by Liaoning pharmaceutical manufacturers before December 31,2018 was obtained from Qixinbao APP,and then the retrieval data was also obtained through detailed search on patent information inquiry websites in China and other countries.The types of drug patents were separately extracted by Excel.Data analysis was carried out according to drug category,applicant type,legal status and transfer situation.Results and Conclusion A thorough discussion on the current situation of patent applications in pharmaceutical industry of Liaoning Province reveals that the number of patent applications is large but they are lack of creativity.Meanwhile,few patent applications are made by individual.Besides,there are fewer international patent applications for pharmaceutical patents in Liaoning Province.The problems in patent applications include the followings,such as insufficient patent applications and unbalanced proportion of patent applications.In order to promote the stable development of pharmaceutical market in Liaoning Province,some suggestions are raised. | Zhao Zhe Sheng Mengdi Fan Junyan Liu Yanwen Dong Li | 2019 | Asian Journal of Social Pharmacy2019，14，4： | 0 |
| 4 | Short-and medium-chain chlorinated paraffins in imported commercial dry cat and dog food in China:Concentrations,distributions and risk assessment显示文摘Chlorinated paraffins(CPs)are produced in large amounts and used worldwide.Dietary intake is the primary pathway for the exposure of pets to CPs,but limited information is available concerning the potential contamination of pet food by CPs.In the present study,the concentrations and congener group profiles of short-chain CPs(SCCPs)and medium-chain CPs(MCCPs)were assessed in 35 imported commercial dry cat and dog foods collected in China,and the estimated daily intakes of SCCPs and MCCPs for cats and dogs through the consumption of such foods was calculated.The concentrations of SCCPs and MCCPs in the cat and dog foods were determined to be in the ranges of 108e45,300 ng/g(median:1340 ng/g)and 3.8e52,700 ng/g(median:11 ng/g),respectively.The predominant congener groups were C10Cl6 for SCCPs and C14Cl7-8 for MCCPs.The high levels of CPs found in certain pet foods suggest the potential for adverse health effects. | Shujun Dong Su Zhang Ruiguo Wang Xiaolong Xia Mengdie Fan Yaxin Wang Jie Cheng Xiaomin Li Tong Li Wei Zhang Shulin Wei Yun Zou Peilong Wang | 2020 | Emerging Contaminants2020，6，1： | 0 |
| 5 | Lung cancer burden and trends from 2000 to 2018 in China:Comparison between China and the United States显示文摘Objective: This study aims to provide an analysis of the current status and trends of lung cancer incidence and mortality rates in China, comparing trends with those in the United States(U.S.).Methods: Data on lung cancer incidence and mortality rates spanning 2000 to 2018 were extracted from the China Cancer Registry Annual Report and the Surveillance, Epidemiology, and End Results database for China and the U.S., respectively. Crude incidence and mortality rates were calculated by sex and age, with age-standardized incidence rates(ASIR) and mortality rates(ASMR) calculated using the Segi-Doll world standard population.Trend analyses employed Joinpoint regression models to determine average annual percentage change(AAPC).The study also assessed the proportion of new cases and deaths by sex and age.Results: In 2018, the ASIR of lung cancer for males in China was 50.72 per 100,000 and the ASMR was 39.69 per 100,000, the ASIR for females was 26.25 per 100,000 and the ASMR was 15.24 per 100,000. Both ASIR and ASMR were higher in males and the highest in the population aged 65 years and older, with the lowest among those aged 20-49 years. In China, female ASIR demonstrated an increasing trend(AAPC: 1.16%), while ASMR decreased in both sexes(AAPCs:-0.48% for males,-1.00% for females). The U.S. exhibited decreasing trends in both ASIR and ASMR across sexes and age groups.Conclusions: The study identified an increasing trend in lung cancer incidence among females and a decreasing mortality trend in both sexes in China. These trends are likely linked to factors such as smoking prevalence,advancements in cancer screening, and improved medical care. The findings underscore the need for tailored lung cancer prevention measures in China, particularly the reinforcement of anti-smoking policies. | Yi Teng Changfa Xia Maomao Cao Fan Yang Xinxin Yan Siyi He Mengdi Cao Shaoli Zhang Qianru Li Nuopei Tan Jiachen Wang Wanqing Chen | 2023 | Chinese Journal of Cancer Research2023，35，6： | 0 |
