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| 1 | HCV-RNA positivity in peripheral blood mononuclear cells of patients with chronic HCV-infection: does it really mean viral replication?显示文摘AIM To analyze the association of HCV-RNA with peripheral blood mononuclear cells (PBMC)and to answer the question whether HCV-RNA positivity in PBMC is due to viral replication,METHODS HCV-RNA was monitored in serumand PBMC preparations from 15 patients with chronic HCV infection before, during and after an IFN-α therapy using a nested RT/ PCRtechnique. In a second approach, PBMC from healthy donors were incubated in HCV positive plasma.RESULTS In the IFN-α responding patients,HCV-RNA disappeared first from total RNApreparations of PBMC and then from serum. In contrast, in relapsing patients, HCV-RNAreappeared first in serum and then in PBMC. A quantitative analysis of the HCV-RNAconcentration in serum was performed before and after transition from detectable to nondetectable HCV-RNA in PBMC-RNA and vice versa. When HCV-RNA was detectable in PBMCpreparations, the HCV concentration in serum was significantly higher than the serum HCV-RNA concentration when HCV-RNA in PBMC was not detectable. Furthermore, at no time during the observation period was HCV specific RNA observed in PBMC, if HCV-RNA in serum was under the detection limit. Incubation of PBMCfrom healthy donors with several dilutions of HCV positive plasma for two hours showed a concentration-dependent PCR-positivity for HCV-RNA in reisolated PBMC.CONCLUSION The detectability of HCV-RNA in total RNA from PBMC seems to depend on the HCV concentration in serum. Contamination or passive adsorption by circulating virus could be the reason for detection of HCV-RNA in PBMCpreparations of chronically infected patients. | Volker Meier Sabine Mihm Perdita Wietzke-Braun Guliano Ramadori | 2001 | World Journal of Gastroenterology2001，7，2： | 29 |
| 2 | Current treatment of ulcerative colitis显示文摘Ulcerative colitis (UC) is a chronic disease featuring re- current inflammation of the colonic mucosa. The goal of medical treatment is to rapidly induce a steroid-free remission while at the same time preventing complica- tions of the disease itself and its treatment. The choice of treatment depends on severity, localization and the course of the disease. For proctitis, topical therapy with 5-aminosalicylic acid (5-ASA) compounds is used. More extensive or severe disease should be treated with oral and local 5-ASA compounds and corticosteroids to induce remission. Patients who do not respond to this treatment require hospitalization. Intravenous steroids or, when refractory, calcineurin inhibitors (cyclosporine, tacrolimus), tumor necrosis factor-α antibodies (infliximab) or immunomodulators (azathioprine, 6-mercaptopurine) are then called for. Indications for emergency surgery include refractory toxic megacolon, perforation, and continuous severe colorectal bleeding. Close collaboration between gastroenterologist and surgeon is mandatory in order not to delay surgical therapy when needed. This article is intended to give a general, practice-orientated overview of the key issues in ulcerative colitis treatment. Recommendations are based on published consensus guidelines derived from national and international guidelines on the treatment of ulcerative colitis. | Johannes Meier Andreas Sturm | 2011 | World Journal of Gastroenterology2011，17，27： | 28 |
