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| 1 | Interplay between intestinal alkaline phosphatase, diet, gut microbes and immunity显示文摘Intestinal alkaline phosphatase(IAP) plays an essential role in intestinal homeostasis and health through interactions with the resident microbiota, diet and the gut. IAP's role in the intestine is to dephosphorylate toxic microbial ligands such as lipopolysaccharides, unmethylated cytosine-guanosine dinucleotides and flagellin as well as extracellular nucleotides such as uridine diphosphate. IAP's ability to detoxify these ligands is essential in protecting the host from sepsis during acute inflammation and chronic inflammatory conditions such as inflammatory bowel disease. Also important in these complications is IAP's ability to regulate the microbial ecosystem by forming a complex relationship between microbiota, diet and the intestinal mucosal surface. Evidence reveals that diet alters IAP expression and activity and this in turn can influence the gut microbiota and homeostasis. IAP's ability to maintain a healthygastrointestinal tract has accelerated research on its potential use as a therapeutic agent against a multitude of diseases.Exogenous IAP has been shown to have beneficial effects when administered during ulcerative colitis,coronary bypass surgery and sepsis.There are currently a handful of human clinical trials underway investigating the effects of exogenous IAP during sepsis,rheumatoid arthritis and heart surgery.In light of these findings IAP has been marked as a novel agent to help treat a variety of other inflammatory and infectious diseases.The purpose of this review is to highlight the essential characteristics of IAP in protection and maintenance of intestinal homeostasis while addressing the intricate interplay between IAP,diet,microbiota and the intestinal epithelium. | Mehrbod Estaki Daniella DeCoffe Deanna L Gibson | 2014 | World Journal of Gastroenterology2014，20，42： | 6 |
| 2 | Ocular trauma treated with pars plana vitrectomy: early outcome report显示文摘AIM: To evaluate demographic variables and visual outcomes, among patients with ocular injuries involving the posterior segment, managed with pars plana vitrectomy.· METHODS: The records of patients were studied retrospectively from March to September 2010, to determine the age, gender, place of occurrence of trauma, visual acuity, anatomical site, nature of injury,wound length, the presence of an afferent pupillary defect, and the timing of vitrectomy. The Ocular Trauma Score was measured. The minimum follow-up from presentation was 6mo.·RESULTS: Ninety patients(77 males, 13 females), with a mean age of 32.7 ±15.8y were included over the 6-month period. The majority of cases occurred in the workplace(47 patients), followed by home(14 patients).The mean visual acuity(log MAR) of patients significantly improved from 2.36 ±0.72 preoperatively to 1.50 ±1.14 postoperatively. Twenty-three patients had preoperative vision better than 2.0 log MAR, the postoperative visual acuity was significantly better among these patients than patients with worse than 2.0 log MAR(P <0.001). Visual improvement between groups with early vitrectomy(<7d)and delayed vitrectomy(>7d) was not significantly different(P =0.66). Postoperative visual acuity was not significantly different between patients with injury in Zone I and II(P =0.64), but patients with injury in Zone III had significantly poorer visual acuity(P =0.02). Patients with relative afferent pupillary defect had significantly poorer postoperative visual acuity(P =0.02). Preoperative visual acuity, the difference of preoperative and postoperative visual acuity, and postoperative visualacuity were significantly different between groups with different ocular trauma scores(P <0.001).·CONCLUSION: Trauma is more likely to occur in men under 40 y of age and in the workplace. The favorable final visual outcome is associated with the absence of afferent pupillary defect, ocular trauma score and presenting visual acuity as well as the zone of injury, and not associated with the timing of vitrectomy. | Mohammad Reza Mansouri Seyed Ali Tabatabaei Mohammad Soleimani Mohammad Yaser Kiarudi Saber Molaei Mehdi Rouzbahani Meysam Mireshghi Mohsen Zaeferani Mehrbod Ghasempour | 2016 | International Journal of Ophthalmology(English edition)2016，9，5： | 5 |