| 6 | Cancer statistics for young adults aged 20 to 49 years in China from 2000 to 2017:a population-based registry study显示文摘An increasing cancer incidence among adults younger than 50 years has been reported for several types of cancer in multiple countries.We aimed to report cancer profiles and trends among young adults in China.Data from the China Cancer Registry Annual Report were used to estimate incidence and mortality among young adults(ages 20–49 years)in China in 2017,and an age-period-cohort model was employed to estimate the average annual percent change(AAPC)in incidence and mortality from 2000 to 2017.All 25 cancer types were grouped into obesity-or overweight-associated cancers(12 cancer types)and additional cancers(13 cancer types).In 2017,there were 681,178new cases and 214,591 cancer deaths among young adults in China.Among young adults,the most common cancers were thyroid,breast,cervical,liver,lung,and colorectal cancer,and the leading causes of cancer deaths were liver,lung,cervical,stomach,breast,and colorectal cancer.From 2000 to 2017,the cancer incidence increased for all cancers combined among young adults,with the highest AAPC(1.46%)for adults aged 20–24 years,while cancer mortality decreased,with the highest AAPC(-1.63%)for those aged 35–39 years.In conclusion,the cancer incidence in China has increased among young adults,while cancer mortality has decreased for nearly all ages.Cancer control measures,such as obesity control and appropriate screening,may contribute to reducing the increasing cancer burden among young adults. | Yi Teng Changfa Xia He Li Maomao Cao Fan Yang Xinxin Yan Siyi He Mengdi Cao Shaoli Zhang Qianru Li Wanqing Chen | 2024 | Science China(Life Sciences)2024，67，4： | 0 |
| 7 | Detecting gravitational wave with an interferometric seismometer array on lunar nearside显示文摘Our Moon is by far the easiest natural, extraterrestrial celestial object for us to reach, and many space agencies, in particular the China National Space Administration, have publicized plans for manned missions there. Such high-profile projects must yield commensurate scientific outputs to justify their cost to the taxpayers. An important criterion for the selection of candidate experiments is the extent to which the Moon plays an integral and irreplaceable role, as opposed to offering only marginal advantages over Earth-orbit, space-based alternatives. In this study, we propose an experiment that excels in this regard, which considers the Moon as part of the experimental apparatus. Specifically, the Moon acts as a Weber bar-style resonant mass that responds to deci-Hertz gravitational waves(GWs). GW-excited lunar vibrations can be picked up by an array of(prefabricated on Earth and easy to transport to the Moon) small laser interferometric seismometers yielding GW detection. Such a setup would plug a gap in the GW frequency range already covered by the existing or underdevelopment detectors, and it can inform us on important astrophysics topics, such as the progenitors of Type Ia supernovae(SNe Ia) or intermediate mass black holes. We provide the instrument design as well as its deployment strategy, and we also summarize relevant science cases according to the estimated viable sensitivity. | Junlang Li Fangfei Liu Yuan Pan Zijian Wang Mengdi Cao Mengyao Wang Fan Zhang Jinhai Zhang Zong-Hong Zhu | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，10： | 0 |