| 3 | 基于面向服务体系结构的制造企业协同化工程支持技术显示文摘研究了协同服务、网络化制造以及云制造的信息化制造技术,引入云计算的部分思想,基于面向服务的体系结构,构建了一个示范性协同服务系统平台。该平台底层应用现场设备工具/设备类型管理和OPC标准构架技术实现了各异构设备和控制系统间的通信和数据共享,上层结合网络技术实现了网络制造和协同服务。该系统实现了异构设备的互连和通信,使其具有远程监控、诊断等功能;整合了企业内生产、管理和采购方面的资源,初步实现了远程协同化管理。 | 沈斌 齐党进 樊留群 Horst Meier | 2011 | 计算机集成制造系统2011，17，4： | 24 |
| 4 | Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump显示文摘AIM: To study the association of three common ABCB11 and ABCC2 polymorphisms (ABCB11: 1331T>C V444A; ABCC2: 3563T>A V1188E and 4544G>A C1515Y) with intrahepatic cholestasis of pregnancy (ICP) and contraceptive-induced cholestasis (CIC). METHODS: ABCB11 and ABCC2 genotyping data were available from four CIC patients and from 42 and 33 ICP patients, respectively. Allele-frequencies of the studied polymorphisms were compared with those in healthy pregnant controls and Caucasian individuals. Furthermore, serum bile acid levels were correlated with the presence or absence of the 1331 C allele.RESULTS: The ABCB11 1331T>C polymorphism was significantly more frequent in cholestatic patients than in pregnant controls: C allele 76.2% (CI, 58.0-94.4) vs 51.3% (CI 35.8-66.7), respectively (P = 0.0007); and CC allele 57.1% (CI 36.0-78.3) vs 20% (CI 7.6-32.4), respectively (P = 0.0065). All four CIC patients were homozygous carriers of the C allele. In contrast, none of the studied ABCC2 polymorphism was overrepresented in ICP or CIC patients. Higher serum bile acid levels were found in carriers of the 1331CC genotype compared to carriers of the TT genotype.CONCLUSION: Our data support a role for the ABCB11 1331T>C polymorphism as a susceptibility factor for the ←←← development of estrogen-induced cholestasis, whereas no such association was found for ABCC2. Serum bile acid and γ-glutamyl transferase levels might help to distinguish ABCB4- and ABCB11-related forms of ICP and CIC. | Yvonne Meier Tina Zodan Carmen Lang Roland Zimmermann Gerd A Kullak-Ublick Peter J Meier Bruno Stieger Christiane Pauli-Magnus | 2008 | World Journal of Gastroenterology2008，14，1： | 20 |
| 5 | Combination of 'low-dose' ribavirin and interferon alfa-2a therapy followed by interferon alfa-2a monotherapy in chronic HCV-infected nonresponders and relapsers after interferon alfa-2a monotherapy显示文摘AIM To report on the efficacy, safety and tolerability of interferon alfa-2a combined with a 'low dose' of ribavirin for relapsers and non responders to alpha interferon monotherapy.METHODS Thirty-four chronic hepatitis C virus-infected non-responders to interferon alfa2a monotherapy (a course of at least 3 months treatment) and 13 relapsers to interferon alfa 2a monotherapy (a dose of 3 to 6 million units three times per week for at least 20 weeks but not more than 18 months) were treated with the same dose of interferon alfa-2a used before (3 to 6 million units three times per week) and ribavirin (10 mg/ kg daily) for 6 months. In complete responders, interferon alfa-2a was administered for further 6 months at the same dose used before as monotherapy.RESULTS Seven (20.6%) of 34 non-responders stopped the combined therapy due to adverse events, including two patients with histological and clinical Child A cirrhosis. In 17/27 (63%)non-responders, the combined therapy was stopped after three months because of non-response. Ten of the 27 non-responders completed the 1;2-month treatment course. At a mean follow up of 28 months (16- 37 months)after the treatment, 4/10 (15%) previous non-responders still remained complete responders,All 13 previous