|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Molecular targets in the treatment of alcoholic hepatitis显示文摘Alcohol related costs to health and society are high. One of the most serious complications of alcohol misuse to the individual is the development of alcoholic hepatitis (AH), a clinical syndrome of jaundice and progressive inflammatory liver injury in patients with a history of recent heavy alcohol use. It has a poor outcome and few existing successful therapies. The use of glucocorticoids in patients with severe AH is still controversial and there remains a group of patients with glucocorticoid-resistant disease. However, as our understanding of the pathogenesis of the condition improves there are opportunities to develop new targeted therapies with specific actions to control liver inflammation without having a detrimental effect on the immune system as a whole. In this article we review the molecular mechanisms of AH concentrating on the activation of the innate and adaptive immune response. We consider existing treatments including glucocorticoids, anti-tumor necrosis factor therapy and pentoxifylline and their limitations. Using our knowledge of the disease pathogenesis we discuss possible novel therapeutic approaches. New targets include pro-inflammatory cytokines such as interleukin (IL)-17, chemokines and their receptors (for example IL-8, CXCL9 and CXCR3) and augmentation of anti-inflam- matory molecules such as IL-10 and IL-22. And there is also future potential to consider combination therapy to selectively modulate the immune response and gain control of disease. | Ashwin D Dhanda Richard WL Lee Peter L Collins C Anne McCune | 2012 | World Journal of Gastroenterology2012，18，39： | 9 |
| 2 | Is liver biopsy necessary in the management of alcoholic hepatitis?显示文摘Acute alcoholic hepatitis(AAH)is characterised by deep jaundice in patients with a history of heavy alcohol use,which can progress to liver failure.A clinical diagnosis of AAH can be challenging to make in patients without a clear alcohol history or in the presence of risk factors for other causes of acute liver failure.Other causes of acute on chronic liver failure such as sepsis or variceal haemorrhage should be considered.Liver biopsy remains the only reliable method to make an accurate diagnosis.However,there is controversy surrounding the use of liver biopsy in patients with AAH because of the risks of performing a percutaneous biopsy and limitations in access to transjugular biopsy.We review the existing literature and find there are few studies directly comparing clinical and histological diagnosis of AAH.In the small number of studies that have been conducted the correlation between a clinical and histological diagnosis of AAH is poor.Due to this lack of agreement together with difficulties in accessing transjugular liver biopsy outside tertiary referral centres and research institutions,we cannot advocate universal biopsy for AAH but there remains a definite role for liver biopsy where there is clinical diagnostic doubt or dual pathology.Italso adds value in a clinical trial context to ensure a homogeneous trial population and to further our understanding of the disease pathology.Further prospective studies are required to determine whether non-invasive markers can be used to accurately diagnose AAH. | Ashwin D Dhanda Peter L Collins C Anne McCune | 2013 | World Journal of Gastroenterology2013，19，44： | 4 |
| 3 | Endoscopic canulation of the ampulla of vater: a preliminary report显示文摘 | McCune WS Shorb PE Moscovitz H | 1968 | Ann Surg1968，167，5： | 1 |
| 4 | Comparative osteology of the Danio ( Cyp- rinidae: Ostariophysi) axial skeleton with comments on Danio rela- tionships based on molecules and morphology显示文摘 | Sanger T J McCune A R | 2002 | Zoological Journal of the Linnean Society2002，135，： | 1 |
| 5 | The TGF-alpha precursor expressed on the cell surface binds to the EGF receptor on adjacent cells,leading to signal transduction显示文摘 | Wong S T Winchell L F McCune B K | 1989 | Cell1989，56，3： | 1 |
| 6 | Using Epiphytic Macrolichen Communities for Biomonitoring Ammonia in Forests of the Greater Sierra Nevada, California显示文摘 | Sarah Jovan Bruce Mccune | 2006 | Water Air and Soil Pollution (-)2006，，1： | 1 |
| 7 | Adjunctive GnRHa treatment attenuates depletion of ovarian reserve associat- ed with cyclophosphamide therapy in pre-menopausal SLE patients 显示文摘 | Marder W McCune WJ Wang L | 2012 | Gynecology Endocrinol2012，28，8： | 1 |
| 8 | Renal cell carcinoma treated by vaccines for active specific immunotherapy: correlation of survival with skin testing by autologous tumor cell显示文摘 | McCune C S O'Donnell R W Marquis D M | 1990 | Cancer Immunol Immunother1990，32，： | 1 |
| 9 | Maternal and fetal outcome in neonatal lupus erythematosus 显示文摘 | McCune AB Weston WL Lee LA | 1987 | Ann Intern Med1987，106，4： | 1 |
| 10 | Regulation of pineal alpha1B -adrenergic receptor mRNA: day/night rhythm and beta- adrenergic receptor/cyclic AMP control 显示文摘 | Coon SL McCune SK Sugden D | 1997 | Mol Pharmacol1997，51，4： | 1 |
| 11 | Spontaneous gastric rupture in the newborn 显示文摘 | Bayatpour M Bernard L McCune F | 1979 | Ant J Surg1979，137，2： | 1 |
| 12 | Characterization of copper layers produced by cold gas-dynamic spraying 显示文摘 | Donlon W T Popoola O O | 2000 | Journal of Thermal Spray Technology2000，9，1： | 1 |
| 13 | Magnitude and frequency of debris flows 显示文摘 | Johnson P A McCune R H Hromadka T V | 1991 | Journal of Hydrology1991，123，： | 1 |
| 14 | Quantitative reversed-phase high-performance liquid chromatography of major and modified nucleosides in DNA显示文摘 | Gehrke CW McCune RA Gama-Sosa MA | 1984 | J Chromatogr1984，301，1： | 1 |
| 15 | Acidization Ⅲ- The Kinetics of the Dissolution of Sodium and Potassium Feldspar in HF/HCI Acid Mixtures 显示文摘 | Fogler H S Lund K McCune C C | 1975 | Chemical Engineering Science1975，30，： | 1 |
| 16 | Ondansetron, prochlorpera- zine, and dexamethasone have similar effects on prevention of de-layed chemotherapy - induced nausea and vomiting 显示文摘 | Lindley C Goodin S McCune J | 2006 | Cancer Treatment Reviews2006，32，： | 1 |
| 17 | Comparative osteology of the Danio (Cyprinidae:Ostariophysi) axial skeleton with comments on Danio relationships based on molecules and morphology显示文摘 | Sanger T J McCune A R | 2002 | Zoological Journal of the Linnean Society2002，135，： | 1 |
| 18 | Population pharmacokinetics of cyclophosphamideand metabolites in children with neuroblastoma: a report from the Children's Oncology Group 显示文摘 | McCune JS Salinger DH Vicini P | 2009 | J Clin Pharmacol2009，49，1： | 1 |
| 19 | hnmunosuppressive drug therapy of systemic lupus erythematosus 显示文摘 | Fox D A McCune W J | 1994 | Rheum Dis Clin North Am1994，20，1： | 1 |
| 20 | Osteodystrophia fibrosa: report of a case in which condition was combined with precocious puberty, pathologic pigmentation of skin and hyperthyroidism, with a review of the literature 显示文摘 | McCune DJ Bruch H | 1937 | Am J Dis Child1937，54，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员