| 8 | Exploring the psychological impact of the 2022 SARS-CoV-2 Omicron variant outbreak in China显示文摘To the editor:The impact of the coronavirus disease 2019(COVID-19)pandemic in 2020 on mental health was substantialin Chinai2and various other countries.34 Beyond the direct consequences of COVID-19,the pandemic created an environment in which many determinants of mental health were affected.Issues associated with the pandemic,such as loss of livelihood,limited access to medical services,reduced social interactions,and economic downturn,could potentially have adverse effects on the population's mental well-being.5 In November 2021,the World Health Organization(WHO)designated the new variant of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),variant B.1.1.529,as a variant of concern and named it Omicron;its rapid mutation and spread raised a new global health concern. | Gangbin Han Guirong Cheng Feifei Hu Chunli Li Dan Liu Juan Zhou Jing Liu Linya Huang Xiaochang Liu Qianqian Nie Dan Song Deyang Zeng Lang Xu Jinquan Li Yushan Chen Zhen Wei Qiong Wu Xiaoming He Qingming Wu Wei Tan Yufei Mei Xingxing Chen Yangming Ou Jingjing ZhangYafu Yu Mengliu Yang Pengfei Lian Fukai Zhou Renjia Fan Hong Wan Chenlu Hu Yidi Fu Shiyue Li Junyi Wang Cheng Cai Mengdie Pei Yuyang Cui Wanying Cai Yiqing Li Shiyao Pan Chang Chen Yan He Zhaoxia Wu Liu Hu Liang Tao Hongyan Xiao Xinyan Xie Yan Zeng | 2023 | General Psychiatry2023，36，6： | 0 |
| 9 | Erratum to:Detecting gravitational wave with an interferometric seismometer array on lunar nearside[Sci.China-Phys.Mech.Astron.66,109513(2023)]显示文摘This paper'Detecting gravitational wave with an interferometric seismometer array on lunar nearside'[1]was published in SCIENCE CHINA Physics,Mechanics&Astronomy(66,109513(2023),doi:10.1007/s11433-023-2179-9).Due to an oversight on our part,some errors were made in the originally published paper.We apologize for these errors and offer the corresponding explanations and corrections for the readers. | Junlang Li Fangfei Liu Yuan Pan Zijian Wang Mengdi Cao Mengyao Wang Fan Zhang Jinhai Zhang Zong-Hong Zhu | 2024 | Science China(Physics,Mechanics & Astronomy)2024，67，1： | 0 |
| 10 | Immunogenic cell death effects induced by doxorubicin improved chemo-immunotherapy via restoration of granzyme B activity显示文摘Chemotherapy remains one of the irreplaceable treatments for cancer therapy.The use of immunogenic cell death(ICD)-inducing chemotherapeutic drugs offers a practical strategy for killing cancer cells,simultaneously eliciting an antitumor immune response by promoting the recruitment of cytotoxic immune cells and production of granzyme B(GrB).However,numerous malignant cancers adaptively acquired the capacity of secreting serpinb9(Sb9),a physiological inhibitor of GrB,which can reversibly inhibit the biological activity of GrB.To circumvent this dilemma,in this study,an integrated tailor-made nanomedicine composed of tumor-targeting peptide(Arg-Gly-Asp,RGD)decorated liposome,doxorubicin(DOX,an effective ICD inducer),and the compound 3034(an inhibitor of Sb9),is developed(termed as D3RL)for breast cancer chemo-immunotherapy.In vitro and in vivo studies show that D3RL can directly kill tumor cells and trigger the host immune response by inducing ICD.Meanwhile,D3RL can competitively relieve the inhibition of Sb9 to GrB.The restored GrB can not only effectively induce tumor immunotherapy,but also degrade matrix components in the tumor microenvironment,consequently improving the infiltration of immune cells and the penetration of nanomedicines,which in return enhance the combined antitumor effect.Taken together,this work develops an integrated therapeutic solution for targeted production and restoration of GrB to achieve a combined chemo-immunotherapy for breast cancer. | Tao Huang Xiaofan Sun Yingqiu Qi Xi Yang Linyao Fan Mengdie Chen Yale Yue Hong Ge Yiye Li Guangjun Nie Huan Min Xianfu Sun | 2023 | Nano Research2023，16，12： | 0 |
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