relapsers completed the 12-month treatment course. At a mean follow up of 22months (9 - 36 months) after treatment, 6/13(46%) the previous relapsers were stillsustained complete responders.CONCLUSION Our treatment schedule of the combined therapy for 6 months of interferon alfa2a with a low dose of ribavirin (10 mg/kg/day)followed by 6 months of interferon alfa-2amonotherapy is able to induce a sustainedcomplete response rate in 15% of non-responders and 46% of relapsers with chronic hepatitis C virus-related liver diseases comparable to those obtained with the standarddoses of ribavirin 1000 - 1200 mg/day.Randomized prospective controlled trials using lower total amounts of ribavirin in combination with interferon should be performed. | Perdita Wietzke-Braun Volker Meier Felix Braun Giuliano Ramadori | 2001 | World Journal of Gastroenterology2001，7，2： | 19 |
| 6 | ESPEN营养风险筛选(NRS2002)——循证的方法及在欧洲的应用显示文摘 | Rémy Meier 陈凌(翻译) | 2007 | 中国临床营养杂志2007，15，1： | 17 |
| 7 | Nonlinear optics in all-dielectric nanoantennas and metasurfaces:a review显示文摘Free from phase-matching constraints,plasmonic metasurfaces have contributed significantly to the control of optical nonlinearity and enhancement of nonlinear generation efficiency by engineering subwavelength meta-atoms.However,high dissipative losses and inevitable thermal heating limit their applicability in nonlinear nanophotonics.All-dielectric metasurfaces,supporting both electric and magnetic Mie-type resonances in their nanostructures,have appeared as a promising alternative to nonlinear plasmonics.High-index dielectric nanostructures,allowing additional magnetic resonances,can induce magnetic nonlinear effects,which,along with electric nonlinearities,increase the nonlinear conversion efficiency.In addition,low dissipative losses and high damage thresholds provide an extra degree of freedom for operating at high pump intensities,resulting in a considerable enhancement of the nonlinear processes.We discuss the current state of the art in the intensely developing area of all-dielectric nonlinear nanostructures and metasurfaces,including the role of Mie modes,Fano resonances,and anapole moments for harmonic generation,wave mixing,and ultrafast optical switching.Furthermore,we review the recent progress in the nonlinear phase and wavefront control using all-dielectric metasurfaces.We discuss techniques to realize alldielectric metasurfaces for multifunctional applications and generation of second-order nonlinear processes from complementary metal–oxide–semiconductor-compatible materials. | Basudeb Sain Cedrik Meier Thomas Zentgraf | 2019 | Advanced Photonics2019，1，2： | 17 |
| 8 | Endoscopic full-thickness resection: current status显示文摘Conventional endoscopic resection techniques such as endoscopic mucosal resection or endoscopic submucosal dissection are powerful tools for treatment of gastrointestinal neoplasms. However,those techniques are restricted to superficial layers of the gastrointestinal wall. Endoscopic full-thickness resection(EFTR) is an evolving technique,which is just about to enter clinical routine. It is not only a powerful tool for diagnostic tissue acquisition but also has the potential to spare surgical therapy in selected patients. This review will give an overview about current EFTR techniques and devices. | Arthur Schmidt Benjamin Meier Karel Caca | 2015 | World Journal of Gastroenterology2015，21，31： | 14 |