| 3 | Molecular de-terminants of FGF-21 activity-synergy and cross-talk withPPARgamma signaling显示文摘 | Moyers J S Shiyanova T L Mehrbod F | 2007 | J Cell Physiol2007，210，1： | 1 |
| 4 | Alpha-2 adrenoceptor agonist protects retinal function after acute retinal ischemic injury in the rat显示文摘 | LAI RK CHUN T HASSON D LEE S MEHRBOD F WHEEL- ER L | 2002 | Vis Neuros- ci2002，19，2： | 1 |
| 5 | Activated pro-tein C decreases tumor necrosis factor related apoptosis-inducingligand by an EPCR-independent mechanism involving Egr-l/Erk-1/2 activation显示文摘 | O’Brien LA Richardson MA Mehrbod SF | 2007 | Arterioscler Thromb Vase Biol2007，2712，26： | 1 |
| 6 | Molecular de- terminants of FGF- 21 activity: synergy and cross-talk with PPAR7 signaling 显示文摘 | Moyers JS Shiyanova TL Mehrbod F | 2007 | J Cell Physiol2007，210，1： | 1 |
| 7 | Molecular determinants of FGF-21 aetlvity-synergy and cross-talk with PPARgamma signaling显示文摘 | Moyers J S Shiyanova T L Mehrbod F etal | 2007 | J Cell Physiol2007，210，1： | 1 |
| 8 | Molecular de- terminants of FGF- 21 activity-synergy and cross-talk with PPARgamma signaling 显示文摘 | Moyers JS Shiyanova TL Mehrbod F | 2007 | J Cell Physiol2007，210，： | 1 |
| 9 | Molecular determinants of FGF-21 activity-synergy and cross-talk with PPARgamma signaling显示文摘 | Moyers J S Shiyanova T L Mehrbod F | 2007 | J Cell Physiol2007，210，1： | 1 |
| 10 | Attenuation of influenza virus infectivity with herbal-marine compound (HESA-A):an in vitro study in MDCK cells显示文摘 | Mehrbod P Ideris A Omar AR | | 0，，： | 1 |
| 11 | Molecular determinants ofFGF-21 activity-synergy and cross-talk with PPAR Signaling 显示文摘 | Moyers JS Shiyanova TL Mehrbod F | 2007 | J Cell Physio12007，210，： | 1 |
| 12 | Molecular determi-nants of FGF-activity-synergy and cross-talk with PPAR gamma signaling显示文摘 | Moyers JS Shiyanova TL Mehrbod F et a1 | | Ceil Physiol0，，： | 1 |
| 13 | Molecular deter- minants of FGF-21 acfivity-synergy and cross-talk with PPARgmmr signaling显示文摘 | Moyers JS Shiyanova TL Mehrbod F | 2007 | J Cell Physiol2007，210，1： | 1 |
| 14 | Activated protein C decreases tumor necrosis factor related apoptosisinducing ligand by an EPCR-independent mechanism involving Egr-1/Erk-1/2 activation显示文摘 | O'Brien LA Richardson MA Mehrbod SF | | 0，，： | 1 |
| 15 | SPQD14110400009006显示文摘 | Chan Yee Kwan Estaki Mehrbod Gibson Deanna L | 2013 | Annals of Nutrition & Metabolism2013，，： | 1 |
| 16 | Activated protein C decreases tumor necrosis factor related apoptosis - inducing ligand by an EPCR independent mechanism involving Egr - 1/Erkl/2 activation 显示文摘 | O'Brien LA Richardson MA Mehrbod SF | 2007 | Arterioscler Thromb Vasc Biol2007，27，12： | 1 |
| 17 | Molecular determinants of FGF-21 activity-synergy and cross-talk with PPAR-gamma signaling 显示文摘 | Moyers JS Shiyanova TL Mehrbod F | 2007 | J Cell Physiol2007，210，： | 1 |
| 18 | Molecular determinants of FGF-21 activity-synergy and cross-talk with PPAR gamma signaling 显示文摘 | Moyers JS Shiyanova TL Mehrbod F | 2007 | J Cell Physiol2007，210，6： | 1 |
| 19 | Molecular de- terminants of FGF-21 activity-synergy and cross-talk with PPARY signaling 显示文摘 | Moyers JS Shiyanova TL Mehrbod F | 2007 | J Cell Physiol2007，210，1： | 1 |
| 20 | On the activation of integrin alphaIIbbeta3:outside-in and inside-out pathways显示文摘 | Mehrbod M Trisno S Mofrad MR | 2013 | Biophys J2013，105，6： | 1 |
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