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| 1 | The model of cytokine release syndrome in CAR T-cell treatment for B-cell non-Hodgkin lymphoma显示文摘Chimeric antigen receptor T(CAR T)cell therapy has demonstrated efficacy in the treatment of haematologic malignancies.However,the accompanying adverse events,the most common of which is cytokine release syndrome(CRS),substantially limit its wide application.Due to its unique physiological characteristics,CRS in CAR T-cell treatment for B-cell non-Hodgkin lymphoma(BNHL)may exhibit some special features.Although existing guidelines had greatly promoted the recognition and management of CRS,many recommendations are not fully applicable to B-NHL.Therefore,it is imperative to identify responses that are specific to CRS observed following CAR T treatment for B-NHL.Based on underlying biological processes and known pathophysiological mechanisms,we tentatively propose a new model to illustrate the occurrence and evolution of CAR T-cell-therapy-related CRS in BNHL.In this model,tumour burden and bone marrow suppression are considered determinants of CRS.Novel phenomena after CAR T-cell infusion(such as local inflammatory response)are further identified.The proposed model will help us better understand the basic biology of CRS and recognize and manage it more rationally. | Jianshu Wei Yang Liu Chunmeng Wang Yajing Zhang Chuan Tong Guanghai Dai Wei Wang John E.J.Rasko J.Joseph Melenhorst Wenbin Qian Aibin Liang Weidong Han | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 2 | CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies显示文摘The current standard of care in hematological malignancies has brought considerable clinical benefits to patients.However,important bottlenecks still limit optimal achievements following a current medical practice.The genetic complexity of the diseases and the heterogeneity of tumor clones cause difficulty in ensuring long-term efficacy of conventional treatments for most hematological disorders.Consequently,new treatment strategies are necessary to improve clinical outcomes.Chimeric antigen receptor T-cell(CAR T)immunotherapy opens a new path for targeted therapy of hematological malignancies.In this review,through a representative case study,we summarize the current experience of CAR T-cell therapy,the management of common side effects,the causative mechanisms of therapy resistance,and new strategies to improve the efficacy of CAR T-cell therapy. | Jian-Qing Mi Jie Xu Jianfeng Zhou Weili Zhao Zhu Chen J.Joseph Melenhorst Saijuan Chen | 2021 | Frontiers of Medicine2021，15，6： | 2 |
| 3 | The artificial bo- wel sphincter for fecal incontinence: a single centre study显示文摘 | Melenhorst J Koch SM van Gemert WG | 2008 | Int J Colorectal Dis2008，23，1： | 1 |
| 4 | Sacral nerve stimulation for intractable constipation 显示文摘 | Kamm MA Dudding TC Melenhorst J | 2010 | Gut2010，59，： | 1 |
| 5 | Analysis of T-cell repertoire in hepatitis-associated aplastic anemia 显示文摘 | Lu J Basu A Melenhorst JJ Young NS Brown KE | 2004 | Blood2004，103，12： | 1 |
| 6 | Nerve decompression surgery as treatment for peripheral diabetic neuropathy: literature overview and awareness among medical professionals 显示文摘 | Melenhorst WB Overgoor ML | 2009 | Ann Plast Surg2009，63，2： | 1 |
| 7 | T cells selectively infiltrate bone marrow areas with residual haemopoiesis of patients with acquired aplastic anaemia显示文摘 | MELENHORST J J VAN KRIEKEN J H DREEF E | 1997 | Br J Haematol1997，99，： | 1 |
| 8 | T cells selectively infiltrate bone marrow areas with residual haemopoiesis of patients with acquired aplastic anaemia显示文摘 | Melenhorst JJ van Krieken JHJM Dreef E | 1997 | Br J Haematol1997，99，3： | 1 |
| 9 | Neutrophil elastase enzymatically atagonizes the in vitro action of G-CSF:implications for the regulation of granulopoiesis显示文摘 | EI Ouriaghli F Fujiwara H Melenhorst JJ | 2003 | Blood2003，101，： | 1 |
| 10 | Prospective study of colonic irrigation for the treatment of defaecation dis- orders显示文摘 | Koch SM Melenhorst J van Gemert WG | 2008 | Br J Surg2008，95，10： | 1 |
| 11 | Analysis of T-cell clonality in bone marrow of patients with acquired aplastic anemia显示文摘 | MELENHORST J J FIBBE W E STRUYK L | 1997 | Br J Haematol1997，96，1： | 1 |
| 12 | Innovation and opportunity for chimeric antigen receptor targeted T cells 显示文摘 | Melenhorst J J Levine BL | 2013 | Cytotherapy2013，15，9： | 1 |
| 13 | Analysis of T-cell repertoire in hepatitis-associated aplastic anemia显示文摘 | LU J BASU A MELENHORST J J | 2004 | Blood2004，103，12： | 1 |
| 14 | Cemented total hip arthroplasty with impacted morcellized bone-grafts to restore acetabular bone defects in congenital hip dysplasia显示文摘 | Bolder SB Melenhorst J Gardeniers JW | 2001 | J Arthroplasty2001，1，： | 1 |
| 15 | Nerve decompression surgery as treatment for peripheral diabetic neuropathy: literature overview and awareness among medical professionals 显示文摘 | Melenhorst WB Overgoor ML Gonera EG | 2009 | Ann Plast Surg2009，63，2： | 1 |
| 16 | Sacral nerve stimulation for constipation:an international multi-centre study显示文摘 | Kamm MA Dudding TC Melenhorst J | 2007 | Gastroenterology2007，132，4： | 1 |
| 17 | Nerve decompression surgery as treatment for peripheral diabetic neuropathy:literature overview and awareness among medical professionals显示文摘 | Melenhorst WB Overgoor ML | 2009 | Ann Plast Surg2009，63，2： | 1 |
| 18 | The artificial bowel sphincter for faecal incontinence:a single centre study显示文摘 | Jarno Melenhorst Sacha M Wim G | | 0，，： | 1 |
| 19 | Adaml7 upregulation in human renal disease : a role in modulating TGF-alpha availability? 显示文摘 | Melenhorst WB Visser L Timmer A | 2009 | Am J Physiol Renal Physiol2009，297，3： | 1 |
| 20 | Molecular and flow cytometric characterization of the CD4 and CD8 T-cell repertoire in patients with myelodysplastie syndrome显示文摘 | MELENHORST J J ENIAFE R FOLLMANN D | 2002 | Br J Haematol2002，119，： | 1 |
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