| 9 | 关于西罗莫司和紫杉醇洗脱支架用于新发冠状动脉病变的随机对照试验:REALITY试验显示文摘Context: Compared with bare metal stents, sirolimus-elut-ing and paclitaxel-eluting stents have been shown to markedly improve angiographic and clinical outcomes after percutaneous coronary revascularization, but their performance in the treatment of de novo coronary lesions has not been compared in a prospective multicenter study. Objective: To compare the safety and efficacy of sirolimus-eluting vs paclitaxel-eluting coronary stents. Design: Prospective, randomized comparative trial(the REALITY trial) conducted between August 2003 and February 2004, with angiographic follow-up at 8 months and clinical follow-up at 12 months. Setting: Ninety hospitals in Europe, Latin America, and Asia. Patients: A total of 1386 patients(mean age, 62.6 years; 73.1% men; 28.0% with diabetes)with angina pectoris and 1 or 2 de novo lesions(2.25-3.00 mm in diameter) in native coronary arteries. Intervention: Patients were randomly assigned in a 1 ∶ 1 ratio to receive a sirolimus-eluting stent(n=701) or a paclitaxel-eluting stent(n=685). Main Outcome Measures: The primary end point was in-lesion binary restenosis(presence of a more than 50% luminal diameter stenosis) at 8 months. Secondary end points included 1-year rates of target lesion and vessel revascularization and a composite end point of cardiac death, Q-wave or non-Q-wave myocardial infarction, coronary artery bypass graft surgery, or repeat target lesion revascularization. Results: In-lesion binary restenosis at 8 months occurred in 86 patients(9.6% ) with a sirolimus-eluting stent vs 95(11.1% ) with a paclitaxel-eluting stent(relative risk [RR], 0.84; 95% confidence interval [CI], 0.61-1.17; P=.31). For sirolimus- vs paclitaxel-eluting stents, respectively, the mean(SD) in-stent late loss was 0.09(0.43) mm vs 0.31(0.44) mm(difference,-0.22 mm; 95% CI,-0.26 to-0.18 mm; P<.001), mean(SD) in-stent diameter stenosis was 23.1% (16.6% ) vs 26.7% (15.8% )(difference,-3.60% ; 95% CI,-5.12% to-2.08% ; P< .001), and the number of major adverse cardiac events at 1 year was 73(10.7% ) vs 76(11.4% )(RR, 0.94; 95% CI, 0.69-1.27; P=.73). Conclusion: In this trial comparing sirolimus- and paclitaxel-eluting coronary stents, there were no differences in the rates of binary restenosis or major adverse cardiac events. Clinical Trial Registration: ClinicalTrials.gov Identifier: | Morice M. -C. Colombo A. Meier B. 任付先(译) 杜媛(校) | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，2，8： | 12 |
| 10 | 湖南黔阳镁铁-超镁铁质岩Sm-Nd年龄测定显示文摘本文首次报导湘西黔阳一怀化地区隘口岩体全岩Sm-Nd等时年龄为890±104Ma,钕同位素初始比值为ε_Nd(T)=+1.63±1.90。样品的岩矿地球化学体系表明,岩体源自略亏损的地幔原区,并非为典型的反映大洋成因的蛇绿岩套,而更可能是晚元古宙江南碰撞造山带中段的一个组成部分,如弧后盆地开张初期产物。这一推论对研究华南地区构造演化史有重要指示意义。 | 周新华 程海 陈海泓 Martin Meier | 1992 | 地质科学1992，27，4： | 11 |
| 11 | Measurement of calprotectin in ascitic fluid to identify elevated polymorphonuclear cell count显示文摘AIM: To evaluate the diagnostic capability of calprotectin in ascitic fluid for detecting a polymorphonuclear (PMN) cell count > 250/μL ascites. METHODS: In this prospective observational study, a total of 130 ascites samples were analysed from 71 consecutive patients referred for paracentesis. Total and differential leukocyte cell counts were determined manually with a Neubauer chamber and gentianviolet stain. Calprotectin was measured in 1 mL ascetic fluid by enzyme-linked immunosorbent assay (ELISA) and a point-of-care (POC) lateral flow assay with the Quantum Blue Reader (Bühlmann Laboratories). All measurements were carried out in a central