|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Toxic Effects of Three Heavy Metallic Ions on Rana zhenhaiensis Tadpoles显示文摘Heavy metal pollution is widespread in some areas of China and results in contamination of land, water, and air with which all living organisms interact. In this study, we used three heavy metallic ions(Cu2+, Pb2+ and Zn2+) to assess their toxicity effects on mortality, blood biomarker and growth traits(body length and body mass) of Rana zhenhaiensis tadpoles. The results showed that the toxicity levels of the three metallic ions were different when conducted with different experiment designs. For acute toxicity tests, Cu2+ was the most toxic with the highest tadpole mortality. The mortalities of tadpoles showed significant differences among the treatments at the same exposure time endpoints(24, 48, 72 and 96h). Results from repeated measures ANOVA indicated that metallic ion concentration, exposure time and their interactions significantly affected the mortalities of R. zhenhaiensis tadpoles. Also, the toxicity effects of all binary combinations of the three metallic ion treatments showed synergism. The half lethal concentrations(LC50) decreased with increasing exposure time during the experimental period, and the safe concentration(SC) values of Cu2+, Pb2+ and Zn2+ were different from each other. Combined and compared LC50 values with previous data reported, it is suggestes that the toxicity levels of metal pollution to anuran tadpoles should be species-and age-related. For blood biomarker tests, Zn2+ was the most toxic with the highest total frequencies of abnormal erythrocytic nucleus. All three metallic ions caused higher abnormal erythrocytic nucleus compared with control groups. In a chronic toxicity test, Pb2+ was the most toxic with lowest growth traits. Survival rate(except for 18 days), total body length and body mass showed significant differences among the treatments. These findings indicated that tadpoles of R. zhenhaiensis should be as a bioindicator of heavy metals pollution. | Li WEI Guohua DING Sainan GUO Meiling TONG Wenjun CHEN Jon FLANDERS Weiwei SHAO Zhihua LIN | 2015 | Asian Herpetological Research2015，6，2： | 3 |
| 2 | Heterogeneous nuclear ribonuclear protein K interacts with the entero- virus 71 5runtranslated region and participates in virus replication显示文摘 | Lin Jingyi Li Meiling Huang Pengnien Chien Kun Yi Horng Jim Tong Shih Shin Ru | 2008 | J Gen Virol2008，89，10： | 1 |
| 3 | Optical Amplification at 1525 nm in BaYF5: 20% Yb3+, 2% Er3+ Nanocrystals Doped SU-8 Polymer Waveguide显示文摘 | Pengcheng Zhao Meiling Zhang Tianjiao Wang Xinyang Liu Xuesong Zhai Guanshi Qin Weiping Qin Fei Wang Daming Zhang Tong Zhang | 2014 | Journal of Nanomaterials2014，，： | 1 |
| 4 | Cx43 reverses the resistance of A549 lung adenocarcinoma cells to cisplatinby inhibiting EMT显示文摘 | Meiling Yu Cuiling Zhang Li Li Shuying Dong Naiju Zhang Xuhui Tong | 2014 | Oncology Reports2014，，6： | 1 |
| 5 | Role of gap junction intercellular communication in testicular leydigcell apoptosis induced by oxaliplatin via the mitochondrial pathway显示文摘 | Xuhui Tong Xi Han Binbin Yu Meiling Yu Guojun Jiang Jie Ji Shuying Dong | 2015 | Oncology Reports2015，，1： | 1 |
| 6 | Vitrified-warmed blastocyst transfer cycles yield higher pregnancy and implantation rates compared with fresh blastocyst transfer cycles—time for a new embryo transfer strategy?显示文摘 | Dandan Zhu Juanjuan Zhang Shanren Cao Junqiang Zhang Boon Chin Heng Meiling Huang Xiufeng Ling Tao Duan Guo Qing Tong | 2011 | Fertility and Sterility2011，，5： | 1 |
| 7 | Xylanase improves the intestinal barrier function of Nile tilapia(Oreochromis niloticus)fed with soybean(Glycine max)meal显示文摘Background Soybean(Glycine max)meal is one of the important protein sources for fish,but the non-starch polysaccharides(NSP)in soybean meal impair the intestinal barrier function.Here we aimed to investigate whether xylanase can alleviate the adverse effects on the gut barrier induced by soybean meal in Nile tilapia and to explore the possible mechanism.Results Nile tilapia(Oreochromis niloticus)(4.09±0.02 g)were fed with two diets including SM(soybean meal)and SMC(soybean meal+3,000 U/kg xylanase)for 8 weeks.We characterized the effects of xylanase on the gut barrier,and the transcriptome analysis was performed to investigate the underlying mechanism.Dietary xylanase improved intestinal morphology and decreased the concentration of lipopolysaccharide(LPS)in serum.The results of transcriptome and Western blotting showed that dietary xylanase up-regulated the expression level of mucin2(MUC2)which may be related to the inhibition of protein kinase RNA-like endoplasmic reticulum kinase(perk)/activating transcription factor 4(atf4)signaling pathways.Microbiome analysis showed that addition of xylanase in soybean meal altered the intestinal microbiota composition and increased the concentration of butyric acid in the gut.Notably,dietary sodium butyrate was supplemented into the soybean meal diet to feed Nile tilapia,and the data verified that sodium butyrate mirrored the beneficial effects of xylanase.Conclusions Collectively,supplementation of xylanase in soybean meal altered the intestinal microbiota composition and increased the content of butyric acid which can repress the perk/atf4 signaling pathway and increase the expression of muc2 to enhance the gut barrier function of Nile tilapia.The present study reveals the mechanism by which xylanase improves the intestinal barrier,and it also provides a theoretical basis for the application of xylanase in aquaculture. | Tong Wang Nannan Zhou Junyi He Zhenzhen Hao Chentao Zhou Yidi Du Zhenyu Du Xiaoyun Su Meiling Zhang | 2023 | Journal of Animal Science and Biotechnology2023，14，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员