laboratory by senior personnel blinded to patient history. A PMN count > 250/μL was the primary endpoint of the study. The diagnostic value of ascitic calprotectin measurement was assessed by comparing to the final diagnosis of each patient that had been adjudicated by investigators blinded to calprotectin values. RESULTS: The PMN count was > 250/μL in 19 samples (14.6%) from 15 patients (21.1%) and varied widely among the study population (range 10-19 800/mL and 1-17 820/mL, respectively). Spontaneous bacterial peritonitis (SBP) was the final diagnosis in four patients (5.6%). All patients with PMN ≤ 250/μL had negative bacterial culture. PMN count was elevated in five patients with peritoneal carcinomatosis, three with lymphoma, one with neuroendocrine carcinoma, and two with secondary peritonitis due to abdominal perforation. PMN cell counts correlated with ascitic calprotectin values (Spearman's rho; r = 0.457 for ELISA, r = 0.473 for POC). A considerable range of ascitic calprotectin concentrations was detected by ELISA [median 0.43 μg/mL, interquartile range (IQR) 0.23-1.23 (range 0.10-14.93)] and POC [median 0.38 μg/mL, IQR 0.38-0.56 (range 0.38-13.31)]. Ascitic calprotectin levels were higher in samples with PMN > 250/μL, by both ELISA [median (IQR) 2.48 μg/mL (1.61-3.65) vs 0.10 μg/mL (0.10-0.36), P < 0.001] and POC [2.78 μg/mL (2.05-5.37) vs 0.38 μg/mL (0.38-0.41), P < 0.001]. The area under the receiver operating characteristics curve for identifying an elevated PMN count was 0.977 (95%CI: 0.933 to 0.995) for ELISA and 0.982 (95%CI: 0.942 to 0.997) for POC (P = 0.246 vs ELISA). Using the optimal cut-off value for ELISA (0.63 μg/mL), ascitic calprotectin had 94.8% sensitivity, 89.2% specificity, positive and negative likelihood ratios of 8.76 and 0.06 respectively, positive and negative predictive values of 60.0% and 99.0% respectively, and 90.0% overall accuracy. Using the optimal cut-off value for POC (0.51 μg/mL), the respective values were 100.0%, 84.7%, 6.53, 0.00, 52.8%, 100% and 87.7%. Correlation between ELISA and POC was excellent (r = 0.873, P < 0.001). The mean ± SD of the difference was -0.11 ± 0.48 μg/mL with limits of agreement of + 0.8 μg/mL (95%CI: 0.69 to 0.98) and -1.1 μg/mL (95%CI: -1.19 to -0.91). CONCLUSION: Ascitic calprotectin reliably predicts PMN count > 250/μL, which may prove useful in the diagnosis of SBP, especially with a readily available bedside testing device. | Emanuel Burri Felix Schulte Jürgen Muser Rémy Meier Christoph Beglinger | 2013 | World Journal of Gastroenterology2013，19，13： | 10 |
| 12 | 分布式设备远程监控系统研究显示文摘针对现有设备远程监控系统不能真正有效地支持分布式网络化生产和管理模式,提出一种基于中间件技术的分布式工业设备远程维护系统,该系统不依赖于具体的硬件和软件平台,设备能方便地加入或退出系统。阐述了系统总体结构和系统安全性设计,重点分析了实现分布式结构的关键技术—查询服务器的4个机制及其实现技术方案,并讨论了系统的总体通讯方案,为分布式设备远程服务系统的实现提供了很好的参考价值。该系统有效地提升了企业关键设备的维护效能,为设备远程监控系统的应用推广奠定了基础。 | 虞敏 张为民 Horst Meier | 2009 | 计算机工程与应用2009，45，5： | 10 |
| 13 | 支持复杂设备运行的全新服务模式——协同服务显示文摘由于复杂设备的高度集成和智能化,现有的工业服务模式已不能满足企业需求。在阐述复杂设备协同服务支持必要性的基础上,分析了协同服务与传统工业服务模式的差别,简要论述了建立协同服务支持的关键技术:复杂设备协同服务的组织形式、协同服务的识别与商业模型构建和设备控制与信息支撑技术,为协同服务支持的进一步研究打下了基础。 | 李鹏忠 张为民 Horst Meier GU Rongxin | 2007 | 机电一体化2007，13，2： | 7 |
| 14 | 立止血—蛇毒液制备的止血剂的历史及作用方式显示文摘 | Meier J 吴云林 | 1993 | 国外学者来访报告1993，13，4： | 5 |
| 15 | 激光瑞利散射法在火焰温度测量中的应用显示文摘近年来为了进行燃烧诊断,发展了一些成功的激光测试技术,由于瑞利散射法(LRS)具有许多很有价值的特点,因此在紊流燃烧研究中愈来愈引起人们的注意。通过证实瑞利散射可以用来测量火焰温度。本文阐述了瑞利散射原理、应用中问题和火焰温度的实际测量。 | 曹明骅 W Meier | 1996 | 航空动力学报1996，11，1： | 4 |
| 16 | Introductory to the ESPEN Guidelines on Enteral Nutrition: Terminology, Definitions and General Topics显示文摘 | H. Lochs S.P. Allison R. Meier M. Pirlich J. Kondrup St. Schneider G. van den Berghe C. Pichard | 2006 | Clinical Nutrition2006，，2： | 3 |
| 17 | ESPEN Guidelines on Enteral Nutrition: Pancreas显示文摘 | R. Meier J. Ockenga M. Pertkiewicz A. Pap N. Milinic J. MacFie C. L?ser V. Keim | 2006 | Clinical Nutrition2006，，2： | 3 |
| 18 | Synthesis and host-guest properties of pillar[6]arenes显示文摘A facile method for the synthesis of pillar[6]arenes was developed.A series of pillar[6]arenes were prepared with FeCl 3 as catalyst and chloroform as solvent at room temperature in moderate yields(30%-40%).Their host-guest properties with n-cetyltrimethyl ammonium bromide were investigated by 1 HNMR.The results showed that high selectivity in the host-guest relationship became apparent between pillar[6]arenes and pillar[5]arenes based on the different size of the inner cavity. | TAO HongQi CAO DeRong LIU LuZhi KOU YuHui WANG LingYun MEIER Herbert | 2012 | Science China Chemistry2012，55，2： | 3 |
| 19 | Preserved liver regeneration capacity after partial hepatectomy in rats with non-alcoholic steatohepatitis显示文摘AIM To evaluate the liver regeneration capacity(LRC) after partial hepatectomy(PH) in experimental non-alcoholic steatohepatitis(NASH).METHODS Fifty-four female rats were fed a high-fat, high-cholesterol diet(HFCD, 65% fat, 1% cholesterol) or standard diet(STD) for 16 wk. A 70% PH was performed and the animals were euthanised before PH or 2 or 5 d postPH. LRC was evaluated using: The total number of Ki-67 positive hepatocytes in the caudate lobe, N(Ki-67, lobe) evaluated in a stereology-based design, the regenerated protein ratio(RPR), prothrombin-proconvertin ratio(PP), and m RNA expression of genes related to regeneration.RESULTS The HFCD NASH model showed significant steatosis with ballooning and inflammation, while no fibrosis was present. Mortality was similar in HFCD and STD animals following PH. HFCD groups were compared to respective STD groups and HFCD animals had a significantly elevated alanine transaminase at baseline(P < 0.001), as well as a significantly elevated bilirubin at day 2 after PH(P < 0.05). HFCD animals had a higher N(Ki-67, lobe) at baseline,(P < 0.0001), day 2 after PH(P = 0.06) and day 5 after PH(P < 0.025). We found no significant difference in RPR or PP neither 2 or 5 d post-PH. Expression of liver regeneration genes(e.g., hepatic growth factor) was higher at both day 2 and 5 post-PH in HFCD groups(P < 0.05).CONCLUSION NASH rats had a preserved LRC after hepatectomy when compared to STD rats. The methods and models of NASH are essential in understanding and evaluating LRC. | David Haldrup Sara Heeboll Karen Louise Thomsen Kasper Jarlhelt Andersen Michelle Meier Frank Viborg Mortensen Jens Randel Nyengaard Stephen Hamilton-Dutoit Henning Gronbaek | 2018 | World Journal of Hepatology2018，10，1： | 3 |
| 20 | Synthesis of pillar[7]arene显示文摘支柱的第一合成[7 ] arene 与二个方法被报导。方法 A:有在 CHCl3 的 paraformaldehyde 的 1,4-dimethoxybenzene (1 ) 的催化 FeCl3 的冷凝作用反应给了 dimethoxypillar [7 ] arene (3 ) 。方法 B:p-toluenesulfonic 酸催化在 CH2Cl2 的 -1,4-dimethoxybenzene (2 ) 给了化合物 3 的 2,5 二度(benzyloxymethyl ) 的冷凝作用反应。有 BBr3 的 3 的 Demethylation 给了支柱[7 ] arene (4 ) 。支柱[7 ] arene 可能是在 hostguest 化学的一位观点 macrocyclic 主人。 | Yu Chen Hong Qi Tao Yu Hui Kou Herbert Meier Jian Long Fu De Rong Cao | 2012 | Chinese Chemical Letters2012，23，5： | 3 |
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